ORIGINAL_ARTICLE
Association between the Functional Polymorphism of Vascular Endothelial Growth Factor Gene and Breast Cancer: A Meta-Analysis
The vascular endothelial growth factor (VEGF) gene single-nucleotide polymorphism involved in the regulation of the protein levels has been implicated in breast cancer. However, the published studies have produced contentious and controversial results. Herein, we performed a meta-analysis (from January to October 2013); to further evaluate the association between +936 C/T polymorphism and the risk of breast cancer. By searching the EMBASE, PubMed, and Web of Science databases, we identified a total of 12 case-control studies with 8,979 cancer patients and 9,180 healthy controls. The strength of the association was assessed using Odds Ratios (ORs) with 95% Confidence Intervals (CI). We found no evidence indicating that the allelic model or the genotype models of +936 C/T polymorphism were associated with the risk of breast cancer in total population (ORCC vs. TT=1.01, 95% CI=0.96-1.06, Ph=1.00; ORCC+CT vs. TT=1.00, 95% CI=0.96-1.05, Ph=1.00; ORCC vs. CT+TT=1.02, 95% CI=0.98-1.07, Ph=0.94; OR allele C vs. allele T=1.01, 95% CI=0.98-1.04, Ph=0.99; ORCT vs. TT=1.01, 95% CI=0.93-1.09, Ph=1.00). Such lack of association with breast cancer was also observed in subgroup analyses according to ethnicity as well as in the analysis by source of controls. In conclusion, this meta-analysis suggests that the functionally important +936 C/T polymorphism may not be associated with breast cancer risk. Larger well-designed studies with gene-to-gene and gene-to-environment interactions are clearly required to validate the results further.
https://ijms.sums.ac.ir/article_39713_741c7f4e0f6fb53acd280839949fa7b4.pdf
2015-01-01
2
12
Vascular endothelial growth factor A
Breast neoplasms
Polymorphism
Risk
Juan
Li
jvyongjian@163.com
1
Department of Radiotherapy, The Second Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, Jiangsu Province, China
AUTHOR
Yongjian
Ju
juyongjian1973@163.com
2
Department of Radiotherapy, The Second Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, Jiangsu Province, China
LEAD_AUTHOR
ORIGINAL_ARTICLE
Combined Femoral and Acetabular Osteotomy in Children of Walking Age for Treatment of DDH; A Five Years Follow-Up Report
Background: The prevalence of neglected developmental dysplasia of the hip (DDH) has been decreasing. Nowadays, the disease is rarely seen in walking age children. The purpose of this study is to assess the results of simultaneous osteotomy of femur and pelvic bones in such children.Method: We performed a retrospective study on 30 children aged 3.8±0.9 (range: 1.5-7) years old, with DDH who underwent surgical operation in our hospital from August 2001 to September 2006. Tönnis and Severin grading systems were used to classify the radiographic status of the hip in pre- and postoperative era, respectively. Improvement in function and limp was also evaluated by the modified McKay’s classification.Results: From the 30 cases, six patients excluded in the course of the study and among the remaining patients, 12 had bilateral involvement. The mean follow-up period was 7.6±0.8 (range: 5.1-11.3) years. During the last visit, radiographic status of the operated joints, according to Severin classification was as follows: Class I: 12 patients; Class II: 20 patients; Class III: 3 patients; Class IV: 1 patient; and Class VI: 1 patient. Conclusion: Although through the follow-up, two hips subluxated, necrosis happened in three and one joint was re-dislocated, simultaneous femoral and innominate osteotomy in the walking age children with DDH has relatively good clinical outcomes.
