TY - JOUR ID - 44961 TI - The Healing Effects of Hydroalcoholic Extract of Carum Copticum L. on Experimental Colitis in Rats JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Firoozi, Donya AU - Nekooeian, Ali Akbar AU - Tanideh, Nader AU - Mazloom, Zohreh AU - Mokhtari, Maral AU - Mohammadi Sartang, Mohsen AD - Department of Nutrition and Diet Therapy, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Clinical Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran; AD - Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Nutrition, School of Nutrition and Food Science, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2019 PY - 2019 VL - 44 IS - 6 SP - 501 EP - 510 KW - Colitis KW - Ulcerative KW - Rats KW - Cytokines KW - Antioxidants KW - Anti-Inflammatory agents DO - 10.30476/ijms.2019.44961 N2 - Background: Ulcerative colitis is an inflammatory disease with indefinite treatment. The present study aimed to assess the anti-inflammatory and antioxidant effects of Carum copticum L. (CC) extract on induced colitis in rats. Methods: Sixty male rats were randomly divided into six groups (n=10 per group). Acetic acid-induced colitis rats were orally administered with doses of 100, 200, and 400 mg/kg CC extract, and 100 mg/kg sulfasalazine for seven consecutive days, respectively. Colonic biopsies were taken to measure histopathological parameters as well as the tumor necrosis factor (TNF-α), interleukin-6 (IL-6), myeloperoxidase (MPO), malondialdehyde (MDA), and glutathione (GSH). Data analysis was performed using the one-way ANOVA and Tukey’s test for normally distributed data. Kruskal-Wallis test followed by Dunn’s test was used for non-normally distributed data. The analysis was performed at P≤0.05 using SigmaStat software (version 10.0).Results: The control colitis group had a significantly higher total colitis index (P=0.01), TNF-α (P=0.01), IL-6 (P=0.01), MPO (P=0.01), and MDA (P=0.01); and lower GSH (P=0.01) than those of the sham group. The colitis group receiving a dose of 200 mg/kg/day CC extract had a significantly lower total colitis index (P=0.01), TNF-α (P=0.01), IL-6 (P=0.01), MPO (P=0.01), and MDA (P=0.01); and higher GSH (P=0.01) than those of the control colitis group. The colitis group receiving a dose of 200 mg/kg/day CC extract had a significantly lower total colitis index (P=0.04), TNF-α (P=0.03), IL-6 (P=0.04), MPO (P=0.03), and MDA (P=0.03); and higher GSH (P=0.01) than those of the colitis group receiving sulfasalazine. Conclusion: The present study revealed that CC extract had healing effects on colitis, possibly due to its antioxidant and anti-inflammatory properties. UR - https://ijms.sums.ac.ir/article_44961.html L1 - https://ijms.sums.ac.ir/article_44961_cebf6b2a69c72e159bf38cbf9258b7f3.pdf ER -