Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
Gastrointestinal Basidiobolomycosis, a Rare and Under-diagnosed Fungal Infection in Immunocompetent Hosts: A Review Article
90
97
EN
Bita
Geramizadeh
Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
geramib@sums.ac.ir
Mina
Heidari
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Golsa
Shekarkhar
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
10.30476/ijms.2015.39727
Gastrointestinal Basidiobolomycosis (GIB) is an unusual, rare, but emerging fungal infection in the stomach, small intestine, colon, and liver.It has been rarely reported in the English literature and most of the reported cases have been from US, Saudi Arabia, Kuwait, and Iran. In the last five years, 17 cases have been reported from one or two provinces in Iran, and it seems that it has been undiagnosed or probably unnoticed in other parts of the country.In this review, we explored the English literature from 1964 through 2013 via PubMed, Google, and Google scholar using the following search keywords:1) Basidiobolomycosis2) Basidiobolus ranarum3) Gastrointestinal BasidiobolomycosisIn this review, we attempted to collect all clinical, pathological, and radiological findings of the presenting patients; complemented with previous experiences regarding the treatment and prognosis of the GIB.Since 1964, only 71 cases have been reported, which will be fully described in terms of clinical presentations, methods of diagnosis and treatment as well as prognosis and follow up.
Gastrointestinal,Entomophthorales,Basidiobolus ranarum,Immunocompetent
https://ijms.sums.ac.ir/article_39727.html
https://ijms.sums.ac.ir/article_39727_501f260863e1be7cf3c7b8b9efae04af.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
The Shape of Uterine Contractions and Labor Progress in the Spontaneous Active Labor
98
103
EN
Samira
Ebrahimzadeh Zagami
Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran;
Nahid
Golmakani
Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran;
golmakanin@mums.ac.ir
Seyyed Ali-Reza
Saadatjoo
Department of Nursing, School of Nursing and Midwifery, Birjand University of Medical Science, Birjand, Iran
Nayyereh
Ghomian
Department of Gynecology, Emam-Reza Hospital, Mashhad University of Medical Science, Mashhad, Iran
Behjat
Baghbani
Omolbanin Hospital, Mashhad University of Medical Science, Mashhad, Iran
Background: Dystocia is the most common indication of primary cesarean section. The most common cause of dystocia is uterine dysfunction. In prolonged labor, more attention is usually paid to the fetus and pelvis rather than to the role of uterine contractions in a delivery. Therefore, we decided to determine the relationship between the labor progress and uterine contractions shapes.Methods: In this cross-sectional study, 200 primiparous women participated having a single pregnancy and cephalic presentation. Uterus contractions were recorded using electronic fetal monitoring at the beginning of the active phase of labor (dilatation 3-5 cm) for 30 min. Fall to rise (F:R) ratio was calculated by determining the duration of returning from a contraction peak to its baseline (fall) and the duration of the rise time from baseline to peak (rise) in two groups. The data were analyzed using t-test and Chi-square test.Results: In this study, 162 women had a normal delivery and 38 women had a cesarean (CS) delivery due to the lack of labor progress. The average F:R ratio was 1.13±0.193 seconds in the vaginal delivery group and 1.64±0.301 seconds in the CS group. This difference was statistically significant (P<0.001). The frequency of contractions in the vaginal delivery group was more than the CS group (P=0.008).Conclusion: Our findings demonstrated that uterine contractions shapes change; and F:R ratio was higher in the group that lacked labor progress. Therefore, contraction shapes can be used to predict the labor progress.
