%0 Journal Article %T Effect of Garlic Extract on Cutaneous Leishmaniasis and the Role of Nitric Oxide %J Iranian Journal of Medical Sciences %I Shiraz University of Medical Sciences %Z 0253-0716 %A Ahmadi-Renani, K %A Mahmoodzadeh, A. %A Cheraghali, AM. %A Esfahani, AA. %D 2015 %\ 11/30/2015 %V 27 %N 3 %P 97-100 %! Effect of Garlic Extract on Cutaneous Leishmaniasis and the Role of Nitric Oxide %R %X Background: The production of nitric oxide (NO) is important in the final outcome of leishmaniasis in animal models.Objective: The efficacy of garlic therapy and a combination of garlic and vitamin A were compared with an antimonial drug (glucantime) to assess healing and regulation of NO release in mice infected with Leishmania major.Methods: The mice were subjected to 3´105 promastigotes and allowed to induce a lesion.  The mice were treated with above compounds twice a day for 45 days. The diameter of the lesion was measured on days 1, 10, 20, 30 and 45.  In a separate experiment, NO release by peritoneal macrophages was measured.Results: The diameter of lesion was reduced by aqueous extract of garlic within 30 days of treatment.  However, the maximum reduction was induced when mice were subjected to vitamin A for 10 days before the administration of the aqueous extract for 30 days.  A significant correlation between healing and the amount of NO release was also found.Conclusion:  A combination of aqueous extract of garlic and vitamin A can treat leishmanisis. %U https://ijms.sums.ac.ir/article_40256_0241e8165e9a5934f9fc745efde6ebbe.pdf