@article { author = {Roohi, A. and Aghamohammadi, A. and Shokri, F.}, title = {Association between Anti-IgA Antibody and Development of Adverse Reactions in Immunodeficient Patients Under Immunoglobulin Therapy}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {90-94}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: Mild to severe post-transfusion adverse reactions have been reported in a proportion of immunodeficient patients receiving intravenous immunoglobulin (IVIg). Anti-IgA antibody has been proposed to be associated with development of such reactions. Objective: To assess the association between anti-IgA levels of different isotypes and adverse reactions induced in immunodeficient patients following infusion of IVIg. Methods: In this study, IgM, IgG and IgE anti-IgA antibodies were measured by an indirect ELISA method in serum samples from 31 patients with a variety of immunodeficiencies receiving IVIg and 24 normal individuals.Results: Anti-IgA antibody of all three isotypes were detectable in all sera. However, when presented as proportion of total IgA (anti –IgA/total IgA)IgG, IgE isotypes are significantly higher in patients with adverse reactions compared to those without reactions or normal subjects.Conclusion: Both IgG and IgE anti-IgA antibodies may contribute to the development and severity of adverse reactions in some patients receiving IVIg.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40314.html}, eprint = {https://ijms.sums.ac.ir/article_40314_f389ea2dd70bd04429b5c57d3035aa88.pdf} } @article { author = {Jaberi, F.M and Dehghani, F. and Tanideh, N. and Torabinezhad, S.}, title = {Autogenous Osteochondral Transplantation Mosaicplasty (An Animal Study on Sheep)}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {95-101}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: Autogenous osteochondral grafting of articular defect in weight-bearing surface of large joints has proven to be a proper biomechanical and physiological solution for localized full-thickness defects.Objective: To study the gross and histopathological results of mosaicplasty in an animal model (sheep’s medial femoral condyle), evaluating the factors of defect and graft size, assessing the effect of fixation with only cancellous bone impaction between graft columns, and early free post-operative motion.Methods: Fourteen medium sized sheep were the subject of the study. Cylindrical osteochondral grafts of 4 mm and 6 mm diameter and 1 cm length from the periphery of the medial femoral condyles at the patellofemoral joint were used to fill corresponding 8 mm and 15 mm diameter cylindrical defects of 1 cm depth at the weight-bearing surface of medial femoral condyles.  The spaces between the grafts were packed with cancellous bone with double gloved thumb. The sheep were free for activities and weight bearing after the operation. Two of the 14 sheep died.  The first due to sepsis and the other of cardiorespiratory arrest during anesthesia induction.  All sheep were sacrificed after 4 months and their knees collected as specimens for further gross and histopathological studies.Results: All grafted defects except one healed with smooth cartilage. The quality of cartilage was evaluated by   histopathological criteria, rating the cellular morphology, surface regularity as well as structural integrity and thickness of cartilage, binding to adjacent normal cartilage and clustering.  Twenty-three out of 24 specimen showed excellent or good result, that is a success rate of 95.8%.Conclusion: Mosaicplasty, autogenous osteochondral grafting in this animal study was effective and successful even in larger defects of 15 mm diameter. Cancellous bone cementing between the cylindrical grafts, respecting the normal convexity of the femoral condyle insertion of obliquely harvested grafts at the periphery of the defects and freedom of motion and activity were all helpful in obtaining good results 4 months after graft implantation. }, keywords = {}, url = {https://ijms.sums.ac.ir/article_40317.html}, eprint = {https://ijms.sums.ac.ir/article_40317_55d0f45518c4b177400eb6b74c503fd6.pdf} } @article { author = {Sheikhi, A.K. and Amirghofran, Z.}, title = {Effect of Soluble HLA Class I Molecule on NK/LAK Cells Activation Induced by Poly I:C}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {102-109}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background:  Natural Killer cells express killer inhibitory receptors specific for HLA-class I molecules.  These receptors could induce signals that determine NK cells ability to mediate cytotoxicity.  Purified soluble form of HLA class I molecules (sHLA) could bind to NK cell receptors and down-regulate the NK killer function. Objective:  To evaluate the influence of sHLA and two monoclonal antibodies (mAbs) against killer inhibitory receptors on the poly I:C-treated freshly and IL-2 activated NK cells (LAK cells).Methods:  Isolation of CD56+ NK cells and CD56– cells was performed using the magnetic cell separation technique.  