ORIGINAL_ARTICLE
Nutritional Assessment in Critically Ill Patients
Background: Malnutrition is an important factor in the survival of critically ill patients. The purpose of the present study was to assess the nutritional status of patients in the intensive care unit (ICU) on the days of admission and discharge via a detailed nutritional assessment. Methods: Totally, 125 patients were followed up from admission to discharge at 8ICUs in Shiraz, Iran. The patients’ nutritional status was assessed using subjective global assessment (SGA), anthropometric measurements, biochemical indices, and body composition indicators. Diet prescription and intake was also evaluated.Results: Malnutrition prevalence significantly increased on the day of discharge (58.62%) compared to the day of admission (28.8%) according to SGA (p <0.001). The patients’ weight, mid-upper-arm circumference, mid-arm muscle circumference, triceps skinfold thickness, and calf circumference decreased significantly as well (p <0.001). Lean mass weight and body cell mass also decreased significantly (p <0.001). Biochemical indices showed no notable changes except for magnesium, which decreased significantly (P=0.013). A negative significant correlation was observed between malnutrition on discharge day and anthropometric measurements. Positive and significant correlations were observed between the number of days without enteral feeding, days delayed from ICU admission to the commencement of enteral feeding, and the length of ICU stay and malnutrition on discharge day. Energy and protein intakes were significantly less than the prescribed diet (26.26% and 26.48%, respectively).Conclusion: Malnutrition on discharge day increased in the patients in the ICU according to SGA. Anthropometric measurements were better predictors of the nutritional outcome of our critically ill patients than were biochemical tests.
https://ijms.sums.ac.ir/article_40350_2e1adeb5a72ef561d6c5d5a1f5f6568f.pdf
2016-05-01
171
179
10.30476/ijms.2016.40350
Malnutrition
Critical illness
Intensive care unit
Anthropometry
Nutrition assessment
Najmeh
Hejazi
najmehhejazi@gmail.com
1
Nutrition and Food Sciences Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
zohreh
Mazloom
zohreh_mazloom@yahoo.com
2
Nutrition and Food Sciences Research Center, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Farid
Zand
zandf@sums.ac.ir
3
Shiraz Anesthesiology and Critical Care Research Center, Department of Anesthesia, Nemazee Teaching Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Abbas
Rezaianzadeh
4
Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Afshin
Amini
afshinaminie@gmail.com
5
Department of Anesthesia, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Vice Chancellor for Clinical Affairs, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
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40
ORIGINAL_ARTICLE
Effects of Arbutin on Radiation-Induced Micronuclei in Mice Bone Marrow Cells and It's Definite Dose Reduction Factor
Background: Interactions of free radicals from ionizing radiation with DNA can induce DNA damage and lead to mutagenesis and carsinogenesis. With respect to radiation damage to human, it is important to protect humans from side effects induced by ionizing radiation.In the present study, the effects of arbutin were investigated by using the micronucleus test for anti-clastogenic activity, to calculate the ratio of polychromatic erythrocyte to polychromatic erythrocyte plus normochromatic erythrocyte (PCE/PCE+NCE) in order to show cell proliferation activity.Methods: Arbutin (50, 100, and 200 mg/kg) was intraperitoneally (ip) administered to NMRI mice two hours before gamma radiation at 2 and 4 gray (Gy). The frequency of micronuclei in 1000 PCEs (MnPCEs) and the ratio of PCE/PCE+NCE were calculated for each sample. Data were statistically evaluated using one-way ANOVA, Tukey HSD test, and t-test.Results: The findings indicated that gamma radiation at 2 and 4 Gy extremely increased the frequencies of MnPCE (P<0.001) while reducing PCE/PCE+NCE (P<0.001) compared to the control group. All three doses of arbutin before irradiation significantly reduced the frequencies of MnPCEs and increased the ratio of PCE/PCE+NCE in mice bone marrow compared to the non-drug-treated irradiated control (P<0.001). All three doses of arbutin had no toxicity effect on bone marrow cells. The calculated dose reduction factor (DRF) showed DRF=1.93 for 2Gy and DRF=2.22 for 4 Gy.Conclusion: Our results demonstrated that arbutin gives significant protection to rat bone against the clastogenic and cytotoxic effects of gamma irradiation.
https://ijms.sums.ac.ir/article_40353_39056d98c28390d06d1433068bb01f56.pdf
2016-05-01
180
185
Gamma rays
Micronucleus tests
Erythrocytes
Bone marrow cell
Arbutin
Radiation protective agents
Saba
Nadi
1
Department of Radiobiology and Radiation Protection, Babol University of Medical Sciences, Babol, Iran
AUTHOR
Ali
Shabestani Monfared
2
Cellular & Molecular Biology Research Center, Department of Medical physics, Babol University of Medical Sciences, Babol, Iran
LEAD_AUTHOR
Hossein
Mozdarani
mozdarah@modares.ac.ir
3
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
AUTHOR
Aziz
Mahmodzade
4
Laboratory of Cytogenetic, Novin Medical Radiation Institute, Tehran, Iran
AUTHOR
Mahdi
Pouramir
5
Department of Biochemistry, Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
AUTHOR
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1
- Lenarczyk M, Goddu SM, Rao DV, Howell RW. Biologic dosimetry of bone marrow: induction of micronuclei in reticulocytes after exposure to 32P and 90Y. J Nucl Med. 2001;42:162-9. PubMed PMID: 11197968.
2
- Watanabe N, Kanegane H, Kinuya S, Shuke N, Yokoyama K, Kato H, et al. The radiotoxicity of 131I therapy of thyroid cancer: assessment by micronucleus assay of B lymphocytes. J Nucl Med. 2004;45:608-11. PubMed PMID: 15073256.
3
- Eberlein U, Haenscheid H, Biko J, Reiners C, Lassmann M. Blood-based dosimetry and the formation of micronuclei in thyroid cancer patients. J Nucl Med. 2012;53:1498.
4
- Fenech M. Cytokinesis-block micronucleus cytome assay. Nat Protoc. 2007;2:1084-104. doi: 10.1038/nprot.2007.77. PubMed PMID: 17546000.
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- Tsai MH, Hwang JS, Chen KC, Lin YP, Hsieh WA, Chang WP. Dynamics of changes in micronucleus frequencies in subjects post cessation of chronic low-dose radiation exposure. Mutagenesis. 2001;16:251-5. doi: 10.1093/mutage/16.3.251. PubMed PMID: 11320151.
6
- Cardoso R, TakahashiâHyodo S, Peitl P, GhilardiâNeto T, SakamotoâHojo E. Evaluation of chromosomal aberrations, micronuclei, and sister chromatid exchanges in hospital workers chronically exposed to ionizing radiation. Teratog., Carcinog. Mutagen.. 2001;21:431-9. doi: 10.1002/tcm.1030.
7
- Lubsandorzhieva P, Zhigzhitov B, Dargaeva T, Bazarova ZG, Nagaslaeva L. Chromatospectrophotometric determination of arbutin in the leaves of Bergenia crassifolia (L.) Fritsch. Pharmaceutical Chemistry Journal. 2000;34:261-4.
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- Kang MJ, Ha HW, Kim HG, Lee DH, Kong MJ, Ahn YT, et al. Role of metabolism by intestinal bacteria in arbutin-induced toxicity in vitro. Arch Pharm Res. 2011;34:687-93. doi: 10.1007/s12272-011-0420-9. PubMed PMID: 21544735.
10
- Schmid W. The micronucleus test. Mutat Res. 1975;31:9-15. doi: 10.1016/0165-1161(75)90058-8. PubMed PMID: 48190.
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- Hosseinimehr SJ, Tavakoli H, Pourheidari G, Sobhani A, Shafiee A. Radioprotective effects of citrus extract against gamma-irradiation in mouse bone marrow cells. J Radiat Res. 2003;44:237-41. PubMed PMID: 14646227.
12
- Wallner M, Blassnigg SM, Marisch K, Pappenheim MT, Mullner E, Molzer C, et al. Effects of unconjugated bilirubin on chromosomal damage in individuals with Gilbert's syndrome measured with the micronucleus cytome assay. Mutagenesis. 2012;27:731-5. doi: 10.1093/mutage/ges039. PubMed PMID: 22874647.
13
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14
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15
- Thierens H, Vral A, Morthier R, Aousalah B, De Ridder L. Cytogenetic monitoring of hospital workers occupationally exposed to ionizing radiation using the micronucleus centromere assay. Mutagenesis. 2000;15:245-9. doi: 10.1093/mutage/15.3.245. PubMed PMID: 10792018.
16
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18
- Shahidi M, Mozdarani H. Potent radioprotective effect of therapeutic doses of ranitidine and famotidine against gamma-rays induced micronuclei in vivo. Iran J Radiat Res. 2003;1:29-35.
19
- Shokrzadeh M, Naghshvar F, Ahmadi A, Chabra A, Jeivad F. The potential ameliorative effects of melatonin against cyclophosphamide-induced DNA damage in murine bone marrow cells. Eur Rev Med Pharmacol Sci. 2014;18:605-11. PubMed PMID: 24668699.
20
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21
Pavlovic RD, Lakusic B, Doslov-Kokorus Z, Kovacevic N. Arbutin content and antioxidant activity of some Ericaceae species. Pharmazie. 2009;64:656-9. PubMed PMID: 19947168.
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- Lukas B, Schmiderer C, Mitteregger U, Novak J. Arbutin in marjoram and oregano. Food Chemistry. 2010;121:185-90. doi: 10.1016/j.foodchem.2009.12.028.
24
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- Mazur L. Radioprotective effects of the thiols GSH and WR-2721 against X-ray-induction of micronuclei in erythroblasts. Mutat Res. 2000;468:27-33. doi: 10.1016/S1383-5718(00)00037-1. PubMed PMID: 10863155.
