TY - JOUR ID - 40314 TI - Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Roohi, A. AU - Aghamohammadi, A. AU - Shokri, F. AD - Y1 - 2001 PY - 2001 VL - 26 IS - 3-4 SP - 90 EP - 94 DO - N2 - Background: Mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (IVIg). Anti-IgA antibody has been proposed to be associated with development of such reactions. Objective: To assess the association between anti-IgA levels of different isotypes and adverse reactions induced in immunodeficient patients following infusion of IVIg. Methods: In this study, IgM, IgG and IgE anti-IgA antibodies were measured by an indirect ELISA method in serum samples from 31 patients with a variety of immunodeficiencies receiving IVIg and 24 normal individuals.Results: Anti-IgA antibody of all three isotypes were detectable in all sera. However, when presented as proportion of total IgA (anti –IgA/total IgA)IgG, IgE isotypes are significantly higher in patients with adverse reactions compared to those without reactions or normal subjects.Conclusion: Both IgG and IgE anti-IgA antibodies may contribute to the development and severity of adverse reactions in some patients receiving IVIg. UR - https://ijms.sums.ac.ir/article_40314.html L1 - https://ijms.sums.ac.ir/article_40314_f389ea2dd70bd04429b5c57d3035aa88.pdf ER -