@article { author = {Karimi, Mehran and Panahandeh Shahraki, Golam Reza and Yavarian, Majid and Afrasiabi, Abdolreza and Dehbozorgian, Javad and Bordbar, Mohammadreza and Mannucci, Pier M.}, title = {Frequency of Factor V Leiden and Prothrombin Polymorphism in South of Iran}, journal = {Iranian Journal of Medical Sciences}, volume = {34}, number = {2}, pages = {137-140}, year = {2009}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of these mutations in a group of the population of southern Iran. In total, 198 healthy volunteers with the age range of 1-64 years were selected and screened for factor V Leiden and prothrombin mutations using polymerase chain reaction and restriction fragment length polymorphism techniques. The carrier frequencies for factor V Leiden and prothrombin mutation in the studied cohort were 4.1% and 3.07%, respectively.In the studied area, the allele frequency of factor V is higher than the prothrombin G20210A mutation (0.0204 v 0.0153). According to the data and Hardy-Weinberger equation, the total risk of thrombosis caused by homozygosity and heterozygosity of factor V Leiden, prothrombin G20210A mutation and compound heterozygosity of these mutations are about 1 in 500 individuals.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_39871.html}, eprint = {https://ijms.sums.ac.ir/article_39871_1c1ba4c8143cf38e9968b7263aed239d.pdf} }