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- Mozdarani H, Gharbali A. Radioprotective effects of cimetidine in mouse bone marrow cells exposed to gamma-rays as assayed by the micronucleus test. Int J Radiat Biol. 1993;64:189-94. PubMed PMID: 8103543.
28
- Cheng SL, Liu RH, Sheu JN, Chen ST, Sinchaikul S, Tsay GJ. Toxicogenomics of A375 human malignant melanoma cells treated with arbutin. J Biomed Sci. 2007;14:87-105. doi: 10.1007/s11373-006-9130-6. PubMed PMID: 17103032.
29
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30
ORIGINAL_ARTICLE
Comparison of Auditory Perception in Cochlear Implanted Children with and without Additional Disabilities
Background: The number of children with cochlear implants who have other difficulties such as attention deficiency and cerebral palsy has increased dramatically. Despite the need for information on the results of cochlear implantation in this group, the available literature is extremely limited. We, therefore, sought to compare the levels of auditory perception in children with cochlear implants with and without additional disabilities.Methods: A spondee test comprising 20 two-syllable words was performed. The data analysis was done using SPSS, version 19.Results: Thirty-one children who had received cochlear implants 2 years previously and were at an average age of7.5 years were compared via the spondee test. From the 31 children,15 had one or more additional disabilities. The data analysis indicated that the mean score of auditory perception in this group was approximately 30 scores below that of the children with cochlear implants who had no additional disabilities.Conclusion: Although there was an improvement in the auditory perception of all the children with cochlear implants, there was a noticeable difference in the level of auditory perception between those with and without additional disabilities. Deafness and additional disabilities depended the children on lip reading alongside the auditory ways of communication. In addition, the level of auditory perception in the children with cochlear implants who had more than one additional disability was significantly less than that of the other children with cochlear implants who had one additional disability.
https://ijms.sums.ac.ir/article_40356_f27a63ff9b9255fd6b1ce60473a24374.pdf
2016-05-01
186
190
Cochlear implant
Auditory perception
Disabilities
Child
Seyed Basir
Hashemi
1
Department of Otorhinolaryngology, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Leila
Monshizadeh
lmon1008@yahoo.com
2
Department of Speech Therapy, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
- Edwards LC. Children with cochlear implants and complex needs: a review of outcome research and psychological practice. J Deaf Stud Deaf Educ. 2007;12:258-68. doi: 10.1093/deafed/enm007. PubMed PMID: 17493953.
1
-Gallaudet Research Institute.Annual Survey of Deaf and Hard of Hearing Children & Youth. Washington: Gallaudet Research Institute; 2003. p. 336-49.
2
- Diefendorf AO. Behavioral audiometry with children. In: Seewald RC, Tharpe AM, editors. Comprehensive Handbook of Pediatric Audiology. San Diego: Plural Pub; 2011.p. 497-510.
3
- Lachowska M, Rozycka J, Lukaszewicz Z, Konecka A, Niemczyk K. Auditory skills in multi-handicapped children with cochlear implants. Otolaryngol Pol. 2010;64:22-6. doi: 10.1016/S0030-6657(10)70004-4. PubMed PMID: 21171306.
4
- Youm HY, Moon IJ, Kim EY, Kim BY, Cho YS, Chung WH, et al. The auditory and speech performance of children with intellectual disability after cochlear implantation. Acta Otolaryngol. 2013;133:59-69. doi: 10.3109/00016489.2012.720031. PubMed PMID: 23066719.
5
- Kreisman BM, John AB. A case law review of the individuals with disabilities education act for children with hearing loss or auditory processing disorders. J Am Acad Audiol. 2010;21:426-40. doi: 10.3766/jaaa.21.7.2. PubMed PMID: 20807479.
6
-Diefendorf AO. Behavioral hearing assessment: Considerations for the young child with developmental disabilities. Semin Hear. 2003:24;189-200.
7
-Roush J, Holcomb MA, Roush PA, Escolar ML. When hearing loss occurs with multiple disabilities. Semin Hear. 2004;25:333-45.doi: 10.1055/s-2004-836135.
8
-Hashemi S, Monshizadeh L. The quality of life in pre-lingual deaf children after 1.5 years of cochlear implantation from the point of view of parents in Shiraz, Iran. Iran Red Crescent Med J. 2011;13:431.
9
- Hashemi SB, Monshizadeh L. The effect of cochlear implantation in development of intelligence quotient of 6-9 deaf children in comparison with normal hearing children (Iran, 2009-2011). Int J Pediatr Otorhinolaryngol. 2012;76:802-4. doi: 10.1016/j.ijporl.2012.02.046. PubMed PMID: 22418074.
10
- Hashemi SB, Monshizadeh L. A comparison between the mothers of cochlear implanted children and mothers of children with hearing aid in the level of depression, anxiety and stress. Biomedical and Pharmacology Journal. 2012;5:241-5.doi: 10.13005/bpj/350.
11
- Palmieri M, Berrettini S, Forli F, Trevisi P, Genovese E, Chilosi AM, et al. Evaluating benefits of cochlear implantation in deaf children with additional disabilities. Ear Hear. 2012;33:721-30. doi: 10.1097/AUD.0b013e31825b1a69. PubMed PMID: 22785571.
12
-Corrales CE, Oghalai JS. Cochlear implant considerations in children with additional disabilities. Curr Otorhinolaryngol Rep. 2013;1:61-8. doi: 10.1007/s40136-013-0011-z.
13
- Pyman B, Blamey P, Lacy P, Clark G, Dowell R. The development of speech perception in children using cochlear implants: effects of etiologic factors and delayed milestones. Otol Neurotol. 2000;21:57-61. doi: 10.1016/S0196-0709(00)80113-1.
14
- Fukuda S, Fukushima K, Maeda Y, Tsukamura K, Nagayasu R, Toida N, et al. Language development of a multiply handicapped child after cochlear implantation. Int J Pediatr Otorhinolaryngol. 2003;67:627-33. doi: 10.1016/S0165-5876(03)00016-8.PubMed PMID: 12745156.
15
- Holt RF, Kirk KI. Speech and language development in cognitively delayed children with cochlear implants. Ear Hear. 2005;26:132-48. doi: 10.1097/00003446-200504000-00003.PubMed PMID: 15809541.
16
- Waltzman SB, Scalchunes V, Cohen NL. Performance of multiply handicapped children using cochlear implants. Am J Otol. 2000;21:329-35. doi: 10.1016/S0196-0709(00)80040-X.PubMed PMID: 10821544.
17
- Shinghal T, Cushing S, Gordon KA, Huber JF, Lee J, Papsin B. Seizure activity following cochlear implantation: is it the implant? Int J Pediatr Otorhinolaryngol. 2012;76:704-7. doi: 10.1016/j.ijporl.2012.02.024. PubMed PMID: 22386273.
18
- Meinzen-Derr J, Wiley S, Grether S, Choo DI. Language performance in children with cochlear implants and additional disabilities. Laryngoscope. 2010;120:405-13. doi: 10.1002/lary.20728. PubMed PMID: 19950380.
19
- Bacciu A, Pasanisi E, Vincenti V, Ormitti F, Di Lella F, Guida M, et al. Cochlear implantation in children with cerebral palsy. A preliminary report. Int J Pediatr Otorhinolaryngol. 2009;73:717-21. doi: 10.1016/j.ijporl.2009.01.010. PubMed PMID: 19201488.
20
- Hamzavi J, Baumgartner WD, Egelierler B, Franz P, Schenk B, Gstoettner W. Follow up of cochlear implanted handicapped children. Int J Pediatr Otorhinolaryngol. 2000;56:169-74. doi: 10.1016/S0165-5876(00)00420-1.PubMed PMID: 11137590.
21
- Daneshi A, Hassanzadeh S. Cochlear implantation in prelingually deaf persons with additional disability. J Laryngol Otol. 2007;121:635-8. doi: 10.1017/S0022215107005051. PubMed PMID: 17147840.
22
ORIGINAL_ARTICLE
Usage Pattern and Serum Level Measurement of Amikacin in the Internal Medicine Ward of the Largest Referral Hospital in the South of Iran: A Pharmacoepidemiological Study
Background: The inappropriate use of aminoglycosides has harmful effects such as the development of resistant pathogens and the incidence of nephrotoxicity and ototoxicity. Therefore, drug utilization evaluation of these drugs may improve their usage remarkably. The aim of this study was to assess the usage pattern of amikacin in an internal medicine ward.Methods: This cross-sectional study was conducted in the Internal Medicine Ward of Nemazee Teaching Hospital, Shiraz, Iran, in 2011. The guideline for amikacin use was approved by the institutional Pharmacy and Therapeutics Committee, and the study criteria were developed to assess several parameters involved in amikacin therapy such as appropriateness of drug use, dosage, duration of therapy, toxicity monitoring, and serum concentration assay. Serum concentration was assayed using a Cobas Mira AutoAnalyzer. Clinical and paraclinical parameters such as glomerular filtration rate, culture, microbial sensitivity, white blood cell count, and fever were collected.Results: Sixty-three patients were evaluated. Fifty-seven percent of the patients needed dose readjustment; however, it was not performed for 89% of them. Culture between48 and 72 hours after amikacin administration was not controlled for 79% of the patients. In 19% of the patients, optimum therapeutic effect was not achieved. The mean±SD of the trough and peak concentrations was 7.63±5.4 μg/mL and 15.67±7.79 μg/mL, respectively. Forty-five percent of the trough and 38% of the peak levels were within the therapeutic range. The overall adherence of amikacin usage to the guideline was only 48%.Conclusion: To achieve appropriate treatment and prevent toxic effects, we recommend that pharmacokinetic dosing methods, amikacin guideline, and serum monitoring be considered.
https://ijms.sums.ac.ir/article_40359_ba6642964d485d3de82117d6a6435b7b.pdf
2016-05-01
191
199
Guideline
Amikacin
Drug utilization review
Soha
Namazi
namazisoha@yahoo.com
1
Department of Pharmacotherapy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Mohammad Mahdi
Sagheb
saghebf@gmail.com
2
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mohammad Mahdi
Hashempour
hashempourmm@gmail.com
3
Department of Pharmacotherapy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Arman
Sadatsharifi
armansh28@yahoo.com
4
Department of Pharmacotherapy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
WHO Expert Committee. The selection of essential drugs. Geneva: World Health Organization; 1977. 36 p.
