Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences

Peripheral Primitive Neuroectodermal Tumor of the Pelvis

Document Type : Case Report(s)

Authors

Zohreh Yousefi 1
Nourieh Sharifhi 2
Malihe Hasanzadeh 3
Mansoureh Mottaghi 4
Somayeh Bolandy 3

1 Cancer Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Department of Pathology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

3 Department of Obstetrics and Gynecology, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

4 Gynecologist, Mashhad, Iran

Abstract
The primitive neuroectodermal tumor (PNET) belongs to a group of highly malignant tumors and is composed of small round cells of a neuroectodermal origin. Categorized in the same tumor family as Ewing sarcoma, the PNET is most likely to occur in bones and soft tissues. However, a small number of PNET cases arising in the pelvis have been reported as well. We present three cases of pelvic PNET: two cases in the ovary and one case in the broad ligament. The PNET often exhibits aggressive clinical behavior with worse outcomes than other small round cell tumors. The significant prognostic factors of the PNET include site of tumor, volume of neoplasm, and presence of metastasis. The treatment protocol is multimodal and includes local surgical treatment followed by chemotherapy. We herein describe three PNET cases as a rare entity in the pelvis. Pelvic PNETs should be included in the differential diagnosis of pelvic masses.

Keywords

Primitive neuroectodermal tumors
Ewing’s sarcoma
Pelvic neoplasm
Ovary
Broad ligament
Iranian Journal of Medical Sciences
Volume 39, Issue 1 - Serial Number 1
12
January 2014
Pages 71-74

  • Received 22 December 2013
  • Revised 23 August 2020
  • Accepted 24 December 2018

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