https://ijms.sums.ac.ir/article_39714_9f67264f255e0e206ec232d6ad423416.pdf
2015-01-01
13
18
Developmental dysplasia of the hip
Osteotomy
Radiography
Mahdi
Mazloumi
mazloumim@mums.ac.ir
1
Department of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Farzad
Omidi-Kashani
omidif@mums.ac.ir
2
Department of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohamad Hosein
Ebrahimzadeh
3
Department of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hadi
Makhmalbaf
makhmalbafh@mums.ac.ir
4
Department of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohamad Mahdi
Hoseinayee
5
Department of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
ORIGINAL_ARTICLE
Comparison of Prophylactic Infusion of Phenylephrine with Ephedrine for Prevention of Hypotension in Elective Cesarean Section under Spinal Anesthesi: A Randomized Clinical Trial
Background: Spinal anesthesia is an accepted technique in elective cesarean sections. However, hypotension, resulted from sympathectomy is a common problem, especially in pregnant women. Prevention of this complication by sympathomimetic agents is of potential clinical significance. The aim of this study is to compare the effect of prophylactic infusion of Phenylephrine versus Ephedrine in the prevention of hypotension during spinal anesthesia in elective cesarean section.Methods: Eighty-three patients were enrolled in this study and randomly divided into three groups. Group Ph received phenylephrine infusion, group E received ephedrine infusion while group P were delivered placebo. Vital signs (blood pressure, heart rate, and arterial oxygen saturation) were recorded throughout the surgery. Maternal and neonatal perioperative complications were also controlled and recorded.Results: There was an insignificant difference in demographic data between the groups. Systolic and diastolic blood pressures were higher in the phenylephrine group than control, but not higher than the ephedrine group. Maternal dysrhythmias were more common in ephedrine and phenylephrine groups than the control group. Vomiting was more common in ephedrine group (P<0.05). In addition, the fifth-minute Apgar score of neonates was higher in phenylephrine and ephedrine groups than the control group (P<0.05). Neonates of phenylephrine group had less acidosis than the other groups.Conclusion: Prophylactic infusion of phenylephrine can effectively decrease spinal anesthesia related hypotension without any significant complication for mother or her fetus. Trial Registration Number: IRCT2012120911700N1
https://ijms.sums.ac.ir/article_39717_7dc3448b6b310eb288334c350ec3acb6.pdf
2015-01-01
19
26
Phenylephrine
Ephedrine
Spinal Anesthesia
Cesarean Section
Hypotension
Farnaz
Moslemi
moslemifa@gmail.com
1
Women’s Reproductive Health Research Center, Department of Anesthesiology, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
LEAD_AUTHOR
Sousan
Rasooli
rasooli_s@yahoo.com
2
Women’s Reproductive Health Research Center, Department of Anesthesiology, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
AUTHOR
ORIGINAL_ARTICLE
Comparison of Appetite-regulating Hormones and Body Composition in Pediatric Patients in Predialysis Stage of Chronic Kidney Disease and Healthy Control Group
Background: Protein-energy malnutrition (PEM) is a common complication in pediatric patients with chronic kidney disease (CKD). Components incorporated in the regulation of appetite and body composition appear to be of the focus in renal insufficiency and may influence the CKD-associated PEM. The purpose of this study was to investigate plasma levels of appetite-regulating hormones and their correlation with the body composition variables in a pediatric in predialysis stage of CKD.Methods: Thirty children with CKD in predialysis stage were selected and compared with 30 healthy sex- and age-matched controls. Blood samples were collected in fasting. Serum total ghrelin, leptin, and obestatin levels were measured using enzyme immunometric assay methods. Anthropometric parameters measurement and body composition analysis were done using the bioelectric impedance analysis (BIA) method.Results: Patients showed insignificant elevated total ghrelin (105.40±30.83 ng/l), leptin (5.32±1.17 ng/ml) and obestatin (5.07±1.09 ng/ml) levels in comparison with healthy participants. By using BIA, patients had significantly different Dry Lean Weight (P=0.048), Extra Cellular Water (P=0.045), Body Cell Mass (BCM) (P=0.021), Basal Metabolic Rate (P=0.033) and Body Mass Index (P=0.029) compared with controls. Furthermore, the total body water was slightly and the ECW was significantly higher in CKD participants. There were significant negative correlation between obestatin and BCM (r=-0.40, P=0.03) and fat free mass index (FFMI) (r=-0.40, P=0.029) in patients.Conclusion: It seems that our results are insufficient to clarify the role of appetite-regulating hormones in PEM in CKD patients. It is apparent that there are still many unknown parameters related to both appetite regulating and CKD-associated PEM.