1
Sathvik B. Drug Utilisation Review/Evaluation. In: Parthasarathi G, Nyfort-Hansen K, Nahata MC, editors. A Text Book of Clinical Pharmacy Practice: Essential Concepts and Skills. India: Orient Longman; 2004. p. 362-75.
2
Niederman MS. Appropriate use of antimicrobial agents: challenges and strategies for improvement. Crit Care Med. 2003;31:608-16. doi: 10.1097/01.CCM.0000050464.70382.D6. PubMed PMID: 12576973.
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Edson RS, Terrell CL. The aminoglycosides. Mayo Clin Proc. 1999;74:519-28. doi: 10.4065/74.5.519. PubMed PMID: 10319086.
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Ramesh M, John S, Narayanappa D. Audit of aminoglycosides usage. Indian J Pediatr. 2002;69:385-8. doi: 10.1007/BF02722623.PubMed PMID: 12061669.
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Shrimpton SB, Milmoe M, Wilson AP, Felmingham D, Drayan S, Barrass C, et al. Audit of prescription and assay of aminoglycosides in a UK teaching hospital. J Antimicrob Chemother. 1993;31:599-606. doi: 10.1093/jac/31.4.599.PubMed PMID: 8514654.
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41
ORIGINAL_ARTICLE
Anticonvulsant Effect of the Aqueous Extract and Essential Oil of Carum Carvi L Seeds in a Pentylenetetrazol Model of Seizure in Mice
Background: Carum carvi L. (caraway), known as black zeera in Iran, has been indicated for the treatment of epilepsy in Iranian folk medicine. This study evaluated whether the aqueous extract and essential oil of caraway seeds have anticonvulsant effects in mice.Methods: The anticonvulsant effects of the aqueous extract (200, 400, 800, 1600, and 3200 mg/kg, i.p.) and essential oil (25, 50, 100, 200, and 400 mg/kg, i.p.) of caraway were assessed using pentylenetetrazol (PTZ; 95 mg/kg i.p.) induced convulsions. Diazepam (3 mg/kg) was used as positive control. The latency time before the onset of myoclonic, clonic, and tonic convulsions and the percentage of mortality were recorded. In addition, the effect of caraway on neuromuscular coordination was evaluated using the rotarod performance test.Results: The extract and essential oil dose-dependently increased the latency time to the onset of myoclonic (ED50, 1257 and 62.2 mg/kg, respectively) and clonic (ED50, 929 and 42.3 mg/kg, respectively) seizures. The extract and essential oil of caraway prevented the animals from tonic seizure with ED50s of 2142.4 and 97.6 mg/kg, respectively. The extract and essential oil of caraway protected 28.6 and 71.4% of the animals from PTZ-induced death, respectively, and had no significant effect on neuromuscular coordination.Conclusion: This study showed that the aqueous extract and essential oil of caraway had anticonvulsant properties. However, the essential oil was more potent and effective than was the aqueous extract as an anticonvulsant. Additionally, the anticonvulsant effect of caraway was not due to a muscle relaxant activity. These findings support the acclaimed antiepileptic effect of caraway in folk medicine and propose its potential use in petit mal seizure in humans.
https://ijms.sums.ac.ir/article_40361_be7ed07a04465ffc989b9baedabd30f3.pdf
2016-05-01
200
208
Carum
Anticonvulsants
Pentylenetetrazole
Seizures
mice
Alireza
Showraki
1
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Masoumeh
Emamghoreishi
emamm@sums.ac.ir
2
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Somayeh
Oftadegan
somayeh.oftadegan@gmail.com
3
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Duncan JS, Sander JW, Sisodiya SM, Walker MC. Adult epilepsy. Lancet. 2006;367:1087-100. doi: 10.1016/S0140-6736(06)68477-8. PubMed PMID: 16581409.
1
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de Almeida RN, Agra Mde F, Maior FN, de Sousa DP. Essential oils and their constituents: anticonvulsant activity. Molecules. 2011;16:2726-42. doi: 10.3390/molecules16032726. PubMed PMID: 21441872.
4
Johri RK. Cuminum cyminum and Carum carvi: An update. Pharmacogn Rev. 2011;5:63-72. doi: 10.4103/0973-7847.79101. PubMed PMID: 22096320; PubMed Central PMCID: PMC3210012.
5
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Mirheidar H. Carum carvi. In: Application of Plants in Prevention and Treatment of Illnesses. Tehran: Office of Islamic Culture Publications; 1992.
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Iacobellis NS, Lo Cantore P, Capasso F, Senatore F. Antibacterial activity of Cuminum cyminum L. and Carum carvi L. essential oils. J Agric Food Chem. 2005;53:57-61. doi: 10.1021/jf0487351. PubMed PMID: 15631509.
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Khayyal MT, el-Ghazaly MA, Kenawy SA, Seif-el-Nasr M, Mahran LG, Kafafi YA, et al. Antiulcerogenic effect of some gastrointestinally acting plant extracts and their combination. Arzneimittelforschung. 2001;51:545-53. doi: 10.1055/s-0031-1300078. PubMed PMID: 11505785.
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Saghir MR, Sadiq S, Nayak S, Tahir MU. Hypolipidemic effect of aqueous extract of Carum carvi (black Zeera) seeds in diet induced hyperlipidemic rats. Pak J Pharm Sci. 2012;25:333-7. PubMed PMID: 22459457.
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Gorji A, Khaleghi Ghadiri M. History of epilepsy in Medieval Iranian medicine. Neurosci Biobehav Rev. 2001;25:455-61. doi: 10.1016/S0149-7634(01)00025-2. PubMed PMID: 11566482.
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Hosseinzadeh H, RAMEZANI M, Fadishei M, Basirat M. Anticonvulsant effects of Cuminium cyminum L. seeds extracts and essential oil in mice. Journal of Medicinal Plants. 2002;1.
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Sayyah M, Kamalinejad M, Bahrami Hidage R, Rustaiyan A. Antiepileptic potential and composition of the fruit essential oil of Ferula gummosa boiss. Iran Biomed J. 2001;5:69-72.
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Tosun F, Kızılay ÃA, Erol K, Kılıç FS, KürkçüoÄlu M, BaÅer KHC. Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium. Food Chem. 2008;107:990-3. doi: 10.1016/j.foodchem.2007.08.085.
19
Karimzadeh F, Hosseini M, Mangeng D, Alavi H, Hassanzadeh GR, Bayat M, et al. Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. BMC Complement Altern Med. 2012;12:76. doi: 10.1186/1472-6882-12-76. PubMed PMID: 22709243; PubMed Central PMCID: PMC3416669.
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Rezvani ME, Roohbakhsh A, Mosaddegh MH, Esmailidehaj M, Khaloobagheri F, Esmaeili H. Anticonvulsant and depressant effects of aqueous extracts of Carum copticum seeds in male rats. Epilepsy Behav. 2011;22:220-5. doi: 10.1016/j.yebeh.2011.07.017. PubMed PMID: 21849259.
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de Sousa DP, de Farias Nobrega FF, de Almeida RN. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality. 2007;19:264-8. doi: 10.1002/chir.20379. PubMed PMID: 17299731.
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Agrahari P, Singh DK. A review on the pharmacological aspects of Carum carvi. Journal of Biology and Earth Sciences. 2014;4:M1-M13.
23
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Jalali-Heravi M, Zekavat B, Sereshti H. Use of gas chromatography-mass spectrometry combined with resolution methods to characterize the essential oil components of Iranian cumin and caraway. J Chromatogr A. 2007;1143:215-26. doi: 10.1016/j.chroma.2007.01.042. PubMed PMID: 17258753.
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Salehi Surmaghi MH, Amin GhR, Kaveh Sh. Carvi fructus. In: Iranian herbal pharmacopeia, editors: Iranian herbal pharmacopeia scientific committee. 1st ed. Tehran: Iranian Ministry of Health & Medical Education Publications; 2002. p. 419-24.
27
Keshavarz M, Showraki A, Emamghoreishi M. Anticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice. Iran J Med Sci. 2013;38:116-21. PubMed PMID: 23825891; PubMed Central PMCID: PMC3700057.
28
Uma Devi P, Pillai KK, Vohora D. Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine. Fundam Clin Pharmacol. 2006;20:247-53. doi: 10.1111/j.1472-8206.2006.00401.x. PubMed PMID: 16671959.
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Sayyah M, Mahboubi A, Kamalinejad M. Anticonvulsant effect of the fruit essential oil of Cuminum cyminum in mice. Pharm Biol. 2002;40:478-80. doi: 10.1076/phbi.40.6.478.8446.
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Pourgholami MH, Majzoob S, Javadi M, Kamalinejad M, Fanaee GH, Sayyah M. The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. J Ethnopharmacol. 1999;66:211-5. doi: 10.1016/S0378-8741(98)00161-5. PubMed PMID: 10433480.
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Costa DA, de Oliveira GA, Lima TC, dos Santos PS, de Sousa DP, de Freitas RM. Anticonvulsant and antioxidant effects of cyano-carvone and its action on acetylcholinesterase activity in mice hippocampus. Cell Mol Neurobiol. 2012;32:633-40. doi: 10.1007/s10571-012-9812-8. PubMed PMID: 22373695.
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de Almeida RN, de Sousa DP, Nobrega FF, Claudino Fde S, Araujo DA, Leite JR, et al. Anticonvulsant effect of a natural compound alpha,beta-epoxy-carvone and its action on the nerve excitability. Neurosci Lett. 2008;443:51-5. doi: 10.1016/j.neulet.2008.07.037. PubMed PMID: 18657594.
