Background: The purpose of this study was to determine the relationship between early onset sepsis and increased levels of C-reactive protein (CRP) and interleukin-6 (IL-6) in cord plasma. Methods: A prospective study was conducted in 141 premature infants delivered with gestational ages of 26-35 weeks. IL-6 and CPR were measured by enzyme-linked immunoassay in the cord plasma of the neonates. According to clinical, laboratory findings and blood culture results, newborn infants were allocated into four groups (A-D): documented early onset infection, clinical sepsis, possible infection, and control groups respectively. Results: Mean IL-6 levels in group A-D was 264, 212, 160, and 33.3 pg/ml respectively. Difference between groups was statistically significant (p=.002). With cut off point of 18 pg/ml, the sensitivity and specificity of IL-6 for diagnosis of early onset sepsis was 72% and 55% respectively. There was not significant difference between mean levels of CRP among groups (p=0.28). Conclusion: Having considered the relatively good sensitivity and moderate specificity of cord IL-6, using this test can be recommended as a useful detector of early onset sepsis and non-infected sick neonates.
Gharehbaghi, M., Maamuri, G., Peirovifar, A., Boskabadi, H., Afshari, J. & Shakeri, M. (2007). Immediate Diagnosis of Early Onset Sepsis in Premature Newborns by Measurement of Cord C-Reactive Protein and Interleukin-6. Iranian Journal of Medical Sciences, 32(4), 217–221.
MLA
Gharehbaghi, M., Maamuri, G., Peirovifar, A., Boskabadi, H., Afshari, J., & Shakeri, M. "Immediate Diagnosis of Early Onset Sepsis in Premature Newborns by Measurement of Cord C-Reactive Protein and Interleukin-6", Iranian Journal of Medical Sciences, 32, 4, 2007, 217–221.
HARVARD
Gharehbaghi, M., Maamuri, G., Peirovifar, A., Boskabadi, H., Afshari, J., & Shakeri, M. (2007). 'Immediate Diagnosis of Early Onset Sepsis in Premature Newborns by Measurement of Cord C-Reactive Protein and Interleukin-6', Iranian Journal of Medical Sciences, 32(4), pp. 217–221.
CHICAGO
Gharehbaghi, M., Maamuri, G., Peirovifar, A., Boskabadi, H., Afshari, J. & Shakeri, M., "Immediate Diagnosis of Early Onset Sepsis in Premature Newborns by Measurement of Cord C-Reactive Protein and Interleukin-6." Iranian Journal of Medical Sciences, 32 4 (2007): 217–221,
VANCOUVER
Gharehbaghi M., Maamuri G., Peirovifar A., Boskabadi H., Afshari J., Shakeri M. Immediate Diagnosis of Early Onset Sepsis in Premature Newborns by Measurement of Cord C-Reactive Protein and Interleukin-6. Iranian Journal of Medical Sciences. 2007;32(4):217–221.