https://ijms.sums.ac.ir/article_39720_2afb34f11ccaf2ea706bb1ac9b858f6c.pdf
2015-01-01
27
33
Chronic renal insufficiency
Ghrelin
Leptin
Obestatin
Mohammad Hassan
Eftekhari
ranjbarmaryam29@yahoo.com
1
Department of Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Maryam
Ranjbar-Zahedani
2
Department of Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Mitra
Basiratnia
m_basiratnia@yahoo.com
3
Department of Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Abbas
Rezaianzadeh
4
Department of Epidemiology,
Research Center for Health Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Shiva
Faghih
5
Department of Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
Application of Bland-Altman Method in Comparing Transrectal and Transabdominal Ultrasonography for Estimating Prostate Volume
Background: Estimating prostate volume using less invasive transabdominal ultrasonography (TAUS) instead of transrectal ultrasonography (TRUS) is of interest in terms of identifying their agreement level. Previous reports on this subject, applied general correlation coefficient as the level of agreement. This study uses Bland-Altman method to quantify TAUS and TRUS agreement on estimating prostate volume.Methods: Total prostate gland volume of 40 patients with signs and symptoms of benign prostatic hyperplasia were measured using TAUS and TRUS. The study was carried out at the Urology Research Center, Razi Hospital, Guilan University of Medical Sciences (Rasht, Iran) from March to October 2010. Both methods were performed in one session by the same experienced radiologist. Data were analyzed using Pearson correlation coefficient and Bland-Altman method.Results: Total prostate volume estimated by TAUS and TRUS were 50.30±23 and 50.73±24.6 mL, respectively. The limits of agreement for the total prostate volume were -6.86/9.84 that was larger than predefined clinical acceptable margin of 5 mL.Conclusion: There is a lack of agreement between TAUS and TRUS for estimating the total prostate volume. It is not recommended to apply TAUS instead of TRUS for estimating prostate volume.
https://ijms.sums.ac.ir/article_39723_faa73cd670e9d12180212418139e8c48.pdf
2015-01-01
34
39
Prostate
Ultrasonography
cross-sectional study
Bland-Altman approach
Ali
Babaei Jandaghi
abjandaghi@gmail.com
1
Department of Radiology,
Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Maryam
Shakiba
shakiba_mm@yahoo.com
2
Department of Epidemiology,
Shahid Beheshti University of Medical Science, Tehran, Iran
LEAD_AUTHOR
Hamidreza
Nasseh
3
Urology Research Center,
Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Yaser
Korouji
4
Urology Research Center,
Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Samaneh
Esmaeili
5
Urology Research Center,
Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Ali Akbar
Khadem Maboudi
6
Department of Biostatistics, Shahid Beheshti University of Medical Science, Tehran, Iran
AUTHOR
Ali
Khorshidi
7
Department of Epidemiology,
Shahid Beheshti University of Medical Science, Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
On-Pump Beating Coronary Artery Bypass in High Risk Coronary Patients
Background: There are some conflicting results with Conventional Coronary Artery Bypass Grafts (CCABG) with arrested heart in coronary high-risk patients. Moreover, performing off-pump CABG in these cases may be associated with serious complications. The objective of this study is to evaluate the efficacy of the on-pump beating CABG (OPBCABG) in coronary high-risk patients in comparison with the conventional methods.Methods: In a prospective research study, 3000 off-pump CABG patients were considered during June 2003 to December 2011. Among these, 157 patients with one or more of the following risk factors were included for OPBCABG; severe left main stenosis, early post-acute myocardial infarction with ongoing chest pain, unstable angina, intractable ventricular arrhythmia, post complicated coronary intervention and severe left ventricular dysfunction. These patients were compared with 157 similar patients undergone CCABG with aortic cross clamp before 2003.Results: Preoperative patient characteristics revealed no significant differences between the two groups. The patients’ mean age and number of grafts were 57 years and 3 per patient respectively. Hospital mortality was 3.2% and 9% in OPBCABG and CCABG groups, respectively (P<0.001). Preoperative myocardial infarction, requirement of inotropic agents and intraaortic balloon pump, renal dysfunction and prolonged ventilation time were significantly higher in CCABG group.Conclusion: Our results suggest that OPBCABG is effective in coronary high-risk patients and significantly reduces mortality and the incidence of perioperative MI and other major complications.
