TY - JOUR ID - 39658 TI - Non-Diethylstilbestrol-Associated Primary Clear Cell Carcinoma of the Vagina: Two Case Reports with Immunohistochemical Studies and Literature Review JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Mufti, Shagufta T. AU - Ali, Hiba Hassan AD - Department of Anatomic Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia Y1 - 2014 PY - 2014 VL - 39 IS - 3 SP - 298 EP - 303 KW - Diethylstilbestrol KW - Clear cell carcinoma KW - Vagina DO - N2 - Primary clear cell adenocarcinomas most commonly involve the genitourinary system, including the vagina. Previously, primary clear cell adenocarcinomas of the vagina have been discussed within the context of prenatal exposure to diethylstilbestrol. Due to its widely proven role in the development of this carcinoma, administration of diethylstilbestrol is prohibited. We present two cases of non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina from the archives of the Anatomical Pathology Department at King Abdulaziz University in order to improve our understanding of its biological behavior. Our findings suggest that primary clear cell adenocarcinoma of the vagina may be unrelated to diethylstilbestrol exposure and that non-diethylstilbestrol-associated primary clear cell adenocarcinoma of the vagina, when present at a younger age, may have a worse prognosis. UR - https://ijms.sums.ac.ir/article_39658.html L1 - https://ijms.sums.ac.ir/article_39658_2b702d66fb2c9f4b646bb0fd4f145e68.pdf ER -