CD56+ cells were activated by rIL-2 and anti-HLA-B7 specific cytotoxic T lymphocytes (CTLs) were established from CD56- cells.  Flow cytometry analysis was performed to determine the percentage of CD3, CD16/CD56 and CD8 positive cells.  LAK and specific CTLs were tested for cytotoxicity against M4 cells using the 51Cr-release assay.  Freshly isolated NK cells and LAK cells were pre-incubated with 0.7-11 µg/ml of sHLA-B7 fused to the Fc portion of IgG molecule and subsequently tested for killing activity.  The influence of the sHLA molecule on the cytotoxicity of the cells after treatment with poly I:C as an inducer of interferon was also studied.  LAK cells were pre-treated with 0.01 to 10 µg/ml of two mAbs against NK inhibitory receptors, NKB1 and NKAT2.  The effect of these mAbs on the killing activity of poly I:C and non-poly I:C treated LAK cells against K562 target cell was determined.  Results:  In flow cytometry analysis of LAK cells, 99.5% were found to be CD56+.  Analysis of generated CTLs showed 88.4 % positivity for CD8.  Cytotoxicity of M4 stimulated CTLs was 12.3% at 1.5/1 E/T ratio to 97.1% at 25/1 E/T ratio.  NK cells had no effect on M4 cells.  Anti-NKB1 and Anti-NKAT2 mAbs decreased the cytotoxic activity of LAK cells.  These mAbs showed no effect on the poly I:C activated LAK cells.  Increasing concentrations of sHLA molecule decreased cytotoxic activity of LAK cells from 17.2% to 13.8% and poly I:C activated NK cells from 62.5% to 51.8%.  Treatment of LAK cells with poly I:C and exposure of these cells with increasing concentrations of sHLA resulted in an increase in the target cell killing of LAK cells from 20.1% to 27.6%.Conclusion:  LAK cells were not able to kill M4 cells with high expression of HLA molecules, whereas CTLs were efficient in killing these cells.  Recombinant sHLA fusion protein inhibited NK/LAK activity against K562 cells, whereas poly I:C activation of LAK cells reverted this effect indicating that poly I:C treatment of LAK cells could change the expression of NK inhibitory receptors.  }, keywords = {}, url = {https://ijms.sums.ac.ir/article_40320.html}, eprint = {https://ijms.sums.ac.ir/article_40320_dac3997f5cb72e26a912b74ad7dded4b.pdf} } @article { author = {Besharat, M.A.}, title = {The Predictive Value of Family Expressed Emotion in Eating Disorders}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {110-115}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: The measure of Expressed Emotion (EE) has been extensively used for the investigation of family interaction in different clinical populations. However, very few clinical data exist which clarify the nature of the relationship between family EE and eating disorders, as well as the prognostic value of the EE variables.Objective: The purpose of this study is to determine if family EE predicts psychotherapy outcome in eating disorders.Methods:Using the Standardised Clinical Family Interview (SCFI), fifty-eight eating disorder patients (45 anorexia nervosa, 13 bulimia nervosa), were randomly assigned to one of four types of psychological treatments: Family Therapy, Individual Focal Psychoanalytic Psychotherapy, Cognitive Analytic Therapy, or Supportive Therapy. An extensive evaluation for both pre- and post-treatment phases was made of the patients and their families.Results: This study showed remarkable potential for measuring family EE in families with an eating disorder patient. The results revealed that EE is sensitive to changes in the patient. Symptomatic improvement could reduce level of negative attitudes, as well as increase in positive attitudes like warmth. It also became apparent that EE can predict the treatment outcome.Conclusion: In general, the findings revealed that EE can predict the treatment outcome. This study has demonstrated that at least two factors - a family attitude (EE), and a patient attribute (symptomatology) - interact in some manner with the treatment settings in determining outcome of treatment. }, keywords = {}, url = {https://ijms.sums.ac.ir/article_40322.html}, eprint = {https://ijms.sums.ac.ir/article_40322_530b28a866f822266560d60bc2c111f2.pdf} } @article { author = {Sabri, M.R. and Zohouri, D. and Ghaderi, A. and Alavian Ghavanini, A. and Kohan Teb, J. and Borzouee, M.