https://ijms.sums.ac.ir/article_39724_7676224bcbb4b9feb6e263cae0c2f163.pdf
2015-01-01
40
44
Cardio pulmonary bypass
Off pump coronary artery bypass
Efficacy
Abbas
Afrasiabirad
1
Department of Cardiac Surgery,
Madani Heart Hospital,
Tabriz University of Medical Sciences,
Tabriz, Iran
LEAD_AUTHOR
Naser
Safaie
2
Department of Cardiac Surgery,
Madani Heart Hospital,
Tabriz University of Medical Sciences,
Tabriz, Iran
AUTHOR
Hosein
Montazergaem
3
Department of Cardiac Surgery,
Madani Heart Hospital,
Tabriz University of Medical Sciences,
Tabriz, Iran
AUTHOR
ORIGINAL_ARTICLE
Effect of S-Methyl-L-Cysteine on Oxidative Stress, Inflammation and Insulin Resistance in Male Wistar Rats Fed with High Fructose Diet
Background: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. The purpose of the present study was to investigate the protective effect of SMC on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome.Methods: Male Wistar rats were divided into five groups (6 rats in each group), namely; control, control+S-methyl cysteine (SMC), high fructose diet (HFD), HFD+SMC and HFD+metformin. The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study. The fasting glucose, insulin, insulin resistance, and tumor necrosis factor alpha and erythrocyte enzymatic antioxidants were measured.Results: Increased levels of plasma glucose, insulin, malondialdehyde, tumor necrosis factor-alpha, and insulin resistance and decreased levels of glutathione, glutathione peroxidase, and catalase were found in rats on a high fructose diet. Oral administration of SMC (100 mg/kg bw/day/rat) for 60 days resulted in significant attenuation of plasma glucose, insulin, tumor necrosis factor–alpha, insulin resistance and improved antioxidant enzyme activities.Conclusion: Oral treatment of SMC is effective in improving insulin resistance while attenuating metabolic syndrome, inflammation, and oxidative stress in male rats fed with fructose rich diet.
https://ijms.sums.ac.ir/article_39725_89e46d909afa4c795a7735bec010e623.pdf
2015-01-01
45
50
10.30476/ijms.2015.39725
Fructose
Insulin Resistance
Inflammation
Oxidative stress
Sithara
Thomas
biosenthilkumar@gmail.com
1
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
AUTHOR
Gandhipuram Periyasamy
Senthilkumar
2
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
LEAD_AUTHOR
Kuppuswamy
Sivaraman
3
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
AUTHOR
Zachariah
Bobby
4
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
AUTHOR
Sankar
Paneerselvam
5
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
AUTHOR
Kotten Thazhath
Harichandrakumar
6
Department of Medical Biometrics and Informatics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India
AUTHOR
ORIGINAL_ARTICLE
An Experience of Qualified Preventive Screening: Shiraz Smart Screening Software
Background: Computerized preventive screening software is a cost effective intervention tool to address non-communicable chronic diseases. Shiraz Smart Screening Software (SSSS) was developed as an innovative tool for qualified screening. It allows simultaneous smart screening of several high-burden chronic diseases and supports reminder notification functionality. The extent in which SSSS affects screening quality is also described.Methods: Following software development, preventive screening and annual health examinations of 261 school staff (Medical School of Shiraz, Iran) was carried out in a software-assisted manner. To evaluate the quality of the software-assisted screening, we used quasi-experimental study design and determined coverage, irregular attendance and inappropriateness proportions in relation with the manual and software-assisted screening as well as the corresponding number of requested tests.Results: In manual screening method, 27% of employees were covered (with 94% irregular attendance) while by software-assisted screening, the coverage proportion was 79% (attendance status will clear after the specified time). The frequency of inappropriate screening test requests, before the software implementation, was 41.37% for fasting plasma glucose, 41.37% for lipid profile, 0.84% for occult blood, 0.19% for flexible sigmoidoscopy/colonoscopy, 35.29% for Pap smear, 19.20% for mammography and 11.2% for prostate specific antigen. All of the above were corrected by the software application. In total, 366 manual screening and 334 software-assisted screening tests were requested.Conclusion: SSSS is an innovative tool to improve the quality of preventive screening plans in terms of increased screening coverage, reduction in inappropriateness and the total number of requested tests.
