Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Quality Assessment of Published Articles in Iranian Journals Related to Economic Evaluation in Health Care Programs Based on Drummond’s Checklist: A Narrative Review
427
436
EN
Aziz
Rezapour
Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Health Economics, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran; Center of Excellence in Health Management and Economics, Iran University of Medical Sciences, Tehran, Iran
asloiy@yahoo.com
Abdosaleh
Jafari
0000-0003-3035-2798
Department of Health Economics, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran
abdosaleh.jafari@gmail.com
Kosha
Mirmasoudi
Student Research Committee, Department of Health Care Management, School of Management and Medical Information, Shiraz University of Medical Science, Shiraz, Iran
Hamid
Talebianpour
Student Research Committee, Department of Health Care Management, School of Management and Medical Information, Shiraz University of Medical Science, Shiraz, Iran
AbstractHealth economic evaluation research plays an important role in selecting cost-effective interventions. The purpose of this study was to assess the quality of published articles in Iranian journals related to economic evaluation in health care programs based on Drummond’s checklist in terms of numbers, features, and quality. In the present review study, published articles (Persian and English) in Iranian journals related to economic evaluation in health care programs were searched using electronic databases. In addition, the methodological quality of articles’ structure was analyzed by Drummond’s standard checklist. Based on the inclusion criteria, the search of databases resulted in 27 articles that fully covered economic evaluation in health care programs. A review of articles in accordance with Drummond’s criteria showed that the majority of studies had flaws. The most common methodological weakness in the articles was in terms of cost calculation and valuation. Considering such methodological faults in these studies, it is anticipated that these studies would not provide an appropriate feedback to policy makers to allocate health care resources correctly and select suitable cost-effective interventions. Therefore, researchers are required to comply with the standard guidelines in order to better execute and report on economic evaluation studies.
Iranian journals,Cost-benefit analysis,Checklist,Economics,Medical,Review
https://ijms.sums.ac.ir/article_40471.html
https://ijms.sums.ac.ir/article_40471_db53d9e60104b40451e0b65fb39a9d0e.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Reliability of Interaural Time Difference-Based Localization Training in Elderly Individuals with Speech-in-Noise Perception Disorder
437
442
EN
Maryam
Delphi
Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
delphi.maryam1@gmail.com
Yones
Lotfi
0000-0001-8563-312X
Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
yones1333@gmail.com
Abdollah
Moossavi
Department of Otolaryngology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
amoosavi@gmail.com
Enayatollah
Bakhshi
Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
bakhshi@razi.tums.ac.ir
Maryam
Banimostafa
Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Background: Previous studies have shown that interaural-time-difference (ITD) training can improve localization ability. Surprisingly little is, however, known about localization training vis-à-vis speech perception in noise based on interaural time difference in the envelope (ITD ENV). We sought to investigate the reliability of an ITD ENV-based training program in speech-in-noise perception among elderly individuals with normal hearing and speech-in-noise disorder.Methods: The present interventional study was performed during 2016. Sixteen elderly men between 55 and 65 years of age with the clinical diagnosis of normal hearing up to 2000 Hz and speech-in-noise perception disorder participated in this study. The training localization program was based on changes in ITD ENV. In order to evaluate the reliability ofthe training program, we performed speech-in-noise tests before the training program, immediately afterward, and then at 2 months’ follow-up. The reliability of the training program was analyzed using the Friedman test and the SPSS software. Results: Significant statistical differences were shown in the mean scores of speech-in-noise perception between the 3 time points (P=0.001). The results also indicated no difference in the mean scores of speech-in-noise perception between the 2 time points of immediately after the training program and 2 months’ follow-up (P=0.212).Conclusion: The present study showed the reliability of an ITD ENV-based localization training in elderly individuals with speech-in-noise perception disorder.
