Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

Epidemiology of Inflammatory Bowel Diseases in Iran and Asia; A Mini Review

Document Type : Review Article

Authors

Davood Mehrabani 1
Ali Reza Safarpour 2
Seyed Vahid Hosseini 3

1 Stem Cell and Transgenic Technology Research Center, Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

2 Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

3 Laparoscopy Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran

https://doi.org/10.30476/ijms.2013.44096
Abstract
The prevalence of inflammatory bowel diseases (IBDs) is set to stabilize in Western Europe and North America, as opposed to its increasing trend in developing countries in Asia. The epidemiology of IBDs in areas where the incidence and prevalence are relatively low provides an opportunity for researchers to determine the unknown aspects of them. In this review article, the PubMed and MEDLINE databases were searched from 1970 to 2012 and the epidemiological aspects assessed in Iranian articles were compared with identical subjects in other Asian countries. During this period, there were 21 documented articles on IBD epidemiology in Iran and 52 in Asia. According to the present review, CTLA-gene polymorphism and male/female ratio in ulcerative colitis (UC), incidence of extra-intestinal manifestations, extent of intestinal involvement, and family history in both UC and Crohn's disease (CD) seemed to be different between Asia and Iran. In contrast, the incidence of primary sclerosing cholangitis in IBD patients and association between NO2/CARD15 mutation and CD as C3435-T allele and UC were nearly the same. The rate of IBD has increased significantly in Iran, as has that of other Asian countries during the last decade. A thorough, well-designed, population-based, multi-regional epidemiologic study seems mandatory due to the substantial demographic and characteristic variability in IBD patients in our region.

Keywords

Inflammatory bowel disease
Epidemiology
Prevalence
Iran
Iranian Journal of Medical Sciences
Volume 38, June Supplement 2013
June 2013
Pages 140-149


  • Received 30 November 2013
  • Revised 23 August 2020
  • Accepted 06 March 2019

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