Iranian Journal of Medical Sciences

Document Type: Original Article(s)

Authors

1 Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2 Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

3 Department of Cardiac Surgery, Shiraz University of Medical Sciences, Shiraz, Ira

4 Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Background: Remote ischemic preconditioning (RIPC) protects other organs from subsequent lethal ischemic injury, but uncertainty remains. We investigated if RIPC could prevent acute kidney injury (AKI) in patients undergoing coronary artery bypass graft (CABG) surgery.Methods: This parallel-group, double-blind, randomized, controlled trial was done on adults undergoing elective or urgent on-pump CABG surgery from 2013 to 2017 in Shiraz, Iran. Patients were allocated to RIPC or control groups through permuted blocking. The patients in the RIPC group received three cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia. We placed an uninflated cuff on the arm for 30 min in the control group. The study primary endpoint was an incidence of AKI. Secondary endpoints included short-term clinical outcomes. We compared categorical and continuous variables using Pearson χ2 and unpaired t tests, respectively. P

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