Aged,Speech disorders,Speech perception,Humans
https://ijms.sums.ac.ir/article_40472.html
https://ijms.sums.ac.ir/article_40472_f209d6909ce7c455713eb9a08b7f61f9.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Multilocus Sequence Typing of the Clinical Isolates of Salmonella Enterica Serovar Typhimurium in Tehran Hospitals
443
448
EN
Reza
Ranjbar
Molecular Biology Research Center, Baqiyatallah University of Medical Sciences of Tehran, Tehran, Iran
ranjbarr@yahoo.com
Parisa
Elhaghi
Department of Microbiology, Faculty of Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
parisa.elhaghi@yahoo.com
Leili
Shokoohizadeh
Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
shokoohizadeh@yahoo.com
Background: Salmonella enterica serovar Typhimurium is one of the most important serovars of Salmonella enterica and is associated with human salmonellosis worldwide. Many epidemiological studies have focused on the characteristics of Salmonella Typhimurium in many countries as well as in Asia. This study was conducted to investigate the genetic characteristics of Salmonella Typhimurium using multilocus sequence typing (MLST).Methods: Clinical samples (urine, blood, and stool) were collected from patients, who were admitted to 2 hospitals in Tehran between April and September, 2015. Salmonella Typhimurium strains were identified by conventional standard biochemical and serological testing. The antibiotic susceptibility patterns of the Salmonella Typhimurium isolates against 16 antibiotics was determined using the disk diffusion assay. The clonal relationship between the strains of Salmonella Typhimurium was analyzed using MLST.Results: Among the 68 Salmonella isolates, 31% (n=21) were Salmonella Typhimurium. Of the total 21 Salmonella Typhimurium isolates, 76% (n=16) were multidrug-resistant and showed resistance to 3 or more antibiotic families. The Salmonella Typhimurium isolates were assigned to 2 sequence types: ST19 and ST328. ST19 was more common (86%). Both sequence types were further assigned to 1 eBURST group.Conclusion: This is the first study of its kind in Iran to determine the sequence types of the clinical isolates of Salmonella Typhimurium in Tehran hospitals using MLST. ST19 was detected as the major sequence type of Salmonella Typhimurium.
Salmonella Typhimurium,Multilocus sequence typing,Salmonella infections animal
https://ijms.sums.ac.ir/article_40476.html
https://ijms.sums.ac.ir/article_40476_b946ec10933e85ee284b0d5d6571230d.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
The Effects of Piper Guineense versus Sesamum Indicum Aqueous Extracts on Lipid Metabolism and Antioxidants in Hypercholesterolemic Rats
449
456
EN
Sarah
O
Nwozo
Nutritional and Industrial Research Laboratories, Department of Biochemistry, Faculty of Basic Medical Science, College of Medicine, University of Ibadan, Ibadan, Nigeria
sonwozo@yahoo.com
Yetunde
T
Lewis
Department of Biochemistry, College of Science, Afe Babalola University, Ado Ekiti, Nigeria
Babatunji
E
Oyinloye
Department of Biochemistry, College of Science, Afe Babalola University, Ado Ekiti, Nigeria
Background: Piper guineense (PG) and Sesamum indicum (SI) have been shown to be rich sources of antioxidants and other health benefits; hence, we evaluated the impact of its consumption in hypercholesterolemic model on lipid metabolism. Methods: Forty-eight animals were divided into eight groups of six rats each. Rats were given cholesterol (40 mg/0.3ml), PG and SI extract (100 and 200 mg/kg), and Questran (0.26 g/kg) orally, five times a week for 28 days. Lipid profile, hepatic antioxidant status, biomarkers of liver toxicity, and tissue histopathology were examined. Data were analyzed using one-way ANOVA and P<0.05 were considered statistically significant.Results: Cholesterol feeding caused 100% gain in weight, significantly increased AST, LPO (P=0.41 and 0.002) but significantly decreased SOD (P=0.003) compared to control. CHPG(1)/(2) and CHSI(1)/(2) caused a significant decrease (P=0.01, 0.005, 0.003, and 0.023) in cholesterol-induced body-weight gain and decreased serum total cholesterol by 20-30% compared to untreated-hypercholesterolemic rats. Triglyceride and LDL-c decreased with extract administration and specifically HDL-c increased significantly (P<0.001) by CHSI(1) compared to untreated-hypercholesterol rats. Furthermore, an increase in HDL-c was higher (P=0.04 and 0.002) by SI compared to PG at both doses. Conclusion: These results indicate that PG and SI exerts a hypolipidemic effect, reduces cholesterol intake induced body weight gain, and increases the body’s antioxidant defense system in experimental hypercholesterolemia.
