ORIGINAL_ARTICLE
Prevalence and Incidence of Multiple Sclerosis in Fars Province, Southern Iran
Background: Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system, which is accompanied by significant disabilities. Although there are some published data regarding the epidemiological features of MS in other parts of Iran, scarce data are available about the prevalence and demographic characteristics of MS in Fars province. The current study aimed to address the prevalence and incidence rate of MS as well as the temporal trend of the disease in Fars province, southern Iran. Methods: This historical retrospective cohort study was carried out in Fars Multiple Sclerosis Society affiliated with Shiraz University of Medical Sciences. All the consecutive patients who fulfilled 2010 McDonald criteria for definite MS were included in the study. The patients’ gender, age at time of diagnosis, education, and clinical course were recorded. The prevalence and incidence rates were also calculated.Results: This study was conducted on 3,354 patients. Among the patients, 2,689 (80.2%) were female and 665 (19.8%) were male. The female/male ratio was 4.04. The point prevalence rate of the disease was 72.1/100,000 persons in October 2013. This index was 116.5 per 100,000 persons in females (95% CI: 113.4-119.6) and 28.3 per 100,000 persons in males (95% CI: 26.8-29.9). The mean annual incidence rate was 5.2/100,000 from 2002 until 2012. Conclusion: Considering Kurtzke classification, Fars is a high-risk area for MS and women are affected more compared with men. Moreover, the incidence rate sharply increased in the last decade.
https://ijms.sums.ac.ir/article_39986_38bf24d0bf992ade3588d3b1dadd572b.pdf
2015-09-01
390
395
Multiple Sclerosis
Incidence
prevalence
Iran
Sadegh
Izadi
izadisad@sums.ac.ir
1
Shiraz University of Medical Science, Shiraz, Iran
AUTHOR
Ali Reza
Nikseresht
nikar7@yahoo.com
2
Shiraz University of Medical Science, Shiraz, Iran
AUTHOR
Maryam
Poursadeghfard
3
Shiraz University of Medical Science, Shiraz, Iran
LEAD_AUTHOR
Afshin
Borhanihaghighi
4
Shiraz University of Medical Science, Shiraz, Iran
AUTHOR
Seyyed Taghi
Heydari
heidaryt@sums.ac.ir
5
Shiraz University of Medical Science, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
The Effect of Cognitive Behavior Therapy in Insomnia due to Methadone Maintenance Therapy: A Randomized Clinical Trial
Background: Sleep disturbance is a common complaint of patients undergoing methadone maintenance therapy (MMT). There are limited studies about the effect of different treatments on insomnia due to MMT. In this study, we evaluated the effect of cognitive-behavioral treatment for insomnia (CBTI) on sleep disorders in patients undergoing MMT.Methods: Twenty-two patients with insomnia due to MMT (aged 18-60 years) participated in this randomized double-blind clinical trial. The intervention group received CBTI from a clinical psychologist for 8 weeks, whereas the control group received behavioral placebo therapy (BPT). The duration of individual sessions was 45 minutes, which was conducted once a week. The primary outcome was sleep disturbance assessed with Pittsburgh Sleep Quality Index (PSQI). Data were analyzed using SPSS software version 19.Results: Eleven patients were assigned to each group. Two groups were matched according to demographic characteristics (age, marital status, education, and daily methadone doses). Although PSQI score was significantly reduced during weeks 5 and 8 after both interventions, there was a significant difference in intervention versus time interaction (P<0.02). The effects of CBTI versus placebo were significantly different (P<0.001). The time course was also significant (P<0.001).Conclusion: This study showed that CBTI is more effective than BPT in overall sleep quality. We recommend further studies, with a larger sample, on CBTI in patients undergoing MMT.