}, title = {Immunologic Factors in Acute Rheumatic Fever Compared to Rheumatic Heart Disease}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {116-119}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background/Objective: To clarify the state of different immunologic factors in patients with acute rheumatic fever (ARF) and rheumatic heart disease (RHD) compared to healthy individuals.Patients and Methods: Patients with ARF (#21), patients with RHD six months after the onset of ARF (#19), and healthy children from the same age group with normal physical examination and no history of pharyngitis during the previous month as the control group (#20) were studied. All patients were evaluated and followed for the presence and the severity of carditis, heart failure, and valvular involvement with echocardiography. Antistreptolysin-O (ASO) titer, erythrocyte sedimentation rate (ESR), serum complements C3 and C4, immunoglobins IgA, IgM, and IgG, IgM Rheumatoid Factor (RF), IgM and IgG anti-cardiolipin antibody (ACLA), and IgM and IgG anti-M group A streptococcal protein (AMP) were compared.Results: There was a significant difference for IgG and IgM ACLA between groups (p=0.005 and p=0.0001, respectively). These results were shown to reflect the difference between patients with ARF and the other two groups. There was a significant difference for IgG AMP between ARF and RHD groups (p=0.05). There was a significant difference for IgM RF between ARF and RHD groups (p=0.05). There was a significant difference for serum IgG between groups (p=0.0005). This was shown to reflect a significant difference between patients with ARF and the two other groups. Serum IgG was significantly lower in patients with, than in patients without, aortic valve involvement (p=0.039). Similarly, Serum IgG was significantly lower in patients with pericardial effusion (p=0.013).Conclusion: There are significant differences for IgG and IgM ACLA and IgG AMP and serum IgG levels and IgM RF between ARF patients and the other two groups. Whether IgG has a “protective effect” in patients with ARF preventing them from developing pericardial effusion, aortic valve involvement, or other complications is a notable question that must be answered.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40324.html}, eprint = {https://ijms.sums.ac.ir/article_40324_b748cb750920195c870f201baaa239fa.pdf} } @article { author = {Ghafourian Boroujerdnia, M. and Chinipardaz, R.}, title = {Immunopathological Aspects of Decidual Tissues in Women with First-Trimester Recurrent Spontaneous Abortion}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {120-126}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background/objective: Studies of the decidual leukocyte populations in women suffering from spontaneous early pregnancy loss may provide insight into immunpathological aspects and even cast light on the etiology of recurrent spontaneous abortion.Methods: In order to clarify the immunological role of endometrial leukocytes in repetitive abortion of unknown etiology, a comparative analysis of phenotypes of leukocyte sub-populations was performed on first-trimester decidual tissues obtained from thirty patients with recurrent spontaneous abortion and thirty samples at therapeutic abortion. Paraffin-embedded sections of these samples were labeled with a panel of monoclonal antibodies against leukocyte markers, CD68, CD3, CD45RA, CD57 using streptavidin-conjugated peroxidase technique. The numbers of positive cells for each monoclonal antibody for all control and pathological cases were counted microscopically at ´400 magnification.Results: Many macrophages were observed in pathological decidual tissues compared with normal early pregnancy decidua, however the difference was not significant (p=0.36). There was no significant difference in the number of T cells and B cells despite a slight decrease in recurrent spontaneous aborters (p=0.36; p=0.15, respectively).  Scantly CD57-positive classical NK cells were in normal pregnancy decidua.  Although the number of classical CD57-positive natural killer cells varies in pathological cases compared with normal pregnancy cases, the difference between the two groups reached significant level (p=0.003).Conclusion: These findings suggest that classical NK cells possibly play a role together with other activated decidual cell populations in the control of trophoblast growth and placental development.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40326.html}, eprint = {https://ijms.sums.ac.ir/article_40326_3fef2f5ac06f3b5abe999424e2a0bb65.pdf} } @article { author = {Khalili, G. and Partovi, F. and Ajdary, S.}, title = {Immunodiagnosis of Human Fascioliasis by Elisa Using Excretory–Secretory Products as Antigen}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {127-132}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: Different immunological methods are used for the serodiagnosis of Fasciola hepatica infections, however, they have limited specificity and/or sensitivity.Objective: To improve the specificity of ELISA using a partially modified method for preparation of excretory-secretory (ES) antigens.Methods: Studied groups were as follows: 75 patients with parasitological evidence of fascioliasis; 250 samples from normal individuals from non-endemic areas with no history of fascioliasis; 50 patients who were infected with other parasites.  