TY - JOUR ID - 40498 TI - Deltamethrin-Induced Hepatotoxicity and Virgin Olive Oil Consumption: An Experimental Study JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Khalatbary, Ali Reza AU - Nasiry Zarrin Ghabaee, Davood AU - Ahmadvand, Hassan AU - Talebpour Amiri, Fereshteh AU - Tadayoni Lehi, Somaieh AD - Molecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran AD - Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran AD - Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran; and Razi Herbal Medicine Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran Y1 - 2017 PY - 2017 VL - 42 IS - 6 SP - 586 EP - 592 KW - Decamethrin KW - Olive oil KW - Antioxidants KW - Inflammation KW - apoptosis KW - Hepatotoxicity DO - N2 - Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide which can lead to pathological effects in mammals through oxidative stress. On the other hand, virgin olive oil (VOO) is a rich source of phenolic compounds with antioxidants. The aim of the present study was to determine the protective effects of VOO against DM-induced hepatotoxicity. Methods: Thirty-six mice were randomly separated into 4 groups: vehicle group, VOO group, DM group, and DM plus VOO group. Immunohistochemistry of PARP, COX-2, and caspase-3 with the biochemical analysis of malondialdehyde and total antioxidant capacity levels were performed in the liver samples 5 weeks after gavaging. Statistical analysis was performed using SPSS, version 15. The data were compared between the groups using the Tukey multiple comparison tests and the analysis of the variance. A P value <0.05 was considered significant.Results: The malondialdehyde level in the liver was increased in the DM group (71.18±0.01), whereas it was significantly (P=0.001) decreased after VOO administration in the DM plus VOO group (39.59±2.43). While the total antioxidant capacity level in the liver was decreased in the DM group (3.05±0.05), it was significantly increased (P=0.03) after VOO administration in the DM plus VOO group (3.95±0.04). A greater expression of caspase-3 (P=0.008), COX-2 (P =0.004), and PARP (P 0.006) could be detected in the DM group, while it was significantly (P=0.009) attenuated in the DM plus VOO group. Also, the degeneration of hepatocytes, which was detected in the DM group, was attenuated after VOO consumption.Conclusions: VOO exerted protective effects against DM-induced hepatotoxicity, which might be associated with its anti-apoptotic, anti-inflammatory, and antioxidative properties. UR - https://ijms.sums.ac.ir/article_40498.html L1 - https://ijms.sums.ac.ir/article_40498_268ff44e3e61781b46b730712dfc05e9.pdf ER -