Thyroid Hormones Status in Iron Deficient Adolescent Girls
M. H.
Eftekhari
Department of Nutrition and Bioche-mistry,
School of Public Health and Institute of Public Health Research,
Tehran University of Medical Sciences,
Tehran, Iran
author
S. A.
Keshavarz
Department of Nutrition and Bioche-mistry,
School of Public Health and Institute of Public Health Research,
Tehran University of Medical Sciences,
Tehran, Iran
author
M.
Jalali
Department of Nutrition and Bioche-mistry,
School of Public Health and Institute of Public Health Research,
Tehran University of Medical Sciences,
Tehran, Iran
author
N.
Saadat
Endocrine Research Center,
Shaheed Beheshti University of
Medical Sciences,
Tehran, Iran
author
F.
Seyasi
Department of Nutrition and Bioche-mistry,
School of Public Health and Institute of Public Health Research,
Tehran University of Medical Sciences,
Tehran, Iran
author
M. R.
Eshraghian
Department of Biostatistics,
School of Public Health and In-stitute of Public Health Research,
Tehran University of Medical Sciences,
Tehran, Iran
author
text
article
2015
eng
Background: Iron deficiency is the most common single-nutrient deficiency disease in the world and is a major concern for about 15% of the world population. It has been shown that iron deficiency may affect thyroid hormones. Objective: To determine thyroid hormone status in iron deficient adolescent girls. Methods: A cross-sectional study was carried out in Lar Province and its’ vicinity in South of Iran. By a stepwise random sampling from all public girls’ high schools in Lar and its’ vicinity, using World Health Organization (WHO) criteria, 94 iron deficient subjects were selected. Urine and serum samples were collected and assayed for urinary iodine and serum ferritin, iron, TIBC, TSH, T4, T3, FT4, FT3, T3RU, rT3, selenium and albumin concentrations. Results: Hematological indices for iron status confirmed that all of subjects were iron deficient. There was a positive correlation between plasma T4 and serum ferritin (p<0.001). Subjects with low serum ferritin had a higher T3/T4 ratio (p<0.001). Using a stepwise regression analysis, it was found that among the variables studied, only ferritin contributed significantly to rT3 concentration (p<0.004). Conclusion: Iron deficiency may impair thyroid hormone status in iron deficient adolescent girls.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
161
165
https://ijms.sums.ac.ir/article_40206_8663a65c803619831ea39d8cefcc24a9.pdf
Cord Hemoglobin in Newborns in Correlation with Maternal Hemoglobin in Northeastern Iran
G.H.
Mamoury
Division of Neonatology,
Department of Pediatrics,
Ghaem Hospital,
Mashhad University of Medical Science,
Mashhad, Iran
author
A.B.
Hamedy
Department of Pediatrics,
Emam Reza Hospital,
Mashhad University of Medical Science,
Mashhad, Iran
author
F.
Akhlaghi
Department of Obstetrics &
Gynecology,
Zeynab Hospital,
Mashhad University of Medical Science,
Mashhad, Iran
author
text
article
2015
eng
Background: Hemoglobin (Hb) and hematocrit (Hct) have been used routinely in the diagnosis of neonatal anemia and polycythemia. Objective: To measure the cord blood Hb and Hct and to determine their association with maternal Hb and Hct. Methods: 170 healthy neonates born through normal vaginal delivery with gestation age of 37-42 wks and birth weight of 2.5-4 kg, and their mothers were included in this cross-sectional study. Cord blood Hb and Hct of these infants and their mothers were measured by an electronic Coulter counter. Results: We studied 97 male and 73 female neonates. The mean cord blood Hb was 15.8 (range: 11-21.4) g/dl, and Hct was 48% (range: 34%-63%). The mean±SD cord Hb of males (16.0±1.4 g/dl) was significantly (p<0.05) more than that of females (15.3±1.8 g/dl). Polycythemia (Hct>63%) was not found in any infants. However, 11.7% of newborns had an Hb<14 g/dl. Mean Hb of mothers was 12.3 g/dl. 18% of mothers had an Hb<11 g/dl. No significant correlation could be found between cord Hb and parity, birth weight and maternal age. No association could be found between cord blood and maternal Hb. Nevertheless, anemic neonates were born more frequently to mothers with low Hb. Conclusion:We found that mean Hb in our newborns was less than previously reported values. Furthermore, we could find no correlation between cord and maternal Hb.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
166
168
https://ijms.sums.ac.ir/article_40210_ffba23d0b23c14eb76e9447bf46bf4b3.pdf
Normal Value of Left Ventricular End-Systolic Elastance in Infants and Children
A.
