%0 Journal Article %T Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat %J Iranian Journal of Medical Sciences %I Shiraz University of Medical Sciences %Z 0253-0716 %A Fallahzadeh, M.H. %A Noorafshan, A. %A Tanideh, N. %A Badeli, H.R. %A Bazargani, A. %D 2015 %\ 09/29/2015 %V 29 %N 3 %P 130-133 %! Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat %R %X Background: Pyelonephritis can lead to renal scar. Objective: To evaluate the effects of betamethasone in preventing renal scarring in rat model of pyelonephritis. Methods: Sixty three female Sprague-Dawley rats were divided into seven groups. Group A was the control. Mannose-sensitive E coli was directly inoculated into the left kidney exposed under general anesthesia in groups C–G. Group B received normal saline. Two days after bacterial inoculation, groups C, E and F received gentamicin for 10 days. Betamethasone was injected for three days to animals in groups of D, E (2 days after bacterial inoculation) and F (5 days after bacterial inoculation). Group G received no treatment. Eight weeks after bacterial inoculation, animals were sacrificed and the volume (amount) of renal scar was determined using the stereological techniques. Results: Changes in the weight and volume of the kidneys were not statistically significant. No scar was detected in group A, but all other groups including group B with intrarenal injections showed scarring. The volume density and absolute volume of the scar in groups C–G were significantly more than group B (p<0.001), whereas they did not differ significantly from each other. Conclusion: Betamethasone and/or gentamicin, when used two days after induction of pyelonephritis were not effective in preventing renal scar. %U https://ijms.sums.ac.ir/article_40148_92836663022a060b2731c76e3a730b43.pdf