Shiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review194061210.30476/ijms.2019.40612ENDavoodHekmatpouDepartment of Nursing, Nursing and Midwifery Faculty, Arak University of Medical Sciences, Arak, IranFatemehMehrabiStudent of Nursing, Nursing and Midwifery Faculty, Arak University of Medical Sciences, Arak, Iran0000000346162569KobraRahzaniDepartment of Nursing, Nursing and Midwifery Faculty, Arak University of Medical Sciences, Arak, IranAtefehAminiyanDepartment of Clinical Pharmacology; Arak University of Medical Sciences, Arak, IranJournal Article20170423Background: Aloe vera is an herbaceous and perennial plant that belongs to the Liliaceae family and used for many medicinal purposes. The present study aimed to systematically review clinical trials regarding the effect of Aloe vera on the prevention and healing of skin wounds.Methods: To identify all related published studies, we searched SID, IRANDOC, Google Scholar, PubMed, MEDLINE, Scopus, Cochrane Library, and ScienceDirect databases in both the English and Persian languages from 1990 to 2016. The keywords used were Aloe vera, wound healing, and prevention. All clinical trials using Aloe vera gel, cream, or derivatives that included a control group with placebo or comparison with other treatments were included in the study. The PRISMA checklist (2009) was used to conduct the review.Results: In total, 23 trials that met the inclusion criteria were studied. The results of the studies showed that Aloe vera has been used to prevent skin ulcers and to treat burn wounds, postoperative wounds, cracked nipples, genital herpes, psoriasis, and chronic wounds including pressure ulcers.Conclusion: Considering the properties of Aloe vera and its compounds, it can be used to retain skin moisture and integrity and to prevent ulcers. It seems that the application of Aloe vera, as a complementary treatment along with current methods, can improve wound healing and promote the health of society.https://ijms.sums.ac.ir/article_40612_9c39dcf2b78f6947dd218f4e8380f65f.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Intralesional Injection of the Measles–Mumps–Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial10174061310.30476/ijms.2019.40613ENMohammad SadeghRezaiPediatric Infectious Diseases Superspecialist, Infectious Diseases Research Center with focus on Nosocomial Infections, Mazandaran University of Medical Sciences, Sari, Ira0000-0003-4585-9954HivaGhasempouriGeneral physician, Mazandaran University of Medical Sciences, Sari, IranOzraAsqary MarzidarehGeneral physician, Mazandaran University of Medical Sciences, Sari, IranJamshidYazdani CheratiEpidemiologist, Department of Biostatistics, Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, IranGhasemRahmatpour RokniGeneral physician, Mazandaran University of Medical Sciences, Sari, Iran and Dermatologist, Clinical Research Development Unit of Bou-Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, IranJournal Article20170515Background: Common resistant-to-therapy warts pose a challenge to both clinicians and patients. Among many destructive and immunotherapeutic options, no single, fully effective treatment has been suggested yet. Many investigations, including those using intralesional antigen administrations, have demonstrated that cellular immunity plays a major role in the clearance of human papilloma virus (HPV) infection. The aim of the present study was to evaluate the effects of the intralesional injection of the measles–mumps–rubella (MMR) vaccine into resistant-to- treatment palmoplantar warts and its complications.Methods: In this single-blind, randomized, controlled clinical trial, 60 cases with resistant-to-therapy palmoplantar warts referring to the Dermatology Clinic of Bou-Ali Sina Hospital of Sari between June 2015 and 2016 were randomly assigned to 2 equal groups: the MMR Group received intralesional MMR and the Placebo Group was given saline injection. The injections were administered at 2-week intervals until complete clearance was achieved or for a maximum of 5 injections (https://ijms.sums.ac.ir/article_40613_40a6b824003448046e4f8c79fad2037e.