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Viana GS, do Vale TG, Silva CM, Matos FJ. Anticonvulsant activity of essential oils and active principles from chemotypes of Lippia alba (Mill.) N.E. Brown. Biol Pharm Bull. 2000;23:1314-7. PubMed PMID: 11085358.
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de Sousa DP, Nobrega FF, Santos CC, de Almeida RN. Anticonvulsant activity of the linalool enantiomers and racemate: investigation of chiral influence. Nat Prod Commun. 2010;5:1847-51. PubMed PMID: 21299105.
35
Quintans-Júnior LJ, Guimarães AG, Araújo BE, Oliveira GF, Santana MT, Moreira FV, et al. Carvacrol,(-)-borneol and citral reduce convulsant activity in rodents. Afr J Biotechnol. 2013;9:6566-72.
36
Matsumura T, Ishikawa T, Kitajima J. Water-soluble constituents of caraway: carvone derivatives and their glucosides. Chem Pharm Bull (Tokyo). 2002;50:66-72. doi: 10.1248/cpb.50.66. PubMed PMID: 11824587.
37
Zhu HL, Wan JB, Wang YT, Li BC, Xiang C, He J, et al. Medicinal compounds with antiepileptic/anticonvulsant activities. Epilepsia. 2014;55:3-16. doi: 10.1111/epi.12463. PubMed PMID: 24299155.
38
ORIGINAL_ARTICLE
Inter- and Intraspecific Variations of Leishmania Strains Isolated from Patients with Cutaneous and Visceral Leishmaniases in Fars Province, South of Iran
Background: Cutaneous and visceral leishmaniases are present in Fars Province in the south of Iran. The current study aimed to evaluate the inter- and intragenic diversities of Leishmania species isolated from patients with leishmaniasis in Fars Province, using PCR-based analyses and DNA sequencing of the N-acetylglucosamine-1-phosphate transferase (nagt) gene.Methods: Clinical samples were taken from the skin lesions of 120 individuals with clinical suspicion of cutaneous leishmaniasis (CL) referred to the major health centers of Shiraz. Along with microscopic examination, a part of each sample was used for in vitro cultivation. DNA was extracted from the cultured parasites and the nagt gene was PCR-amplified. For RFLP analysis, the PCR product of the nagt gene was digested with the Acc1 restriction enzyme. Moreover, the PCR products of 23 isolates were sequenced and analyzed, using MEGA5.Results: From the 120 patients with clinical suspicion of CL, 110 (91.7%) cases were found to be positive by direct microscopy while 77 (64.1%) of the cultures were positive. Digestion of the PCR product with the Acc1 restriction enzyme detected L. major in 57 out of the 77 (74.1%) and L. tropica, in 20 out of the 77 (25.9%) cases with CL. Phylogenetic analysis grouped the Leishmania isolates into 3 main clades, representing L. major, L. infantum, and L. tropica, encompassing 2, 2, and 2 haplotypes, respectively. Within the clades, the L. tropica intraspecies divergence was more pronounced in L. major.Conclusion: The findings of this study demonstrated that the causative agent of CL in Fars Province was mainly L. major and that there was considerable heterogeneity between the Leishmania species and also within the L. major isolates.
https://ijms.sums.ac.ir/article_40362_9d1aa8fbd9242c54ee769130613eae9b.pdf
2016-05-01
209
216
Leishmaniasis
Cutaneous
Visceral
Genetic variation
Nagt gene
Iran
Bahador
Sarkari
1
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Niloofar
Bavarsad Ahmadpour
bavarsad.niloofar@yahoo.com
2
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mohammad Hossein
Motazedian
3
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Hamed
Mirjalali
bsh1392@yahoo.com
4
Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroentrology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Mohammad
Akhoundi
5
Faculty of Pharmacy, University of Reims Champagne-Ardenne, France
AUTHOR
Mehdi
Mohebali
mohebali@sina.tums.ac.ir
6
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Homa
Hajjaran
hhajjaran@yahoo.com
7
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
- Antinori S, Schifanella L, Corbellino M. Leishmaniasis: new insights from an old and neglected disease. Eur J Clin Microbiol Infect Dis. 2012;31:109-18. doi: 10.1007/s10096-011-1276-0. PubMed PMID: 21533874.
1
- Postigo JA. Leishmaniasis in the World Health Organization Eastern Mediterranean Region. Int J Antimicrob Agents. 2010;36:S62-5. doi: 10.1016/j.ijantimicag.2010.06.023. PubMed PMID: 20728317.
2
- Motazedian H, Noamanpoor B, Ardehali S. Characterization of Leishmania parasites isolated from provinces of the Islamic Republic of Iran. East Mediterr Health J. 2002;8:338-44. PubMed PMID: 15339122.
3
- Hajjaran H, Mohebali M, Mamishi S, Vasigheh F, Oshaghi MA, Naddaf SR, et al. Molecular identification and polymorphism determination of cutaneous and visceral leishmaniasis agents isolated from human and animal hosts in Iran. Biomed Res Int. 2013;2013:789326. doi: 10.1155/2013/789326. PubMed PMID: 24286085; PubMed Central PMCID: PMC3826333.
4
- Mohebali M. Visceral leishmaniasis in Iran: Review of the epidemiological and clinical features. Iran J Parasitol. 2013;8:348-58. PubMed PMID: 24454426; PubMed Central PMCID: PMC3887234.
5
- Asgari Q, Motazedian MH, Mehrabani D, Oryan A, Hatam GR, Owji SM, et al. Zoonotic cutaneous leishmaniasis in Shiraz, Southern Iran: A molecular, isoenzyme and morphologic approach. J Res Med Sci. 2007;12:7-15.
6
- Razmjou S, Hejazy H, Motazedian MH, Baghaei M, Emamy M, Kalantary M. A new focus of zoonotic cutaneous leishmaniasis in Shiraz, Iran. Trans R Soc Trop Med Hyg. 2009;103:727-30. doi: 10.1016/j.trstmh.2008.12.013. PubMed PMID: 19223055.
7
- Davami MH, Motazedian MH, Sarkari B. The changing profile of cutaneous leishmaniasis in a focus of the disease in Jahrom district, southern Iran. Ann Trop Med Parasitol. 2010;104:377-82. doi: 10.1179/136485910X12786389891083. PubMed PMID: 20819305.
8
- Oryan A, Shirian S, Tabandeh MR, Hatam GR, Randau G, Daneshbod Y. Genetic diversity of Leishmania major strains isolated from different clinical forms of cutaneous leishmaniasis in southern Iran based on minicircle kDNA. Infect Genet Evol. 2013;19:226-31. doi: 10.1016/j.meegid.2013.07.021. PubMed PMID: 23892374.
9
- Mohebali M, Edrissian GH, Shirzadi MR, Akhoundi B, Hajjaran H, Zarei Z, et al. An observational study on the current distribution of visceral leishmaniasis in different geographical zones of Iran and implication to health policy. Travel Med Infect Dis. 2011;9:67-74. doi: 10.1016/j.tmaid.2011.02.003. PubMed PMID: 21419708.
10
- Hatam GR, Adnani SJ, Asgari Q, Fallah E, Motazedian MH, Sadjjadi SM, et al. First report of natural infection in cats with Leishmania infantum in Iran. Vector Borne Zoonotic Dis. 2010;10:313-6. doi: 10.1089/vbz.2009.0023. PubMed PMID: 19492951.
11
- Sarkari B, Hatam GR, Adnani SJ, Asgari Q. Seroprevalence of feline leishmaniasis in areas of Iran where Leishmania infantum is endemic. Ann Trop Med Parasitol. 2009;103:275-7. doi: 10.1179/136485909X398276. PubMed PMID: 19341541.
12
- Sarkari B, Hatam G, Ghatee M. Epidemiological features of visceral leishmaniasis in fars province, southern iran. Iran J Public Health. 2012;41:94-9. PubMed PMID: 23113170; PubMed Central PMCID: PMC3481615.
13
- Mirzaei A, Schweynoch C, Rouhani S, Parvizi P, Schonian G. Diversity of Leishmania species and of strains of Leishmania major isolated from desert rodents in different foci of cutaneous leishmaniasis in Iran. Trans R Soc Trop Med Hyg. 2014;108:502-12. doi: 10.1093/trstmh/tru085. PubMed PMID: 24980555.
14
- Akhoundi M, Hajjaran H, Baghaei A, Mohebali M. Geographical distribution of leishmania species of human cutaneous leishmaniasis in fars province, southern iran. Iran J Parasitol. 2013;8:85-91. PubMed PMID: 23682265; PubMed Central PMCID: PMC3655245.
15
- Azizi K, Badzohreh A, Sarkari B, Fakoorziba MR, Kalantari M, Moemenbellah-Fard MD, et al. Nested polymerase chain reaction and sequence- based detection of leishmania infection of sand flies in recently emerged endemic focus of zoonotic cutaneous leishmaniasis, southern iran. Iran J Med Sci. 2013;38:156-62. PubMed PMID: 24031105; PubMed Central PMCID: PMC3771217.
16
- Davami MH, Motazedian MH, Kalantari M, Asgari Q, Badzohre A, Mohammadpour I. First microscopical and molecular-based characterization of Leishmania major within naturally infected Phlebotomus salehi (Diptera; Psychodidae) in Fars province, southern Iran. Ann Trop Med Parasitol. 2011;105:485-91. doi: 10.1179/1364859411Y.0000000037. PubMed PMID: 22185942; PubMed Central PMCID: PMC4100315.
17
- Fakhar M, Mikaeili F, Hatam G, Habibi P, Karamian M, Motazedian M, et al. A molecular epidemiology survey of cutaneous leishmaniasis in patient referring to parasitology lab at shiraz school of medicine and the importance of pcr assay. jjums. 2010; 8:1-6.