ES was prepared by incubation of adult worms in protease inhibitor containing media.  ELISA was performed using this antigen.  The antigenic components of ES were revealed by sodium dodecyl sulfate polyacrylamide gel electrophoresis.Results: The sensitivity and specificity of the test were 100% and 99.7%, respectively. Conclusion: Our results showed that the ES of adult worms of Fasciola hepatica is a suitable antigen for ELISA procedure. }, keywords = {}, url = {https://ijms.sums.ac.ir/article_40328.html}, eprint = {https://ijms.sums.ac.ir/article_40328_2897c96aff13b00db3b8fcd1c62d0519.pdf} } @article { author = {Azizi, Z. and Delmaghani, S. and Zeinali, M. and Moghaddam, Z. and Zeinali, S.}, title = {The Value of ARMS/PCR and RFLP/PCR In Prenatal Diagnostic Accuracy Of -Thalassemia}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {133-136}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: It is estimated that about 3,000 pregnancies in Iran are at risk for b-thalassemia each year. Objective: To evaluate the diagnostic accuracy of combination of ARMS/PCR and  RFLP/PCR techniques in prenatal diagnosis of b-thalassemia.Methods: Sixty-seven b-thalassemia carrier families were enrolled in this study. To analyze b-globin gene, amplification refractory mutation system (ARMS) and restriction fragment length polymorphism (RFLP) methods were used. In order to obtain fetal cells for DNA analysis, chorionic villous sampling (CVS) was implemented.Results: Using the two techniques (i.e. ARMS and RFLP), prenatal diagnosis (PND) was successfully performed in 98.6% of subjects. From 72 cases, 20 fetuses (27.8%) were found to be affected, 32 (44.4%) were heterozygous carriers and 19 (26.4%) were homozygous normal. In 62 families (including 5 twins) the ARMS technique enabled us to trace the mutation in either one or both parents, out of which 46 were further confirmed by RFLP. However, in 16 cases RFLP could not be informative and the diagnosis was based only on ARMS results. In the remaining 10 families, diagnosis was possible only with RFLP.Conclusion: ARMS coupled with RFLP provides an effective way for prenatal diagnosis of b-thalassemia. Using the two techniques together increases the accuracy of PND and in cases in which ARMS is not sufficient to reach a final conclusion, it can be replaced with RFLP.  In addition, using these two methods in parallel increases accuracy, saves time and increases confidence.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40330.html}, eprint = {https://ijms.sums.ac.ir/article_40330_b854bef05280941a9fcf7694983e4c79.pdf} } @article { author = {Alborzi, S. and Parsanezhad, M.E. and Zarei, A.}, title = {Factors Influencing the Outcome of Laparoscopic Ovarian Electerocauterization in Women with Polycystic Ovarian Syndrome}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {137-142}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background/Objective: To evaluate factors which increase the chance of ovulation and pregnancy after laparoscopic ovarian electerocauterization (LEC) in Clomiphene Citrate (CC) resistant polycystic ovarian syndrome (PCOS) patients.Methods: An experimental prospective study was carried out in the infertility division of a university teaching hospital. Two hundred and ninety-nine women with PCOS who were resistant to CC were enrolled in this study.  LEC was performed over a four years period between 1996 till 1999.  Serum concentration of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), testosterone (T), dehydroepiandesterone sulfate (DHEAS), were measured before and ten days after LEC.  The ovulation and pregnancy rates were also determined over a period of one year of follow-up.Results: The overall ovulation rate was 78.3% but cumulative pregnancy rate 12 months after LEC was 47.8%. Women who conceived following surgery had mainly a shorter duration of infertility, secondary infertility and higher pre-operational LH levels. Conclusion: PCOS women with anovulatory infertility responded favorably to LEC (clinic & para clinic). Three main factors that affect the outcome of surgery are duration of infertility, type of infertility and amount of pre-operational LH levels.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40332.html}, eprint = {https://ijms.sums.ac.ir/article_40332_1e72dcf9f6a421e2a6eeef19fd1840fe.pdf} } @article { author = {Pishva, N. and Amoozgar, H.}, title = {Hyperbilirubinemia Following Exchange Transfusion with G-6-PD Deficient Donor Blood}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {143-145}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: The incidence of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in Iran is estimated at 10-14.9%.  