Kiani
Department of Pediatrics Cardiology,
Day Hospital,
Tehran, Iran
author
J.
Gilani Shakibi
Department of Pediatrics Cardiology,
Day Hospital,
Tehran, Iran
author
text
article
2015
eng
Background: In certain conditions, there is a need for a specific and improved measure of cardiac performance. Routine methods for assessing left ventricular (LV) function are based on image-analysis or right heart monitoring which do not allow evaluation of ventriculo-arterial interaction. Chen et al presented a noninvasive method allowing measurement of end-systolic pressure–volume relation and its slope, the so-called end-systolic elastance (Ees), which is a major determinant of LV systolic performance and heart interaction with the systemic vasculature. Objective: To determine the normal values of LV elastance in infants and children based on Chen et al's method. Methods: The method involves measurement of the LV Ees using the equation Ees(sb) = [Pd–(End(est)×Ps×0.9]/[SV×End(est)] in 114 normal children: Group 1; 24 infants 1 to 12 months of age. Group2; 26 children aged between 1 and 5 years. Group3; 55 children 5 to 16 years of age and Group 4; 9 young adults aged between 16 and 20 years. Results: The mean±SD of the LV Ees in the 4 groups were 10.16± 4.7 mm Hg/ml for group 1, 5.44±1.36 for group 2, 3.29±0.94 for group 3, and 2.76±0.68 mm Hg/ml for group 4. Conclusion: There are significant inter-group differences which make the use of the provided normal values essential for assessment of LV function.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
169
172
https://ijms.sums.ac.ir/article_40213_22e8ccec8da89b5b31808a3240380e8f.pdf
A Cross-Sectional Study of Mandibular Fracture in Southern Iran: 1997–'98
F.
Eghtedari
Department of ENT,
Khalili Hospital,
Shiraz University of Medical Sciences,
Shiraz, Iran
author
S.
Khezri
Department of ENT,
Khalili Hospital,
Shiraz University of Medical Sciences,
Shiraz, Iran
author
text
article
2015
eng
Background: The fracture of the mandible is the second most common facial bone injury. When this injury occurs, it could be serious with complications that may even result in death. Objective: To evaluate the current trends in mandibular fracture (MF) in southern Iran. Methods: In a cross-sectional study, several parameters including age, sex, cause of fracture, anatomical site of fracture, presenting symptoms and sings of patients and associated injuries were determined in 162 patients with facial bone injuries referring to Khalili Hospital, the referral center in Shiraz, southern Iran. 51 of 162 patients had sustained 77 independent lines of fractures in their mandibles. Results: The greatest number of mandibular fractures occurred in patients aged between 11 and 30 years with male/female ratio of 5.25/1. Motor vehicle accident was found to be the leading etiological factor (39.1%) followed by falls (33.3%) and violence (21.5%). Facture of the condyle of mandible was the most frequently type of fracture followed by fracture of the body, angle, symphysis, parasmphysis, alveolar region, coronoid process and ramus. Approximately, 40% of the studied patients also suffered from injuries to other body organs, most commonly to their eyes, limbs and brain. Conclusion: The epidemiology of mandibular fracture in our region is far different from other reports.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
173
175
https://ijms.sums.ac.ir/article_40215_9622c467552d6764014fc378ff797663.pdf
The Clinical Presentation and Outcome of Infants with Nodular Lymphoid Hyperplasia: Experience with 34 Cases from Southern Iran
M.
Haghighat
Departments of Pediatric Gastroenterology and Pathology,
Shiraz University of Medical Sciences, Shiraz, Iran
author
B.