18
- Motazedian H, Karamian M, Noyes HA, Ardehali S. DNA extraction and amplification of leishmania from archived, Giemsa-stained slides, for the diagnosis of cutaneous Leishmaniasis by PCR. Ann Trop Med Parasitol. 2002;96:31-4. doi: 10.1179/000349802125000484. PubMed PMID: 11989531.
19
- Schonian G, Kuhls K, Mauricio IL. Molecular approaches for a better understanding of the epidemiology and population genetics of Leishmania. Parasitology. 2011;138:405-25. doi: 10.1017/S0031182010001538. PubMed PMID: 21078222.
20
- Schonian G, Nasereddin A, Dinse N, Schweynoch C, Schallig HD, Presber W, et al. PCR diagnosis and characterization of Leishmania in local and imported clinical samples. Diagn Microbiol Infect Dis. 2003;47:349-58. doi: 10.1016/S0732-8893(03)00093-2. PubMed PMID: 12967749.
21
- Reithinger R, Dujardin JC. Molecular diagnosis of leishmaniasis: current status and future applications. J Clin Microbiol. 2007;45:21-5. doi: 10.1128/JCM.02029-06. PubMed PMID: 17093038; PubMed Central PMCID: PMC1828971.
22
- Waki K, Dutta S, Ray D, Kolli BK, Akman L, Kawazu S, et al. Transmembrane molecules for phylogenetic analyses of pathogenic protists: Leishmania-specific informative sites in hydrophilic loops of trans- endoplasmic reticulum N-acetylglucosamine-1-phosphate transferase. Eukaryot Cell. 2007;6:198-210. doi: 10.1128/EC.00282-06. PubMed PMID: 17142569; PubMed Central PMCID: PMC1797956.
23
- Liu X, Chang KP. N-acetylglucosamine-1-phosphate transferase gene is conserved in five Leishmania spp. and overexpressed due to its amplification in their tunicamycin-resistant variants. Mol Biochem Parasitol. 1993;59:177-9. doi: 10.1016/0166-6851(93)90020-X. PubMed PMID: 8390612.
24
- Hajjaran H, Mohebali M, Teimouri A, Oshaghi MA, Mirjalali H, Kazemi-Rad E, et al. Identification and phylogenetic relationship of Iranian strains of various Leishmania species isolated from cutaneous and visceral cases of leishmaniasis based on N-acetylglucosamine-1-phosphate transferase gene. Infect Genet Evol. 2014;26:203-12. doi: 10.1016/j.meegid.2014.05.026. PubMed PMID: 24911282.
25
- Mahmoudzadeh-Niknam H, Ajdary S, Riazi-Rad F, Mirzadegan E, Rezaeian A, Khaze V, et al. Molecular epidemiology of cutaneous leishmaniasis and heterogeneity of Leishmania major strains in Iran. Trop Med Int Health. 2012;17:1335-44. doi: 10.1111/j.1365-3156.2012.03078.x. PubMed PMID: 22947226.
26
- Tashakori M, Kuhls K, Al-Jawabreh A, Mauricio IL, Schonian G, Farajnia S, et al. Leishmania major: genetic heterogeneity of Iranian isolates by single-strand conformation polymorphism and sequence analysis of ribosomal DNA internal transcribed spacer. Acta Trop. 2006;98:52-8. doi: 10.1016/j.actatropica.2006.01.010. PubMed PMID: 16513079.
27
- Ghatee MA, Sharifi I, Kuhls K, Kanannejad Z, Harandi MF, de Almeida ME, et al. Heterogeneity of the internal transcribed spacer region in Leishmania tropica isolates from southern Iran. Exp Parasitol. 2014;144:44-51. doi: 10.1016/j.exppara.2014.06.003. PubMed PMID: 24932536.
28
ORIGINAL_ARTICLE
Effect of Aspirin on Spinal Cord Injury: An Experimental Study
Aspirin is an anti-inflammatory drug, peroxyl radical scavenger, and antioxidant agent that inhibits phospholipases, nitric oxide synthetases, and cyclooxygenase enzymes. The existing literature contains no studies on the effects of various doses of aspirin on spinal cord injury (SCI). Therefore, we sought to investigate the putative effects of aspirin on experimental SCI.The weight-drop injury model was used to produce SCI in 100 albino Wistar rats. The animals were allocated to five groups: a control group, where the rats did not undergo any surgical or medical intervention except for anesthesia; a sham-treated group, where laminectomy was performed without SCI and no further therapy was administered; and three other groups, where the rats with SCI received low-dose aspirin [20 mg/kg], high-dose aspirin [80 mg/kg], and a vehicle, respectively. Half of the rats were sacrificed 24 hours later, and their spinal cords were excised for biochemical studies. The other rats were subjected to Basso, Beattie, and Bresnahan (BBB) locomotor rating scale scoring once a week for 6 consecutive weeks.Aspirin decreased lipid peroxidation following SCI as the mean (± standard error) catalase level was significantly higher in the high-dose aspirin group (46.10±12.01) than in the sham-treated group (16.07±2.42) and the vehicle-treated group (15.31±3.20) (P<0.05; P<0.05, respectively). Both of the groups treated with high-dose and low-dose aspirin demonstrated a higher mean BBB score than did the control group (P<0.001) and the sham-treated group (P<0.001).Our data provide evidence in support of the potential effects of aspirin in biochemical and neurobehavioral recovery after SCI
https://ijms.sums.ac.ir/article_40351_0dd6dbce62d97c31bacdfb267e8e6ae3.pdf
2016-05-01
217
222
Aspirin
Antioxidant
Spinal cord injury
Hamed
Reihani Kermani
h_reihani@hotmail.com
1
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Nouzar
Nakhaee
nakhaeen@yahoo.com
2
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Reza
Fatahian
rfatahian@gmail.com
3
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Ahmad
Gholamhosseinian Najar
agnajar@yahoo.com
4
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
van den Berg ME, Castellote JM, Mahillo-Fernandez I, de Pedro-Cuesta J. Incidence of spinal cord injury worldwide: a systematic review. Neuroepidemiology. 2010;34:184-92; discussion 92. doi: 10.1159/000279335. PubMed PMID: 20130419.
1
Yip PK, Malaspina A. Spinal cord trauma and the molecular point of no return. Mol Neurodegener. 2012;7:6. doi: 10.1186/1750-1326-7-6. PubMed PMID: 22315999; PubMed Central PMCID: PMC3299607.
2
Saunders RD, Dugan LL, Demediuk P, Means ED, Horrocks LA, Anderson DK. Effects of methylprednisolone and the combination of alpha-tocopherol and selenium on arachidonic acid metabolism and lipid peroxidation in traumatized spinal cord tissue. J Neurochem. 1987;49:24-31. PubMed PMID: 3108455.
3
Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 1995;12:1-21. doi: 10.1089/neu.1995.12.1. PubMed PMID: 7783230.
4
Erol FS, Kaplan M, Tiftikci M, Yakar H, Ozercan I, Ilhan N, et al. Comparison of the effects of octreotide and melatonin in preventing nerve injury in rats with experimental spinal cord injury. J Clin Neurosci. 2008;15:784-90. doi: 10.1016/j.jocn.2007.06.009. PubMed PMID: 18407497.
5
Pantovic R, Draganic P, Erakovic V, Blagovic B, Milin C, Simonic A. Effect of indomethacin on motor activity and spinal cord free fatty acid content after experimental spinal cord injury in rabbits. Spinal Cord. 2005;43:519-26. doi: 10.1038/sj.sc.3101763. PubMed PMID: 15852057.
6
Yeo JE, Kim JH, Kang SK. Selenium attenuates ROS-mediated apoptotic cell death of injured spinal cord through prevention of mitochondria dysfunction; in vitro and in vivo study. Cell Physiol Biochem. 2008;21:225-38. doi: 10.1159/000113764. PubMed PMID: 18209489.
7
Ates O, Cayli S, Altinoz E, Gurses I, Yucel N, Kocak A, et al. Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury. Acta Pharmacol Sin. 2006;27:1317-25. doi: 10.1111/j.1745-7254.2006.00416.x. PubMed PMID: 17007738.
8
Gok B, Okutan O, Beskonakli E, Kilinc K. Effects of magnesium sulphate following spinal cord injury in rats. Chin J Physiol. 2007;50:93-7. PubMed PMID: 17608147.
9
Kaptanoglu E, Solaroglu I, Okutan O, Surucu HS, Akbiyik F, Beskonakli E. Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: effect on lipid peroxidation and early ultrastructural findings. Neurosurg Rev. 2004;27:113-20. doi: 10.1007/s10143-003-0300-y. PubMed PMID: 12920606.
10
Fujita Y, Shingu T, Kurihara M, Miyake H, Kono T, Tsujimura M, et al. Evaluation of a low dose administration of aspirin, dipyridamol and steroid. Therapeutic effects on motor function and protective effects on Na+-K+-activated ATPase activity against lipid peroxidation in an experimental model of spinal cord injury. Paraplegia. 1985;23:56-7. doi: 10.1038/sc.1985.9. PubMed PMID: 2984632.
11
Kwon BK, Okon E, Hillyer J, Mann C, Baptiste D, Weaver LC, et al. A systematic review of non-invasive pharmacologic neuroprotective treatments for acute spinal cord injury. J Neurotrauma. 2011;28:1545-88. doi: 10.1089/neu.2009.1149. PubMed PMID: 20146558; PubMed Central PMCID: PMC3143410.
12
Charan J, Kantharia N. How to calculate sample size in animal studies? Journal of Pharmacology & Pharmacotherapeutics. 2013;4:303. doi: 10.4103/0976-500X.119726.
13
Metz GA, Curt A, van de Meent H, Klusman I, Schwab ME, Dietz V. Validation of the weight-drop contusion model in rats: a comparative study of human spinal cord injury. J Neurotrauma. 2000;17:1-17. 10.1089/neu.2000.17.1. PubMed PMID: 10674754.