Antioxidants,Hypercholesterolemia,Hyperlipidemias,Piper guineense,Sesamum indicum
https://ijms.sums.ac.ir/article_40480.html
https://ijms.sums.ac.ir/article_40480_d6d6b186081873e128e579ef6c23aee0.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Combined Extract of Heated 4T1 and a Heat-Killed Preparation of Lactobacillus Casei in a Mouse Model of Breast Cancer
457
464
EN
Sajjad
Jafari
Division of Immunology, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
alireza.alirezai@gmail.com
Seyyed Meysam
Abtahi Froushani
0000-0003-2579-6618
Division of Immunology, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
meysamabtahi@hotmail.com
Amir
Tokmachi
Division of Immunology, Department of Microbiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
ahmadreza.reza4@gmail.com
Background: The adjuvanticity potential of Lactobacillus casei was first suggested in an old survey. The present study was designed to investigate the efficacy of a new immunotherapy against breast cancer made by mixing an extract of heated 4T1 mammary carcinoma cell line and a heat-killed preparation of Lactobacillus casei.Methods: Female BALB/c mice (6–8 weeks old, n=40) were challenged subcutaneously in the right flanks with 4T1 cells. When all the animals developed a palpable tumor, they were allocated to 4 equal groups and immunotherapy was initiated. The tumor-bearing mice in the experimental groups received the extract of heated 4T1 or heated Lactobacillus casei and/or a combination of both, twice at a 1-week interval. The mice in the control group received phosphate-buffered saline. One week after the last immunotherapy, one half of the mice were euthanized to determine the immune response profile. The remaining animals were kept until death occurred spontaneously.Results: The animals receiving the combined treatment significantly showed more favorable survival curves and slower rates of tumor development than the tumor-bearing mice receiving only the heated 4T1 and/or the negative control mice. The combined immunization significantly amplified the production of nitric oxide and the cytotoxicity of natural killer cells in the spleen cell culture of the tumor-bearing mice. Moreover, the combined immunotherapy significantly increased the secretion of IFN-γ and conversely diminished the secretion of IL-4 and TGF-β in the splenocyte population compared to the splenocytes from the other groups.Conclusion: The combined immunotherapy with heated 4T1 cells and heated Lactobacillus casei conferred beneficial outcomes in our mouse model of breast cancer.
4T1 cell line,Breast neoplasms,Lactobacillus casei,immunotherapy
https://ijms.sums.ac.ir/article_40481.html
https://ijms.sums.ac.ir/article_40481_11321104ddd0bd0389426ad3f7eb0c1c.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Vitamin E-Coated Polysulfone Membrane-Based Hemodiafiltration Attenuates Inflammation in a Rat Model of Lipopolysaccharide-Induced Systemic Inflammation
465
472
EN
Yoshihiro
Hatanaka
Medical Material Laboratory, Asahi Kasei Medical Company, Oaza-Sato, Oita, Japan
hatanaka.yc@om.asahi-kasei.co.jp
Satoru
Inoue
Medical Material Laboratory, Asahi Kasei Medical Company, Oaza-Sato, Oita, Japan
Koji
Goto
Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Idaigaoka-Hasamamachi, Yufu City, Oita, Japan
ko.goto@oita-u.ac.jp
Norihisa
Yasuda
Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Idaigaoka-Hasamamachi, Yufu City, Oita, Japan
yasu@oita-u.ac.jp
Seigo
Hidaka
Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Idaigaoka-Hasamamachi, Yufu City, Oita, Japan
sehidaka@oita-u.ac.jp
Takaaki
Kitano
Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Oita University, Idaigaoka-Hasamamachi, Yufu City, Oita, Japan
tkitano@oita-u.ac.jp
Background: Acute blood purification (ABP) therapy is used regularly in the clinical setting and reportedly alleviates organ failure associated with severe systemic inflammatory responses, leading to reduced mortality. The present study aimed to determine whether there is a difference in efficacy between polysulfone (PS) membranes, which are currently used regularly in the clinical setting, and vitamin E-coated polysulfone (VEPS) membranes, which are anticipated to exhibit the antioxidant and anti-inflammatory properties of vitamin E.Methods: Male Wistar rats (n=15/group) were intravenously administered 10 mg/kg of lipopolysaccharide (LPS) to establish a systemic inflammatory response model. Six hours after LPS administration, hemodiafiltration (HDF) was performed for 30 minutes using a PS or VEPS membrane under general anesthesia. Blood was collected at various time points, lung tissue was evaluated histologically, and 24-hour survival was assessed.Results: The rats in the VEPS group tended to have a higher survival rate than those in the PS group when undergoing HDF, although the difference was not significant. With respect to lung tissue, the inflammatory response was suppressed to a greater extent in the VEPS group than the PS group. Serum interleukin (IL)-6 levels were reduced at an early stage, plasma antioxidant activity was increased, and oxidative stress was reduced in the VEPS group compared to the PS group.Conclusion: Relative to PS membrane-based HDF, the survival rate tended to improve and inflammation was subdued earlier due to the antioxidant activity and early attenuation of inflammation associated with VEPS membrane-based HDF.
