Serologic Evidence of Pertussis Infection in Vaccinated Iranian Children

Document Type: Original Article(s)


1 Department of Pediatric Infectious Diseases, Pediatric Ward, Pediatric Infections Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Department of Pediatrics, Pediatric Ward, Shahrekord University of Medical Sciences, Shahrekord, Iran

3 Vice-Chancellor for Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4 Health Policy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran


Background: It seems that the incidence of pertussis-like illnesses is considerably increasing despite the wide coverage of immunization with the whole cell pertussis vaccine. We aimed to investigate the occurrence of pertussis in vaccinated children by measuring anti-pertussis antibodies.
Methods: In this cross-sectional study, blood samples were taken from vaccinated children aged 2, 4, 6, 12, 18, and 72 months. Anti-pertussis IgG and IgA were measured by ELISA. P