https://ijms.sums.ac.ir/article_39726_1568bb59d93a13d2ca235b82e8e213aa.pdf
2015-01-01
51
57
cancer
Chronic disease
Software
Quality Improvement
Parisa
Islami Parkoohi
islamip@sums.ac.ir
1
Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Hashem
Zare
2
Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Gholamreza
Abdollahifard
abdolahigh@sums.ac.ir
3
Department of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Transvaginal Sacrospinous Ligament Fixation for Pelvic Organ Prolapse Stage III and Stage IV Uterovaginal and Vault Prolapse
The result of transvaginal sacrospinous ligament fixation technique, as part of the vaginal repair procedure for massive uterovaginal (Pelvic Organ Prolapse stage III and stage IV and vault prolapse) is evaluated. A total of 32 women were included in the present case series. Marked uterovaginal prolapse was present in 28 women and four had vault prolapse following hysterectomy. Patients with vault prolapse and marked uterovaginal prolapse underwent sacrospinous colpopexy. The mean follow-up period was 2.5 years. Out of the 28 patients with previous marked uterovaginal prolapse, only one had small cystocele 3 years after the surgery. This patient was asymptomatic and did not require repeat surgery. One woman had post-operative urinary tract infection and two had buttock discomfort, one had ischiorectal abscess and two had cuff cellulitis. All complications were dealt with successfully. No other major intra- and post-operative complications occurred. Transvaginal sacrospinous colpopexy can be performed together with vaginal hysterectomy, with marked uterovaginal prolapse and vault prolapse.
https://ijms.sums.ac.ir/article_39715_d92e1cf87080fc6ec209bdf11f8da50a.pdf
2015-01-01
58
62
Prolapse
Vaginal hysterectomy
Repair
Pratiksha
Gupta
drpratiksha@gmail.com
1
Department of Gynecology and Obstetrics, Post Graduate Institute of Medical Sciences and Research, ESI Hospital, Basai Darapur, New Delhi, India
LEAD_AUTHOR
ORIGINAL_ARTICLE
Identification of Aptamer-Binding Sites in Hepatitis C Virus Envelope Glycoprotein E2
Hepatitis C Virus (HCV) encodes two envelope glycoproteins, E1 and E2. Our previous work selected a specific aptamer ZE2, which could bind to E2 with high affinity, with a great potential for developing new molecular probes as an early diagnostic reagents or therapeutic drugs targeting HCV. In this study, the binding sites between E2 and aptamer ZE2 were further explored. E2 was truncated to 15 peptides (P1 to P15) and these peptides were used to detect the affinity with ZE2 by ELISA respectively. The peptide with high affinity was then further truncated, detected and compared with six kinds of HCV genotypes. The basic amino acid in 500 aa bound to ZE2 with high affinity, while acidic amino acid in 501 aa reduced the reaction between E2 and ZE2. The results showed the 500 aa and 501 aa of E2 were the key sites that bound to ZE2.