Vitamin E,Inflammatory response,Polysulfone,Hemodiafiltration,Rats
https://ijms.sums.ac.ir/article_40483.html
https://ijms.sums.ac.ir/article_40483_f267c69c8d3b71d264861f239e6ba2b5.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Role of the Nitrergic System of the Cuneiform Nucleus in Cardiovascular Responses in Urethane-Anesthetized Male Rats
473
480
EN
Esmaeil
Farrokhi
Department of Physiology, Faculty
of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mohammad Naser
Shafei
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
shafeimn@mums.ac.ir
Abolfazl
Khajavirad
Department of Physiology, Faculty
of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; and Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud
Hosseini
Neurocognetive Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Reza
Ebrahimzadeh Bideskan
Department of Anatomy and Cellular Biology, Mashhad University of Medical Sciences, Mashhad, Iran
Background: The presence of nitric oxide (NO) in the cuneiform nucleus (CnF) has been previously shown. In this study, NG-nitro-L-arginine methyl ester (L-NAME) (an inhibitor of NO synthase), L-arginine (L-Arg) (a precursor of NO), and sodium nitroprusside (SNP) (a donor of NO) were microinjected into the CnF and cardiovascular responses were investigated. Methods: Seventy male rats were divided into 7 groups (n=10 each): 1) saline, 2 and 3) L-NAME (30 and 90 nmol), 4 and 5) L-Arg (20 and 60 nmol), and 6 and 7) SNP (9 and 27 nmol). After anesthesia, the femoral artery was cannulated and cardiovascular parameters were recorded using a PowerLab system. Time course changes in mean arterial pressure (ΔMAP) and heart rate (ΔHR) were calculated and compared with those in the control group (repeated measures ANOVA). Maximum ∆MAP and ∆HR were also compared with those in the control group (independent sample t test).Results: ∆MAP with both doses of L-NAME (30: P=0.026 and 90: P=0.007) and ∆HR with the higher dose (P=0.034) were significantly higher than those in the control group. Maximal ∆MAP with both doses (P<0.01 and P<0.001, n=10) and maximal ∆HR with the higher dose (P<0.01) were significantly higher than those in the control group. Changes in L-Arg with both doses were not significantly higher than those in the control group (P=0.26, n=8). ∆MAP and ∆HR of SNP only with the higher dose were significantly lower than those in the control group (P=0.006 and P=0.035), and maximal responses with the higher dose were lower than those in the control group (∆MAP: P<0.01 and ∆HR: P<0.05, n=7).Conclusion: Our results showed that the nitrergic system of the CnF had an inhibitory effect on central cardiovascular regulation.