https://ijms.sums.ac.ir/article_39989_9f607f15dc65a15d4e49dd28ef23f45b.pdf
2015-09-01
396
403
Methadone
Substance-Related Disorders
Insomnia
Cognitive therapy
Behavior Therapy
Robabeh
Soleimani
soleimani.dr@gmail.com
1
Addiction Research Center, Shafa Hospital, Guilan University of Medical Sciences, Iran
AUTHOR
Mohammad Jafar
Modabbernia
jafar.modabbernia@yahoo.com
2
Addiction Research Center, Shafa Hospital, Guilan University of Medical Sciences, Iran
AUTHOR
Sharareh
Habibi
sh_habibi7@yahoo.com
3
Guilan University of Medical Sciences
LEAD_AUTHOR
Maryam
Habibi Roudsary
maryamhabibi17@gmail.com
4
Guilan University of Medical Sciences
AUTHOR
Masoumeh
Elahi
elahi.masoumeh@yahoo.com
5
Guilan University of Medical Sciences
AUTHOR
ORIGINAL_ARTICLE
Oxford Shoulder Score: A Cross-Cultural Adaptation and Validation Study of the Persian Version in Iran
Background: Oxford shoulder score is a specific 12-item patient-reported tool for evaluation of patients with inflammatory and degenerative disorders of the shoulder. Since its introduction, it has been translated and culturally adapted in some Western and Eastern countries. The aim of this study was to translate the Oxford Shoulder Score (OSS) in Persian and to test its validity and reliability in Persian speaking population in Iran.Methods: One hundred patients with degenerative or inflammatory shoulder problem participated in the survey in 2012. All patients completed the Persian version of OSS, Persian DASH and the SF-36 for testing validity. Randomly, 37 patients filled out the Persian OSS again three days after the initial visit to assess the reliability of the questionnaire.Results: Cronbach’s alpha coefficient was 0.93. The intraclass correlation coefficient was 0.93. In terms of validity, there was a significant correlation between the Persian OSS and DASH and SF-36 scores (P<0.001).Conclusion: The Persian version of the OSS proved to be a valid, reliable, and reproducible tool as demonstrated by high Cronbach’s alpha and Pearson’s correlation coefficients. The Persian transcript of OSS is administrable to Persian speaking patients with shoulder condition and it is understandable by them.
https://ijms.sums.ac.ir/article_39992_64391882a38e2831a14f0ac7d7a793a9.pdf
2015-09-01
404
410
Shoulder pain
Oxford shoulder score
Validation
reliability
Iran
Mohammad
Ebrahimzadeh
ebrahimzadehmh@mums.ac.ir
1
Associate Professor, Shoulder and Knee Surgeon Director, Orthopedic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ali
Birjandinejad
birjandinejada@mums.ac.ir
2
Orthopedic and Trauma Research Center
Mashhad University of Medical Sciences
AUTHOR
Shiva
Razi
razi.shiva@gmail.com
3
Orthopedic Research Center, Mashhad University of Medical Sciences
AUTHOR
Mohsen
Mardani-Kivi
dr_mohsen_mardani@yahoo.com
4
Orthopedic Research Center
Guilan University of Medical Sciences, Rasht, Guilan, Iran
AUTHOR
Amir Reza
Kachooei
akachooei@mgh.harvard.edu
5
Assistant Professor, Mashhad University of Medical Sciences, Mashhad, Iran
Research Fellow, Massachusetts General Hospital, Harvard Medical School, Boston, USA
LEAD_AUTHOR
ORIGINAL_ARTICLE
QuantiFERON-TB Gold and Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Children
Background: Appropriate diagnosis and treatment of latent tuberculosis infection (LTBI) play the most important role in the control of tuberculosis. This study aimed to determine the prevalence of LTBI among healthy tuberculosis unexposed children vaccinated with BCG using the tuberculin skin test (TST) and QuantiFERON TB Gold In-Tube (QFT-GIT) and comparing the agreement between the two tests. Methods: A cross-sectional study was carried out between October 2009 and March 2010 in 24 schools and 11 daycare centers. A total of 967 children were divided into 15 age groups, with a minimum of 64 children per group.Results: The prevalence rates of LTBI with TST were 3.8%, and 2.2% with QFT-GIT. One case was positive in TST and QFT-GIT, 20 cases were QFT-GIT positive, but TST negative and 36 cases were TST positive, but QFT-GIT negative, and finally, 910 cases were negative in both. There was poor agreement between TST and QFT-GIT (1.8%, 95%, CI: 0%-5.3%, k=0.007). The specificity of QFT-GIT in the BCG vaccinated, children aged 1-15 years old, was 97.8% (97.8%, 95% CI: 96.8%-98.8%). After three months, 2/17 (11.8%) of those initially QFT-GIT negative converted, and 10/15 (66%) of those initially QFT-GIT positive reverted.Conclusion: It seems that TST and QFT-GIT are not appropriate tests for the diagnosis of LTBI among healthy tuberculosis unexposed BCG vaccinated children. There was a low reproducibility rate of QFT-GIT. The cause of the the poor agreement requires further studies.