https://ijms.sums.ac.ir/article_39718_5ccd4a2527e8f115bc37c5f9d1b566ed.pdf
2015-01-01
63
67
Fan
Chen
chf188@163.com
1
Department of Biochemistry and Molecular Biology, Life Sciences School of Hubei University, Wuhan, China
LEAD_AUTHOR
Si-Chong
Chen
2
Evolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, The University of New South Wales, Sydney, Australia
AUTHOR
Jing
Zhou
3
Clinical laboratory, Wuhan Tuberculosis Dispensary, Wuhan Health Bureau, Wuhan, China
AUTHOR
Zhi-De
Chen
4
Department of Biochemistry and Molecular Biology, Life Sciences School of Hubei University, Wuhan, China
AUTHOR
Fang
Chen
5
Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Wuhan University, Wuhan, China
AUTHOR
ORIGINAL_ARTICLE
MEFV Gene Profile in Northwest of Iran, Twelve Common MEFV Gene Mutations Analysis in 216 Patients with Familial Mediterranean Fever
Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease with autosomal recessive inheritance pattern often seen around the Mediterranean Sea. It is characterized by recurrent episodes of fever and polyserositis and rash. Recently, MEFV gene analysis determines the definitive diagnosis of FMF. In this study, we analyzed 12 MEFV gene mutations in more than 200 FMF patients, previously diagnosed by Tel-Hashomer clinical criteria, in northwest of Iran, located in the proximity of the Mediterranean Sea. In the northwest of Iran (Ardabil), 216 patients with FMF diagnosis, based on Tel-Hashomer criteria, referred to the genetic laboratory to be tested for the following mutations; P369S, F479L, M680I(G/C), M680I(G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q. All patients were screened for MEFV gene mutations by a reverse hybridization assay (FMF Strip Assay, Vienna lab, Vienna, Austria) according to manufacturer’s instructions. Among these FMF patients, no mutation was detected in 51 (23/62%) patients, but 165 (76/38%) patients had one or two mutations, 33 patients (15/28%) homozygous, 86 patients (39/81%) compound heterozygous and 46 patients (21/29%) were heterozygous. The most common mutations were M694V (23/61%), V726A (11/11%) and E148Q (9/95%) respectively.MEFV gene mutations showed similarities and dissimilarities in different ethnic groups, while it is common among Arabs and Armenians genotype. Since common 12 MEFV gene analysis could not detect up to 50% of our patients, who had FMF on the basis of clinical Tel-Hashomer criteria, clinical criteria is still the best way in the diagnosis of FMF in this area.
https://ijms.sums.ac.ir/article_39721_18bb54b305c74c6026876d404edfc4df.pdf
2015-01-01
68
72
familial Mediterranean fever
MEFV gene
Iran
Tel-Hashomer criteria
Farhad
Salehzadeh
salehzadeh_f@yahoo.com
1
Departments of Pediatrics, Bouali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran
LEAD_AUTHOR
Mehdi
Jafari Asl
2
Departments of Pediatrics, Bouali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Saeid
Hosseini Asl
3
Molecular-Genetic Laboratory, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Sepideh
Jahangiri
4
Departments of Pediatrics, Bouali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Shahram
Habibzadeh
s.habibzadeh@arums.ac.ir
5
Department of Infectious Diseases, Bouali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
ORIGINAL_ARTICLE
Sheehan’s Syndrome Presenting as Major Depressive Disorder
Sheehan’s syndrome or Simmond’s disease is a rare endocrine disorder seen in clinical practice. The clinical spectrum is diverse and a high index of suspicion together with a good clinical acumen and proper diagnostic approach helps in early diagnosis and prompt treatment of this endocrinopathy. Sheehan’s syndrome presenting as a major depressive disorder finds less mention in the literature.The patient discussed here is a 45-year-old female who had been on antidepressants and psychiatry follow up for a long time until she presented to our Out Patient Department (OPD), where she was evaluated in detail and diagnosed as a case of Sheehan’s syndrome. The patient is doing well and is on a regular follow-up with us. Further studies are required to demystify the strength of this association in more detail and to elucidate the possible underlying mechanism.
