Herein, we reported on a middle-aged woman presented with painless cervical lymphadenopathy. Past medical history was not significant. Pathologic examination of incisional biopsy show partial effacement of lymph node architecture with many reactive inflammatory cells admixed with Reed-Sternberg cells, many Charcot-Leyden crystals, and noncaseating granuloma. Immunohistochemical staining was positive for the classic Reed-Sternberg cells for CD15 and CD30 and was negative for CD45 and CD20. All these findings confirmed the diagnosis of Hodgkin's lymphoma. Charcot-Leyden crystals, is considered a morphologic hallmark of eosinophil-related diseases. However, to the best of our knowledge, only one case of Hodgkin's lymphoma has been reported in the world literature who has had Charcot-Leyden crystals.