Cuneiform nucleus,Nitroprusside,Nitric oxide,Blood pressure,NG-nitro-L-arginine methyl ester
https://ijms.sums.ac.ir/article_40484.html
https://ijms.sums.ac.ir/article_40484_198a88831deefc4d005708e505d69c4d.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Urban-Rural Differences in the Prevalence of Self-Reported Diabetes and its Risk Factors: The WHO STEPS Iranian Noncommunicable Disease Risk Factor Surveillance in 2011
481
487
EN
Zahra
Khorrami
Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Shahin
Yarahmadi
Center for Noncommunicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran
drshyarahmadi@yahoo.com
Koorosh
Etemad
Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Soheila
Khodakarim
Department of Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran
lkhodakarim@gmail.com
Mohammad Esmaeil
Kameli
Department of Health, Ministry of Health and Medical Education, Tehran, Iran
kameli@health.gov.ir
Ali Reza
Mahdavi Hazaveh
Center for Noncommunicable Diseases Control, Ministry of Health and Medical Education, Tehran, Iran
armahdavi@yahoo.com
AbstractThe high prevalence of diabetes in Iran and other developing countries is chiefly attributed to urbanization. The objectives of the present study were to assess the prevalence of self-reported diabetes and to determine its associated risk factors. This study is a part of the national noncommunicable disease risk factor surveillance, conducted in 31 provinces of Iran in 2011. First, 10069 individuals, between 20 and 70 years old (3036 individuals from rural and 7033 from urban areas), were recruited. The major risk factors were studied using a modified WHO STEPS approach. Diabetes was considered based on self-reported diabetes. The prevalence of self-reported diabetes was 10% overall. The prevalence in the rural and urban settings was 7.4% and 11.1%, respectively. Moderate physical activity (OR=0.45, 95% CI=0.29–0.71) and family history of diabetes) OR=6.53, 95% CI=4.29–9.93) were the most important risk factors among the rural residents and systolic blood pressure (OR=1.01, 95% CI=1–1.02), waist circumference (OR=1.02, 95% CI=1.01–1.03), and overweight (OR=1.36, 95% CI= 1–1.84) were significantly associated with self-reported diabetes in the urban residents. The prevalence of self-reported diabetes in the urban setting was higher than that in the rural setting. Physical inactivity, abdominal obesity, and high blood pressure were the most important risk factors associated with self-reported diabetes in Iran.
Self report,prevalence,Risk factors,Non-communicable disease,Iran
https://ijms.sums.ac.ir/article_40473.html
https://ijms.sums.ac.ir/article_40473_0864de13b9505222356aa6e86e73a427.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy
488
492
EN
Farhad
Handjani
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
hanjanif@yahoo.com
Saeed Reza
Yousef
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
josephmartin284@yahoo.com
Nasrin
Saki
0000-0002-9795-6898
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
nasrinsa85@yahoo.com
Nasrin
Hamidizadeh
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
nhamidizadeh@gmx.net
AbstractPentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cryotherapy besides its local effects in the treatment of CL. Twenty patients with CL were selected. The disease was confirmed via a direct smear. A venous blood sample was collected to determine IL-10 and IFN-γ levels before starting cryotherapy. Then, 1 week after 8 sessions of cryotherapy were completed (i.e., 63 d), a 2nd venous sample was taken in order to compare the results with the pretreatment levels of these cytokines using the ELISA method. Cryotherapy resulted in no change in the levels of IL-10 and significantly increased the IFN-γ levels in our patients with CL. Given these inconclusive or even mixed results, a larger sample size is needed in order to better assess the systemic immunological effects of cryotherapy.
Leishmaniasis,Cutaneous,Interleukin-10,Interferon-gamma
https://ijms.sums.ac.ir/article_40478.html
https://ijms.sums.ac.ir/article_40478_163375b3aa5e5219b9c08a7e67756ffc.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Lymph Node Enlargement in Neck Filariasis as a Rare Cause: A Case Report
493
496
EN
Rindu
Raveendran
0000-0003-1546-6607
Department of ENT, Kannur Medical College, Anjarakandy, Kerala, India
rinduraveendran@ymail.com
Lymphatic filariasis is endemic to tropical countries and is the most common cause of acquired lymphedema in the world. Wuchereria bancrofti is the main etiological agent responsible. While the presentation of filariasis in limbs is common, isolated presentation as a single enlarged lymph node in the neck is very rare. We describe a 48-year-old Indian woman, who presented with a hard lymph node in the neck. There was no other significant lymph node enlargement. The overlying skin was erythematous, and no other findings were present on examination. Ultrasonography of the neck revealed a single enlarged lymph node in the left level 2 region, and fine-needle aspiration cytology showed microfilariae with surrounding inflammatory infiltrate. The patient was started on oral diethylcarbamazine and after 2 weeks of therapy, the lymph node enlargement in the neck subsided and the erythema was relieved.
