%0 Journal Article %T The Efficacy of Implant of Octacalcium Phos-phate in Combination with Bone Matrix Gelatin on Bone Regeneration in Skull Defects in Rat %J Iranian Journal of Medical Sciences %I Shiraz University of Medical Sciences %Z 0253-0716 %A Sargolzaei-Aval, F. %A Sobhani, A. %A Arab, M.R. %A Sarani, S.A . %A Heydari, M.H. %D 2015 %\ 09/29/2015 %V 29 %N 3 %P 124-129 %! The Efficacy of Implant of Octacalcium Phos-phate in Combination with Bone Matrix Gelatin on Bone Regeneration in Skull Defects in Rat %R %X Background: In several conditions we have face cranial bone defects. Reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons. Objective: To evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (OCP/BMG). Methods: We used 40, 5–6-week-old male Sprague-Dawley rats.  A full thickness standardized trephine defect—5-mm in diameter—was made in the rat parietal bone and OCP/BMG was implanted into the defect.  No OCP/BMG particles were implanted in control group that was otherwise treated identically. After sacrificing the rats chronologically and processing the tissues by routine histological procedures, 5-mm thick sections of bone were stained and examined under light microscope. Results: On the 5th day of implantation, inflammatory cells were seen around the implanted materials, especially around the OCP particles.  By the end of 21st day, almost all of the OCP/BMG particles were absorbed and bone trabeculae, bone marrow cavities and bone marrow tissues were seen. In the control group, at the end of 21th day, a few areas of new bone were seen near to the defect margins and host bone, however, in much less amount than in the experimental group. Conclusion: Implant of OCP/BMG appears to stimulate new bone regeneration in bone defects. These biomaterials can be used for repair of cranial bone defects. %U https://ijms.sums.ac.ir/article_40147_8625194ce23afbc65571f8311fc53a75.pdf