https://ijms.sums.ac.ir/article_39994_9cc8b2626cbbadceecffb71f67ee4c92.pdf
2015-09-01
411
417
Tuberculin Test
QuantiFERON TB gold
Latent tuberculosis
Child
Iran
Hossein
Masoumi Asl
dr_masoumiasl@yahoo.com
1
Center for Communicable Disease Control, Ministry of Health and Medical Education
LEAD_AUTHOR
Abdolvahab
Alborzi
alborziiraj2004@yahoo.com
2
Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences
AUTHOR
Bahman
Pourabbas
3
Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences
AUTHOR
Mehdi
Kalani
mkalani@sums.ac.ir
4
Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences
AUTHOR
ORIGINAL_ARTICLE
Cementless Hip Arthroplasty in Southern Iran, Midterm Outcome and Comparison of Two Designs
Background: Cementless hip prosthesis was designed to provide biologic fixation, without the use of cement. The second generation components have shown more reliable bone ingrowths and survival rates. We are reporting a midterm result of two designs of cementless prosthesis in a unique culture with different social habits and expectations.Methods: 52 primary cementless total hip arthroplasty in 42 patients with the mean age of 48.8 years were retrospectively studied. Two groups of prosthesis had been implanted: Harris-Galante II (HGII) in 15 and Versys-Trilogy (V-T) in 37 hips, both from Zimmer company. The patients were assessed clinically, radiographically and with Harris hip score, SF36, WOMAC, and MACTAR questionnaires, with 65 months (26-136) mean follow-up.Results: All the V-T prostheses had survived well. Eight of HG II were revised by the last follow-up in 19-102 months. All had undergone acetabular revision and 2 combined with femoral revision. Broken tines of HGII cups were seen in 4 radiographs. The 65 months overall survival was 96.2% for femoral and 84.6% for acetabular components. 90% had good or excellent Harris hip scores. The functional scores were poorer in the HG II group. Pain relief and improved walking were the two main patients’ expectations fulfilled in 97.6% and 92.8%, respectively.Conclusions: The outcome of cementless total hip arthroplasty (THA) is satisfactory and comparable with the literature based on the results of function and survival of this small comparative group. The use of HGII acetabular component should be abandoned.