https://ijms.sums.ac.ir/article_39716_a4ad08cbe4fbd565c7af9f14f9107c8b.pdf
2015-01-01
73
76
Hypopituitarism
Postpartum hemorrhage
Major depressive disorder
Mehmood I
Qadri
qadriimehmood@gmail.com
1
Department of General Medicine, Sher-e-Kashmir Institute of Medical Sciences, Medical College Hospital, Srinagar, India
LEAD_AUTHOR
Mohsin Bin
Mushtaq
2
Department of General Medicine, Sher-e-Kashmir Institute of Medical Sciences, Medical College Hospital, Srinagar, India
AUTHOR
Iram
Qazi
3
Department of Ophthalmology, Shri Maharaja Hari Singh Hospital, Srinagar, India
AUTHOR
Sameena
Yousuf
4
Department of Preventive and Social Medicine, Sher-e-Kashmir Institute of Medical Sciences, Soura, Srinagar, India
AUTHOR
Aaliya
Rashid
5
Division of Phaco Surgery, Al-Kabir Medical Center, Srinagar, India
AUTHOR
ORIGINAL_ARTICLE
Periosteal Osteoblastoma of the Pelvis: A Rare Case
Among the rare bone tumors, the osteoblastoma is a fascinating tumor. The rarity, the predisposition to occur in any bone and the diagnostic dilemma makes this infrequent tumor interesting. It is sporadically reported in the literature and what is rarer is its occurrence in the pelvis. The unusual location and inconclusive radiographic findings with diffused diagnostic evidences delays the management of benign osteoblastoma. We encountered a patient with benign osteoblastoma of the pubic ramus of right side. An excisional biopsy was performed. Peroperatively, the tumor appeared as oval, reddish brown, bony hard mass lying just over the cortex of the right pubic ramus and not breaching the cortex. Histopathological study revealed an osteoid rich lesion. Its presence in pubis must not be ignored and periosteal osteoblastoma should be considered as a differential diagnosis.
https://ijms.sums.ac.ir/article_39719_61da72faebbd0ac25952d54908aac872.pdf
2015-01-01
77
80
Periosteal
Osteoblastoma
Pubic bone
Osteochondroma
Swaroop
Patel
1
Department of Orthopaedics, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, India
LEAD_AUTHOR
Atul
Agrawal
atulscastle@gmail.com
2
Department of Orthopaedics,
Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, India
AUTHOR
Rajesh
Maheshwari
3
Department of Orthopaedics,
Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, India
AUTHOR
Vijendra D.
Chauhan
4
Department of Orthopaedics,
Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, India
AUTHOR
ORIGINAL_ARTICLE
Low Grade Endometrial Stromal Sarcoma: A Case Report
Endometrial stromal sarcoma (ESS) is a rare malignant tumor of the endometrium, occurring in the age group of 40–50 years. We report a case of low-grade ESS in a 39-year-old woman, presenting as rapid enlargement of a uterine fibroid polyp associated with irregular and excessive vaginal bleeding. Polypectomy followed by pan hysterectomy was performed. Histopathological examination and immunohistochemistry confirmed LGESS. As the tumor is rarely encountered, management protocols are still questionable. In our case, we tried a different post-surgical protocol and the patient is being closely followed up. Although rare, ESS should be considered in the differential diagnosis of all women who present with a rapid enlargement of a uterine leiomyoma.
https://ijms.sums.ac.ir/article_39722_989e64387826fdaf1c84bd6375500ffb.pdf
2015-01-01
81
84
Endometrial stromal sarcoma
Uterine leiomyoma
Immunohistochemistry
Reena
Jain
reenajain.gynae@gmail.com
1
Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, India
AUTHOR
Swaraj
Batra
sbatra28@gmail.com
2
Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, India
AUTHOR
Ayesha
Ahmad
docayeshaahmad@gmail.com
3
Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, India
LEAD_AUTHOR
Arifa Anwar
Elahi
4
Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, India
AUTHOR
Monika
Gupta
monikashashwat@hotmail.com
5
Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, India
AUTHOR
Poonam
Saith
6
Department of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, India
AUTHOR