Uterine contraction,Dystocia,First stage labor
https://ijms.sums.ac.ir/article_39728.html
https://ijms.sums.ac.ir/article_39728_d4f13529cb4a1b9817d33d1d1af7f4c7.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
Designing a Prognostic Scoring System for Predicting the Outcomes of Proximal Fifth Metatarsal Fractures at 20 Weeks
104
109
EN
Mohammad Ali
Tahririan
0000-0003-2122-1091
Department of Orthopaedic Surgery, Kashani University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
tahririan@med.mui.ac.ir
Amir
Momeni
Department of Orthopaedic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
Amir
Moayednia
Department of Physical Medicine and Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran
Elham
Yousefi
Department of Orthopaedic Surgery, Isfahan University of Medical Sciences, Isfahan, Iran
Background: Fractures of the proximal fifth metatarsal bone are among the most common fractures observed in the foot and their classification and management has been subject to much discussion and disagreement. In this study, we aim to identify and quantify the effect of possible predictors of the outcome of the treatment of proximal fifth metatarsal fractures.Methods: Patients with established proximal fifth metatarsal fractures were enrolled in this prospective cohort and the outcome of their treatment was assessed using the AOFAS mid foot scale at 6 and 20 weeks.Results: 143 patients were included in the study. Our study showed that displacement, weight and type III fractures were significant independent predictors of poor outcome at 6 weeks while at 20 weeks in addition to these factors, gender and diabetes mellitus were also shown to be significant independent predictors of poor outcome. A scoring system was designed by assigning weight to these factors and it was shown to be a strong predictor of outcome at 20 weeks.Conclusion: We recommend that our scoring system would help surgeons to decide whether patients’ prognostic factors are significant enough for him/her to opt for a surgical approach to treatment rather than a conservative approach.
Metatarsal bone,Fracture,Prognosis
https://ijms.sums.ac.ir/article_39731.html
https://ijms.sums.ac.ir/article_39731_3339e7293b8f73b67407d792d96753de.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
Comparison of Cell Viability and Embryoid Body Size of Two Embryonic Stem Cell Lines After Different Exposure Times to Bone Morphogenetic Protein 4
110
117
EN
Nehleh
Zarei Fard
Laboratory for Stem Cell Research, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Tahereh
Talaei-Khozani
Laboratory for Stem Cell Research, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Soghra
Bahmanpour
0000-0001-9598-2796
Laboratory for Stem Cell Research, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
bahmans@sums.ac.ir
Tahereh
Esmaeilpour
Laboratory for Stem Cell Research, Department of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
esmaeilpor@yahoo.com
Background: Activation of bone morphogenetic protein 4 (BMP4) signaling pathway in embryonic stem (ES) cells plays an important role in controlling cell proliferation, differentiation, and apoptosis. Adverse effects of BMP4 occur in a time dependent manner; however, little is known about the effect of different time exposure of this growth factor on cell number in culture media. In this study, we investigated the role of two different exposure times to BMP4 in cell viability, embryoid body (EB), size, and cavitation of ES cells.Methods: Embryonic stem cells (R1 and B1 lines) were released from the feeder cell layers and were cultured using EBs protocol by using the hanging drop method and monolayer culture system. The cells were cultured for 5 days with 100 ng/mL BMP4 from the beginning (++BMP4) or after 48 h (+BMP4) of culture and their cell number were counted by trypan blue staining. The data were analyzed using non-parametric two-tailed Mann-Whitney test. P
Embryonic stem cells,Bone morphogenetic protein 4,Embryoid body
https://ijms.sums.ac.ir/article_39734.html
https://ijms.sums.ac.ir/article_39734_0a3439cee95e1fc2b17b112f606a0378.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
Acute and Chronic Effects of N-acetylcysteine on Pentylenetetrazole-induced Seizure and Neuromuscular Coordination in Mice
118
124
EN
Sasan
Zaeri
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Masoumeh
Emamghoreishi
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
emamm@sums.ac.ir
Background: N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses.Methods: Following intraperitoneal (i.p.) administration of N-acetylcysteine acutely (50-300 mg/kg) or chronically for 8 days (25-300 mg/kg), mice were injected with PTZ (90 mg/kg, i.p.) and latency times to the onset of myoclonic and clonic seizures and protection against death were recorded. Changes in body weight and mortality rate were considered as parameters for drug safety. The muscle-relaxant activity of NAC was assessed by rotarod test.Results: Acute and chronic treatment with NAC delayed latency times to myoclonic and clonic seizures in a dose-dependent manner, but with no significant prevention against PTZ-induced death. Chronic administration of 300 mg/kg NAC was fully lethal while lower doses (100 and 150 mg/kg) resulted in a significant weight loss and decreased stay time on rotarod. Acute treatment with NAC had no significant effect on stay time on rotarod at all studied doses.Conclusion: NAC exerts a dose-dependent anticonvulsant effect in acute and chronic uses, with no muscle relaxant activity. NAC has higher efficacy in preventing seizure in chronic than acute treatment, but its chronic use at higher doses of 75 mg/kg may be associated with side effects and/or toxicity. These findings suggest that low doses of NAC may have a potential use as a prophylactic treatment for absence seizure in human.