Geramizadeh
Departments of Pediatric Gastroenterology and Pathology,
Shiraz University of Medical Sciences, Shiraz, Iran
author
text
article
2015
eng
Background: Rectal bleeding is a relatively uncommon, but potentially important problem in early infancy. The common causes of fresh rectal bleeding in this age group are: bleeding diathesis (vit. K deficiency), infectious colitis, cow’s milk protein allergy and anal fissure. Nodular lymphoid hyperplasia (NLH) is another cause of prolonged fresh rectal bleeding in early infancy. Objective: To evaluate the clinical presentation and outcome of infants with fresh rectal bleeding and final diagnosis of NLH. Methods: During a period of 3 years, from Sept. 1999 to Sept. 2002, 34 consecutive infants with prolonged fresh rectal bleeding were diagnosed as NLH and followed in our center. Results: There were 18 boys and 16 girls. The mean age of onset of rectal bleeding was 1.82 months and the mean age of diagnosis 4.25 months. None of the cases had any signs or symptoms of underlying systemic diseases. All cases showed resolution of bleeding and dramatic response to exclusion of cow’s milk and its by-products from mothers’ diet or replacement of babies' formula with hypoallergenic substitutes. By the age of one year all cases tolerated regular, unrestricted diets without recurrence of bleeding. Conclusion: NLH is an important cause of prolonged fresh rectal bleeding in early infancy. The disease is limited to rectosigmoid area in otherwise healthy infants without underlying disease. Excluding cow’s milk from mother's diet or changing of the infants' formula to hypoallergenic types is the best way of treatment. The long term prognosis of infants with NLH is excellent.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
176
179
https://ijms.sums.ac.ir/article_40216_b3faba953530980a0f2f155c8bda5b35.pdf
Cyclosporine Effects on Chick Limb Bud Mesenchyme and DNA Content
S.
Bahmanpour
Department of Anatomy,
School of Medicine,
Shiraz University of Medical Sci-ences,
Shiraz, Iran.
author
D.F.
Paulsen
Department of Anatomy and
Neurobiology,
Morehouse School of Medicine,
Atlanta, GA, USA.
author
text
article
2015
eng
Background: Cyclosporine A (CsA) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. Many transplant recipients must take this medicine for the rest of their lives. Females in reproductive age group on prolonged CsA therapy have legitimate concerns about drug effects on pregnancy. Objective: To explore CsA's teratogenicity in embryonic limb development. Methods: Mesenchymal cells obtained from stage 23-24 chick embryo limb buds were grown in 96-well plates using chemically defined tissue culture medium. Cultures were treated with a range of CsA concentrations and incubated (at 37 ºC, 5% CO2) with daily medium changes for 4 days. After incubation, each well received Hoechst 33342 and DNA content was assayed using a 96-well fluorometer. Results: It was found that high concentrations of CsA caused cell loss and intermediate concentrations decreased DNA content. Low CsA concentrations however had no significant effect on DNA content in these cultures. Thus, the decrease in DNA content was dose-dependent. Conclusion: CsA teratogenicity may involve reducing the number of dividing cells or reducing the proliferation rate in developing structures.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
180
184
https://ijms.sums.ac.ir/article_40217_610a2891efcfeb32f2203450aa60df90.pdf
Sclerosing Cholangitis Induced by Intra-Biliary Tree Injection of Silver Nitrate or Hypertonic Saline Solutions in Rabbit
S.V.
Hosseini
Department of Surgery,
Faghihi Hospital,
Shiraz University of Medical Sci-ences, Shiraz, Iran.
author
V.
Kumar
Department of Pathology,
Faghihi Hospital, and
Shiraz University of Medical Sci-ences, Shiraz, Iran.
author
M. H.
Bagheri
Department of Radiology,
Nemazee Hospital,
Shiraz University of Medical Sci-ences, Shiraz, Iran.
author
A.
Izadpanah
Department of Surgery,
Faghihi Hospital,
Shiraz University of Medical Sci-ences, Shiraz, Iran.
author
A.A..
Mohammadi
Department of Surgery,
Faghihi Hospital,
Shiraz University of Medical Sci-ences, Shiraz, Iran.
author
H.
Yarmohammadi
Department of Surgery,
Faghihi Hospital,
Shiraz University of Medical Sci-ences, Shiraz, Iran.
author
text
article
2015
eng
Background: One of the most serious late complications, after evacuation of liver hydatid cyst and instillation of scolicidal agents is sclerosing cholangitis, most probably caused by the type of scolicidal agents instilled. Objective: To determine the incidence of sclerosing cholangitis after intra-biliary tract infusion of 5% saline and 0.5% silver nitrate. Methods: 5% hypertonic saline and 0.5% silver nitrate were injected trans-hepatically into the gallbladder of two equal groups (n=15/group) of rabbits. 4 months later, the livers were biopsied and cholangiography was performed, investigating for signs of sclerosing cholangitis (SC). Results: 30% of the rabbits in group A (hypertonic saline) and 80% of group B (silver nitrate) developed SC. The prevalence of SC and also the severity of pathological findings were significantly (p<0.05) higher in group B (silver nitrate). 5% hypertonic saline seems to cause a significant amount of sclerosis. Conclusions: For treatment of hydatid cyst, intra-cystic injection of 5% hypertonic saline or 0.5% silver nitrate is not safe.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
185
189
https://ijms.sums.ac.ir/article_40218_620b69e6b7d16f3c85fcf1d98e1adad5.pdf
The Effects of Acute Consumption of Heroin on Basal and Vagal-Stimulated Gastric Acid and Pepsin Secretion in Rat
F.