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Health-Related Quality of Life according to the Socioeconomic Status of Living Areas in Iranian Children and Adolescents: Weight Disorders Survey18274061810.30476/ijms.2019.40618ENRoyaKelishadiDepartment of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IranSaeidSafiriManagerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, IraShirinDjalaliniaDevelopment of Research & Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, IranSarehMiranzadehDepartment of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non Communicable Disease, Isfahan University of Medical Sciences, Isfahan, IranMohammad EsmaeilMotlaghDepartment of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranHamidAsayeshDepartment of Medical Emergencies, Qom University of Medical Sciences, Qom, IranShaghayeghBeshtarStudent Research Committee, Alborz University of Medical Sciences, Karaj, IranMortezaMansourianDepartment of Health Education and Promotion, School of Health, Iran University of Medical Sciences, Tehran, IranArmitaMahdavi GorabiDepartment of Basic and Clinical Research, Tehran Heart Research Center, Tehran University of Medical Sciences, Tehran, IranOmidSafariNon-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, IranMostafaQorbaniNon-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran; and Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, IranJournal Article20170704Background: Health-related quality of life (HRQoL) has become a major concern in the field of children’s health research. We assessed HRQoL among Iranian children and adolescents according to the socioeconomic status (SES) of their living region.Methods: Via multistage cluster sampling from rural and urban school students aged 6 to 18 years, this nationwide study was conducted from 2011 to 2012. HRQoL was assessed using the adolescent core version of the Pediatric Quality of Life questionnaire. Through survey data analysis methods, the data were compared according to the SES of the living region, sex, and the living area.Results: Overall, 23043 students participated in the survey (participation rate=92.2%). The mean age of the participants was 12.55±3.31 years. Boys accounted for 50.8% of the study population, and 73.4% were from urban areas. At national level, the mean of the HRQoL total score was 81.7 (95% CI: 81.3 to 82.1) with a mean of 83.5 (95% CI: 83.0 to 84.1) for the boys and 79.8 (95% CI: 79.1 to 80.5) for the girls. The highest and the lowest scores, respectively, belonged to social functioning (90.0 [95% CI: 89.7 to 90.3]) and emotional functioning (78.2 [95% CI: 77.7 to 78.7]). The highest total HRQoL score belonged to the second highest SES region of the country (mean=83.1; 95% CI: 82.5 to 83.7). The association between total HRQoL and the score of all the subscales and SES in the living area was statistically significant (P<0.001).Conclusion: The results of the present study showed that in the children and adolescents, SES was associated with HRQoL. Accordingly, HRQoL and the related SES differences should be considered one of the priorities in health research and health policy.https://ijms.sums.ac.ir/article_40618_e5d5e57ce6024ede2c1c61a0d413edd9.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Protoscolicidal Effects of the Garlic Chloroformic Extract on the Protoscolices of Hydatid Cyst at a Short Exposure Time, up to Five Minutes28344062010.30476/ijms.2019.40620ENZahraBarzinDepartment of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranSeyed MahmoudSadjjadiDepartment of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, IranMohammad RezaPanjehshahinDepartment of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran0000-0002-9327-7548Journal Article20170307Background: The treatment of choice for hydatidosis as an important zoonotic disease is surgery. Different agents are injected into the cyst to prevent secondary hydatidosis. To avoid the side effects of such protoscolicidal agents, considering the high protoscolicidal effects of the garlic extract, we conducted the present study on protoscolices in limited applicable times and compared the extract with some chemical agents. Methods: Sheep’s liver and lung cysts were collected. Ninety tubes were selected and divided into 3 sets (for different exposure times), each one comprising 5 groups of 6 tubes. Each tube contained 3000–4000 protoscolices. The groups were 0.5% cetrimide (as positive control), 20% hypertonic sodium chloride, 0.5% silver nitrate, 0.9% normal saline (as negative control), and the garlic chloroformic extract (200 mg/mL). The viability of the protoscolices was assessed using 0.1% eosin. The ANOVA and LSD were used to compare the mean viability of the protoscolices after exposure to the different agents at different times and concentrations. The data were analyzed using SPSS software, version 17. A Phttps://ijms.sums.ac.ir/article_40620_2e263eeb6051515db345b302473ed781.