14
Dogruer ZN, Unal M, Eskandari G, Pata YS, Akbas Y, Cevik T, et al. Malondialdehyde and antioxidant enzymes in children with obstructive adenotonsillar hypertrophy. Clin Biochem. 2004;37:718-21. doi: 10.1016/j.clinbiochem.2004.01.004. PubMed PMID: 15302619.
15
Berker KI, Ozdemir Olgun FA, Ozyurt D, Demirata B, Apak R. Modified Folin-Ciocalteu antioxidant capacity assay for measuring lipophilic antioxidants. J Agric Food Chem. 2013;61:4783-91. doi: 10.1021/jf400249k. PubMed PMID: 23627440.
16
Rangan U, Bulkley GB. Prospects for treatment of free radical-mediated tissue injury. Br Med Bull. 1993;49:700-18. PubMed PMID: 8221033.
17
Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012;5:9-19. doi: 10.1097/WOX.0b013e3182439613. PubMed PMID: 23268465; PubMed Central PMCID: PMC3488923.
18
Grosser N, Schroder H. Aspirin protects endothelial cells from oxidant damage via the nitric oxide-cGMP pathway. Arterioscler Thromb Vasc Biol. 2003;23:1345-51. doi: 10.1161/01.ATV.0000083296.57581.AE. PubMed PMID: 12829521.
19
He Z, Liao Q, Xu X, Luo C, Zhou T, Li Q, et al. A study of the acting mechanism of aspirin for resistance to oxidative damage. Hua Xi Yi Ke Da Xue Xue Bao. 2001;32:413-6. PubMed PMID: 12536580.
20
ORIGINAL_ARTICLE
Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province
Alterations in the expression of microRNAs (miRNAs) have been proposed to play a role in the pathogenesis of acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). Dicer is one of the main regulators of miRNA biogenesis, and deregulation of its expression has been indicated as a possible cause of miRNA alterations observed in various cancers. Our aim was to analyze the expression of the Dicer protein and its relationship with ALL and CLL. This cross-sectional study was performed from 2010 to 2012 in Shahid Faghihi Hospital, Shiraz, Iran. In this study, 30 patients with CLL, 21 patients with ALL, 10 child healthy donors, and 19 adult healthy donors were recruited. The patients’ samples were checked via flow cytometry, immunohistochemistry, and immunocytochemistry. The controls’ samples were also examined in the hematology ward. Total RNA was extracted from the bone marrow and peripheral blood samples of the patients and controls. Then, reverse-transcription polymerase chain reaction was used to estimate the level of Dicer miRNA. The outcomes of the expression analysis of Dicer revealed statistically significant differences between the ALL patients/child healthy controls (mean±SD, 0.19±0.28 vs. 0.73±0.12; P<0.001) and the CLL patients/adult healthy controls (mean±SD, 0.24±0.25 vs. 0.41±0.28; P=0.033). This is the first piece of evidence showing that the expression of the Dicer gene greatly decreased in the patients with ALL in comparison to the child controls. The expression of the Dicer gene was also downregulated in the patients with CLL compared to the adult controls. Given the above findings, the expression of Dicer may play an important role in the progression and prognosis of these diseases.
https://ijms.sums.ac.ir/article_40354_b0d62a56eec39da3743df55438177004.pdf
2016-05-01
223
229
DICER1 protein
Gene expression
Leukemia
Mohamad
Farzaneh
mrfarzaneh@yahoo.com
1
Department of Pathology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
LEAD_AUTHOR
Jahanbanoo
Shahryari
jshahryari@yahoo.com
2
Department of Pathology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Akbar
Safaei
mrfarzaneh@sums.ac.ir
3
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Behnaz
Valibeigi
bvalibeigi@gmail.com
4
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Shahrbanou
Karimi Davani
shahrbanoukarimi@yahoo.com
5
Department of Biology, School of Sciences, University of Sistan and Baluchistan, Zahedan, Iran
AUTHOR
Narjes
Tabibi
sahatabibi@yahoo.com
6
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
- Cancer Treatment and Survivorship Facts & Figures 2014-2015 [Internet]. American Cancer Society. [cited 2014 Dec 8]. Available from: http://www.cancer.org/acs/groups/content/@research/documents/document/acspc-042801.pdf
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- Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet. 2008;371:1030-43. doi: 10.1016/S0140-6736(08)60457-2. PubMed PMID: 18358930.
2
- Cancer Facts & Figures 2014 [Internet]. American Cancer Society. [Cited 2014 Dec 8]. Available from: http://www.cancer.org/acs/groups/content/@research/documents/webcontent/acspc-042151.pdf.
3
- Mehrabani D, Tabei S, Heydari S, Shamsina S, Shokrpour N, Amini M, et al. Cancer occurrence in Fars Province, Southern Iran. Iran Red Crescent Med J. 2008;10:314-22.
4
- Belson M, Kingsley B, Holmes A. Risk factors for acute leukemia in children: a review. Environ Health Perspect. 2007;115:138-45. doi: 10.1289/ehp.9023. PubMed PMID: 17366834; PubMed Central PMCID: PMC1817663.
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- Zhang S, Kipps TJ. The pathogenesis of chronic lymphocytic leukemia. Annu Rev Pathol. 2014;9:103-18. doi: 10.1146/annurev-pathol-020712-163955. PubMed PMID: 23987584; PubMed Central PMCID: PMC4144790.
6
- Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9-29. doi: 10.3322/caac.21208. PubMed PMID: 24399786.
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- Mozaheb Z. Epidemiology of Lymphoid Malignancy in Asia. Croatia: INTECH Open Access Publisher; 2012.
8
- Xu L, Liang YN, Luo XQ, Liu XD, Guo HX. Association of miRNAs expression profiles with prognosis and relapse in childhood acute lymphoblastic leukemia. Zhonghua Xue Ye Xue Za Zhi. 2011;32:178-81. PubMed PMID: 21535956.
9
- Moussay E, Wang K, Cho JH, van Moer K, Pierson S, Paggetti J, et al. MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2011;108:6573-8. doi: 10.1073/pnas.1019557108. PubMed PMID: 21460253; PubMed Central PMCID: PMC3081030.
10
- Zhu DX, Fan L, Lu RN, Fang C, Shen WY, Zou ZJ, et al. Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia. Cancer Sci. 2012;103:875-81. doi: 10.1111/j.1349-7006.2012.02234.x. PubMed PMID: 22320315.
11
- Ji X. The mechanism of RNase III action: how dicer dices. Curr Top Microbiol Immunol. 2008;320:99-116. PubMed PMID: 18268841.
12
- Merritt WM, Lin YG, Han LY, Kamat AA, Spannuth WA, Schmandt R, et al. Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med. 2008;359:2641-50. doi: 10.1056/NEJMoa0803785. PubMed PMID: 19092150; PubMed Central PMCID: PMC2710981.
13
- Lin RJ, Lin YC, Chen J, Kuo HH, Chen YY, Diccianni MB, et al. microRNA signature and expression of Dicer and Drosha can predict prognosis and delineate risk groups in neuroblastoma. Cancer Res. 2010;70:7841-50. doi: 10.1158/0008-5472.CAN-10-0970. PubMed PMID: 20805302; PubMed Central PMCID: PMC4095771.
14
- Wu JF, Shen W, Liu NZ, Zeng GL, Yang M, Zuo GQ, et al. Down-regulation of Dicer in hepatocellular carcinoma. Med Oncol. 2011;28:804-9. doi: 10.1007/s12032-010-9520-5. PubMed PMID: 20405249.
15
- Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Dohner H, et al. Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood. 2008;111:5446-56. doi: 10.1182/blood-2007-06-093906. PubMed PMID: 18216293; PubMed Central PMCID: PMC2972576.
16
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17
- Costinean S, Sandhu SK, Pedersen IM, Tili E, Trotta R, Perrotti D, et al. Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice. Blood. 2009;114:1374-82. doi: 10.1182/blood-2009-05-220814. PubMed PMID: 19520806; PubMed Central PMCID: PMC2727407.
18
- Koralov SB, Muljo SA, Galler GR, Krek A, Chakraborty T, Kanellopoulou C, et al. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell. 2008;132:860-74. doi: 10.1016/j.cell.2008.02.020. PubMed PMID: 18329371.
19
- Xu S, Guo K, Zeng Q, Huo J, Lam KP. The RNase III enzyme Dicer is essential for germinal center B-cell formation. Blood. 2012;119:767-76. doi: 10.1182/blood-2011-05-355412. PubMed PMID: 22117047.
20
- Grelier G, Voirin N, Ay AS, Cox DG, Chabaud S, Treilleux I, et al. Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer. 2009;101:673-83. doi: 10.1038/sj.bjc.6605193. PubMed PMID: 19672267; PubMed Central PMCID: PMC2736830.
21
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22
- He L, Wang HY, Zhang L, Huang L, Li JD, Xiong Y, et al. Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer. Cell Death Dis. 2014;5:e1205. doi: 10.1038/cddis.2014.127. PubMed PMID: 24787017; PubMed Central PMCID: PMC4047899.
23
- Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet. 2007;39:673-7. doi: 10.1038/ng2003. PubMed PMID: 17401365.
24
- Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW, et al. Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res. 2007;67:2345-50. doi: 10.1158/0008-5472.CAN-06-3533. PubMed PMID: 17332367.
25
- Fujino T, Risinger JI, Collins NK, Liu FS, Nishii H, Takahashi H, et al. Allelotype of endometrial carcinoma. Cancer Res. 1994;54:4294-8. PubMed PMID: 8044774.
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- Sercan HO, Sercan ZY, Kizildag S, Undar B, Soydan S, Sakizli M. Consistent loss of heterozygosity at 14Q32 in lymphoid blast crisis of chronic myeloid leukemia. Leuk Lymphoma. 2000;39:385-90. doi: 10.3109/10428190009065838. PubMed PMID: 11342319.