Nabavizadeh Rafsanjani
Department of Physiology,
Kerman University of Medical Sciences, Kerman, Iran
author
A.
Najafi
Hospital of Borazjan,
Borazjan, Iran
author
F.
Esmaeili
Department of Pharmacology,
Kerman University of Medical Sci-ences, Kerman, Iran.
author
text
article
2015
eng
Background: Opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract. Heroin is one of the opioid derivatives that abuse increasingly today. So far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion. Objective: To define the effect of the acute heroin consumption on basal and vagal-stimulated gastric acid and pepsin secretion in rat. Methods: Pure heroin (0.5 mg/kg, ip) was injected to 24 rats. After confirming the signs of heroin effect, animals were anesthetized with sodium thiopental (60 mg/kg, ip). Then, tracheostomy and laparotomy were done, gastric contents were collected by wash out technique over 15 min. The total titrable acid was measured by acid titrator. The pepsin content was measured by Anson method. Vagal electrical stimulation was used to stimulate the secretion of acid and pepsin. Results: A significant increase in both basal and vagotomized state of gastric acid secretion in that group that received heroin, as compared to the control group was shown. Also, in comparison to the control group, electrical stimulation of vagus nerve increased the gastric acid secretion in animals that received heroin. This change, however, was not significant. The basal and vagally stimulated secretion of pepsin was increased, though not significantly, in heroin group in comparison to control group. Conclusion: Basal and stimulated gastric acid and pepsin secretions increase after acute heroin administration in rat.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
190
194
https://ijms.sums.ac.ir/article_40219_50520d8e38b1301b1060253aa59b1e51.pdf
Intensification of Anemia by Secondary Hyperparathyroidism in Hemodialysis Patients
H.
Nasri
Hajar Hospital, Section of Dialysis, Shahrekord, Iran.
author
text
article
2015
eng
The excessive amounts of parathyroid hormone in secondary hyperparathyroidism (SHPTH) is suggested to interfere with normal erythropoiesis. In SHPTH, during chronic renal failure, due to the impairment of erythropoietin synthesis, this effect is more pronounced. In the present study the role of secondary hyperparathyroidism in the severity of anemia was evaluated in hemodialysis patients (n=36; 16 females and 20 males) with the end-stage renal failure. CBC, Hgb, Hct, calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone (iPTH), serum iron, total iron binding capacity, transferin saturation, ferritin as well as dialysis adequacy were measured. Partial correlation test was performed for analysis of the data making adjustments for age, duration of hemodialysis and ferritin levels. The mean±SD for iPTH, Hgb and Hct were 439.4 ± 433 pg/ml, 9 ± 1.9 and 28.8 ± 6.3 respectively. The mean duration of hemodialysis for the patients was 25.1 ± 24 months. A reverse correlation was found between iPTH and Hct and Hgb as well as between alkaline phosphatase and Hgb and Hct (0<0.05). It was shown that severity of hyperparathyroidism correlated with severe of anemia. It is concluded that secondary hyperparathyroidism per se can intensify anemia in hemodialysis patients. A more efficient control of hyperphosphatemia and parathormone hypersecretion is thus needed to achieve a better management of anemia in hemodialysis patients.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
195
197
https://ijms.sums.ac.ir/article_40207_2e33b9a9f3067bef9d8a34231c1e5823.pdf
Hyperuricemia and Perinatal Outcomes in Patients with Severe Preeclampsia
F.
Yassaee
Department of Obstetrics and
Gynecology,
School of Medicine,
Shaheed Beheshti University of Medical Sciences,
Tehran, Iran.
author
text
article
2015
eng
Maternal, fetal and neonatal complications are correlated with hypertensive disorders during pregnancy. In this context, the maternal blood uric acid level is reported to be one of the prognostic factors in determining the prenatal outcome. Based on the existing data, the present descriptive study was performed on two groups of women with severe preeclampsia; the first group (n=53) with a uric acid level of ≥6 mg/dl, was compared with the second group (n=50) with a uric acid level of <6 mg/dl. A comparison between the two groups revealed that hyperuricemia in patients with severe preeclampsia, is certainly a risk factor for several perinatal complications.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
198
199
https://ijms.sums.ac.ir/article_40211_22aad6d78d9b383560ac829bd85bf559.pdf
Gender Difference in Endothelial Permeability of Aorta in Rabbits Consuming Normal or High-Cholesterol Diets
M.