N-acetylcysteine,Pentylenetetrazole,Anticonvulsant,Seizure
https://ijms.sums.ac.ir/article_39737.html
https://ijms.sums.ac.ir/article_39737_e3c59a3980b70a7a51ee16bae912e99c.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
Attenuation of Morphine Withdrawal Syndrome by Various Dosages of Curcumin in Comparison with Clonidine in Mouse: Possible Mechanism
125
132
EN
Majid
Motaghinejad
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
m-motaghinejad@razi.tums.ac.ir
Mohammad Yasan
Bangash
Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Pantea
Hosseini
Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
pantahosseini@gmail.com
Seyed Morteza
Karimian
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
motaghinejadmajid@yahoo.com
Ozra
Motaghinejad
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
motaghinejad69@gmail.com
Background: Herbal medical compounds and their major constituent have been used in the management and treatment of opioid withdrawal syndrome and pain. This study was carried out to clarify the effect of curcumin, the major compound of turmeric, on morphine withdrawal syndrome in mouse model and its possible mechanisms of pain relieving activity by assessing in writhing test as a model of visceral pain.Methods: Due to two separate protocols (withdrawal syndrome and pain), 144 male albino mice were divided in two major groups. In withdrawal syndrome group, test effect of various dosages of curcumin (10, 20, and 40 mg/kg) was assessed on withdrawal signs and compared with positive and negative control and standard treatment (clonidine 0.4 mg/kg) groups. In pain groups, to determine the mechanism of pain relieving activity of curcumin, various dosages of curcumin (10, 20, and 40 mg/kg) in three separated groups, were used against acetic acid induced writhing (which is a constriction) test. The most effective dose (40 mg/kg) was used in writhing test and compared with groups pretreated with antagonist of major neurotransmitters involved in pain; and compared with group pretreated with vehicle (DMSO, 0.05%) as control.Results: Curcumin attenuates withdrawal syndrome in a dose dependent manner in comparison with the dependent positive control group (P<0.05). It also indicated that pretreatment with naloxone and cyproheptadine significantly attenuate antinociception effect of curcumin (P<0.05).Conclusion: This study advocate that antinociception of curcumin was mediated by opioidergic and adrenergic system.
Curcumin,Morphine,Withdrawal syndrome,Visceral pain
https://ijms.sums.ac.ir/article_39738.html
https://ijms.sums.ac.ir/article_39738_9f4279ee3868f9d5fd3e95eb1e37dade.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
The Role of Apoptosis in the Cellular Response of Liver and Spleen of BALB/c Mice in Cutaneous Leishmaniasis
133
142
EN
Mahvash
Jafari
Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
h.sadraei5@gmail.com
Shanaz
Shirbazou
Department of Parasitology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Seyed Homayoon
Sadraie
Neuroscience Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Gholamreza
Kaka
0000-0001-8878-3481
Neuroscience Research Center, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
gh_kaka@yahoo.com
Majid
Norozi
Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
Background: Cutaneous leishmaniasis is a common parasitic disease in Iran being mainly caused by Leishmania (L.) major. The aim of this study was to investigate the occurrence of apoptosis in the spleen and liver of female mice infected with L. major.Methods: BALB/c mice were randomly assigned into the control and experimental groups (ten mice per group). The experimental groups were subcutaneously inoculated with promastigotes of L. major at stationary phase. The animals were sacrificed after 20, 40, 60, 90, and 120 days of injection. The liver and spleen were analyzed for various parameters of apoptosis.Results: Activities of superoxide dismutase and caspase-3, levels of superoxide anion production and malondialdehyde, and the percent of DNA fragmentation were increased in the liver and spleen of the infected mice. Catalase activity in the liver was increased, while glutathione level in both tissues was decreased after 90 and 120 days of infection. The numbers of apoptotic nuclei in the spleen were higher than the liver at 90 and 120 days post-infection using the TUNEL method.Conclusion: L. major infection induces a time-dependent increase in apoptosis in the liver and spleen as evidenced by the production of ROS, increasing activation of caspase-3, elevated DNA fragmentation, and increasing lipid peroxidation. Induction of oxidative stress was observed in the liver and spleen after 90 and 120 days of initiation of the infection. However, the spleen tissue appears to be more sensitive to the infection to L. major on oxidative stress and apoptosis induction compared with the liver tissue.