27
- Agueli C, Cammarata G, Salemi D, Dagnino L, Nicoletti R, La Rosa M, et al. 14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a. Am J Hematol. 2010;85:575-8. doi: 10.1002/ajh.21758. PubMed PMID: 20578197.
28
- Rio Frio T, Bahubeshi A, Kanellopoulou C, Hamel N, Niedziela M, Sabbaghian N, et al. DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA. 2011;305:68-77. doi: 10.1001/jama.2010.1910. PubMed PMID: 21205968; PubMed Central PMCID: PMC3406486.
29
- Pampalakis G, Diamandis EP, Katsaros D, Sotiropoulou G. Down-regulation of dicer expression in ovarian cancer tissues. Clin Biochem. 2010;43:324-7. doi: 10.1016/j.clinbiochem.2009.09.014. PubMed PMID: 19782670.
30
ORIGINAL_ARTICLE
Combined Effect of Trolox and EDTA on Frozen-Thawed Sperm Quality
The freezing and thawing process not only is associated with serious damage to sperm such as damage to the plasma membrane and the acrosomal membrane but also changes the membrane permeability to some ions including calcium. Also, the generation of oxygen free radicals is increased during the freezing-thawing process. The purpose of this study was to evaluate of the effects of Trolox as an antioxidant and edetic acid (EDTA) as a calcium chelator on frozen-thawed (FT) sperm and compare these effects with those on fresh sperm. This study was done on these men of 25 healthy men, who referred to Shiraz Infertility Centerbetween2012 and2013. Normal samples were transferred to the ReproductivePhysiology Laboratory, Department of Physiology,Shiraz University of Medical Sciences, Shiraz. The samples were divided into two groups randomly: fresh and FT sperm groups. Each group was divided into five subgroups:control group, the solvent group (0.1%dimethyl sulfoxide [DMSO]), Trolox group (200μM), EDTA group (1.1mM), and Trolox+EDTA group. The percentages of motility, viability, and acrosome-reacted sperm were tested. The percentages of motility and viability in the FT sperm were lower than those in the fresh sperm. The progressive motility of the FT sperm was improved nonsignificantly with Trolox+EDTA. However, the effect of Trolox+EDTA on the progressive motility of the FT sperm was much more than that on the fresh sperm. The fewest acrosome-reacted sperm were observed in the EDTA-containingFT sperm. Antioxidant supplementation or omission of extracellular calcium may partly improve motility and also reduce acrosomal damage in FT sperm.
https://ijms.sums.ac.ir/article_40357_7484c173d5270c43395d6939d674b5d8.pdf
2016-05-01
230
237
Freezing
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
Edetic Acid
Sperm Motility
Acrosome reaction
Sara
Keshtgar
keshtgar@sums.ac.ir
1
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Farideh
Iravanpour
faridehiravanpour@yahoo.com
2
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Behrooz
Gharesi-Fard
3
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Marjaneh
Kazerooni
mkaz380@yahoo.com
4
Shiraz Infertility Center, Shiraz, Iran
AUTHOR
Day JG, Stacey G. Cryopreservation and freeze-drying protocols. 2nd ed. New Jersey: Humana Press; 2007. 347 p.
1
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Gadea J, Molla M, Selles E, Marco MA, Garcia-Vazquez FA, Gardon JC. Reduced glutathione content in human sperm is decreased after cryopreservation: Effect of the addition of reduced glutathione to the freezing and thawing extenders. Cryobiology. 2011;62:40-6. doi: 10.1016/j.cryobiol.2010.12.001. PubMed PMID: 21156167.
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Maia Mda S, Bicudo SD, Sicherle CC, Rodello L, Gallego IC. Lipid peroxidation and generation of hydrogen peroxide in frozen-thawed ram semen cryopreserved in extenders with antioxidants. Anim Reprod Sci. 2010;122:118-23. doi: 10.1016/j.anireprosci.2010.08.004. PubMed PMID: 20813469.
14
da Silva Maia M, Bicudo SD, Azevedo HC, Sicherle CC, de Sousa DB, Rodello L. Motility and viability of ram sperm cryopreserved in a Tris-egg yolk extender supplemented with anti-oxidants. Small Ruminant Research. 2009;85:85-90. doi: 10.1016/j.smallrumres.2009.07.001.
15
Martinez-Pastor F, Aisen E, Fernandez-Santos MR, Esteso MC, Maroto-Morales A, Garcia-Alvarez O, et al. Reactive oxygen species generators affect quality parameters and apoptosis markers differently in red deer spermatozoa. Reproduction. 2009;137:225-35. doi: 10.1530/REP-08-0357. PubMed PMID: 19028926.
16
Minaei MB, Barbarestani M, Nekoonam S, Abdolvahabi MA, Takzare N, Asadi MH, et al. Effect of Trolox addition to cryopreservation media on human sperm motility. Iran J Reprod Med. 2012;10:99-104. PubMed PMID: 25242981; PubMed Central PMCID: PMC4163270.
17
Breininger E, Beorlegui NB, O'Flaherty CM, Beconi MT. Alpha-tocopherol improves biochemical and dynamic parameters in cryopreserved boar semen. Theriogenology. 2005;63:2126-35. doi: 10.1016/j.theriogenology.2004.08.016. PubMed PMID: 15826678.
18
Kalthur G, Raj S, Thiyagarajan A, Kumar S, Kumar P, Adiga SK. Vitamin E supplementation in semen-freezing medium improves the motility and protects sperm from freeze-thaw-induced DNA damage. Fertil Steril. 2011;95:1149-51. doi: 10.1016/j.fertnstert.2010.10.005. PubMed PMID: 21067726.
19
Pena FJ, Johannisson A, Wallgren M, Rodriguez Martinez H. Antioxidant supplementation in vitro improves boar sperm motility and mitochondrial membrane potential after cryopreservation of different fractions of the ejaculate. Anim Reprod Sci. 2003;78:85-98. PubMed PMID: 12753785.
20
Yoshimoto T, Nakamura S, Yamauchi S, Muto N, Nakada T, Ashizawa K, et al. Improvement of the post-thaw qualities of Okinawan native pig spermatozoa frozen in an extender supplemented with ascorbic acid 2-O-alpha-glucoside. Cryobiology. 2008;57:30-6. doi: 10.1016/j.cryobiol.2008.05.002. PubMed PMID: 18589410.
21
Okazaki T, Yoshida S, Teshima H, Shimada M. The addition of calcium ion chelator, EGTA to thawing solution improves fertilizing ability in frozen-thawed boar sperm. Anim Sci J. 2011;82:412-9. doi: 10.1111/j.1740-0929.2010.00856.x. PubMed PMID: 21615834.
22
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O'Toole CM, Arnoult C, Darszon A, Steinhardt RA, Florman HM. Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction. Mol Biol Cell. 2000;11:1571-84. PubMed PMID: 10793136; PubMed Central PMCID: PMC14868.
24
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27
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Anel L, Gomes-Alves S, Alvarez M, Borragan S, Anel E, Nicolas M, et al. Effect of basic factors of extender composition on post-thawing quality of brown bear electroejaculated spermatozoa. Theriogenology. 2010;74:643-51. doi: 10.1016/j.theriogenology.2010.03.004. PubMed PMID: 20494423.
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Hossain MS, Johannisson A, Siqueira AP, Wallgren M, Rodriguez-Martinez H. Spermatozoa in the sperm-peak-fraction of the boar ejaculate show a lower flow of Ca(2+) under capacitation conditions post-thaw which might account for their higher membrane stability after cryopreservation. Anim Reprod Sci. 2011;128:37-44. doi: 10.1016/j.anireprosci.2011.08.006. PubMed PMID: 21962836.
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Aisen EG, Alvarez HL, Venturino A, Garde JJ. Effect of trehalose and EDTA on cryoprotective action of ram semen diluents. Theriogenology. 2000;53:1053-61. doi: 10.1016/S0093-691X(00)00251-X. PubMed PMID: 10798483.
37
ORIGINAL_ARTICLE
Ileoileal Knot as a Content of Obstructed Hernia: What Are the Odds?
An obstructed inguinal hernia is a common surgical emergency, which presents with a variety of contents like the small intestine, omentum, and colon. Intestinal knotting is a rare entity encountered in surgical practice; it occurs when one coil of intestine wraps around the other and eventually leads to complications such as intestinal obstruction, ischemia, and gangrene. Both conditions are considered surgical emergencies and should be dealt with through appropriate surgical measures forthwith. We report the case of an obstructed inguinal hernia, which, on exploration, showed an ileoileal knot as its content. Ileoileal knotting is a very rare phenomenon and, to the best of our knowledge, such an ileoileal knot as a content of obstructed inguinal hernia has not been reported in the surgical literature so far.
https://ijms.sums.ac.ir/article_40352_18c997a503db68399010c52fb82e8e5f.pdf
2016-05-01
238
240
Intestinal obstruction
Hernia
Inguinal
India
Madhusudhan
Gopivallabh
dr.mgiyengar@gmail.com
1
Department of General Surgery, Rajarajeshwari Medical College and Hospital, Bangalore, India
LEAD_AUTHOR
Kajekar
Jaganmaya
2
Department of General Surgery, Rajarajeshwari Medical College and Hospital, Bangalore, India
AUTHOR
Kunthurdoddi
Hanumanthaiah
3
Department of General Surgery, Rajarajeshwari Medical College and Hospital, Bangalore, India
AUTHOR
Prashantha
Babannavar
4
Department of General Surgery, Rajarajeshwari Medical College and Hospital, Bangalore, India
AUTHOR
Vilas
Crithic
5
Department of General Surgery, Rajarajeshwari Medical College and Hospital, Bangalore, India
AUTHOR
Hayanga AJ, Bass-Wilkins K, Bulkley GB. Current management of small-bowel obstruction. Adv Surg. 2005;39:1-33. doi: 10.1016/j.yasu.2005.05.001. PubMed PMID: 16250544.
