ORIGINAL_ARTICLE
Determinants of Quality of Life in the Caregivers of Iranian War Survivors with Bilateral Lower-Limb Amputation after More than Two Decades
Background: Providing care to a disable relative at home exposesthe caregiver to a potentially higher risk of physical and mentalproblems. We measured health-related quality of life (HRQOL) andits determinants among the caregivers of the Iranian survivors of theIran-Iraq war (1980–1988) with bilateral lower-limb amputation.Methods: Data were collected from 464 individuals comprisingwar-related bilateral lower-limb amputees (n=232) and theircaregivers (n=232) in January 2015 in Shiraz, Iran. The 36-ItemShort-Form Health Survey (SF-36) questionnaire was used toevaluate the caregivers’ QOL. Logistic regression analysis wasperformed to determine the most significant contributing factors.Results: The mean age of the caregivers and the amputees was39.4±6.2 and 42.5±6.2 years, respectively. The mean durationof disability was 22.8±3.9 years in the amputees. Most of thecaregivers were reported to be in their first marriage. The highestand lowest mean scores of the SF-36 domains in the samplepopulation were observed for physical function (76.65±21.97)and bodily pain (53.54±24.95). QOL in the caregivers wassignificantly lower than that in a sample of the general Iranianfemale population (P<0.05). History of hospitalization duringthe preceding year of the study (OR: 2.23, 95% CI: 1.08 to 4.57,P=0.02) and mental health problems (OR: 1.79, 95% CI: 1.02to 3.15, P=0.04) in the amputees constituted the most importantpredicting factors in the caregivers’ QOL.Conclusion: The caregivers of the bilateral lower-limb amputeesin the current study suffered from a poor QOL. Hospitalization andmental problems were the most significant contributing factorsvis-à-vis the caregivers’ HRQOL. Health care and services should,therefore, be provided to both amputees and their caregivers.
https://ijms.sums.ac.ir/article_40364_5ba23cedd1430afaa924da2f734558cb.pdf
2016-07-01
257
264
Amputation
Caregivers
War survivors
Iran
Zohreh
Ganjparvar
zohreh.ganjparvar@gmail.com
1
Janbazan Medical and Engineering
Research Center, Tehran, Iran
AUTHOR
Batool
Mousavi
mousavi.b@gmail.com
2
Janbazan Medical and Engineering
Research Center, Tehran, Iran
LEAD_AUTHOR
Mehdi
Masumi
masoumi48@gmail.com
3
Janbazan Medical and Engineering
Research Center, Tehran, Iran
AUTHOR
Mohammadreza
Soroush
soroush46@gmail.com
4
Janbazan Medical and Engineering
Research Center, Tehran, Iran
AUTHOR
Ali
Montazeri
montazeri@acecr.ac.ir
5
Iranian Institute for Health Sciences
Research, Tehran, Iran
AUTHOR
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21
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22
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23
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24
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26
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34
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35
ORIGINAL_ARTICLE
Cardioprotective Effect of Extended Remote Ischemic Preconditioning in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Clinical Trial
Background: The cardioprotective effect of ischemic preconditioning has been known for many years. Since the temporary ischemia in the heart may cause lethal cardiac effects, the idea of creating ischemia in organs far from the heart such as limbs was raised as remote ischemic preconditioning (RIPC). We hypothesized that the extension of RIPC has more cardioprotective effect in patients undergoing coronary artery bypass graft (CABG) surgeries.Methods: In this triple-blind randomized clinical trial study, 96 patients were randomly divided into 3 groups and two blood pressure cuffs were placed on both upper and lower extremities. In group A, only upper extremity cuff and in group B upper limb and lower limb cuff was inflated intermittently and group C was the control group. RIPC was induced with three 5-min cycles of cuff inflation about 100 mmHg over the initial systolic blood pressure before starting cardiopulmonary bypass. The primary endpoints were troponin I and creatine phosphokinasemyoglobin isoenzyme (CK-MB).Results: Six hours after the termination of CPB, there was a peak release of the troponin I level in all groups (group A=4.90 ng/ml, group B=4.40 ng/ml, and group C=4.50 ng/ml). There was a rise in plasma CK-MB in all groups postoperatively and there were not any significant differences in troponin I and CK-MB release between the three groups.Conclusion: RIPC induced by upper and lower limb ischemia does not reduce postoperative myocardial enzyme elevation in adult patients undergoing CABG.Trial Registration Number: IRCT2012071710311N1
https://ijms.sums.ac.ir/article_40369_50914f506048294cd1e143d4490e3cb9.pdf
2016-07-01
265
274
Ischemic preconditioning
Coronary artery bypass
Troponin I
Ali
Karami
alk1380@gmail.com
1
Shiraz Anesthesiology and Critical Care Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mohamad Bagher
Khosravi
2
Shiraz Anesthesiology and Critical Care
Research Center, Nemazee Hospital,
Shiraz University of Medical Sciences,
Shiraz, Iran;
AUTHOR
Masih
Shafa
shafam@sums.ac.ir
3
Department of Cardiac Surgery, Faghihi
Hospital, Shiraz University of Medical
Sciences, Shiraz, Iran
LEAD_AUTHOR
Simin
Azemati
azemati@sums.ac.ir
4
Shiraz Anesthesiology and Critical Care
Research Center, Nemazee Hospital,
Shiraz University of Medical Sciences,
Shiraz, Iran;
AUTHOR
Saeed
Khademi
saeid.khademi@gmail.com
5
Shiraz Anesthesiology and Critical Care
Research Center, Nemazee Hospital,
Shiraz University of Medical Sciences,
Shiraz, Iran;
AUTHOR
Seyed Hedayatalla
Akhlagh
6
Shiraz Anesthesiology and Critical Care
Research Center, Nemazee Hospital,
Shiraz University of Medical Sciences,
Shiraz, Iran;
AUTHOR
Behzad
Maghsodi
maghsodb@yahoo.com
7
Shiraz Anesthesiology and Critical Care
Research Center, Nemazee Hospital,
Shiraz University of Medical Sciences,
Shiraz, Iran;
AUTHOR
Domanski MJ, Mahaffey K, Hasselblad V, Brener SJ, Smith PK, Hillis G, et al. Association of myocardial enzyme elevation and survival following coronary artery bypass graft surgery. JAMA. 2011;305:585-91. doi: 10.1001/jama.2011.99. PubMed PMID: 21304084.
1
Yau JM, Alexander JH, Hafley G, Mahaffey KW, Mack MJ, Kouchoukos N, et al. Impact of perioperative myocardial infarction on angiographic and clinical outcomes following coronary artery bypass grafting (from PRoject of Ex-vivo Vein graft ENgineering via Transfection [PREVENT] IV). Am J Cardiol. 2008;102:546-51. doi: 10.1016/j.amjcard.2008.04.069. PubMed PMID: 18721510.
2
Mentzer RM, Jr. Myocardial protection in heart surgery. J Cardiovasc Pharmacol Ther. 2011;16:290-7. doi: 10.1177/1074248411410318. PubMed PMID: 21821531.
3
Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993;87:893-9. doi: 10.1161/01.CIR.87.3.893. PubMed PMID: 7680290.
4
Frank A, Bonney M, Bonney S, Weitzel L, Koeppen M, Eckle T. Myocardial ischemia reperfusion injury: from basic science to clinical bedside. Semin Cardiothorac Vasc Anesth. 2012;16:123-32. doi: 10.1177/1089253211436350. PubMed PMID: 22368166; PubMed Central PMCID: PMC3457795.
5
Ramzy D, Rao V, Weisel RD. Clinical applicability of preconditioning and postconditioning: the cardiothoracic surgeons's view. Cardiovasc Res. 2006;70:174-80. doi: 10.1016/j.cardiores.2006.01.020. PubMed PMID: 16524563.
6
Takagi H, Manabe H, Kawai N, Goto SN, Umemoto T. Review and meta-analysis of randomized controlled clinical trials of remote ischemic preconditioning in cardiovascular surgery. Am J Cardiol. 2008;102:1487-8. doi: 10.1016/j.amjcard.2008.07.036. PubMed PMID: 19026301.