The donor blood in blood banks is not screened routinely for this enzyme deficiency and such blood may be used for neonatal exchange transfusion.Objective: To study the effect of G-6-PD deficient blood in neonatal exchange blood transfusion.Methods: In a prospective study, serum bilirubin was checked before and 6 hours after exchange transfusion in three hundred and fifty consecutive neonates who were admitted to Nemazee Hospital, Neonatal Ward. Hemoglobin, direct Coomb’s test, direct bilirubin, reticulocyte count, blood group of neonates and mothers, G-6-PD of neonates and the blood used for exchange transfusion were also checked. For analysis of the data, 102 neonates who weighed more than 2500 gr and with no evidence of hemolysis, liver disease or sepsis were divided into three groups;  Group I: patients in this group were exchanged with G-6-PD deficient blood.  Group IIa: patients in this group were exchanged with normal blood.  Group IIb: the neonates from Group IIa who needed a repeat exchange transfusion.  Group III: G-6-PD deficient patients who were exchanged with normal blood.  Results: Group I neonates had a small drop in bilirubin 6 hours post-exchange transfusion in contrast to groups II and  III (P<0.05).  Exchange transfusion with G-6-PD deficient donor blood led to repeat exchange transfusion due to insufficient fall in bilirubin level in Group I neonates.Conclusion: It is recommended that in areas endemic for G-6-PD deficiency, the donor blood be screened before exchange transfusion.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40333.html}, eprint = {https://ijms.sums.ac.ir/article_40333_567281953f04bae62f187c34c3760b00.pdf} } @article { author = {Amirghofran, Z. and Miri, R. and Javidnia, K. and Davoodi, M.}, title = {Study of Cytotoxic Activity of Daphne Mucronata Royle Grown in Iran}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {146-151}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: Plants are a proven source of anti-tumor compounds and it is reasonable to assume that many such substances remain to be discovered. In Iranian folk medicine, ethanolic extract of the aerial parts of Daphne mucronata Royle is used against various skin disorders.Objective: In order to evaluate anti-neoplastic plants, we initiated a cytotoxic study using Daphne mucronata that is indigenous to Iran.Methods: The cytotoxic activity of two hydroalcoholic and chloroformic extracts of Daphne mucronata Royle were  examined on seven different cell lines by MTT assay. Cell lines used in this study included SK-Br-3 and MDA-MB-435 (breast cancer), Hela (cervical epitheloid carcinoma), K562 (myelogenous leukemia), U937 (monoblastic leukemia), Ag.8 (mouse myeloma) and Vero (primary monkey kidney).Results: The highest cytotoxic activity of the hydroalcoholic extract of D. mucronata was found on breast cancer cell lines. 50 mg/ml of the extract inhibited proliferation of 24-hour cultures of MDA-MB-435 and SK-Br-3 cell lines (73% and 34% inhibition, respectively). The extract showed anti-leukemic activity particularly against the U937 cell line. A 50% inhibition of cell proliferation due to 100 mg/ml of the extract in 24-hour culture of U937 and 48-hour culture of Ag.8 cell lines was observed. Despite the result of MTT assay showing a reduction of Hela cell line viability after 24-hour exposure to 10-50 mg/ml of the extract, a significant stimulatory activity at concentrations more than 400 mg/ml was noted. No significant cytotoxic effect was detected in relation to the Vero cell line. The chloroformic extract showed weak cytotoxic effect on MDA-MB-435,  SK-Br-3 and U937 cells but had no significant effect on the other cell lines.Conclusion: Hydroalcoholic extract of D. mucronata showed anti-tumour activity particularly against breast and leukemia cell lines.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40334.html}, eprint = {https://ijms.sums.ac.ir/article_40334_3d5d60fae86f39bc07a47bff24aed76a.pdf} } @article { author = {Moin, M. and Movahedi, M. and Tavakol, M.}, title = {The Effect of Maternal Age on Childhood Asthma}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {152-154}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Some studies indicate that children born to younger mothers are at a higher risk of wheezing and asthma.  To investigate the maternal age associated with asthma in children, a case-control study on 310 asthmatic and 310 non-asthmatic children aged 3 to 4 years was organized during a one-year period.  A questionnaire was used to obtain information about the child’s personal susceptibility factors, family history of asthma and past infectious diseases, environmental exposure, and sociodemographic characteristics.  