TY - JOUR ID - 40147 TI - The Efficacy of Implant of Octacalcium Phos-phate in Combination with Bone Matrix Gelatin on Bone Regeneration in Skull Defects in Rat JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Sargolzaei-Aval, F. AU - Sobhani, A. AU - Arab, M.R. AU - Sarani, S.A . AU - Heydari, M.H. AD - Departments of Anatomy, Zahedan University of Medical Sciences, Zahedan, Iran. AD - Departments of Anatomy, Tehran University of Medical Sciences, Tehran, Iran. AD - Fasa Faculty of Medical Sciences, Fasa, Iran. Y1 - 2015 PY - 2015 VL - 29 IS - 3 SP - 124 EP - 129 DO - N2 - Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawley rats.  A full thickness standardized trephine defect—5-mm in diameter—was made in the rat parietal bone and OCP/BMG was implanted into the defect.  No OCP/BMG particles were implanted in control group that was otherwise treated identically. After sacrificing the rats chronologically and processing the tissues by routine histological procedures, 5-mm thick sections of bone were stained and examined under light microscope. Results: On the 5th day of implantation, inflammatory cells were seen around the implanted materials, especially around the OCP particles.  By the end of 21st day, almost all of the OCP/BMG particles were absorbed and bone trabeculae, bone marrow cavities and bone marrow tissues were seen. In the control group, at the end of 21th day, a few areas of new bone were seen near to the defect margins and host bone, however, in much less amount than in the experimental group. Conclusion: Implant of OCP/BMG appears to stimulate new bone regeneration in bone defects. These biomaterials can be used for repair of cranial bone defects. UR - https://ijms.sums.ac.ir/article_40147.html L1 - https://ijms.sums.ac.ir/article_40147_8625194ce23afbc65571f8311fc53a75.pdf ER -