7
Takagi H, Umemoto T. Remote ischemic preconditioning for cardiovascular surgery: an updated meta-analysis of randomized trials. Vasc Endovascular Surg. 2011;45:511-3. doi: 10.1177/1538574410379654. PubMed PMID: 21646235.
8
Rahman IA, Mascaro JG, Steeds RP, Frenneaux MP, Nightingale P, Gosling P, et al. Remote ischemic preconditioning in human coronary artery bypass surgery: from promise to disappointment? Circulation. 2010;122:S53-9. doi: 10.1161/CIRCULATIONAHA.109.926667. PubMed PMID: 20837926.
9
Karuppasamy P, Chaubey S, Dew T, Musto R, Sherwood R, Desai J, et al. Remote intermittent ischemia before coronary artery bypass graft surgery: a strategy to reduce injury and inflammation? Basic Res Cardiol. 2011;106:511-9. doi: 10.1007/s00395-011-0185-9. PubMed PMID: 21544683.
10
Wu Q, Gui P, Wu J, Ding D, Purusram G, Dong N, et al. Effect of limb ischemic preconditioning on myocardial injury in patients undergoing mitral valve replacement surgery. -A randomized controlled trial. Circ J. 2011;75:1885-9. PubMed PMID: 21697609.
11
Xie JJ, Liao XL, Chen WG, Huang DD, Chang FJ, Chen W, et al. Remote ischaemic preconditioning reduces myocardial injury in patients undergoing heart valve surgery: randomised controlled trial. Heart. 2012;98:384-8. doi: 10.1136/heartjnl-2011-300860. PubMed PMID: 22107759.
12
Lucchinetti E, Bestmann L, Feng J, Freidank H, Clanachan AS, Finegan BA, et al. Remote Ischemic Preconditioning Applied during Isoflurane Inhalation Provides No Benefit to the Myocardium of Patients Undergoing On-pump Coronary Artery Bypass Graft SurgeryLack of Synergy or Evidence of Antagonism in Cardioprotection? American Society of Anesthesiologists. 2012;116:296-310.
13
Lomivorotov VV, Shmyrev VA, Nepomnyaschih VA, Ponomarev DN, Knyazkova LG, Lomivorotov VN, et al. Remote ischaemic preconditioning does not protect the heart in patients undergoing coronary artery bypass grafting. Interact Cardiovasc Thorac Surg. 2012;15:18-22. doi: 10.1093/icvts/ivs118. PubMed PMID: 22493101; PubMed Central PMCID: PMC3380992.
14
Kottenberg E, Thielmann M, Bergmann L, Heine T, Jakob H, Heusch G, et al. Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol - a clinical trial. Acta Anaesthesiol Scand. 2012;56:30-8. doi: 10.1111/j.1399-6576.2011.02585.x. PubMed PMID: 22103808.
15
Young PJ, Dalley P, Garden A, Horrocks C, La Flamme A, Mahon B, et al. A pilot study investigating the effects of remote ischemic preconditioning in high-risk cardiac surgery using a randomised controlled double-blind protocol. Basic Res Cardiol. 2012;107:256. doi: 10.1007/s00395-012-0256-6. PubMed PMID: 22406977.
16
Wang L, Oka N, Tropak M, Callahan J, Lee J, Wilson G, et al. Remote ischemic preconditioning elaborates a transferable blood-borne effector that protects mitochondrial structure and function and preserves myocardial performance after neonatal cardioplegic arrest. J Thorac Cardiovasc Surg. 2008;136:335-42. doi: 10.1016/j.jtcvs.2007.12.055. PubMed PMID: 18692639.
17
Kharbanda RK, Nielsen TT, Redington AN. Translation of remote ischaemic preconditioning into clinical practice. Lancet. 2009;374:1557-65. doi: 10.1016/S0140-6736(09)61421-5. PubMed PMID: 19880021.
18
Konstantinov IE, Arab S, Kharbanda RK, Li J, Cheung MM, Cherepanov V, et al. The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics. 2004;19:143-50. doi: 10.1152/physiolgenomics.00046.2004. PubMed PMID: 15304621.
19
Gho BC, Schoemaker RG, van den Doel MA, Duncker DJ, Verdouw PD. Myocardial protection by brief ischemia in noncardiac tissue. Circulation. 1996;94:2193-200. doi: 10.1161/01.CIR.94.9.2193. PubMed PMID: 8901671.
20
Lang SC, Elsasser A, Scheler C, Vetter S, Tiefenbacher CP, Kubler W, et al. Myocardial preconditioning and remote renal preconditioning--identifying a protective factor using proteomic methods? Basic Res Cardiol. 2006;101:149-58. doi: 10.1007/s00395-005-0565-0. PubMed PMID: 16283592.
21
Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, et al. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. 2002;106:2881-3. doi: 10.1161/01.CIR.0000043806.51912.9B. PubMed PMID: 12460865.
22
Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, et al. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet. 2007;370:575-9. doi: 10.1016/S0140-6736(07)61296-3. PubMed PMID: 17707752.
23
Thielmann M, Kottenberg E, Boengler K, Raffelsieper C, Neuhaeuser M, Peters J, et al. Remote ischemic preconditioning reduces myocardial injury after coronary artery bypass surgery with crystalloid cardioplegic arrest. Basic Res Cardiol. 2010;105:657-64. doi: 10.1007/s00395-010-0104-5. PubMed PMID: 20495811.
24
Rahman I, Bonser RS. Remote ischaemic preconditioning: the current best hope for improved myocardial protection in cardiac surgery? Heart. 2009;95:1553-5. doi: 10.1136/hrt.2008.159988. PubMed PMID: 19628467.
25
Hoole SP, Khan SN, White PA, Heck PM, Kharbanda RK, Densem CG, et al. Remote ischaemic pre-conditioning does not attenuate ischaemic left ventricular dysfunction in humans. Eur J Heart Fail. 2009;11:497-505. doi: 10.1093/eurjhf/hfp040. PubMed PMID: 19386814.
26
Cheung MM, Kharbanda RK, Konstantinov IE, Shimizu M, Frndova H, Li J, et al. Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans. J Am Coll Cardiol. 2006;47:2277-82. doi: 10.1016/j.jacc.2006.01.066. PubMed PMID: 16750696.
27
Hong DM, Mint JJ, Kim JH, Sohn IS, Lim TW, Lim YJ, et al. The effect of remote ischaemic preconditioning on myocardial injury in patients undergoing off-pump coronary artery bypass graft surgery. Anaesth Intensive Care. 2010;38:924-9. PubMed PMID: 20865880.
28
Pilcher JM, Young P, Weatherall M, Rahman I, Bonser RS, Beasley RW. A systematic review and meta-analysis of the cardioprotective effects of remote ischaemic preconditioning in open cardiac surgery. J R Soc Med. 2012;105:436-45. doi: 10.1258/jrsm.2012.120049. PubMed PMID: 23104947; PubMed Central PMCID: PMC3480853.
29
Hausenloy DJ, Yellon DM. Remote ischaemic preconditioning: underlying mechanisms and clinical application. Cardiovasc Res. 2008;79:377-86. doi: 10.1093/cvr/cvn114. PubMed PMID: 18456674.
30
Zhou C, Liu Y, Yao Y, Zhou S, Fang N, Wang W, et al. beta-blockers and volatile anesthetics may attenuate cardioprotection by remote preconditioning in adult cardiac surgery: a meta-analysis of 15 randomized trials. J Cardiothorac Vasc Anesth. 2013;27:305-11. doi: 10.1053/j.jvca.2012.09.028. PubMed PMID: 23276595.
