TY - JOUR ID - 45805 TI - Effects of Heracleum Persicum Hydroalcoholic Extract on Insulin, Serum Anti-Oxidant Enzymes, Glucose, and Lipid Profiles in Alloxan-Induced Diabetic Rats JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Majidi, Zahra AU - Sadati lamardi, Seyede Nargess AU - Mohajjel-Nayebi, Alireza AU - Vatankhah, Amir Mansour AU - Asnaashari, Solmaz AU - Zakeri-Milani, Parvin AD - Department of Traditional Pharmacy, School of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran AD - Drug Applied Research Center, Department of Pharmacology and Toxicology, Tabriz University of Medical Sciences, Tabriz, Iran AD - Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AD - Liver and Gastrointestinal Diseases Research Center, Department of Pharmaceutics and School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Y1 - 2020 PY - 2020 VL - 45 IS - 3 SP - 199 EP - 206 KW - Heracleum persicum KW - Antioxidants KW - Blood glucose KW - diabetes mellitus KW - Insulin KW - Insulin-like growth factor I DO - 10.30476/ijms.2019.45805 N2 - Background: Heracleum persicum (H. persicum) is a medicinal herb used in Iranian traditional medicine for its anti-toxic property. It is commonly consumed in the form of food additives and as a medicinal herbal tonic to treat liver and kidney diseases. The present study aimed to investigate the anti-oxidant, anti-diabetic, and anti-hyperlipidemic effects of H. persicum hydroalcoholic extract in alloxan-induced diabetic rats. Methods: Adult male Wistar rats (n=30) were assigned to five groups: a normal group, a diabetic control group, and three diabetic groups treated orally with 200 and 400 mg/kg of the extract and 5 mg/kg of glibenclamide, respectively, for two weeks. Blood glucose and bodyweight were measured at the end of each week. On day 15, blood samples were collected to measure the levels of insulin, insulin growth factor-I (IGF-I), antioxidant markers for malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), total antioxidant activity (TAS), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) using commercial kits. The data were analyzed using SPSS Software (version 22.0).Results: Daily treatment with 400 mg/kg of the extract significantly reduced the blood glucose level (p <0.001) and improved bodyweight (P=0.002), insulin (p <0.001), IGF-I (P=0.024), SOD (P=0.001), GPx (P=0.009), MDA (p <0.001), TAS (P=0.006), TG (p <0.001), HDL (P=0.023), LDL (P=0.005), and VLDL (p <0.001) compared with the diabetic control group. Conclusion: Beneficial effects of H. persicum for the treatment of diabetes were confirmed. UR - https://ijms.sums.ac.ir/article_45805.html L1 - https://ijms.sums.ac.ir/article_45805_f058e3114ebc1fb6767a1f487e49339f.pdf ER -