TY - JOUR ID - 39916 TI - Langerhans Cell Histiocytosis Followed by Hodgkin Lymphoma: A Case Report JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Safaei, Akbar AU - Bagheri, Mandana AU - Shahryari, Jahanbanoo AU - Noori, Sadat AU - Esmailzade, Elmira AD - Department of Pathology, Molecular Pathology and Cytogenetic Ward, Shiraz University of Medical Sciences, Iran AD - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2015 PY - 2015 VL - 40 IS - 3 SP - 282 EP - 286 KW - Langerhans cell histiosis KW - Hodgkin disease KW - Immunohistochemistry DO - N2 - Langerhans cell histiocytosis (LCH) is a rare neoplasm defined as the proliferation of bone marrow langerhans cells, which is a kind of dendritic cells. The major pathological features of LCH are expression of CD1a and S100 as well as Birbeck granules. Its presentation can differ from a mild bone lesion to a multi-systemic evolved malignant neoplasm; however, the latter outcome is almost rare. Thus, LCH is mostly known as a benign neoplasm. In this study, we present a case of LCH followed by Hodgkin lymphoma (HL). Accompaniment of this disease with malignant lymphoma is rare and considered as case report. Several cases in which malignant lymphoma occurred prior to LCH are reported; however, few cases can be found with LCH followed by malignant lymphomas. UR - https://ijms.sums.ac.ir/article_39916.html L1 - https://ijms.sums.ac.ir/article_39916_decd64120bb9a06dcf19eebd0d1b9169.pdf ER -