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Apoptosis, Autophagy, and Necrosis in Murine Embryonic Gonadal Ridges and Neonatal Ovaries: An Animal Model35434062210.30476/ijms.2019.40622ENMojdehPajokhDepartment of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranTaherehTalaei-KhozaniDepartment of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranHosseinBordbarDepartment of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran0000-0003-0363-9523FakhroddinMesbahDepartment of Anatomical Sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranJournal Article20170802Background: In mammalian ovaries, loss of over two-thirds of germ cells happens due to cell death. Nonetheless, the exact mechanism of cell death has yet to be determined. The present basic practical study was designed to detect 3 types of programmed cell death, namely apoptosis, autophagy, and necrosis, in murine embryonic gonadal ridges and neonatal ovaries.Methods: Twenty gonadal ridges and ovaries from female mouse embryos 13.5 days post coitum and newborn mice 1 day postnatal were collected. The TUNEL assay was performed to evaluate apoptosis. The interplay of autophagy was evaluated by immunohistochemistry for beclin-1. Necrotic cell death was analyzed by propidium iodide (PI) staining. The count and percentage of the labeled oocytes in the gonadal ridges and ovaries were evaluated and compared using the independent t test and one-way ANOVA. A P value less than 0.05 was considered statistically significant.Results: We detected TUNEL-positive reaction in the embryonic germ cells and in the small and large oocytes of the neonatal ovaries. The germ cells and small oocytes reacted to beclin-1. PI absorption was detected in the embryonic germ cells and the large oocytes of the neonatal ovaries, but not in the small oocytes. The percentage of the TUNEL-positive and PI-labeled oocytes in the gonadal ridges was significantly higher than that in the neonatal ovaries (Phttps://ijms.sums.ac.ir/article_40622_bc00856292dd990b2a8cd64e7c56fd03.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Juglans Regia L. Leaf Extract Attenuates Diabetic Nephropathy Progression in Experimental Diabetes: An Immunohistochemical Study44524062410.30476/ijms.2019.40624ENDavoodNasiryMolecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IranAli RezaKhalatbaryMolecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IranHassanAhmadvandDepartment of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran; and Razi Herbal Medicine Research Center, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, IranFereshtehTalebpour AmiriMolecular and Cell Biology Research Center, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, IranJournal Article20170422Background: There is accumulating evidence that Juglans regia L. (GRL) leaf extract has hypoglycemic and antioxidative properties. The present study aimed to investigate the protective effects of GRL leaf extract against diabetic nephropathy (DN). Methods: In total, 28 male adult Sprague-Dawley rats were used. The DN rat model was generated by intraperitoneal injection of a single 55 mg/kg dose of streptozotocin (STZ). A subset of the STZ-induced diabetic rats received intragastric administration of GRL leaf extract (200 mg/kg/day) starting 1 week (preventive group) and 4 weeks (curative group) after the onset of hyperglycemia up to the end of the 8th week, whereas other diabetic rats received only isotonic saline (diabetic group) as the same volume of GRL leaf extract. To evaluate the effects of GRL leaf extract on the diabetic nephropathy, various parameters of apoptosis and inflammation were assessed. Statistical analysis was performed using the SPSS software, version 15.0. The data were compared between the groups using the Tukey’s multiple comparison test and the analysis of the variance. P values ˂0.05 were considered statistically significant.Results: Fasting blood sugar (FBS) levels (P=0.001) and histopathological changes in the kidney of diabetic rats attenuated after GRL leaf extract consumption. Greater caspase-3 (P=0.004), COX-2 (P=0.008), PARP (P=0.007), and iNOS (P=0.005) expression could be detected in the STZ-diabetic rats, which were significantly (P=0.009) attenuated after GRL leaf extract consumption. In addition, attenuation of lipid peroxidation in the diabetic rats was detected after GRL consumption (P=0.01). Conclusion: GRL leaf extract exerts preventive and curative effects against diabetic nephropathy.https://ijms.sums.ac.ir/article_40624_6e30b691f40ad2a86dc4f7e8d4628f6d.