Lymphadenopathy,Lymph node enlargement,Filariasis,Neck
https://ijms.sums.ac.ir/article_40470.html
https://ijms.sums.ac.ir/article_40470_46a1e4101656e3e88cb54d51ee8b7883.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
A Rare Case of Fixed Drug Eruption due to Ondansetron
497
500
EN
Aditi
Maitra
Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India;
maitra.aditi@yahoo.co.in
Shashwat
Bhattacharyya
Department of Ophthalmology, Calcutta National Medical College, Kolkata, India
bhattacharyya.shashwat@gmail.com
Sabyasachi
Paik
Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India;
Prerna
Pathak
Department of Dermatology and Venereology, Calcutta School of Tropical Medicine, Kolkata, India
prerna27jha@gmail.com
Santanu
Kumar
Tripathi
Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India;
dr.sukantsen@yahoo.co.in
AbstractFixed drug eruption (FDE) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. FDE is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. A 27-year-old woman presented with multiple dark patches over her eyelids, mouth, lips, and shoulders of 1 week’s duration. These lesions followed multiple erythematous plaques over the same areas which appeared within 4 hours of the intake of an ondansetron tablet, 12 days previously. The case was diagnosed as post-inflammatory hyperpigmentation following ondansetron-induced FDE. There was an identical episode 1 year earlier due to the intake of the same drug. The causality assessment pointed toward a probable/likely association as per the Naranjo algorithm and the WHO–UMC scale. There have been only a few cases of FDE due to ondansetron in the reported literature.
Ondansetron,Hyperpigmentation,Fixed drug eruption,5HT3 receptor antagonists
https://ijms.sums.ac.ir/article_40477.html
https://ijms.sums.ac.ir/article_40477_330ed386a297526d7cbc57a45a97cf10.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Ellis-van Creveld with an Unusual Dental Anomaly: A Case Report
501
504
EN
Suzanne
Tanya
Nethan
Department of Oral Medicine and Radiology, Saraswati Dental College, Lucknow, Uttar Pradesh, India
suzanne.nethan@gmail.com
Shruti
Sinha
Department of Oral Medicine and Radiology, Saraswati Dental College, Lucknow, Uttar Pradesh, India
drshrutisinha05@gmail.com
Sunira
Chandra
Department of Oral Medicine and Radiology, Saraswati Dental College, Lucknow, Uttar Pradesh, India
sunira_chandra1@yahoo.co.in
The Ellis-van Creveld (EVC) syndrome is a chondroectodermal dysplasia and is characterized by the cardinal features of disproportionate short stature, polydactyly, hidrotic ectodermal dysplasia, and congenital heart malformations, along with other skeletal and dental abnormalities. It is a rare condition, with very few cases reported in the medical literature. It is inherited as an autosomal recessive disorder with variable expressions, due to the mutation of the EVC syndrome 1 and 2 genes, which are located on chromosome 4p16. The present case report describes the EVC syndrome in a 14-year-old girl, who presented with a tetrad of all the cardinal features and other associated features. Additional unusual dental findings such as single-rooted funnel-shaped molars, reduced crown size, enamel hypoplasia, supernumerary teeth, dental fusion, taurodontism, abnormal occlusal anatomy with wide grooves, and atypical cusps have been reported in most previous cases of this syndrome. However, in our patient, surprisingly, the teeth present were relatively non-anomalous, both clinically and radiographically (i.e., with none of the usually found abnormalities mentioned above). The only abnormal dental findings were those of absent maxillary and mandibular incisors (including impacted permanent incisors) and mild malocclusion, a novel point of this case.