https://ijms.sums.ac.ir/article_39995_319b3775ef24057e0043c6b06b13bec7.pdf
2015-09-01
418
424
Hip arthroplasty replacement
Porous-coated
Outcome
Hip Prosthesis
Gholam Hossein
Shahcheraghi
1
Professor of Orthopaedic Surgery, Bone and Joint Disease Research Center, Department of Orthopedic Surgery, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Seyed Ali
Hashemi
sahashemi1411@gmail.com
2
Assistant professor of Orthopaedic Surgery, Bone and Joint Disease Research Center, Department of Orthopedic Surgery, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Totally Transanal Laparo-Endoscopic Single-Site ProctoColectomy-Ileoanal J-Pouch (TLPC-J): An Experimental Study of a Novel Approach
Background: The natural orifice transluminal endoscopic surgery (NOTES) has become a commonly considered novel approach in the surgical field. The NOTES provide possibility of operation through the natural orifice and decreases the intentional puncture of the systemic organ and subsequent complications. Totally transanal laparo-endoscopic single-site proctoColectomy-Ileoanal J-Pouch (TLPC-J) is a novel method in minimally invasive surgery for total colectomy. The main goal of this study is to perform this new method on an animal model, to assess probable complication and to resolve probable issues by using patients that are candidate for total colectomy.Method: Five dogs were prepared in lithotomy position. The TLPC-I procedure consists of endorectal technique with full thickness rectal dissection starting 1 cm orally from the dentate line above the peritoneal reflection and the proximal bowel was replaced into the abdominal cavity. Afterwards, the TriPort system was inserted in the anal canal and mesentrial resection of the total colon, mobilization of a distal ileal segment and intracorporeal suture of an ileal J-loop was accomplished by this system. An incision in the J-loop was conducted transanally. The J-pouch was created with an Endo-GIA® and sutured to the rectal wall.Results: All animals survived and passed stool with clear post operation situation. There was no infection in site of anastomosis.Conclusion: The TLPC-I provides the possibility of surgery without abdominal wall incision and decreases post operation complication such as pain, abdominal wound infection and wound dehiscence. This technique increases the quality of life and surgeons can discharge the patients early.
https://ijms.sums.ac.ir/article_39996_9acbf0b93bf62892185b6b3596a39086.pdf
2015-09-01
425
429
Natural orifice transluminal endoscopic surgery
Minimally invasive surgical procedures
Mohammad Reza
Vahdad
rvahdad@aol.com
1
Department of Pediatric Surgery of the Ruhr-University Bochum
Marienhospital Herne, widomerstr .8, Germany.
AUTHOR
Ehsan
Rahmanian
rahmane@sums.ac.ir
2
Department of General Surgery, Shiraz university of Medical Sciences, Shiraz, Iran.
AUTHOR
Sam
Moslemi
moslemis@sums.ac.ir
3
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Sultan Mohsen
Najafi
najafisultan@yahoo.com
4
Shiraz University School of Medicine, Shiraz University Laparoscopy Research Center
Department of Pediatric Surgery, Nemazee Hospital, Shiraz, Iran
AUTHOR
Hamid Reza
Foroutan
forotanh@yahoo.com
5
Shiraz University School of Medicine,Shiraz University Laparoscopy Research Center
Department of Pediatric Surgery, Nemazee Hospital, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
The Effects of NDRG2 Overexpression on Cell Proliferation and Invasiveness of SW48 Colorectal Cancer Cell Line
Background: Colorectal cancer (CRC) is one of the most common causes of cancer-related death in the world. The expression of N-myc downstream-regulated gene 2 (NDRG2) is down-regulated in CRC. The aim of this study was to investigate the effect of NDRG2 overexpression on cell proliferation and invasive potential of SW48 cells.Methods: SW48 cells were transfected with a plasmid overexpressing NDRG2. After stable transfection, the effect of NDRG2 overexpression on cell proliferation was evaluated by MTT assay. The effects of NDRG2 overexpression on cell migration, invasion and cell motility and matrix metalloproteinase 9 (MMP9) activities were also investigated using matrigel transwell assay, wound healing assay and gelatin zymography, respectively.Results: MTT assay showed that overexpression of NDRG2 caused attenuation of SW48 cell proliferation. Transwell and wound healing assay revealed that NDRG2 overexpression led to inhibition of migration, invasion, and motility of SW48 cells. The overexpression of NDRG2 also reduced the activity of secreted MMP-9.Conclusions: The results of this study suggest that NDRG2 overexpression inhibits proliferation and invasive potential of SW48 cells, which likely occurs via suppression of MMP-9 activity.