1
Uday S, Venkata PKC, Bhargav P, Kumar S. Ileo-ileal knot causing small bowel gangrene: an unusual presentation. Int J Case Rep Imag. 2012;3:28-30. doi: 10.5348/ijcri-2012-05-121-CR-6.
2
Pendse AK, Prajapat G, Sharma A, Sharma M. Ileo-ileal knotting causing intestinal obstruction. Indian J Pediatr. 1988;55:639-40. doi: 10.1007/BF02868453.PubMed PMID: 3169937.
3
Shepherd JJ. Ninety-two cases of ileosigmoid knotting in Uganda. Br J Surg. 1967;54:561-6. doi: 10.1002/bjs.1800540615.PubMed PMID: 6026331.
4
Yanez Benitez C, Casamayor Franco C, Ligorred Padilla L, Baque Sanz F. Gangrened ileosigmoid knot. Rev Esp Enferm Dig. 2009;101:449-51. PubMed PMID: 19630476.
5
Machado NO. Ileosigmoid knot: a case report and literature review of 280 cases. Ann Saudi Med. 2009;29:402-6. doi: 10.4103/0256-4947.55173.PubMed PMID: 19700901; PubMed Central PMCID: PMC3290047.
6
Mandal A, Chandel V, Baig S. Ileosigmoid knot. Indian J Surg. 2012;74:136-42. doi: 10.1007/s12262-011-0346-y. PubMed PMID: 23542502; PubMed Central PMCID: PMC3309095.
7
VerSteeg KR, Whitehead WA. Ileosigmoid knot. Arch Surg. 1980;115:761-3. doi: 10.1001/archsurg.1980.01380060059017.PubMed PMID: 7387365.
8
Shimizu R, Hoshino Y, Irie H, Ito H, Terauchi T, Kimata M, et al. Ileosigmoid knot at week 13 of pregnancy: report of a case. Int Surg. 2014;99:230-4. doi: 10.9738/INTSURG-D-14-00011.1. PubMed PMID: 24833144; PubMed Central PMCID: PMC4027905.
9
ORIGINAL_ARTICLE
Familial Amyloid Polyneuropathy Type IV (FINNISH) with Rapid Clinical Progression in an Iranian Woman: A Case Report
Familial amyloid polyneuropathy (FAP) type IV (FINNISH) is a rare clinical entity with challenging neuropathy and cosmetic deficits. Amyloidosis can affect peripheral sensory, motor, or autonomic nerves. Nerve lesions are induced by deposits of amyloid fibrils and treatment approaches for neuropathy are challenging. Involvement of cranial nerves and atrophy in facial muscles is a real concern in daily life of such patients. Currently, diagnosis of neuropathy can be made by electrodiagnostic studies and diagnosis of amyloidosis can be made by genetic testing or by detection of amyloid deposition in abdominal fat pad, rectal, or nerve biopsies. It is preferable to consider FAP as one of the differential diagnosis of a case presented with multiple cranial nerves symptoms. The authors present a case of familial amyloid polyneuropathy (FAP) type IV with severe involvement of multiple cranial nerves, peripheral limb neuropathy, and orthostatic hypotension.
https://ijms.sums.ac.ir/article_40355_df685aaf47700053ee19f886dde3b61a.pdf
2016-05-01
241
244
Amyloid neuropathies
Familial
Cranial nerve diseases
Hypotension
Orthostatic
Arash
Babaei-Ghazani
arashbabaie@gmail.com
1
Department of Physical Medicine and Rehabilitation, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Bina
Eftekharsadat
binasadat@yahoo.com
2
Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
LEAD_AUTHOR
Ikeda M, Mizushima K, Fujita Y, Watanabe M, Sasaki A, Makioka K, et al. Familial amyloid polyneuropathy (Finnish type) in a Japanese family: Clinical features and immunocytochemical studies. J Neurol Sci. 2007;252:4-8. doi: 10.1016/j.jns.2006.09.022. PubMed PMID: 17097682.
1
Dumitru D,Amato AA,Zwarts MJ. Electrodiagnostic medicine.2nded. Philadelphia: Hanley &Belfus; 2002.
2
Kiuru-Enari S, Haltia M. Hereditary gelsolin amyloidosis. HandbClin Neurol. 2013;115:659-81. doi: 10.1016/B978-0-444-52902-2.00039-4. PubMed PMID: 23931809.
3
Luttmann RJ, Teismann I, Husstedt IW, Ringelstein EB, Kuhlenbaumer G. Hereditary amyloidosis of the Finnish type in a German family: clinical and electrophysiological presentation. Muscle Nerve. 2010;41:679-84. doi: 10.1002/mus.21534. PubMed PMID: 20229579.
4
Said G. Familial amyloid polyneuropathy: mechanisms leading to nerve degeneration. Amyloid. 2003;10:7-12. doi: 10.1016/j.jns.2009.05.001.PubMed PMID: 14640035.
5
Ueda M, Ando Y. Recent advances in transthyretin amyloidosis therapy. TranslNeurodegener. 2014;3:19. doi: 10.1186/2047-9158-3-19. PubMed PMID: 25228988; PubMed Central PMCID: PMC4165622.
6
Kiuru-Enari S, Keski-Oja J, Haltia M. Cutis laxa in hereditary gelsolin amyloidosis. Br J Dermatol. 2005;152:250-7. doi: 10.1111/j.1365-2133.2004.06276.x. PubMed PMID: 15727635.
7
ORIGINAL_ARTICLE
Acute Hemorrhagic Leukoencephalitis in Children: A Case Report
Acute hemorrhagic leukoencephalitis (AHLE) is a rare demyelinating disease characterized by an acute rapidly progressive fulminant inflammation of the white matter. In this case report, we introduce a case of AHLE in children with an interesting and lengthy process and successful treatment.A previously healthy 13-year-old girl was admitted to the hospital because of fever and loss of consciousness. After 4 days, she was referred to our pediatric intensive care unit in Mashhad, Iran. On admission, she had right-sided parotiditis. With a diagnosis of AHLE, our patient was treated with methylprednisolone, intravenous immunoglobulin, acyclovir, and plasmapheresis.AHLE is a rare and severe demyelinating disease, the mortality and morbidity of which can be decreased by early detection and treatment with steroid therapy, intravenous immunoglobulin, acyclovir, and plasmapheresis.
https://ijms.sums.ac.ir/article_40358_2d1015aa57603e1576030f18bfd96f94.pdf
2016-05-01
245
248
Leukoencephalitis
Acute hemorrhagic encephalomyelitis
Acute disseminated
Demyelinating diseases
Gholam
Khademi
1
Department of Pediatrics, Dr. Sheikh Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad
Aelami
2
Department of Pediatrics & Infection Control and Hand Hygiene Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
- Lee NK, Lee BH, Hwang YJ, Kim SY, Lee JY, Joo M. Serial computed tomography and magnetic resonance imaging findings of biphasic acute hemorrhagic leukoencephalitis localized to the brain stem and cerebellum. Jpn J Radiol. 2011;29:212-6. doi: 10.1007/s11604-010-0523-0. PubMed PMID: 21519996.
1
- Palace J. Acute disseminated encephalomyelitis and its place amongst other acute inflammatory demyelinating CNS disorders. J Neurol Sci. 2011;306:188-91. doi: 10.1016/j.jns.2011.03.028. PubMed PMID: 21664525.
2
- Takeda H, Isono M, Kobayashi H. Possible acute hemorrhagic leukoencephalitis manifesting as intracerebral hemorrhage on computed tomography--case report. Neurol Med Chir (Tokyo). 2002;42:361-3. doi: 10.2176/nmc.42.361. PubMed PMID: 12206493.
3
- Kumar RS, Kuruvilla A. Teaching NeuroImages: Acute hemorrhagic leukoencephalitis after mumps. Neurology. 2009;73:e98. doi: 10.1212/WNL.0b013e3181c2eee3. PubMed PMID: 19917982.
4
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ORIGINAL_ARTICLE
Report of a Case with Trisomy 9 Mosaicism
Trisomy 9 is a rare chromosome disorder with high neonatal mortality. It is often seen in mosaic form. Most patients who survive are severely mentally retarded. The main features of this syndrome are "bulbous" nose, microphthalmia, dislocated limbs, and other anomalies of skeletal, cardiac, genitourinary, and central nervous system. Most patients have developmental and cognitive impairment. Patients with mosaicism survive longer than non-mosaics, but it was believed that the degree of mosaicism in lymphocytes or fibroblasts does not associate with survival or degree of impairment. In this report, we present a 2.5-year-old male case of mosaic trisomy 9, to show the wide range of clinical findings in this chromosome disorder. The patient had cardiac anomalies, inguinal hernia, and undescendent testes. He had low-set slightly malformed ears, deeply-set malformed eyes, small palpebral fissures, micrognathia, developmental delay and unilateral optic hypoplasia. The most prominent facial anomaly in this patient was eye anomalies. Cytogenetic analysis with G banding showed karyotype 47XY,+9 in 44% of peripheral lymphocytes examined (47XY,+9[22], 46XY[28]). His parents’ karyotypes were normal. Moderate developmental delay, which was detected in this patient shows that the range of motor and cognitive impairment in this chromosomal disorder is quite broad. This fact should be considered in genetic counseling as well as prenatal diagnosis of this chromosomal disorder.
https://ijms.sums.ac.ir/article_40360_23ca6ca086c8b2c3b2bb98f3e14919db.pdf
2016-05-01
249
252
Mosaicism
Chromosome 9
trisomy
Cytogenetic analysis
Mohammad
Miryounesi
miryounesi@gmail.com
1
Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Mehdi
Dianatpour
dianatpour@sums.ac.ir
2
Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Zahra
Shadmani
3
Vali-Asr Hospital, Fasa University of Medical Sciences, Fasa, Iran
AUTHOR
Soudeh
Ghafouri-Fard
ghafourifard@razi.tums.ac.ir
4
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
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