31
ORIGINAL_ARTICLE
Effects of Ketamine on Neuronal Spontaneous Excitatory Postsynaptic Currents and Miniature Excitatory Postsynaptic Currents in the Somatosensory Cortex of Rats
Background: Ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. The mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. We aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex by using the whole-cell patch-clamp method.Methods: Sprague-Dawley rats (11–19 postnatal days, n=36) were used to obtain brain slices (300 μM). Spontaneous excitatory postsynaptic currents (data from 40 neurons) were recorded at a command potential of -70 mV in the presence of bicuculline (a competitive antagonist of GABAA receptors, 30 μM) and strychnine (glycine receptor antagonist, 30 μM). Miniature excitatory postsynaptic currents (data from 40 neurons) were also recorded when 1 μM of tetrodotoxin was added into the artificial cerebrospinal fluid. We used GraphPad Prism5for statistical analysis. Significant differences in the mean amplitude and frequency were tested using the Student paired 2-tailed t test. Values of p
https://ijms.sums.ac.ir/article_40372_d729814251e0209b5e8045c40520f683.pdf
2016-07-01
275
282
Ketamine
Patch-clamp techniques
Excitatory postsynaptic potentials
Synaptic transmission
Chengdong
Yuan
zunyiycd@163.com
1
Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Guizhou, China
AUTHOR
Yajun
Zhang
765802920@qq.com
2
Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Guizhou, China
AUTHOR
Yu
Zhang
420557377@qq.com
3
Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Guizhou, China
AUTHOR
Song
Cao
406248093@qq.com
4
Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Guizhou, China
AUTHOR
Yuan
Wang
591104162@qq.com
5
Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Guizhou, China
AUTHOR
Bao
Fu
359062449@qq.com
6
Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Guizhou, China
AUTHOR
Tian
Yu
zyyxyyutian@163.com
7
Guizhou Key Laboratory of Anesthesia and Organ Protection, Zunyi Medical College, Guizhou, China
LEAD_AUTHOR
Schubert D, Kotter R, Staiger JF. Mapping functional connectivity in barrel-related columns reveals layer- and cell type-specific microcircuits. Brain Struct Funct. 2007;212:107-19. doi: 10.1007/s00429-007-0147-z. PubMed PMID: 17717691.
1
Tu Y, Yu T, Fu XY, Xie P, Lu S, Huang XQ, et al. Altered thalamocortical functional connectivity by propofol anesthesia in rats. Pharmacology. 2011;88:322-6. doi: 10.1159/000334168. PubMed PMID: 22116025.
2
Zhang Y, Li Z, Dong H, Yu T. Effects of general anesthesia with propofol on thalamocortical sensory processing in rats. J Pharmacol Sci. 2014;126:370-81. doi: 10.1254/jphs.14153FP. PubMed PMID: 25427432.
3
Li Z, Liu X, Zhang Y, Shi J, Zhang Y, Xie P, et al. Connection changes in somatosensory cortex induced by different doses of propofol. PLoS One. 2014;9:e87829. doi: 10.1371/journal.pone.0087829. PubMed PMID: 24516566; PubMed Central PMCID: PMC3917837.
4
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7
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8
Ferrarelli F, Massimini M, Sarasso S, Casali A, Riedner BA, Angelini G, et al. Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness. Proc Natl Acad Sci U S A. 2010;107:2681-6. doi: 10.1073/pnas.0913008107. PubMed PMID: 20133802; PubMed Central PMCID: PMC2823915.
9
Purdon PL, Pierce ET, Bonmassar G, Walsh J, Harrell PG, Kwo J, et al. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Ann N Y Acad Sci. 2009;1157:61-70. doi: 10.1111/j.1749-6632.2008.04119.x. PubMed PMID: 19351356; PubMed Central PMCID: PMC2855224.
10
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11
Schlunzen L, Juul N, Hansen KV, Cold GE. Regional cerebral blood flow and glucose metabolism during propofol anaesthesia in healthy subjects studied with positron emission tomography. Acta Anaesthesiol Scand. 2012;56:248-55. doi: 10.1111/j.1399-6576.2011.02561.x. PubMed PMID: 22091956.
12
Kaisti KK, Metsahonkala L, Teras M, Oikonen V, Aalto S, Jaaskelainen S, et al. Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. Anesthesiology. 2002;96:1358-70. doi: 10.1097/00000542-200206000-00015. PubMed PMID: 12170048.
13
Sonner JM, Cantor RS. Molecular mechanisms of drug action: an emerging view. Annu Rev Biophys. 2013;42:143-67. doi: 10.1146/annurev-biophys-083012-130341. PubMed PMID: 23451895.
14
Hemmings HC, Jr., Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci. 2005;26:503-10. doi: 10.1016/j.tips.2005.08.006. PubMed PMID: 16126282.
15
Rudolph U, Antkowiak B. Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci. 2004;5:709-20. doi: 10.1038/nrn1496. PubMed PMID: 15322529.
16
Satake S, Imoto K. Cav2.1 channels control multivesicular release by relying on their distance from exocytotic Ca2+ sensors at rat cerebellar granule cells. J Neurosci. 2014;34:1462-74. doi: 10.1523/JNEUROSCI.2388-13.2014. PubMed PMID: 24453334.
17
Schiff ND. Central thalamic contributions to arousal regulation and neurological disorders of consciousness. Ann N Y Acad Sci. 2008;1129:105-18. doi: 10.1196/annals.1417.029. PubMed PMID: 18591473.
18
MacIver MB. Anesthetic agent-specific effects on synaptic inhibition. Anesth Analg. 2014;119:558-69. doi: 10.1213/ANE.0000000000000321. PubMed PMID: 24977633; PubMed Central PMCID: PMC4139451.
19
Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, et al. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012;109:E3377-86. doi: 10.1073/pnas.1210907109. PubMed PMID: 23129622; PubMed Central PMCID: PMC3523833.
20
Alkire MT, Asher CD, Franciscus AM, Hahn EL. Thalamic microinfusion of antibody to a voltage-gated potassium channel restores consciousness during anesthesia. Anesthesiology. 2009;110:766-73. doi: 10.1097/ALN.0b013e31819c461c. PubMed PMID: 19322942.
21
Cheng G, Kendig JJ. Enflurane decreases glutamate neurotransmission to spinal cord motor neurons by both pre- and postsynaptic actions. Anesth Analg. 2003;96:1354-9. doi: 10.1213/01.ANE.0000055649.06649.D2. PubMed PMID: 12707133.
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25
Hanell A, Greer JE, Jacobs KM. Increased Network Excitability Due to Altered Synaptic Inputs to Neocortical Layer V Intact and Axotomized Pyramidal Neurons after Mild Traumatic Brain Injury. J Neurotrauma. 2015;32:1590-8. doi: 10.1089/neu.2014.3592. PubMed PMID: 25789412; PubMed Central PMCID: PMC4593977.
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27
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32
ORIGINAL_ARTICLE
Diagnostic Value of the Urine Mucus Test in Childhood Masturbation among Children below 12 Years of Age: A Cross-Sectional Study from Iran
Background: Childhood masturbation (CM) is considered a variant of normal sexual behavior; however, it is commonly misdiagnosed as epilepsy and movement disorders. As the first study from Iran, we analyzed a large population of infants and children with CM in a case-control study and evaluated the value of mucus in urine analysis as an alternative diagnostic tool for CM.Methods: A total of 623 children referred to the Pediatric Neurology Clinic of Imam Khomeini Hospital for an evaluation of seizure or movement disorders were studied between 2008 and 2011. Totally, 359 children were found to have masturbatory behaviors (Group A) and the rest (264) were assigned to Group B. CM was diagnosed by direct observation. Collected data comprised demographic characteristics, clinical and neurodevelopmental examinations, laboratory findings (particularly urine analysis), and electrocardiography. Results: The age of the children with CM was below 12 years old, and the girl-to-boy ratio was 7:1. Mucus in urine was positive in 357 (99.44%) children in Group A and 22 (8.3%) in Group B (P<0.001). A significant correlation was found between the presence of mucus in urine and masturbatory behaviors (P<0.001).Conclusion: Our findings suggest that the presence of mucus in urine can be used as an alternative laboratory test in children with CM below 12 years old and even in infants (≤24 months old). Further studies are needed to confirm the results.
https://ijms.sums.ac.ir/article_40375_60e35e6c05bacd12c046560d6cab3cf0.pdf
2016-07-01
283
287
Childhood masturbation
Mucus
Urine
Zarin
Keihani Doust
keihanid@sina.tums.ac.ir
1
Department of Pediatric Neurology, School of Medicine, Teheran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Mamak
Shariat
mshariat@tums.ac.ir
2
Fetal Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Neda
Zabandan
mfnhrc@yahoo.com
3
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Aidin
Tabrizi
tabrizi.idin@gmail.com
4
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Fatemeh
Tehrani
drftehrani@googlemail.com
5
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
-Omran MS, Ghofrani M, Juibary AG. Infantile masturbation and paroxysmal disorders. Indian J Pediatr. 2008;75:183-5. doi: 10.1007/s12098-008-0028-3. PubMed PMID: 18334803.