Cutaneous leishmaniasis,apoptosis,Inbred BALB C mice,Liver,Spleen
https://ijms.sums.ac.ir/article_39739.html
https://ijms.sums.ac.ir/article_39739_d79284e85fab756a89c3e83d16ea6630.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
Wharton’s Jelly-derived Mesenchymal Stem Cells can Differentiate into Hepatocyte-like Cells by HepG2 Cell Line Extract
143
151
EN
Maryam
Borhani-Haghighi
Laboratory for Stem Cell Research, Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Tahereh
Talaei-Khozani
Laboratory for Stem Cell Research, Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam
Ayatollahi
Transplantation Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
ayatmb@sums.ac.ir
Zahra
Vojdani
0000-0001-8214-2309
Laboratory for Stem Cell Research, Department of Anatomy, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
vojdaniz@sums.ac.ir
Background: Wharton’s jelly is an unlimited source of stem cells that can be used in cell therapy and tissue engineering without any ethical concern. It has been revealed the cell-free extract could be effective to induce cell differentiation. The objective of this study was to induce Wharton’s jelly-derived mesenchymal stem cells (MSCs) into hepatocyte-like cells by premeabilization of the cells in the presence of HepG2 cell line extract.Methods: MSCs were isolated from the umbilical cord, CD marker profile and their differentiation potential into adipogenic and osteogenic lineages were determined. The cells were then, permeabilized by streptolysin O in the presence of HepG cell extract. The treated cells were cultured for 17 days. The cell phenotype was evaluated and the hepatocyte specific markers were detected by immunofluorescence and immunocytochemistry. The Periodic Acid Schiff (PAS) reaction and the cellular uptake of indocyanine green were performed to evaluate the functional behavior of the differentiated cells.Results: The phenotype of extract-treated MSCs changed into a round or polygonal cells with few short processes and they could express high level of albumin, cytokeratin 18 and 19. The MSCs also could store glycogen and uptake and release indocyanine green.Conclusion: We demonstrated for the first time that Wharton’s jelly-derived MSCs could differentiate into hepatocyte-like cells by premeabilization of them in the presence of HepG2 cell extract. This study suggests a feasible method to differentiate MSCs into functional hepatocyte-like cells.
