TY - JOUR ID - 39573 TI - Hypothyroidism in β-Thalassemia Intermedia Patients with and without Hydroxyurea JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Zekavat, Omid Reza AU - Makarem, Ali Reza AU - Haghpanah, Sezaneh AU - Karamizadeh, Zohreh AU - Javad, Parvin AU - Karimi, Mehran AD - Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran AD - Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran AD - Department of Pediatric Endocrinology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2014 PY - 2014 VL - 39 IS - 1 SP - 60 EP - 63 KW - Thalassemia intermedia KW - Hydroxyurea KW - Thyroid Function DO - N2 - Hydroxyurea (HU) has been successfully used in patients with β-thalassemia intermedia (β-TI). We aimed to evaluate the effect of the long-term use of HU on thyroid function in patients with β-TI. Seventy-five patients with β-TI aged≥11 years and taking HU were randomly selected during 2010 in southern Iran. Thirty-one patients with β-TI without HU were considered as a control group. Serum levels of thyroid stimulating hormone (TSH) and T4 were measured. The mean age of the participants was 22.7±5.1 years (age range=12-41 years). Serum ferritin level had no significant correlation with HU consumption (P>0.05). Overall, we detected 10 (9.4%) patients with hypothyroidism. We found that the use of HU at a dose of 8-15 mg/kg/day has no significant association with thyroid function in β-TI patients. However, due to the small sample size in our study, documentation of this finding needs further studies with higher numbers of patients. UR - https://ijms.sums.ac.ir/article_39573.html L1 - https://ijms.sums.ac.ir/article_39573_ec0b766d45ea9f8bb31c8b9497bcd0f1.pdf ER -