https://ijms.sums.ac.ir/article_39997_1c0708529882e678ab2e5fef901f278b.pdf
2015-09-01
430
439
Colorectal neoplasms
NDRG2 protein
Transfection
Cell movement
Wound healing
Metalloproteinase
Ali
Golestan
golestan_ali64@yahoo.com
1
AUTHOR
Zahra
Mojtahedi
2
AUTHOR
Ghasem
Ghalamfarsa
ghasemghalamfarsa@yahoo.com
3
AUTHOR
Maryam
Hamidinia
marmar2257@yahoo.com
4
AUTHOR
Mohammad Ali
Takhshid
takhshid2001@yahoo.co.uk
5
LEAD_AUTHOR
ORIGINAL_ARTICLE
How Iranian Medical Trainees Approach their Responsibilities in Clinical Settings; A Grounded Theory Research
Background: It seems we are now experiencing “responsibility problems” among medical trainees (MTs) and some of those recently graduated from medical schools in Iran. Training responsible professionals have always been one of the main concerns of medical educators. Nevertheless, there is a dearth of research in the literature on “responsibility” especially from the medical education point of view. Therefore, the present study was carried out with the aim of presenting a theoretical based framework for understanding how MTs approach their responsibilities in educational settings.Method: This qualitative study was conducted at Shiraz University of Medical Sciences (SUMS) using the grounded theory methodology. 15 MTs and 10 clinical experts and professional nurses were purposefully chosen as participants. Data was analyzed using the methodology suggested by Corbin and Strauss, 1998.Results: “Try to find acceptance toward expectations”, “try to be committed to meet the expectations” and “try to cope with unacceptable expectations” were three main categories extracted based on the research data. Abstractly, the main objective for using these processes was “to preserve the integrity of student identity” which was the core category of this research too. Moreover, it was also found that practically, “responsibility” is considerably influenced by lots of positive and negative contextual and intervening conditions.Conclusion: “Acceptance” was the most decisive variable highly effective in MTs’ responsibility. Therefore, investigating the “process of acceptance” regarding the involved contextual and intervening conditions might help medical educators correctly identify and effectively control negative factors and reinforce the constructive ones that affect the concept of responsibility in MTs.
https://ijms.sums.ac.ir/article_39998_1386c1a99f8f0550644cb6019af6f25d.pdf
2015-09-01
440
447
Qualitative research
Responsibility
Medical Students
Iran
Omid
Asemani
asemanio@sums.ac.ir
1
AUTHOR
Mohammad Taghi
Iman
iman@shirazu.ac.ir
2
AUTHOR
Marzieh
Moattari
moattari@yahoo.com
3
AUTHOR
Mohammad
Khayyer
m_khayyer@yahoo.com
4
AUTHOR
Farkhondeh
Sharif
fsharif@sums.ac.ir
5
AUTHOR
Seyed Ziaaddin
Tabei
6
LEAD_AUTHOR
ORIGINAL_ARTICLE
The Prevalence and Risk Factors of Hepatitis Delta Virus in HIV/HBV Co-Infected Patients in Shiraz, Iran, 2012
Evidence has shown that liver disease caused by hepatitis viruses can be more aggressive and severe in HIV infected subjects. Therefore, the present cross-sectional study aimed to evaluate the seroprevalence of HDV infection among HIV/HBV co-infected clients in Shiraz, southwest Iran. In this study, 178 patients co-infected with HBV and HIV individuals were enrolled. The diagnosis of HIV infection was documented based on serological assays. The demographic and complementary data were collected by a questionnaire. HBsAg and HDV Ab were detected by commercial quantitative enzyme linked immunosorbent assay kits according to the manufacturer’s instructions. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also measured. The mean age of the participants was 37.4±7.4 years (range 22-63). 175 (98.4 %) patients were male and 3 (1.6 %) were female. Among 178 patients co-infected with HIV/HBV, 35 cases (19.7%, 95% CI: 14%-25%) were anti-HDV positive and 143 (80.3%) were negative for anti-HDV. HDV exposure in HIV/HBV co-infected patients was associated with blood transfusion (P=0.002, OR: 14.3) and prison history (P=0.01, OR: 2.31) but not with age, marital status, unsafe sex contact, and injection drug abuse. Our data showed a relatively high prevalence of HDV infection in HIV infected population in Shiraz, Iran. The high frequency of HDV Ab in patients with blood transfusion and prison history reveals that HDV transmission occurs more frequently in the parental route than sexual contacts; therefore, blood screening for HDV diagnosis in the high-risk group is recommended.
