TY - JOUR ID - 40433 TI - Tumefactive Fibroinflammatory Lesion: A Diagnostic Dilemma JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Jain, Promil AU - Sen, Rajeev AU - Sharma, Nisha AU - Bhargava, Shilpi AU - Singh, Virender AD - Department of Pathology, Pt BDS PGIMS, University of Health Sciences, Rohtak, India; AD - Department of Oral Pathology, PGIDS, University of Health Sciences, Rohtak, India Y1 - 2017 PY - 2017 VL - 42 IS - 2 SP - 205 EP - 209 KW - Tumefactive fibroinflammatory lesion KW - Sinus KW - Neoplasms DO - N2 - Tumefactive fibroinflammatory lesions (TFLs) are rare idiopathic benign fibrosclerosing lesions that clinically simulate a malignancy. TFLs are seen more frequently in males between 10 and 74 years of age. The usual site of involvement is the head and neck region, but rarely the extremities may be involved. Coexisting fibrosclerotic processes have been reported including retroperitoneal fibrosis, sclerosing cholangitis, sclerosing mediastinal fibrosis, and orbital pseudotumors. The etiology of this poorly understood entity remains unknown. Possible suggestions include exaggerated responses or autoimmune reactions to any chronic infection. The clinical and radiological appearance of TFLs is that of malignancy, but histopathology reveals them to be a benign process broadly classified under non-neoplastic, fibroinflammatory proliferations. The treatment strategies for these lesions are not well defined and variable and include steroids, surgery, and radiotherapy either alone or in combination. TFLs, albeit not fatal, have a high recurrence rate; patients should, therefore, be kept on long-term follow-up. We describe a young female patient presenting with a rapidly developing cheek swelling, which was diagnosed histopathologically as a TFLs. UR - https://ijms.sums.ac.ir/article_40433.html L1 - https://ijms.sums.ac.ir/article_40433_030a3dd363906905c64b20c6c45c7e8e.pdf ER -