TY - JOUR ID - 40620 TI - Protoscolicidal Effects of the Garlic Chloroformic Extract on the Protoscolices of Hydatid Cyst at a Short Exposure Time, up to Five Minutes JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Barzin, Zahra AU - Sadjjadi, Seyed Mahmoud AU - Panjehshahin, Mohammad Reza AD - Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2019 PY - 2019 VL - 44 IS - 1 SP - 28 EP - 34 KW - Echinococcosis KW - Garlic KW - In Vitro techniques DO - 10.30476/ijms.2019.40620 N2 - Background: The treatment of choice for hydatidosis as an important zoonotic disease is surgery. Different agents are injected into the cyst to prevent secondary hydatidosis. To avoid the side effects of such protoscolicidal agents, considering the high protoscolicidal effects of the garlic extract, we conducted the present study on protoscolices in limited applicable times and compared the extract with some chemical agents. Methods: Sheep’s liver and lung cysts were collected. Ninety tubes were selected and divided into 3 sets (for different exposure times), each one comprising 5 groups of 6 tubes. Each tube contained 3000–4000 protoscolices. The groups were 0.5% cetrimide (as positive control), 20% hypertonic sodium chloride, 0.5% silver nitrate, 0.9% normal saline (as negative control), and the garlic chloroformic extract (200 mg/mL). The viability of the protoscolices was assessed using 0.1% eosin. The ANOVA and LSD were used to compare the mean viability of the protoscolices after exposure to the different agents at different times and concentrations. The data were analyzed using SPSS software, version 17. A P UR - https://ijms.sums.ac.ir/article_40620.html L1 - https://ijms.sums.ac.ir/article_40620_2e263eeb6051515db345b302473ed781.pdf ER -