1
-Babu TA. Infantile masturbation: Pitfalls in diagnosis and possible solutions. Indian J Psychiatry. 2012;54:393. doi: 10.4103/0019-5545.104847.
2
Omranifard V, Najafi M, Sharbafchi MR, Emami P, Maracy M. Risperidone as a treatment for childhood habitual behavior. J Res Pharm Pract. 2013;2:29-33. doi: 10.4103/2279-042X.114086. PubMed PMID: 24991601; PubMed Central PMCID: PMC4076896.
3
- Nechay A, Ross LM, Stephenson JB, O'Regan M. Gratification disorder ("infantile masturbation"): a review. Arch Dis Child. 2004;89:225-6. doi: 10.1136/adc.2003.032102. PubMed PMID: 14977696; PubMed Central PMCID: PMC1719833.
4
- Yang ML, Fullwood E, Goldstein J, Mink JW. Masturbation in infancy and early childhood presenting as a movement disorder: 12 cases and a review of the literature. Pediatrics. 2005;116:1427-32. doi: 10.1542/peds.2005-0532.
5
- Mallants C, Casteels K. Practical approach to childhood masturbation--a review. Eur J Pediatr. 2008;167:1111-7. doi: 10.1007/s00431-008-0766-2. PubMed PMID: 18575886. .
6
- Unal F. The clinical outcome of childhood masturbation. Turk J Pediatr. 2000;42:304-7. PubMed PMID: 11196747.
7
- Unal F. Predisposing factors in childhood masturbation in Turkey. Eur J Pediatr. 2000;159:338-42. doi: 10.1007/s004310051283. PubMed PMID: 10834518.
8
- Birol C, Gömeçli E. Effect of the counselling course on the attitude of the students of pre-school teaching towards the children's masturbation behaviour. Procedia Soc Behav Sci. 2010;5:2366-71. doi: 10.1016/j.sbspro.2010.07.465.
9
- Ajlouni HK, Daoud AS, Ajlouni SF, Ajlouni KM. Infantile and early childhood masturbation: Sex hormones and clinical profile. Ann Saudi Med. 2010;30:471-4. doi: 10.4103/0256-4947.72271. PubMed PMID: 21060161; PubMed Central PMCID: PMC2994165.
10
- Livingston S, Berman W, Pauli LL. Masturbation simulating epilepsy. Clin Pediatr (Phila). 1975;14:232-4. PubMed PMID: 1116314.
11
- Mink JW, Neil JJ. Masturbation mimicking paroxysmal dystonia or dyskinesia in a young girl. Movement disorders. 1995;10:518-20. doi: 10.1002/mds.870100421.
12
- Ahmad M, Ahmed H. Childhood masturbation simulating epileptic seizures: A report of two cases and review of the literature. Niger J Paediatr. 2013;40:311-3.
13
- Sheth RD, Bodensteiner JB. Effective utilization of home-video recordings for the evaluation of paroxysmal events in pediatrics. Clinical Pediatrics. 1994;33:578-82. doi: 10.1177/000992289403301001.
14
- Casteels K, Wouters C, Van Geet C, Devlieger H. Video reveals self-stimulation in infancy. Acta Paediatr. 2004;93:844-6. doi: 10.1111/j.1651-2227.2004.tb03029.x. PubMed PMID: 15244238.
15
- Deda G, Caksen H, Suskan E, Gumus D. Masturbation mimicking seizure in an infant. Indian J Pediatr. 2001;68:779-81. doi: 10.1007/BF02752422. PubMed PMID: 11563256.
16
- Shamoâon H. Early childhood masturbation: A clinical study. Jordan Medical Journal. 2010;39:23-6.
17
- Tezcan AE, Namlı M, Semerciöz A. Mixed Type Masturbation: A Case Report. Turgut Ãzal Tip Merkezi Dergisi. 1997;4:306-7.
18
- Jacome DE, Risko MS. Absence status manifested by compulsive masturbation. Arch Neurol. 1983;40:523-4. doi: 10.1001/archneur.1983.04210070063017. PubMed PMID: 6409063.
19
- Rodoo P, Hellberg D. Girls who masturbate in early infancy: diagnostics, natural course and a long-term follow-up. Acta Paediatr. 2013;102:762-6. doi: 10.1111/apa.12231. PubMed PMID: 23488732.
20
- Bodensteiner JB, Sheth RD. Masturbation in infancy and early childhood presenting as a movement disorder. Pediatrics. 2006;117:1861. doi: 10.1542/peds.2005-3145.
21
ORIGINAL_ARTICLE
The Accuracy of Body Mass Index and Gallagher’s Classification in Detecting Obesity among Iranians
Background: The study was conducted to examine the comparability of the BMI and Gallagher’s classification in diagnosing obesity based on the cutoff points of the gold standards and to estimate suitable cutoff points for detecting obesity among Iranians.Methods: The cross-sectional study was comparative in nature. The sample consisted of 20,163 adults. The bioelectrical impedance analysis (BIA) was used to measure the variables of interest. Sensitivity, specificity, positive predictive power (PPV), and negative predictive power (NPV) were used to evaluate the comparability of the two classification methods in detecting obesity.Results: The BMI wrongly classified 29% of the obese persons as overweight. In both classifications, as age increased, the accuracy of detecting obesity decreased. The Gallagher’s classification is better than MBI in detecting obesity in men with the exception of those older than 59 years. In females, the BMI was better in determining sensitivity. In both classifications, either female or male, an increase in age was associated with a decrease in sensitivity and NPV with the exception of the BMI for the 18 year olds. Gallagher can correctly classify males and females who are less than 40 and 19 years old, respectively. Conclusion: Gallagher’s classification is recommended for non-obese in both sexes and in obese males younger than 40 years old. The BMI is recommended for obese females. The suitable cutoff points for the BMI to detect obesity are 27.70 kg/m2 for females and males, 27.70 kg/m2 for females, and 27.30 kg/m2 for males.
https://ijms.sums.ac.ir/article_40377_40eff1709dae8ed2a708ed6c54f16bb9.pdf
2016-07-01
288
295
Fat body
Body mass index
Obesity
Overweight
Alireza
Shahab Jahanlou
alireza.jahanlou@tamucc.edu
1
Department of Health Education, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; and Visiting Scholar, College of Education, Texas A&M University-Corpus Christi, USA;
LEAD_AUTHOR
Kamiar
Kouzekanani
jahanlu@gmail.com
2
Department of Quantitative Methodology, College of Education, Texas A&M University-Corpus Christi, USA
AUTHOR
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1
Sood A, Sundararaj P, Sharma S, Kurpad AV, Muthayya S. BMI and body fat percent: affluent adolescent girls in Bangalore City. Indian Pediatr. 2007;44:587-91. PubMed PMID: 17827634.
2
De Schutter A, Lavie CJ, Milani RV. The impact of obesity on risk factors and prevalence and prognosis of coronary heart disease-the obesity paradox. Prog Cardiovasc Dis. 2014;56:401-8. doi: 10.1016/j.pcad.2013.08.003. PubMed PMID: 24438731.
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5
Yamada Y, Masuo Y, Nakamura E, Oda S. Inter-sport variability of muscle volume distribution identified by segmental bioelectrical impedance analysis in four ball sports. Open Access J Sports Med. 2013;4:97-108. doi: 10.2147/OAJSM.S43512. PubMed PMID: 24379714; PubMed Central PMCID: PMC3871051.
6
Yamada Y, Yamashita D, Yamamoto S, Matsui T, Seo K, Azuma Y, et al. Whole-body and segmental muscle volume are associated with ball velocity in high school baseball pitchers. Open Access J Sports Med. 2013;4:89-95. doi: 10.2147/OAJSM.S42352. PubMed PMID: 24379713; PubMed Central PMCID: PMC3873239.
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Ezzati M, Lopez AD, Rodgers A, Murray CJL. Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. Geneva; World Health Organization: 2004.