Wharton’s jelly,Mesenchymal Stem Cells,Cell differentiation,Cell-free system
https://ijms.sums.ac.ir/article_39740.html
https://ijms.sums.ac.ir/article_39740_552be8b2a1bdc00c48a2c13542259b2b.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
The Effects of Resveratrol in Rats with Simultaneous Type 2 Diabetes and Renal Hypertension: a Study of Antihypertensive Mechanisms
152
160
EN
Masoud
Mozafari
0000-0003-0798-3145
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
masoud.d1353@gmail.com
Ali Akbar
Nekooeian
0000-0001-5643-245X
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
nekooian@yahoo.com
Mohammad Reza
Panjeshahin
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
panjeshm@sums.acir
Hamid Reza
Zare
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
zareh80@yahoo.com
Background: Resveratrol has beneficial effects on cardiovascular system. This study aimed at examining antidiabetic and antihypertensive effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension.Methods: Eight groups (8-10 each) of male Spargue-Dawley rats, including a control, a diabetic (induced by streptozotocin and nicotinamide), a renal hypertensive (induced by placing plexiglas clips on the left renal arteries), a sham, a simultaneously hypertensive-diabetic receiving vehicle, and 3 simultaneous hypertensive-diabetic receiving resveratrol at 5, 10 or 20 mg/kg/day were used. Four weeks after the induction of diabetes, renal hypertension was induced and animals were given vehicle or resveratrol for the next four weeks. Afterwards, blood pressure and glucose, serum markers of oxidative stress were measured and animal’s aortic rings were used for isolated studies.Results: Serum malondialdehyde, systolic blood pressure, heart rate, fasting blood glucose, maximal response and effective concentration 50 of phenylephrine, and inhibitory concentration 50 of acetylcholine of hypertensive-diabetic group receiving vehicle were significantly higher than those of the control group, and treatment with resveratrol caused significant reduction of these variables. Moreover, serum superoxide dismutase, glutathione reductase, and maximal response to acetylcholine of hypertensive-diabetic group receiving vehicle were significantly lower than those of the control group, and treatment with resveratrol caused significant increase of these variables.Conclusion: The findings indicate that resveratrol has antidiabetic and antihypertensive effects, which may be partly due to antioxidant mechanism. They also show that antihypertensive effect of resveratrol may be additionally mediated by improving the release of nitric oxide and sympathoplegic activities.
Resveratrol,diabetes mellitus,Renal hypertension,Oxidative stress,Nitric oxide,Rat
https://ijms.sums.ac.ir/article_39741.html
https://ijms.sums.ac.ir/article_39741_b31c305ab09ac0738750426aeb5b52f5.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
The Prevalence of Latent Tuberculosis Infection and Smear Positive Pulmonary Tuberculosis in People with Household Close Contact with Tuberculosis in North of Iran
161
165
EN
Mahmood
Moosazadeh
0000-0002-5452-514
Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
mmoosazadeh1351@gmail.com
Narges
Khanjani
Research Center for Environmental Health Engineering, Kerman Medical University, Kerman, Iran
narges.khanjani@gmail.com
Mohammadreza
Parsaee
Health Deputy, Kerman University of Medical Sciences, Kerman, Iran
mrparsaie@yahoo.com
One of the recommended strategies for preventing tuberculosis is to screen high-risk populations with respect to Mycobacterium tuberculosis (TB) infection. The aim of the present study was to investigate latent infection and active tuberculosis in people with close household contact. It was a cross-sectional descriptive, analytical study with the sample size of 668 people from homes with one infected resident. In order to diagnose tuberculosis latent infection, the PPD test was done. To determine patients with smear-positive pulmonary tuberculosis, three sputum samples were taken from every patient and were examined using direct microscopy and culture. Data was analyzed by SPSS20 software. The prevalence of latent tuberculosis infection and smear-positive pulmonary tuberculosis were 42.8% and 0.9% respectively. The prevalence of latent tuberculosis infection and smear-positive pulmonary tuberculosis in people with close household contact were less than that of other studies. However, smear-positive pulmonary tuberculosis in people with close household contact was 199.5 times more than that of the general population.
