@article { author = {Foroutan, Hamid Reza and Hosseini, A.H. and Dehghani, S.M. and Banani, S.A. and Bahador, A. and Haghighat, M. and Imanieh, M.H. and Jalli, R. and Gheisari, F.}, title = {Peri-Operative High-Dose v Post-Operative Low Dose Steroid Therapy in the Management of Biliary Atresia: a Preliminary Report}, journal = {Iranian Journal of Medical Sciences}, volume = {33}, number = {2}, pages = {79-83}, year = {2008}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: The use of high-dose steroid therapy peri portoenterostomy may have a positive impact on the frequency of cholangitis and survival rate. Methods: A prospective study was conducted on two groups of patients (less than three months of age) suffering from biliary atresia from 1999 to 2005. The patients in group I (G I) were managed peri-operatively by high-dose methylprednisolone while the other group (G II) received low dose methylprednisolone only post-operatively (2mg/k/day for 1 month). Infants in GI (n=30) received methylprednisolone for 3 successive days before operation (10-8-6mg/kg/day), and 10 mg/k at the day of operation respectively. Thereafter the dose was tapered in the next successive 6 days by 8, 6, 5, 4, 3, and 2 mg/kg/day and continued for one month. Results: Seventy two infants with biliary atresia were operated (39 girls and 33 boys). Twenty-six of the 30 patients (86%) in G I became jaundice-free within 90 days after portoenterostomy while only seven (15%) of the 42 patients in G II had normal bilirubin (p <0.0001). Episodes of postoperative cholangitis in G I were 20% (6 of 30), and 53% (24 of 42) in G II (p <0.005). The difference in 3-year survival rate between the two groups is also remarkable: Eighty seven percent (26 of 30) in GI versus 29% (13 of 45) in G II (p <0.005). Death related to biliary atresia occurred in 1 (3.3%) patient in GI compared with 12 (29%) patients in G II (p <0.005). Conclusion: These results provide strong evidence that peri-operative high dose steroid therapy is not only safe in this patients population, but because of its anti-inflammatory and cholerrhetic effects has a positive impact on preventing recurrent cholangitis, and ultimately survival.}, keywords = {Biliary atresia,Cholangitis,steroid}, url = {https://ijms.sums.ac.ir/article_39823.html}, eprint = {https://ijms.sums.ac.ir/article_39823_42019e5d44e06db7416823cf48928279.pdf} }