TY - JOUR ID - 40544 TI - Prevalence of blaCTX-M Gene among Extended- Spectrum β-Lactamases Producing Klebsiella pneumoniae Clinical Isolates in Iran: A Meta-Analysis JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Eskandari-Nasab, Ebrahim AU - Moghadampour, Mehdi AU - Tahmasebi, Arezoo AD - Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran; and Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran AD - Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Statistical and Actuarial Sciences, University of Western Ontario (UWO), London, ON, Canada Y1 - 2017 PY - 2017 VL - 43 IS - 4 SP - 347 EP - 354 KW - Extended-spectrum beta-lactamase KW - blaCTX-M KW - Klebsiella pneumoniae KW - CTX-M DO - 10.30476/ijms.2017.40544 N2 - Background: CTX-M-type extended-spectrum β-lactamases (ESBLs) are the most prevalent ESBLs in bacterial members of Enterobacteriaceae family including Klebsiella pneumoniae. The global spread of CTX-M-producing K. pneumoniae is a major concern in most countries including Iran. The aim of this meta-analysis was to determine the relative frequency (RF) of blaCTX-M gene among ESBLs-producing K. pneumoniae clinical isolates in Iran and to report an overall prevalence.Methods: A comprehensive literature search of studies published up to July 2016 was carried out. The keywords “Enterobacteriaceae”, “Klebsiella pneumoniae”, “ESBLs”, “CTX-M” and “Iran” were searched in PubMed, Scopus, EBSCO, Google Scholar, Scirus, SID and IranMedex in both English and Persian. Selected articles were published between July 2010 and July 2016 and all of them were in English. STATA SE version 11.0 was used for statistical analysis. Results: Twenty-four articles/abstracts were included in this analysis. Selected studies were performed in Ahvaz, Arak, Ilam, Kashan, Kerman, Mashhad, Shiraz, Tabriz, Tehran, Zabol, and Zahedan. Our pooled evidence showed that the RF of blaCTX-M gene among ESBLs-producing K. pneumoniae clinical isolates varied from 7.7% in Tabriz to 100% in Mashhad, Tehran, and Zahedan, with an overall RF of 56.7%.Conclusion: Our meta-analysis revealed that the RF of CTX-M-type ESBLs-producing K. pneumoniae is diverse in different regions of Iran, and the central and eastern regions had higher prevalence rates compared to western regions. UR - https://ijms.sums.ac.ir/article_40544.html L1 - https://ijms.sums.ac.ir/article_40544_fbec7180ec2282360e4739dae14f3a7b.pdf ER -