Tuberculosis,Household close contact,Iran,prevalence
https://ijms.sums.ac.ir/article_39729.html
https://ijms.sums.ac.ir/article_39729_e9625c4719505590e0dc04c9e33ce4a7.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
Effect of Burn Sites (Upper and Lower Body Parts) and Gender on Extensive Burns’ Mortality
166
169
EN
Ali Akbar
Mohammadi
0000-0002-5769-9508
Shiraz Burn Research Center, Division of Plastic and Reconstructive Surgery, Department of Surgery, Ghotbedin Burn Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
mohamadiaa@sums.ac.ir
Mohammad Reza
Pakyari
Shiraz Burn Research Center, Division of Plastic and Reconstructive Surgery, Department of Surgery, Ghotbedin Burn Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Seyed Morteza
Seyed Jafari
Shiraz Burn Research Center, Division of Plastic and Reconstructive Surgery, Department of Surgery, Ghotbedin Burn Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Ahmad Reza
Tavakkolian
Shiraz Burn Research Center, Ghotbedin Burn Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Hamid Reza
Tolide-ie
Faculty of Public Health, Gonabad University of Medical Sciences, Gonabad, Iran
Zahra
Moradi
Shiraz Burn Research Center, Ghotbedin Burn Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Masumeh
Kherad
Shiraz Burn Research Center, Ghotbedin Burn Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Our recent literature survey indicated a lack of clinical assessment of the influence of gender and site of burn injury on the outcome of patients with extensive burns. This report examines the effect of burn sites and gender on extensive burns’ mortality.Data was gathered from 283 patients with burns larger than 65% of the total body surface area (TBSA) above the belt line or below the belt line; and without underlying diseases and inhalation burn injury. Patients were classified according to gender, site of injury (upper and lower body parts) and hospital stay period. Mortality rates of each category were then compared with each other. The hospital stay period in the female group was significantly higher compared with the male group (P<0.001) and the mortality rate among the female patients was higher compared with the male patients (P=0.004). Although the mortality rate in lower body part of the male group was significantly higher in comparison with the upper body part burn (P=0.001), there was no difference in mortality rate of upper versus lower body part in the female group. The mortality rate was generally higher among the female patients. Additionally, higher mortality rate was observed among male patients with lower body part burn compared with injuries of male patients with upper body part burn.
Body parts,Burns,Female,Male,Outcome
https://ijms.sums.ac.ir/article_39732.html
https://ijms.sums.ac.ir/article_39732_5fe76f39880627156d2625757f65e43e.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
G22A Polymorphism of Adenosine Deaminase and its Association with Biochemical Characteristics of Gestational Diabetes Mellitus in an Iranian Population
170
174
EN
Mohammad Ali
Takhshid
0000-0002-3506-7753
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
takhshid2001@yahoo.co.uk
Zinab
Zahediannejad
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Farzaneh
Aboualizadeh
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Leili
Moezzi
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Reza
Ranjbaran
Diagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
Adenosine deaminase (ADA) is an important regulator of insulin action. The single nucleotide polymorphism (SNP) G22A in the ADA gene decreases enzymatic activity of ADA. The aim of this study was to investigate the relationship between the SNP G22A and blood glycemic control, insulin resistance, and obesity of gestational diabetes mellitus (GDM) patients in an Iranian population. SNP G22A was determined in women with GDM (N=70) and healthy pregnant women (control, N=70) using polymerase chain reaction-restriction fragment length polymorphism. Fasting plasma glucose (FPG), hemoglobin A1C (HbA1c), plasma insulin levels and plasma lipids were measured using commercial kits. Homeostasis model of assessment for insulin resistance (HOMA-IR) was calculated. The distribution of genotypes and alleles among GDM patients was similar to that of the control group. FPG and HbA1c were significantly higher in GDM patients with GG genotype compared with GDM patients with GA+AA genotype and non-GDM patients. The frequency of GG genotype was significantly higher in obese GDM patients compared to lean GDM patients. The SNP G22A in the ADA gene was not associated with the risk of GDM in our population. GG genotype was associated with poor glycemic control and obesity in GDM patients.
Adenosine deaminase,Gestational Diabetes,Single nucleotide polymorphism G22A
https://ijms.sums.ac.ir/article_39735.html
https://ijms.sums.ac.ir/article_39735_85615054f28f72172a2c3f82072715a7.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
An Unusual Case of Metastatatic Renal Cell Carcinoma Presenting as Melena and Duodenal Ulcer, 16 Years After Nephrectomy; a Case Report and Review of the Literature
175
180
EN
Bita
Geramizadeh
Shiraz Transplant Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran;
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
geramib@sums.ac.ir
AmirAhmad
Mostaghni
Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Zeinab
Ranjbar
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Farid
Moradian
Department of Surgery, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
moradian.farid@yahoo.com
Mina
Heidari
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Bagher
Khosravi
0000-0003-1223-2346
Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
khosravimb@sums.ac.ir
Seyed Ali
Malekhosseini
Department of Surgery, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Renal cell carcinoma comprises about 2% of adult tumors. The overall 10-year survival rate of patients with RCC after nephrectomy is about 18-27%. The incidence of metastasis of initial RCC is about 24-28%, but this rate after nephrectomy is as high as 51%. The most common site of recurrence is the lung, however liver and bone metastases are common.There are many reported cases with late metastasis, however isolated late metastasis in the gastrointestinal tract especially duodenum is very rare.Herein we report our experience with a case of gastrointestinal bleeding secondary to metastatic renal cell carcinoma to duodenum, 16 years after nephrectomy.To the best of our knowledge, about 30 of such cases have been reported in the English literature. Many of the previous cases have been part of disseminated disease and isolated duodenal metastasis is very rare. The longest reported duration between nephrectomy for renal cell carcinoma and duodenal metastasis has been 13 years, thus it seems our case to be also unique because of very late duodenal metastasis.