10
Mirzazadeh A, Salimzadeh H, Arabi M, Navadeh S, Hajarizadeh B, Haghdoost AA. Trends of Obesity in Iranian Adults from 1990s to late 2000s; a Systematic Review and Meta-analysis. Middle East J Dig Dis. 2013;5:151-7. PubMed PMID: 24829686; PubMed Central PMCID: PMC3990178.
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12
Shabnam AA, Homa K, Reza M, Bagher L, Hossein FM, Hamidreza A. Cut-off points of waist circumference and body mass index for detecting diabetes, hypercholesterolemia and hypertension according to National Non-Communicable Disease Risk Factors Surveillance in Iran. Arch Med Sci. 2012;8:614-21. doi: 10.5114/aoms.2012.30284.
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Ghorbani B. The assessment of body composition by bioelectrical impedance analysis among personals of Iranian Azerbaijan Shahid Madani University. Sport Physiology. 2013;17:115-13. Persian.
14
Shahneshin M, Neyestani T. Comparison of bioelectrical impedance analysis and body mass index methods in determining the prevalence of overweight and obesity. The Journal of Qazvin University of Medical Sciences. 2012;65:18-25. Persian.
15
Ejtahed HS, Asghari G, Mirmiran P, Hosseinpour-Niazi S, Sherafat-KazemZadeh R, Azizi F. Body mass index as a measure of percentage body fat prediction and excess adiposity diagnosis among Iranian adolescents. Arch Iran Med. 2014;17:400-5. doi: 014176/AIM.005. PubMed PMID: 24916524.
16
Heydari ST, Ayatollahi SM, Zare N. Diagnostic value of bioelectrical impedance analysis versus body mass index for detection of obesity among students. Asian J Sports Med. 2011;2:68-74. doi: 10.5812/asjsm.34777. PubMed PMID: 22375221; PubMed Central PMCID: PMC3289197.
17
Shekari-Ardekani MJ, Afkhami-Ardekani M, Poorsaid Isfahani M, Khosravi S. Bioelectrical Impedance versus Body Mass Index for Predicting Body Composition Parameters in Sedentary Job Women. Iranian Journal of Diabetes and Obesity. 2012;4:172-7.
18
Shakerian S, Nikbakht M. Validity of Body Density with Methods of Body Mass Index, Skin Fold, Bio-Electrical Impedance & Criterion Method of Hydrostatic in Men Athletes of Swimming. Journal of Physical Education & Sports Science/Beden Egitimi ve Spor Bilimleri Dergisi. 2011;5:24-29.
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37
ORIGINAL_ARTICLE
Macrophage Immune Response Suppression by Recombinant Mycobacterium tuberculosis Antigens, the ESAT-6, CFP-10, and ESAT-6/CFP-10 Fusion Proteins
Background: Macrophage immune responses are affected by the secretory proteins of Mycobacterium tuberculosis (Mtb). This study aimed to examine the immune responses of macrophages to Mtb secretory antigens, namely ESAT-6, CFP-10, and ESAT-6/CFP-10.Methods: THP-1 cells (a human monocytic cell line) were cultured and differentiated to macrophages by phorbol 12-myristate 13-acetate. The cytotoxicity of the recombinant Mtb proteins was assessed using the MTT assay. Two important immune responses of macrophages, namely NO and ROS production, were measured in response to the ESAT-6, CFP-10, and ESAT-6/CFP-10 antigens. The data were analyzed using one-way ANOVA with SPSS, version 16, and considered significant at P<0.05.Results: The results showed that the ESAT-6, CFP-10, and ESAT-6/CFP-10 proteins markedly reduced macrophage immune response. The treatment of the THP-1-differentiated cells with ESAT-6, CFP-10, and ESAT-6/CFP-10 reduced NO and ROS production. The treated THP-1-differentiated cells exhibited less inducible NO synthase activity than did the untreated cells. No toxic effect on macrophage viability was observed for the applied proteins at the different concentrations. Conclusion: It seems that the decline in macrophage immune response is due to the suppression of NO and ROS production pathways without any effect on cell viability.
https://ijms.sums.ac.ir/article_40378_f1a8a4f513070a3c17c07d922125afea.pdf
2016-07-01
296
304
Mycobacterium Tuberculosis
Recombinant Proteins
ESAT-6 protein
CFP-10 protein
Reactive Oxygen Species
Atefeh
Seghatoleslam
seghatolea@sums.ac.ir
1
Recombinant Protein Laboratory, Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; and Histomorphometry and Stereology Research Center, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mina
Hemmati
2
Recombinant Protein Laboratory, Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Saeedeh
Ebadat
3
Recombinant Protein Laboratory, Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran;
AUTHOR
Bahram
Movahedi
4
Recombinant Protein Laboratory, Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran;
AUTHOR
Zohreh
Mostafavi-Pour
zmostafavi@sums.ac.ir
5
Recombinant Protein Laboratory, Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran; and Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
World Health Organization [Internet]. Tuberculosis. Fact sheet No. 104, 2013. Available from: http://www.who.int/mediacentre/factsheets/fs104/en/
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Hemmati M, Seghatoleslam A, Rasti M, Ebadat S, Naghibalhossaini F, Mostafavi-Pour Z. Additive effect of recombinant Mycobacterium tuberculosis ESAT-6 protein and ESAT-6/CFP-10 fusion protein in adhesion of macrophages through fibronectin receptors. J Microbiol Immunol Infect. 2014.
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Lee SB, Schorey JS. Activation and mitogen-activated protein kinase regulation of transcription factors Ets and NF-kappaB in Mycobacterium-infected macrophages and role of these factors in tumor necrosis factor alpha and nitric oxide synthase 2 promoter function. Infect Immun. 2005;73:6499-507. doi: 10.1128/IAI.73.10.6499-6507.2005. PubMed PMID: 16177323; PubMed Central PMCID: PMC1230939.
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Gupta D, Sharma S, Singhal J, Satsangi AT, Antony C, Natarajan K. Suppression of TLR2-induced IL-12, reactive oxygen species, and inducible nitric oxide synthase expression by Mycobacterium tuberculosis antigens expressed inside macrophages during the course of infection. J Immunol. 2010;184:5444-55. doi: 10.4049/jimmunol.0903283. PubMed PMID: 20385877.
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Ganguly N, Giang PH, Basu SK, Mir FA, Siddiqui I, Sharma P. Mycobacterium tuberculosis 6-kDa early secreted antigenic target (ESAT-6) protein downregulates lipopolysaccharide induced c-myc expression by modulating the extracellular signal regulated kinases 1/2. BMC Immunol. 2007;8:24. doi: 10.1186/1471-2172-8-24. PubMed PMID: 17915024; PubMed Central PMCID: PMC2082026.
38
ORIGINAL_ARTICLE
Melatonin Reduces Cataract Formation and Aldose Reductase Activity in Lenses of Streptozotocin-induced Diabetic Rat
Background: The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats.Methods: 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diabetic+melatonin received a single dose of STZ (50 mg/kg, intraperitoneally), whereas the normal control and normal+melatonin received vehicle. The melatonin groups were gavaged with melatonin (5 mg/kg) daily for a period of 8 weeks, whereas the rats in the normal control and diabetic control groups received only the vehicle. The rats’ eyes were examined every week and cataract formation scores (0-4) were determined by slit-lamp microscope. At the end of the eighth week, the rats were sacrificed and markers of the polyol pathway and antioxidative (Glutathione, GSH) in their lens were determined. The levels of blood glucose, HbA1c and plasma malondialdhyde (MDA), as a marker of lipid peroxidation, were also measured.Results: Melatonin prevented STZ-induced hyperglycemia by decreased blood glucose and HbA1c levels. Slit lamp examination indicated that melatonin delayed cataract progression in diabetic rats. The results revealed that melatonin feeding increased the GSH levels, decreased the activities of AR and sorbitol dehydrogenase (SDH) and sorbitol formation in catractous lenses as well as plasma MDA content. Conclusion: In summary, for the first time we demonstrated that melatonin delayed the formation and progression of cataract in diabetic rat lenses.
https://ijms.sums.ac.ir/article_40379_4baa1808cf4001847b5d6c147085b737.pdf
2016-07-01
305
313
Aldose reductase
diabetes mellitus
Melatonin
Cataract
Sorbitol dehydrogenase
Marjan
Khorsand
ma.kh58@yahoo.com
1
Department of Biochemistry and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Masoumeh
Akmali
2
Department of Biochemistry, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Sahab
Sharzad
sahab_shahrzad@yahoo.com
3
Department of Ophthalmology, Khalili Hospital, Shiraz University of Medical sciences, Shiraz, Iran
AUTHOR
Mojtaba
Beheshtitabar
m.beheshtitabar@yahoo.com
4
Department of Biochemistry and Molecular Biology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Reiter RJ, Tan DX, Mayo JC, Sainz RM, Leon J, Czarnocki Z. Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans. Acta Biochim Pol. 2003;50:1129-46. doi: 0350041129. PubMed PMID: 14740000.