In comparison with children of mothers who were 30 years of age or older, children of mothers aged 26-30 years had an adjusted odds ratio of 0.99 (95% CI= 0.37-2.64) of developing asthma; children of mothers between 21 and 25 years had an odds ratio of 1.60 (95% CI = 0.47-5.40), and those whose mothers were 20 years old or younger had an odds ratio of 6.74 (95% CI = 1.23-36.72).  Younger mothers have children with a greater risk factor of childhood asthma.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40315.html}, eprint = {https://ijms.sums.ac.ir/article_40315_36bacc112fd1187687f5ba26eab5f685.pdf} } @article { author = {Shakibaie, M.R. and Adeli, S. and Nikian, Y.}, title = {Emergence of Ciprofloxacin Resistance Among Pseudomonas Aeruginosa Isolated from Burn Patients}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {155-159}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Background: Increasing resistance of Pseudomonas aeruginosa to ciprofloxacin in ICU/burn units has created a problem in the treatment of infections caused by this microorganism. Methods: Fifty P. aeruginosa strains were isolated from burn patients hospitalized in the Kerman Hospital during May 1999-April 2000 and were tested for in-vitro sensitivity to different antibiotics by disc diffusion breakpoint assay.  The isolates were subjected to minimum inhibitory concentration (MIC) test by agar dilution method.  Existence of the plasmids was also investigated in the isolates. Results: Thirty-four patients infected with ciprofloxacin strains showed MIC of 8 mg/ml [p<0.001].  Sixteen patients were infected with sensitive strains exhibiting MIC range of 0.0125-0.125 ± 0.033 mg/ml.  The isolates were also also resistant to other antibiotics [p<0.001].  Plasmid isolation and agarose gel electrophoresis (0.7%) revealed three plasmid bands in strains 8 and 16, and one band in strain 35.Conclusion: The emergence of ciprofloxacin resistance of P. aeruginosa in burn patients is alarming since this antibiotic has only recently been introduced onto the market in Iran.  One important observation was that some isolates exhibited cross resistance to other antibiotics.  Furthermore, some strains were carriers of plasmids which might have acted as the potential source of acquired resistance in the hospital setting.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40318.html}, eprint = {https://ijms.sums.ac.ir/article_40318_f5b68555133aeaace6a7859ac9300a2d.pdf} } @article { author = {Ghaffari Nejad, A. and Pouya, F.}, title = {Report of Unusual Self-Mutilation in A Paranoid Schizophrenic Patient}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {160-163}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Self-mutilation is defined as intentional damaging of the body without intent to die.  This behavior is observed among groups of psychiatric patients particularly schizophrenics.  In these patients, self-mutilative behavior may have unusual manifestations related to delusion and hallucination.  In this article, an unusual form of self-mutilation of a paranoid schizophrenic patient is reported.  The subject stuck multiple needles into various parts of his body including head, face, neck, chest wall and genitalia.  He also injected aubergine juice into his right popliteal fossa and ingested two medical thermometers.  The relationship between self-mutilative behavior and delusions and hallucinations is discussed. }, keywords = {}, url = {https://ijms.sums.ac.ir/article_40316.html}, eprint = {https://ijms.sums.ac.ir/article_40316_e5d6c505e4f2bc5b7f617f5a5c0c7d16.pdf} } @article { author = {Meshkini, A. and Fakhrju, A. and Pour Eisa, M.}, title = {Intraventricular Tuberculoma: Report of A Rare Case}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {164-166}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Intraventricular tuberculoma (IVT) is extremely rare, CT and MRI patterns have been only sparsely described.  Herein, a case of intraventricular tuberculoma in a 40 year-old woman is reported.  At admission, the patient displayed malaise and was confused and deteriorated suddenly.  Brain CT and MRI findings were very similar to intraventricular meningioma.  The patient underwent surgery and tuberculoma was removed by transcortical transventricular approach.  IVT should be considered in differential diagnosis of intraventricular lesions in endemic areas and in patients with unexplained malaise.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40319.html}, eprint = {https://ijms.sums.ac.ir/article_40319_fc10a4617619e5c381e20b31caa2222c.pdf} } @article { author = {Taghipoor, M. and Bagheri, M.H.}, title = {Multiple Concomitant Primary CNS Tumors of Different Histology: Report of Two Cases}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {167-170}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Two cases of multiple concomitant CNS tumors of different histologic types are presented.  