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Cloning, Expression, and Refolding of PPE17 Protein of Mycobacterium Tuberculosis as a Promising Vaccine Candidate53594062510.30476/ijms.2019.40625ENAdelNajafiAntimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; and Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMohsenTafaghodiNanotechnology Research Center, Pharmaceutical Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranMojtabaSankianImmunology Research Center,
Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, IranYousefAminiDepartment of Microbiology and Virology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, IranKiarashGhazviniAntimicrobial Resistance Research Center, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; and Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranJournal Article20170405Background: Tuberculosis as a global health problem requires special attention in the contexts of prevention and control. Subunit vaccines are promising strategies to protect burdens of tuberculosis via increasing the BCG protection. The present study aimed to design a vaccine study by means of high-throughput expression and correct refolding of recombinant protein PPE17. Methods: We aimed to clone, express, and refold PPE17 protein of Mycobacterium tuberculosis in bacterial systems as a promising vaccine candidate. The PPE17 (Rv1168c) gene was PCR amplified and inserted into pET-21b(+) vector, cloned in E. coli TOP10, and finally expressed in E. coli BL21(DE3). Results: The expressed recombinant protein was entirely found in insoluble form (inclusion bodies). The insoluble protein was denatured in 6M guanidine-HCl and refolded by descending denaturant concentration dialysis. Moreover, the recombinant protein was purified by Ni–NTA column chromatography. The changing temperature had no effects on solubilizing protein and the maximum expression was achieved at 0.5 mM concentration of isopropyl-D-thiogalactopyranoside (IPTG) induction. Conclusion: Bacterial expression system is a timesaving tool and refolding by descending denaturant concentration dialysis is a rapid and reliable method. https://ijms.sums.ac.ir/article_40625_dcd372f948c84f498a2b135c20354ff5.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Morcellation-Induced Leiomyomatosis Peritonealis Disseminata: A Rare Case Report60644061410.30476/ijms.2019.40614ENAlina VitalievnaGerashchenkoDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaTatyana GrygorievnaFilonenkoDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaElena PetrovnaGolubinskayaDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaMargarita AlexeevnaKalfaDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaMaxim AndreevichKriventsovDepartment of Pathological Anatomy, Faculty of Medicine, Medical Academy Named After S.I. Georgievsky, V.I. Vernadsky Crimean Federal University, Simferopol, RussiaJournal Article20180108Leiomyomatosis peritonealis disseminata (LPD) is a benign disease characterized by the presence of multiple small nodules on the omentum, parietal, and visceral peritoneum. It corresponds to leiomyoma and often resembles metastases of malignant tumors; however, with favorable prognosis. Here we describe a 46-year-old woman, diagnosed with LPD, to demonstrate the etiopathogenesis of the developed leiomyomatosis following endoscopic extirpation of the uterus with the use of a power morcellator. The patient was operated for diffuse leiomyoma using a power morcellator. Six months later, during a follow-up visit, disseminated tumor nodes on the peritoneum were revealed. Histological and immunohistochemical (smooth muscle α-actin, vimentin, estrogen receptors, progesterone receptors, and Ki67) study confirmed the diagnosis of LPD. As part of the follow-up, certain regression of the tumor nodes was noted against the backdrop of the onset of menopause and the corresponding decline of estrogen levels. Currently, the prognosis is favorable and follow-up is ongoing. Such cases are rare, but the condition is particularly important due to its iatrogenic nature. It has attracted the attention of the Food and Drug Administration (FDA) because power morcellation is probably associated with the risk of spreading suspected cancerous tissue. The existing high risk of iatrogenic LPD formation indicates the need for detailed reporting of all similar clinical cases, including the established pathogenetic and pathomorphological mechanisms of this process to prevent morcellator-related complications.https://ijms.sums.ac.ir/article_40614_e82419193fdac9961ff2faae3c1c5f37.