1
Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 2005;27:101-10. doi: 10.1385/ENDO:27:2:101. PubMed PMID: 16217123.
2
Akmali M, Ahmadi R, Vessal M. Pre- and post-treatment of streptozocin administered rats with melatonin: effects on some hepatic enzymes of carbohydrate metabolism. Arch Iran Med. 2010;13:105-10. PubMed PMID: 20187663.
3
Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011;51:1-16. doi: 10.1111/j.1600-079X.2011.00916.x. PubMed PMID: 21752095.
4
Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813-20. doi: 10.1038/414813a. PubMed PMID: 11742414.
5
Suryanarayana P, Saraswat M, Petrash JM, Reddy GB. Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats. Mol Vis. 2007;13:1291-7. PubMed PMID: 17679931.
6
Reddy AB, Tammali R, Mishra R, Srivastava S, Srivastava SK, Ramana KV. Aldose reductase deficiency protects sugar-induced lens opacification in rats. Chem Biol Interact. 2011;191:346-50. doi: 10.1016/j.cbi.2011.02.028. PubMed PMID: 21376710; PubMed Central PMCID: PMC3103638.
7
Thiraphatthanavong P, Wattanathorn J, Muchimapura S, Wipawee TM, Wannanon P, Terdthai TU, et al. Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract. Biomed Res Int. 2014;2014:507435. doi: 10.1155/2014/507435. PubMed PMID: 24527449; PubMed Central PMCID: PMC3914321.
8
Hashim Z, Zarina S. Osmotic stress induced oxidative damage: possible mechanism of cataract formation in diabetes. J Diabetes Complications. 2012;26:275-9. doi: 10.1016/j.jdiacomp.2012.04.005. PubMed PMID: 22609218.
9
Chung YS, Choi YH, Lee SJ, Choi SA, Lee JH, Kim H, et al. Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo. J Ethnopharmacol. 2005;101:49-54. doi: 10.1016/j.jep.2005.03.020. PubMed PMID: 15905053.
10
Giblin FJ. Glutathione: a vital lens antioxidant. J Ocul Pharmacol Ther. 2000;16:121-35. doi: 10.1089/jop.2000.16.121. PubMed PMID: 10803423.
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Zhang S, Chai FY, Yan H, Guo Y, Harding JJ. Effects of N-acetylcysteine and glutathione ethyl ester drops on streptozotocin-induced diabetic cataract in rats. Mol Vis. 2008;14:862-70. PubMed PMID: 18490958; PubMed Central PMCID: PMC2386505.
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Kawakubo K, Mori A, Sakamoto K, Nakahara T, Ishii K. GP-1447, an inhibitor of aldose reductase, prevents the progression of diabetic cataract in rats. Biol Pharm Bull. 2012;35:866-72. doi: 10.1248/bpb.35.866. PubMed PMID: 22687477.
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Kocer I, Taysi S, Ertekin MV, Karslioglu I, Gepdiremen A, Sezen O, et al. The effect of L-carnitine in the prevention of ionizing radiation-induced cataracts: a rat model. Graefes Arch Clin Exp Ophthalmol. 2007;245:588-94. doi: 10.1007/s00417-005-0097-1. PubMed PMID: 16915402.
15
Karslioglu I, Ertekin MV, Taysi S, Kocer I, Sezen O, Gepdiremen A, et al. Radioprotective effects of melatonin on radiation-induced cataract. J Radiat Res. 2005;46:277-82. doi: 10.1269/jrr.46.277. PubMed PMID: 15988147.
16
Shirazi A, Haddadi GH, Asadi-Amoli F, Sakhaee S, Ghazi-Khansari M, Avand A. Radioprotective effect of melatonin in reducing oxidative stress in rat lenses. Cell J. 2011;13:79-82. PubMed PMID: 23508093; PubMed Central PMCID: PMC3584458.
17
Preet A, Gupta BL, Yadava PK, Baquer NZ. Efficacy of lower doses of vanadium in restoring altered glucose metabolism and antioxidant status in diabetic rat lenses. J Biosci. 2005;30:221-30. doi: 10.1007/BF02703702. PubMed PMID: 15886458.
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24
Aktoz T, Aydogdu N, Alagol B, Yalcin O, Huseyinova G, Atakan IH. The protective effects of melatonin and vitamin E against renal ischemia-reperfusion injury in rats. Ren Fail. 2007;29:535-42. doi: 10.1080/08860220701391738. PubMed PMID: 17654314.
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Abdel-Wahab MH, Abd-Allah AR. Possible protective effect of melatonin and/or desferrioxamine against streptozotocin-induced hyperglycaemia in mice. Pharmacol Res. 2000;41:533-7. doi: 10.1006/phrs.1999.0614. PubMed PMID: 10753552.
26
Anwar MM, Meki AR. Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp Biochem Physiol A Mol Integr Physiol. 2003;135:539-47. doi: 10.1016/S1095-6433(03)00114-4. PubMed PMID: 12890544.
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Korkmaz A, Ma S, Topal T, Rosales-Corral S, Tan DX, Reiter RJ. Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state. Mol Cell Endocrinol. 2012;349:128-37. doi: 10.1016/j.mce.2011.10.013. PubMed PMID: 22079284.
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31
Yu JX, Yin XX, Shen JP, Qiu J, Yin HL, Jiang SJ. Protective effects of bendazac lysine on diabetic peripheral neuropathy in streptozotocin-induced diabetic rats. Clin Exp Pharmacol Physiol. 2006;33:1231-8. doi: 10.1111/j.1440-1681.2006.04515.x. PubMed PMID: 17184506.
32
Klepac N, Rudes Z, Klepac R. Effects of melatonin on plasma oxidative stress in rats with streptozotocin induced diabetes. Biomed Pharmacother. 2006;60:32-5. doi: 10.1016/j.biopha.2005.08.005. PubMed PMID: 16332428.
33
Suryanarayana P, Saraswat M, Mrudula T, Krishna TP, Krishnaswamy K, Reddy GB. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest Ophthalmol Vis Sci. 2005;46:2092-9. doi: 10.1167/iovs.04-1304. PubMed PMID: 15914628.
34
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35
Baydas G, Reiter RJ, Yasar A, Tuzcu M, Akdemir I, Nedzvetskii VS. Melatonin reduces glial reactivity in the hippocampus, cortex, and cerebellum of streptozotocin-induced diabetic rats. Free Radic Biol Med. 2003;35:797-804. doi: 10.1016/S0891-5849(03)00408-8. PubMed PMID: 14583344.
36
Vural H, Sabuncu T, Arslan SO, Aksoy N. Melatonin inhibits lipid peroxidation and stimulates the antioxidant status of diabetic rats. J Pineal Res. 2001;31:193-8. doi: 10.1034/j.1600-079X.2001.310301.x. PubMed PMID: 11589752.
37
Baydas G, Canatan H, Turkoglu A. Comparative analysis of the protective effects of melatonin and vitamin E on streptozocin-induced diabetes mellitus. J Pineal Res. 2002;32:225-30. doi: 10.1034/j.1600-079X.2002.01856.x. PubMed PMID: 11982791.