Nematbakhsh
Department of Physiology,
Isfahan University of Medical Sci-ences
Isfahan, Iran.
author
H.R.
Habibi
Department of Physiology,
Isfahan University of Medical Sci-ences
Isfahan, Iran.
author
N.
Soltani
Department of Physiology,
Isfahan University of Medical Sci-ences
Isfahan, Iran.
author
P.
Hayatdavoodi
Department of Physiology,
Isfahan University of Medical Sci-ences
Isfahan, Iran.
author
H.
Naji
Department of Physiology,
Isfahan University of Medical Sci-ences
Isfahan, Iran.
author
L.
Borjian
Department of Physiology,
Isfahan University of Medical Sci-ences
Isfahan, Iran.
author
text
article
2015
eng
The endothelial permeability of aorta (EPA) is influenced by atherosclerosis. Whether the physiological difference in EPA is a sex-dependent phenomenon remains to be determined. The objective of this study was to determine the EPA difference between male and female rabbits. An experimental model was designed to obtain 4 groups of animals. The ovariectomized rabbits were fed with normal (group I) and 1% cholesterol-rich diets (group III). The male rabbits also received normal (group II) and cholesterol-rich diets (group IV). After 5 wks, the EPA was measured by Evan Blue (EB) dye uptake method. The EB uptake was significantly (p<0.05) lower in females, regardless of the diet they used. In groups I to IV, the mean±SD EB uptake was 4.83±2.06, 15.15±2.91, 7.01±2.40, and 20.58±3.62 mg/g weight of aorta, respectively. The lower EPA in females may play a role in reducing the risk of development of atherosclerosis.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
200
202
https://ijms.sums.ac.ir/article_40214_8e137b6966ba832afcee0a923035146f.pdf
Zosteriform Skin Metastases from Breast Cancer
R.
Yaghoobi
Department of Dermatology,
School of Medicine,
Ahwaz University of Medical Sciences, Ahwaz, Iran
author
N E.
Mostoufi
Department of Pathology,
School of Medicine,
Ahwaz University of Medical Sciences, Ahwaz, Iran
author
N.
Sina
Department of Dermatology,
School of Medicine,
Ahwaz University of Medical Sciences, Ahwaz, Iran
author
text
article
2015
eng
Metastatic skin cancer is a rare complication of internal malignancies. Patients who develop cutaneous metastases rarely present with a zosteriform distribution. Herein, we describe a 65-year-old woman with a prior history of breast cancer in whom zosteriform metastases developed along her left T8-9 abdominal dermatomes.
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
203
205
https://ijms.sums.ac.ir/article_40208_41ae88ccfe6e3f9d92436e99ebaf06e7.pdf
The Effect of Semi-Upright Position on Incidence and Intensity of Chemotherapy-Induced Nausea and Vomiting
M.R.
Firouzkuhi
Zabol University of Medical Sciences, Zabol, Iran
author
S.R.
Mazloum
Mashad University of Medical Sciences, Mashad, Iran
author
text
article
2015
eng
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
206
https://ijms.sums.ac.ir/article_40209_05aa097e05e48a5e45357dc5171d3276.pdf
Treatment with Bacteriophages of Experimentally-Infected Mice Caused by Antibiotic-Resistant Pseudomonas Aerugi-nosa
J.
Ghanaat
Department of Microbiology and Virology, Mashad University of Medical Science, Mashad, Iran
author
K.
Ghazvini
Department of Microbiology and Virology, Mashad University of Medical Science, Mashad, Iran
author
A.A.
Aryan
Department of Physiology and Pharmacology, Mashad University of Medical Science, Mashad, Iran
author
E.
Aryan
Department of Microbiology and Virology, Mashad University of Medical Science, Mashad, Iran
author
text
article
2015
eng
Iranian Journal of Medical Sciences
Shiraz University of Medical Sciences
0253-0716
28
v.
4
no.
2015
207
208
https://ijms.sums.ac.ir/article_40212_a87c10269913bdceaa416dac5567503e.pdf