https://ijms.sums.ac.ir/article_39987_9e1ef8fe9b63788a967bce4b0f7e03db.pdf
2015-09-01
448
453
prevalence
Hepatitis delta virus
HIV
hepatitis B virus
Mohammad
Motamedifar
motamedm@sums.ac.ir
1
AUTHOR
Mohammad
Taheri
mohammad_823@yahoo.com
2
AUTHOR
Kamran
Bagheri Lankarani
lankaran@sums.ac.ir
3
AUTHOR
Mina
Gholami
4
AUTHOR
Mahmood
Amini Lari
5
AUTHOR
Hossein
Faramarzi
6
AUTHOR
Jamal
Sarvari
sarvarij@sums.ac.ir
7
Shiraz University of Medical sciences
LEAD_AUTHOR
ORIGINAL_ARTICLE
K-ras Mutation in Colorectal Cancer, A Report from Southern Iran
There are very few studies about K-ras mutations in colorectal cancer (CRC) from developing countries such as Iran. It is therefore essential to conduct studies to learn about the molecular signature of such tumors, allowing the determination of an appropriate management plan. In the present study, we aimed to determine the frequency and types of K-ras mutations among patients with CRC in Iran.Formalin-fixed paraffin-embedded specimens of 100 cases of CRC were collected from hospitals affiliated with Shiraz University of Medical Sciences (June 2011 to June 2013). All of the H&E slides were examined and proper slide with a minimum of necrosis and maximum of well-preserved tumor cells (at least 70% tumor in each slide) were selected. Recurrent, metastatic, and post chemotherapy cases were excluded from the study. Mutation of codons 12 and 13 of K-ras gene by PCR was performed, followed by direct sequencing by Sanger method.From 100 eligible cases (55 male and 45 females with mean age of 59 years), 32% had mutant K-ras gene; the most common substitution was 12G>C followed by 12G>A and 13G>A, respectively.It is found that K-ras mutation rate, among the selected population of the southern province of Iran, was as high as 32% (codon 12: 71.8% and in codon 13: 25% and one in both codons: 3.1%).
https://ijms.sums.ac.ir/article_39990_d71459808f0ca1538165829e8408edc1.pdf
2015-09-01
454
460
K-ras
Colorectal cancer
Frequency
Iran
Navid
Omidifar
1
AUTHOR
Bita
Geramizadeh
geramib@sums.ac.ir
2
LEAD_AUTHOR
Mitra
Mirzai
3
AUTHOR
ORIGINAL_ARTICLE
Hereditary Spherocytosis Unmasked by Human Parvovirus B19 Induced Aplastic Crisis in a Family
Human parvovirus (HPV) B19 induced aplastic crisis in a family leading to the diagnosis of hereditary spherocytosis (HS) is a very rare condition being barely reported in the literature. We herein report a 4-year-old girl, her brother, and their mother who all presented with progressive pallor and jaundice after a febrile illness. The HPV B19 was diagnosed using polymerase chain reaction (PCR) and positive serology for specific anti-HPV B19 IgM. They were further diagnosed with having HS. The clinical importance of this report is that in the case of an abrupt onset of unexplained severe anemia and jaundice, one should consider underlying hemolytic anemias mostly hereditary spherocytosis complicated by HPV B19 aplastic crisis. Herein, we report the occurrence of this condition, simultaneously in three members of a family. The distinguished feature of this report is that all affected family members developed some degrees of transient pancytopenia, not only anemia, all simultaneously in the course of their disease.