38
ORIGINAL_ARTICLE
Effect of Magnetic Fluid Hyperthermia on Implanted Melanoma in Mouse Models
Background: Nowadays, magnetic nanoparticles (MNPs) have received much attention because of their enormous potentials in many fields such as magnetic fluid hyperthermia (MFH). The goal of hyperthermia is to increase the temperature of malignant cells to destroy them without any lethal effect on normal tissues. To investigate the effectiveness of cancer therapy by magnetic fluid hyperthermia, Fe0.5Zn0.5Fe2O4 nanoparticles (FNPs) were used to undergo external magnetic field (f=515 kHz, H=100 G) in mice bearing implanted tumor.Methods: FNPs were synthesized via precipitation and characterized using transmission electron microscopy (TEM), vibrating sample magnetometer, and Fourier transform infrared. For in vivo study, the mice bearing implanted tumor were divided into four groups (two mice per group), namely, control group, AMF group, MNPs group, and MNPs&AMF group. After 24 hours, the mice were sacrificed and each tumor specimen was prepared for histological analyses. The necrotic surface area was estimated by using graticule (Olympus, Japan) on tumor slides.Results: The mean diameter of FNPs was estimated around 9 nm by TEM image and M versus H curve indicates that this particle is among superparamagnetic materials. According to histological analyses, no significant difference in necrosis extent was observed among the four groups.Conclusion: FNPs are biocompatible and have a good size for biomedical applications. However, for MFH approach, larger diameters especially in the range of ferromagnetic particles due to hysteresis loss can induce efficient heat in the target region.
https://ijms.sums.ac.ir/article_40380_57d3f341539bcada71a1eb440ff2bff6.pdf
2016-07-01
314
321
Hyperthermia
Induced
Nanoparticles
Magnetic fields
Melanoma
mice
Maryam
Heidari
heidari_m@sums.ac.ir
1
Department of Medical Physics, School
of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Naghmeh
Sattarahmady
sattarahmady@yahoo.com
2
Department of Medical Physics, School
of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Nanomedicine and Nanobiology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Sirus
Javadpour
javadpour@yahoo.com
3
Department of Materials Science and Engineering, School of Electrical and Computer Engineering, Shiraz University, Shiraz, Iran
AUTHOR
Negar
Azarpira
negarazarpira@yahoo.com
4
Transplant Research Center, Department of Pathology, Namazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Hossein
Heli
hheli7@yahoo.com
5
Department of Nanomedicine, School
of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Alireza
Mehdizadeh
alireza.mehdizadeh@gmail.com
6
Department of Medical Physics, School
of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Nanomedicine and Nanobiology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Amirhossein
Rajaei
rajaeiah@yahoo.com
7
Department of Electrical and Electronic, School of Electrical and Electronic Engineering, Shiraz University of Technology, Shiraz, Iran
AUTHOR
Tahereh
Zare
zaret@yahoo.com
8
Department of Medical Physics, School
of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Doaga A, Cojocariu A, Amin W, Heib F, Bender P, Hempelmann R, et al. Synthesis and characterizations of manganese ferrites for hyperthermia applications. Mater Chem Phys. 2013;143:305-10. doi: 10.1016/j.matchemphys.2013.08.066.
1
Kozissnik B, Bohorquez AC, Dobson J, Rinaldi C. Magnetic fluid hyperthermia: advances, challenges, and opportunity. Int J Hyperthermia. 2013;29:706-14. doi: 10.3109/02656736.2013.837200. PubMed PMID: 24106927.
2
Sun H, Xu L, Fan T, Zhan H, Wang X, Zhou Y, et al. Targeted hyperthermia after selective embolization with ferromagnetic nanoparticles in a VX2 rabbit liver tumor model. Int J Nanomedicine. 2013;8:3795-804. doi: 10.2147/IJN.S50373. PubMed PMID: 24124367; PubMed Central PMCID: PMC3795007.
3
Kut C, Zhang Y, Hedayati M, Zhou H, Cornejo C, Bordelon D, et al. Preliminary study of injury from heating systemically delivered, nontargeted dextran-superparamagnetic iron oxide nanoparticles in mice. Nanomedicine (Lond). 2012;7:1697-711. doi: 10.2217/nnm.12.65. PubMed PMID: 22830502; PubMed Central PMCID: PMC3991127.
4
Motoyama J, Yamashita N, Morino T, Tanaka M, Kobayashi T, Honda H. Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles. Biomagn Res Technol. 2008;6:2. doi: 10.1186/1477-044X-6-2. PubMed PMID: 18298831; PubMed Central PMCID: PMC2266920.
5
Bakoglidis K, Simeonidis K, Sakellari D, Stefanou G, Angelakeris M. Size-dependent mechanisms in AC magnetic hyperthermia response of iron-oxide nanoparticles. IEEE Trans Magn. 2012;48:1320-3. doi: 10.1109/TMAG.2011.2173474.
6
Kumar CS, Mohammad F. Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Adv Drug Deliv Rev. 2011;63:789-808. doi: 10.1016/j.addr.2011.03.008. PubMed PMID: 21447363; PubMed Central PMCID: PMC3138885.
7
Di Barba P, Dughiero F, Sieni E. Magnetic field synthesis in the design of inductors for magnetic fluid hyperthermia. IEEE Trans Magn. 2010;46:2931-4. doi: 10.1109/TMAG.2010.2044769.
8
Bettge M, Chatterjee J, Haik Y. Physically synthesized Ni-Cu nanoparticles for magnetic hyperthermia. Biomagn Res Technol. 2004;2:4. doi: 10.1186/1477-044X-2-4. PubMed PMID: 15132747; PubMed Central PMCID: PMC420488.
9
Pradhan P, Giri J, Rieken F, Koch C, Mykhaylyk O, Doblinger M, et al. Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy. J Control Release. 2010;142:108-21. doi: 10.1016/j.jconrel.2009.10.002. PubMed PMID: 19819275.
10
Pradhan P, Giri J, Samanta G, Sarma HD, Mishra KP, Bellare J, et al. Comparative evaluation of heating ability and biocompatibility of different ferrite-based magnetic fluids for hyperthermia application. J Biomed Mater Res B Appl Biomater. 2007;81:12-22. doi: 10.1002/jbm.b.30630. PubMed PMID: 16924619.
11
Balivada S, Rachakatla RS, Wang H, Samarakoon TN, Dani RK, Pyle M, et al. A/C magnetic hyperthermia of melanoma mediated by iron(0)/iron oxide core/shell magnetic nanoparticles: a mouse study. BMC Cancer. 2010;10:119. doi: 10.1186/1471-2407-10-119. PubMed PMID: 20350328; PubMed Central PMCID: PMC2859385.
12
Zhao Q, Wang L, Cheng R, Mao L, Arnold RD, Howerth EW, et al. Magnetic nanoparticle-based hyperthermia for head & neck cancer in mouse models. Theranostics. 2012;2:113-21. doi: 10.7150/thno.3854. PubMed PMID: 22287991; PubMed Central PMCID: PMC3267386.
13
KöseoÄlu Y, Bay M, Tan M, Baykal A, Sözeri H, Topkaya R, et al. Magnetic and dielectric properties of Mn0. 2Ni0. 8Fe2O4 nanoparticles synthesized by PEG-assisted hydrothermal method. J Nanopart Res. 2011;13:2235-44.
14
Hankare P, Patil R, Sankpal U, Jadhav S, Lokhande P, Jadhav K, et al. Investigation of structural and magnetic properties of nanocrystalline manganese substituted lithium ferrites. J Solid State Chem. 2009;182:3217-21. doi: 10.1016/j.jssc.2009.08.034.
15
Varshosaz J, Sadeghi-aliabadi H, Ghasemi S, Behdadfar B. Use of magnetic folate-dextran-retinoic acid micelles for dual targeting of doxorubicin in breast cancer. Biomed Res Int. 2013;2013:680712. doi: 10.1155/2013/680712. PubMed PMID: 24381941; PubMed Central PMCID: PMC3870081.
16
Hong R, Feng B, Chen L, Liu G, Li H, Zheng Y, et al. Synthesis, characterization and MRI application of dextran-coated Fe 3 O 4 magnetic nanoparticles. Biochem Eng J. 2008;42:290-300.
17
Hong R, Li J, Qu J, Chen L, Li H. Preparation and characterization of magnetite/dextran nanocomposite used as a precursor of magnetic fluid. Chem Eng J. 2009;150:572-80. doi: 10.1016/j.cej.2009.03.034.
