Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

Time to Sputum Smear Conversion in Smear-Positive Pulmonary Tuberculosis Patients and Factors for Delayed Conversion

Document Type : Brief Report(s)

Authors

Zohreh Azarkar 1
Gholamreza Sharifzadeh 2
Azade Ebrahimzadeh 1
Saeeid Olumi 3

1 Hepatitis Research Center, Department of Infectious Disease, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran

2 Department of Public Health, School of Health, Birjand University of Medical Sciences, Birjand, Iran

3 School of Medicine, Birjand University of Medical Sciences, Birjand, Iran

Abstract
Pulmonary tuberculosis is a common infection worldwide. In the eastern part of Iran, fluctuations in tuberculosis prevalence are seen due to the migration of people from Afghanistan. The aim of this study was to evaluate the time of bacteriologic sputum conversion after treatment and affecting factors in those whose smear does not become negative.This study was carried out on 85 smear-positive pulmonary tuberculosis patients with the mean age of 65.6±16.7 years. There were 38 male patients (44.7%), 47 urban residents (55.3%), and only 6 patients (7.1%) from Afghanistan. The mean time of sputum conversion after starting treatment was 1.99±1.06 months. The mean time of sputum conversion was significantly higher in males (P=0.046), increased bacilli density in the primary sputum sample (P<0.0001, R=0.507), and pre-existing medical illness (P=0.001).In this study, it was revealed that pre-existing illness, bacilli density in initial smear, and severe involvement of the lung on radiography, could be associated with delay in sputum smear conversion.

Keywords

Radiography
Sputum
Pulmonary tuberculosis
Bacteriologic conversion
Iranian Journal of Medical Sciences
Volume 41, Issue 1 - Serial Number 1
65
January 2016
Pages 44-47

  • Received 15 March 2014
  • Revised 22 August 2020
  • Accepted 24 December 2018

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