TY - JOUR ID - 40477 TI - A Rare Case of Fixed Drug Eruption due to Ondansetron JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Maitra, Aditi AU - Bhattacharyya, Shashwat AU - Paik, Sabyasachi AU - Pathak, Prerna AU - Tripathi, Santanu Kumar AD - Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India; AD - Department of Ophthalmology, Calcutta National Medical College, Kolkata, India AD - Department of Dermatology and Venereology, Calcutta School of Tropical Medicine, Kolkata, India Y1 - 2017 PY - 2017 VL - 42 IS - 5 SP - 497 EP - 500 KW - Ondansetron KW - Hyperpigmentation KW - Fixed drug eruption KW - 5HT3 receptor antagonists DO - N2 - AbstractFixed drug eruption (FDE) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. FDE is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. A 27-year-old woman presented with multiple dark patches over her eyelids, mouth, lips, and shoulders of 1 week’s duration. These lesions followed multiple erythematous plaques over the same areas which appeared within 4 hours of the intake of an ondansetron tablet, 12 days previously. The case was diagnosed as post-inflammatory hyperpigmentation following ondansetron-induced FDE. There was an identical episode 1 year earlier due to the intake of the same drug. The causality assessment pointed toward a probable/likely association as per the Naranjo algorithm and the WHO–UMC scale. There have been only a few cases of FDE due to ondansetron in the reported literature. UR - https://ijms.sums.ac.ir/article_40477.html L1 - https://ijms.sums.ac.ir/article_40477_330ed386a297526d7cbc57a45a97cf10.pdf ER -