Duodenal ulcer,Gastrointestinal hemorrhage,Renal cell carcinoma,Pancreaticoduodenectomy
https://ijms.sums.ac.ir/article_39730.html
https://ijms.sums.ac.ir/article_39730_8e964b5cf6a9fcf28c5fcaec5b6ee694.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
A Huge Lymphangioma Mimicking Pleural Effusion with Extension to Both Chest Cavities: A Case Report and Review of Literature
181
184
EN
Mohsen
Sokouti
Department of Cardiothoracic Surgery, Tabriz University of Medical Sciences, Tabriz, Iran
zia.hashemi@yahoo.com
Nassir
Rostambeigi
Department of Radiology, University of Minnesota, USA
Monireh
Halimi
Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
Mediastinal lymphangioma is primarily a benign lesion and the majority of the cases are found incidentally. These lesions account for approximately 1% of all mediastinal tumors. Here we present a giant mediastinal cystic mass in a 35-year-old female who was presented with severe respiratory distress. On the plain chest radiography and CT scan, a massive left pleural effusion with large parasternal and mediastinal lymphadenopathy was seen. Thoracentesis was performed and 400 cm³ of clear fluid was drained from the left hemithorax. However, a subsequent CT scan with contrast and the same technique 40 days later showed a large cystic mass in the mediastinum protruding to the right and left hemi thoraces. The giant cystic mass was resected via right and left anterior thoracotomies. Histopathological examination revealed a diagnosis of lymphangioma. The patient has been alive and without tumor recurrence and has been followed for 2 years.
Lymphangioma,Mediastinum,Surgery,Pleural Effusion
https://ijms.sums.ac.ir/article_39733.html
https://ijms.sums.ac.ir/article_39733_6d1b0e9ee57c34817db04f466033ea33.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
40
2
2015
03
01
An Intraoral Epitheloid Hemangioendothelioma Masquerading Clinically as Pyogenic Granuloma
185
189
EN
Bhargavan Sarojini
Sreenivasan
Department of Oral Pathology and Microbiology, Mar Baselios Dental College, Kothamangalam, Ernakulam, Kerala. India
Majo
Ambooken
Department of Periodontics, Mar Baselios Dental College, Kothamangalam, Ernakulam, Kerala, India
Mayeesh
Radhakrishna
Department of Oral Pathology and Microbiology, Mar Baselios Dental College, Kothamangalam, Ernakulam, Kerala. India
Joseph
Sebastian
Department of Oral Pathology and Microbiology, Mar Baselios Dental College, Kothamangalam, Ernakulam, Kerala. India
Epitheloid hemangioendothelioma (EHE) is an uncommon angiocentric neoplasm of intermediate malignant potential. This tumor is frequently seen in the lungs and liver, but its presentation in the oral cavity is rare. In the oral cavity, gingival region is the common sites of occurrence. We report a rare case of epitheloid hemangioendothelioma in a 48-year-old male, presenting as a growth in the upper anterior gingiva of five months duration along with a review of its clinicopathological and immunohistochemical characteristics.
Epithelioid hemangioendothelioma,Neoplasms,Vascular neoplasm
https://ijms.sums.ac.ir/article_39736.html
https://ijms.sums.ac.ir/article_39736_0e4163b8a7f43db03568a6dae0266e78.pdf