https://ijms.sums.ac.ir/article_39988_3dba10a0b49ce663908e9f83f7bb810a.pdf
2015-09-01
461
464
Hereditary spherocytosis
Parvovirus B19
Pancytopenia
Samin
Alavi
saminalavi@hotmail.com
1
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Nahid
Arabi
aarabi_nahid@yahoo.com
2
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Mohammad
Kaji Yazdi
dr_kajiyazdi@yahoo.com
3
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iranii
AUTHOR
Mohammad Taghi
Arzanian
mtarzanian@gmail.com
4
Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Farahnaz
Zohrehbandian
farahnaz_zohrehbandian@yahoo.com
5
Islamic azad university, North branch
AUTHOR
ORIGINAL_ARTICLE
Three Living Fasciola Hepatica in the Biliary Tract of a Woman
Fasciola hepatica (F. hepatica) as a foodborne trematode can occasionally cause hepatobiliary diseases. We report a 67-year-old woman who was referred to our center because of the diagnosis of cholangitis. She was a resident of mountainous area with the history of unsafe water and contaminated vegetables. Endoscopic retrograde cholangiopancreatography (ERCP) was performed as a diagnostic and therapeutic modality for her. Three living F. hepatica was removed from biliary tract with a basket via ERCP. Clinical and laboratory condition of the patient improved after therapy of antibiotics and triclabendazole.
https://ijms.sums.ac.ir/article_39991_cb5d7de719e8ae8a0f77bd7094518769.pdf
2015-09-01
465
468
Fasciola hepatica
Fascioliasis
ERCP
Cholangitis
Biliary tract
Ramin
Niknam
niknam_r@sums.ac.ir
1
1Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Internal group, Fasa University of Medical Sciences, Fasa, Iran
AUTHOR
Mohammad Hassan
Kazemi
kazemi_mh@sums.ac.ir
2
Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Laleh
Mahmoudi
mahmoudi_l@sums.ac.ir
3
department of clinical pharmacy, school of pharmacy, shiraz university of medical sciences
LEAD_AUTHOR
ORIGINAL_ARTICLE
Asymptomatic Isolated Retroperitoneal Castleman’s Disease: A Case Report
Castleman’s disease, giant lymph node hyperplasia, is a kind of benign lymphoproliferative disease with gentle behavior. Its etiology and prevalence are unclear. This rare disease is usually found in mediastinal area asymptomatically and incidentally. It is also rare to see this tumor in the retroperitoneum. In this study, we have introduced a 34-year-old woman who referred just with occasional abdominal pain caused by compressive symptoms. Laboratory findings only reported microcytic anemia (MCH: 18.5, MCV: 63, Hemoglobin 10.2 g/dl). Chest and abdominal X-ray imaging showed no remarkable point. In abdominal ultrasonography, a solid and firm tumor with 12.2×5.3×6.6 cm was reported in patient’s retroperitoneum. Patient’s surgery was done and the tumor (covered by a fibrous thick capsule, with no bizarre appearance and bleeding) was completely removed. Pathologic examination indicated a Castleman’s tumor, type of unicentric and hyaline-vascular. This item had been one of the rare reported items of Castleman’s disease in the retroperitoneal space.
https://ijms.sums.ac.ir/article_39993_7090fa0075912e963bdad41c4d15424a.pdf
2015-09-01
469
472
Castleman’s disease
Giant lymph node Hyperplasia lymph node
Retroperitoneal space
Afsaneh
Rajabiani
1
Assistant Professor of Pathology, Shariati Hospital, Tehran University Medical of sciences
AUTHOR
Alireza
Abdollahi
dr_p_abdollahi@yahoo.com
2
Associate Professor of Pathology, Imam Khomeini Hospital Complex, Vali-Asr Hospital, Central Laboratory, Tehran University Medical of sciences.
LEAD_AUTHOR
Zahra
Farahani
fetuspapyrus@gmail.com
3
Physiologist-Research. Maternal , Fetal and Neonatal Research Center, Tehran University Medical of sciences.
AUTHOR