One was a case of neurofibromatosis type 2 (NF2) with 6 CNS tumors, and the other a case of 4 CNS tumors without any evidence of NF. To our knowledge, there is no report of concomitant occurrence of 6 CNS tumors in the medical literature. Neuroradiological  and operative findings are illustrated and discussed.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40321.html}, eprint = {https://ijms.sums.ac.ir/article_40321_d1234fe679a009f0d0d7021ae8501c9a.pdf} } @article { author = {Samangooei, Sh. and Hakim, S.M. and Mehryar, M.}, title = {Association of Behçet’s Disease with Osteogenesis Imperfecta in A Ten-Year-Old Girl}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {171-173}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Osteogenesis Imperfecta (OI) is a genetic disorder characterized by bones that break easily, often from little or no apparent cause. In this article, we present a patient suffering from OI, who had concomitant active Behçet’s Disease(BD)with repeated oro-genital ulcers, skin postular eruptions and severe recurrent bilateral uveitis. This patient, is, to our knowledge the first reported case in literature.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40323.html}, eprint = {https://ijms.sums.ac.ir/article_40323_d594742543e0288d95ac03e1f340355d.pdf} } @article { author = {Torabi Nezhad, S. and Emami, M.J. and Mojtahed Jaberi, F.}, title = {Ostegogenic Sarcoma with Epithelial Differentiation (Carcinosarcoma): Report of Two Cases}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {174-177}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Epitheloid osteosarcoma (carcinosarcoma) of the bone is a rare malignant tumor and only a few cases have been reported in the literature. In this study, we report two cases of osseous carcinosarcoma (epitheloid osteosarcoma) with immunohistochemical studies.  The morphological and immunohistochemical data in these two cases support the theory of divergent differentiation of primitive, uncommitted multipotiential stem cell to produce biphenotypic tumors. }, keywords = {}, url = {https://ijms.sums.ac.ir/article_40325.html}, eprint = {https://ijms.sums.ac.ir/article_40325_5c66af5a0a04ef65df3eaa7ee9fec38d.pdf} } @article { author = {Faghihi, G. and Iraji, F.}, title = {Incontinentia Pigmenti}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {178-181}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {Incontinentia pigmenti (IP) is an uncommon X-linked dominant genodermatosis characterized by four cutaneous stages and frequent association with dental (90%), central nervous system (33%) and ocular (35%) anomalies. The exact pathogenesis of this disorder remains unknown.Herein, we report a newborn girl with inflammatory vesiculobullous and warty skin lesions and a positive family history of IP, with blood leucocytosis (eosinophilia and also lymphocytosis), but no other extracutaneous findings.}, keywords = {}, url = {https://ijms.sums.ac.ir/article_40327.html}, eprint = {https://ijms.sums.ac.ir/article_40327_4a31fce7fc6b9fbe54a364d072a120b3.pdf} } @article { author = {Haghighat, M and Karamifar, H}, title = {Cystic Fibrosis Presenting with Severe Dehydration in an Otherwise Normal Infant}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {182-184}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {A 4-month-old male infant was referred to our center with clinical signs and symptoms of severe dehydration without fever, diarrhea, vomiting, or respiratory symptoms. The patient had a history of two similar episodes at 1.5 and 2 months of age without any known underlying cause. In each attack the patient was hospitalized and improved with management of dehydration and electrolyte imbalance. The main abnormal laboratory findings on all admissions were: hypochloremic, hyponatremic, hypokalemic metabolic alkalosis. Sweat chloride was checked at all admissions, and was found to be highly abnormal at the last admission. }, keywords = {}, url = {https://ijms.sums.ac.ir/article_40329.html}, eprint = {https://ijms.sums.ac.ir/article_40329_989ac166383fb34d52fd0e34eab9707a.pdf} } @article { author = {Fattahi, M.R. and Izadpanah, A. and Kumar, P.V.}, title = {Giant Esophageal Leiomyoma with Megaesophagus: A Case Report}, journal = {Iranian Journal of Medical Sciences}, volume = {26}, number = {3-4}, pages = {185-187}, year = {2001}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {}, abstract = {A 48-year-old man with a giant leiomyoma of the esophagus accompanied by megaesophagus is reported in this paper. He presented with dysphagia and was treated successfully by means of an esopahgogastric resection. The literature is reviewed and the clinical and pathological aspects of this rare tumor are discussed. }, keywords = {}, url = {https://ijms.sums.ac.ir/article_40331.html}, eprint = {https://ijms.sums.ac.ir/article_40331_7e7af8753cac5927709e8d026f37ab3a.pdf} }