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101The First Case of a Small Supernumerary Marker Chromosome 18 in a Klinefelter Fetus: A Case Report65694061710.30476/ijms.2019.40617ENJamilehSaberzadehMedical Biotechnology Department, School of Advanced Medical Sciences and Technology, Shiraz University of Medical Sciences, Shiraz, Iran0000-0003-0912-9313Mohammad RezaMiriMedical Biotechnology Department, School of Advanced Medical Sciences and Technology, Shiraz University of Medical Sciences, Shiraz, Iran0000-0001-6884-6983MehdiDianatpourDepartment of Medical Genetics, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; and Transgenic Technology Research center, Shiraz University of Medical Sciences, Shiraz, Iran; and Comprehensive Medical Genetic Center, Shiraz University of Medical Sciences, Shiraz, Iran0000-0003-1217-9477AbbasBehzad BehbahaniDiagnostic Laboratory Sciences and Technology Research Center, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, IranMohammad BagherTabeiDepartment of Medical Genetics, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; and Transgenic Technology Research center, Shiraz University of Medical Sciences, Shiraz, Iran; and Comprehensive Medical Genetic Center, Shiraz University of Medical Sciences, Shiraz, IranMohsenAlipourComprehensive Medical Genetic Center, Shiraz University of Medical Sciences, Shiraz, IranMohammad AliFaghihiDepartment of Medical Genetics, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; and Comprehensive Medical Genetic Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Psychiatry, University of Miami Miller School of Medicine, Miami, FL 33136, USAMajidFardaeiDepartment of Medical Genetics, School of Medical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran; and Transgenic Technology Research center, Shiraz University of Medical Sciences, Shiraz, Iran; and Comprehensive Medical Genetic Center, Shiraz University of Medical Sciences, Shiraz, Iran0000-0002-8393-0371Journal Article20171018Small supernumerary marker chromosomes (sSMCs), or markers, are abnormal chromosomal fragments that can be hereditary or de novo. Despite the importance of sSMCs diagnosis, de novo sSMCs are rarely detected during the prenatal diagnosis process. Usually, prenatally diagnosed de novo sSMCs cannot be correlated with a particular phenotype without knowing their chromosomal origin and content; therefore, molecular cytogenetic techniques are applied to achieve this goal. The present study aimed to characterize an sSMC in a case of Klinefelter syndrome using an in-house microsatellite analysis method and fluorescent in situ hybridization (FISH) technique. Amniotic fluid was collected from a pregnant woman who was considered to have risk factors for trisomy higher than the screening cut-off. Karyotype analysis was followed by the amplification of different microsatellite loci and FISH technique. Karyotype analysis identified a fetus with an extra X chromosome and also an sSMC with unknown identity. Further investigation of the parents showed that the sSMC is de novo. Microsatellite amplification by quantitative fluorescent PCR (QF-PCR) and FISH analysis showed that the sSMC is a derivative of chromosome 18. Eventually, the patient decided to terminate the pregnancy. Here, the first case of the coincidence of sSMC 18 in a Klinefelter fetus is reported.https://ijms.sums.ac.ir/article_40617_c8b2ec92854c6811e6fd98189e2b506d.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Surgical and Endoscopic Treatment of a Double Phytobezoar Causing Ileus and Jaundice: A Case Report70734062110.30476/ijms.2019.40621ENKonstantinos APaschosDepartment of General Surgery, General Hospital of Drama, GreeceAnestisChatzigeorgiadisDepartment of General Surgery, General Hospital of Drama, GreeceJournal Article20180115Bezoars are rare conditions of mechanical intestinal occlusion. Among the various types of bezoars, phytobezoars and trichobezoars are the most common types. Symptoms are usually indistinguishable from other more common entities; therefore, it may be difficult to reach a correct diagnosis. Computed tomography (CT) scan is the preferred diagnostic method. Treatment may include surgery, lavage with Coca-Cola or hydrolytic solutions, and endoscopic mechanical or electrical disintegration.The present case report aimed to describe an uncommon symptomatic double phytobezoar (ileal and gastric), which was successfully treated surgically and endoscopically. The patient, an 83-year-old woman, was admitted to the General Hospital of Drama (Drama, Greece) after suffering from abdominal pain for 3 days. Physical examination revealed abdominal distention and pain mainly in the right quadrants. The CT scan revealed an intestinal phytobezoar which was subsequently removed surgically with a longitudinal enterotomy. On the third postoperative day, the patient presented jaundice and a new CT scan showed a second phytobezoar impacted into the duodenal bulb, which was missed during the initial diagnosis. The gastric phytobezoar was fragmented endoscopically using a polypectomy snare with high flow electric current (70-80 Watts) and its pieces were removed orally. The patient had no complications during the hospital stay and was discharged on the eighth postoperative day. Three months later, the follow-up gastroduodenoscopy and CT scan revealed no signs or symptoms of any gastrointestinal mass.The present case report is the first presentation of a double gastrointestinal phytobezoar that caused ileus and temporary jaundice. Moreover, a successful single-session mechanical-electrical fragmentation of a large gastric phytobezoar is described for the first time.https://ijms.sums.ac.ir/article_40621_9bbb69753f3e33043a28d95abcd258c1.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101Blastic Plasmacytoid Dendritic Cell Neoplasm; A Report of Three Cases74784062310.30476/ijms.2019.40623ENAkbarSafaeiDepartment of Hematopathology, Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, IranAhmadMonabatiDepartment of Hematopathology, Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, IranMaralMokhtariDepartment of Hematopathology, Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, IranFreidoonSolhjooDepartment of Hematopathology, Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, IranMehdiMontazerDepartment of Hematopathology, Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, Iran0000-0002-7759-3268Journal Article20171222Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematodermic myeloid malignancy that is known to be derived from plasmacytoid dendritic cells which are characterized by expression of CD4, CD56, and more specific markers such as CD123. Here, the authors present three cases of BPDCN diagnosed in the past two years and address different available diagnostic modalities such as morphology, immunohistochemistry, flow cytometry, and cytogenetics. Overall, we believe that although BPDCN is a rare diagnosis, it should not be left unchecked. Currently, available immunophenotyping markers are of great help, but the main clue to figure out the problem of BPDCN is clinicopathologic suspicion.https://ijms.sums.ac.ir/article_40623_e170b2064129db37dea7be779a279aef.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101First Report on the Isolation of Nocardia Thailandica from the Bronchoalveolar Lavage sample of a Patient in Iran79794061610.30476/ijms.2019.40616ENMahmood D.Al-MendalawiDepartment of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, IraqJournal Article20180930https://ijms.sums.ac.ir/article_40616_729004a45b2538c5c7253ca0691b719b.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101The Authors’ Reply808040619ENSamanehBourbouDepartment of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;MasoudKeikhaDepartment of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranJamshidFaghriDepartment of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranJournal Article20181224https://ijms.sums.ac.ir/article_40619_f1cbbf54425478dfbf48c400f8019ac9.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071644120190101A Spectacular Endoscopic Anatomy of the Pituitary Gland and the Circle of Willis in a Living Person81814061510.30476/ijms.2019.40615ENMohammad SadeghMasoudiDepartment of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran; and Trauma Research Center of Aja university of Medical Sciences, Tehran IranSeyed HosseinOwjiStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran0000-0002-0892-3462Journal Article20180609https://ijms.sums.ac.ir/article_40615_e3a6ec344355716b9d5cf7048a15cd77.pdf