Syndrome,Dwarfism,Polydactyly,Ectodermal dysplasia,Cardiac defect
https://ijms.sums.ac.ir/article_40479.html
https://ijms.sums.ac.ir/article_40479_d275acc6d77d269f87c6eda42df20de2.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Primary Leiomyosarcoma of the Mesentery: A Case Report
505
508
EN
Varsha
Dalal
Department of Pathology, National Institute of Pathology, ICMR, New Delhi, India;
vndreamon12@gmail.com
Manveen
Kaur
Department of Pathology, National Institute of Pathology, ICMR, New Delhi, India;
docmanveen@gmail.com
Reetika
Menia
Department of Pathology, National Institute of Pathology, ICMR, New Delhi, India;
reetika830@gmail.com
Fouzia
Siraj
Department of Pathology, National Institute of Pathology, ICMR, New Delhi, India;
fouziasiraj2009@gmail.com
Amar
Bhatnagar
Department of Cancer Surgery, VMMC and Safdarjung Hospital, New Delhi, India
Usha
Agrawal
Department of Pathology, National Institute of Pathology, ICMR, New Delhi, India;
uagrawal@instpath.gov.in
AbstractMesenteric masses are infrequent lesions ranging from benign cysts to aggressive malignancies and often present a diagnostic and therapeutic challenge. The mesentery is a frequent recipient of metastases from the gastrointestinal tract, pancreas, and biliary cancers. Primary mesenteric tumors are relatively rare, mostly mesenchymal in origin and benign in nature. Examples include gastrointestinal stromal tumors and smooth muscle tumors. We describe a 50-year-old woman, who presented with a lump in the left hypochondrium along with altered bowel habits of 2 years’ duration. Imaging revealed a cystic lesion, raising the differentials of a benign lesion. Exploratory laparotomy revealed a large cystic mass in the mesentery closely abutting the jejunal loops. This was followed by mass resection along with a segment of the jejunum. Histopathological examination revealed features of a leiomyosarcoma. Postoperatively, the patient developed a colocutaneous fistula, which was re-excised. At 6 months’ follow-up, the patient is doing well. Our case demonstrates the diagnostic challenge posed by the atypical clinical and imaging features of this tumor at an unusual site.
Mesentery,Leiomyosarcoma,Gastrointestinal
https://ijms.sums.ac.ir/article_40482.html
https://ijms.sums.ac.ir/article_40482_79ee39f43f38d24a6f6acf60102aff55.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Efficacy of ε-Poly-L-lysine as an Antibacterial Additive for Platelets Stored at Room Temperature
509
511
EN
Hosein
Timori Naghadeh
Department of Pathology, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion
Medicine, Tehran, Iran
Zohreh
Sharifi
Department of Virology, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion
Medicine, Tehran, Iran;
z.sharifi@ibto.ir
Saeideh
Soleimani
Department of Virology, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion
Medicine, Tehran, Iran;
Zainab
Pir Mohamad Jamaat
Department of Biotechnology, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion
Medicine, Tehran, Iran
Shirin
Ferdowsi
Department of Hematology, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran; and Kurdistan Blood Transfusion Organization, Sanandaj, Iran
sh.ferdowsi@tmi.ac.ir
https://ijms.sums.ac.ir/article_40474.html
https://ijms.sums.ac.ir/article_40474_b7944936f182a4b6b51a6c8c659e2878.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
42
5
2017
09
01
Cranial Nerve Lymphomatosis Magnetic Resonance Imaging Findings in a Case of Mantle Cell Lymphoma
512
513
EN
Güliz
Yılmaz
Department of Radiology, Gaziosmanpaşa Hospital, Istanbul Yeni Yüzyıl University, Istanbul, Turkey;
Süha
Akpınar
Department of Radiology, Near East University Hospital, Nicosia, North Cyprus,Turkey;
Nail
Bulakbaşı
Department of Radiology, Near East University Hospital, Nicosia, North Cyprus,Turkey
nbulakbasi@gmail.com
https://ijms.sums.ac.ir/article_40475.html
https://ijms.sums.ac.ir/article_40475_1ce4bc8b74739a1b533a30b17bda373d.pdf