18
Kolhatkar AG, Jamison AC, Litvinov D, Willson RC, Lee TR. Tuning the magnetic properties of nanoparticles. Int J Mol Sci. 2013;14:15977-6009. doi: 10.3390/ijms140815977. PubMed PMID: 23912237; PubMed Central PMCID: PMC3759896.
19
Tiefenauer LX, Kuhne G, Andres RY. Antibody-magnetite nanoparticles: in vitro characterization of a potential tumor-specific contrast agent for magnetic resonance imaging. Bioconjug Chem. 1993;4:347-52. doi: 10.1021/bc00023a007. PubMed PMID: 8274518.
20
Eberbeck D, Lange A, Hentschel M. Identification of aggregates of magnetic nanoparticles in ferrofluids at low concentrations. J Appl Crystallogr. 2003;36:1069-74. doi: 10.1107/S002188980301104X.
21
Morales M, Bomati-Miguel O, De Alejo RP, Ruiz-Cabello J, Veintemillas-Verdaguer S, OâGrady K. Contrast agents for MRI based on iron oxide nanoparticles prepared by laser pyrolysis. Journal of Magnetism and Magnetic Materials. 2003;266:102-9. doi: 10.1016/S0304-8853(03)00461-X.
22
Abdeen S, Praseetha P. Diagnostics and treatment of metastatic cancers with magnetic nanoparticles. J Nanomedine Biotherapeutic Discov. 2013;3:115. doi: 10.4172/2155-983X.1000115.
23
ORIGINAL_ARTICLE
Status of Exudative Pleural Effusion in Adults of South Khorasan Province, Northeast Iran: Pleural Tuberculosis Tending toward Elderly
The causes and situation of exudative pleural effusion vary from one area to another. A cross-sectional study was conducted on 327 patients with exudative pleural effusion in South Khorasan province (Iran). The patients were older than 12 years and comprised 172 (52.6%) males and 155 (47.4%) females. The study commenced in 2007 with seven years duration. The Light’s criteria were used to define exudative effusion. Procedures including pleural fluid analysis, microbiological study, pleural biopsy, and systemic investigations were conducted to determine the special cause of pleural effusion. The mean age of the patients was 63.4±18.4 years. Malignancies, tuberculosis, and parapneumonia pleural exudation were diagnosed in 125 (38.2%), 48 (14.7%), and 45 (13.8%) cases, respectively. Among malignant effusions, metastasis from lung cancer made 48 (38.4%) of the cases. The origin of metastasis was not determined in 44 (35.2%) patients. The mean age of patients was not significantly different between malignant (66.9±14.3 years) and tuberculosis (63.9±19.7 years) cases (P=0.16). The older age of tuberculosis patients could be a new discussion point on the overall impression created on the subject of tuberculosis pleural exudation (TB-PLE) occurring in young people.
https://ijms.sums.ac.ir/article_40365_ec5e859cbfb3173aa9af7cb1b179b389.pdf
2016-07-01
322
327
Tuberculosis
Pleural Effusion
Neoplasms
Sayyed Gholam Reza
Mortazavi-Moghaddam
1
Department of Internal Medicine, Pulmonary Division, Vali-e-Asre Hospital, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
LEAD_AUTHOR
Gholam Reza
Sharifzadeh
2
Department of Epidemiology,
Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Mohammad Reza
Rezvani
3
Department of Internal Medicine, Pulmonary Division, Vali-e-Asre Hospital, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Kalaajieh WK. Etiology of exudative pleural effusions in adults in North Lebanon. Can Respir J. 2001;8:93-7. PubMed PMID: 11320400.
1
Liam CK, Lim KH, Wong CM. Causes of pleural exudates in a region with a high incidence of tuberculosis. Respirology. 2000;5:33-8. PubMed PMID: 10728729. doi: 10.1046/j.1440-1843.2000.00223.x.
2
Boloursaz M, Khalilzadeh S, Abbaszadeh M, Velayati A. Tuberculous Pleural Effusion in Children. Iranian Journal of Pediatric Society. 2010;2:15-9.
3
Ibrahim WH, Ghadban W, Khinji A, Yasin R, Soub H, Al-Khal AL, et al. Does pleural tuberculosis disease pattern differ among developed and developing countries. Respir Med. 2005;99:1038-45. doi: 10.1016/j.rmed.2004.12.012. PubMed PMID: 15950146.
4
Baumann MH, Nolan R, Petrini M, Lee YC, Light RW, Schneider E. Pleural tuberculosis in the United States: incidence and drug resistance. Chest. 2007;131:1125-32. doi: 10.1378/chest.06-2352. PubMed PMID: 17426219.
5
Heidari B, Bijani K, Eissazadeh M, Heidari P. Exudative pleural effusion: effectiveness of pleural fluid analysis and pleural biopsy. East Mediterr Health J. 2007;13:765-73. PubMed PMID: 17955757.
6
Khan FY, Alsamawi M, Yasin M, Ibrahim AS, Hamza M, Lingawi M, et al. Etiology of pleural effusion among adults in the state of Qatar: a l-year hospital-based study. East Mediterr Health J. 2011;17:611-8. PubMed PMID: 21972486.
7
Mekonnen D, Amare A, Alemu A, Hurissa Z, Ali J. Pleural effusion: presentation, causes and treatment outcome in a resource limited area, Ethiopia. Health. 2012;4, 15-19.
8
Towhidi M, FARID HR, Nazari A. Frequency of Tuberculous Pleural Effusion in Northeast of Iran. Iran Red Crescent Med J. 2003;6:57-60.
9
Golshan M, Faghihi M, Ghanbarian K, Ghanei M. Common causes of pleural effusion in referral hospital in Isfahan, Iran 1997-1998. Asian Cardiovasc Thorac Ann. 2002;10:43-6. doi: 10.1177/021849230201000111. PubMed PMID: 12079970.
10
Rafiee S, Besharat S, Jabbari A, Golalipour F, Nasermoaadeli A. Epidemiology of tuberculosis in northeast of Iran: a population-based study. Iran J Med Sci. 2015;34:193-7.
11
Porcel JM, Vives M. Etiology and pleural fluid characteristics of large and massive effusions. Chest. 2003;124:978-83. doi: 10.1378/chest.124.3.978. PubMed PMID: 12970026.
12
Light RW. Update on tuberculous pleural effusion. Respirology. 2010;15:451-8. doi: 10.1111/j.1440-1843.2010.01723.x. PubMed PMID: 20345583.
13
Ghoshal AG, Sarkar S, Majumder A, Chakrabarti S. Unilateral massive pleural effusion: a presentation of unsuspected multiple myeloma. Indian J Hematol Blood Transfus. 2010;26:62-4. doi: 10.1007/s12288-010-0016-4. PubMed PMID: 21629638; PubMed Central PMCID: PMC3002069.
14
Luo Y, Zhang Y, Lou SF. Bilateral pleural effusion in a patient with an extensive extramedullary hematopoietic mass. Case Rep Hematol. 2013;2013:857610. doi: 10.1155/2013/857610. PubMed PMID: 24024051; PubMed Central PMCID: PMC3759280.
15
Koksal D, Bayiz H, Gulgosteren M, Basay N, Mutluay N, Boyaci E, et al. Recurrence of thymoma after 11 years presenting as diffuse pleural thickening. Tuberk Toraks. 2012;60:62-5. doi: 10.5578/tt.1993. PubMed PMID: 22554370.
16
Vega F, Padula A, Valbuena JR, Stancu M, Jones D, Medeiros LJ. Lymphomas involving the pleura: a clinicopathologic study of 34 cases diagnosed by pleural biopsy. Arch Pathol Lab Med. 2006;130:1497-502. doi: 10.1043/1543-2165(2006)130[1497:LITPAC]2.0.CO;2. PubMed PMID: 17090191.
17
McGrath EE, Anderson PB. Diagnosis of pleural effusion: a systematic approach. Am J Crit Care. 2011;20:119-27. doi: 10.4037/ajcc2011685. PubMed PMID: 21362716.
18
Gottehrer A, Roa J, Stanford GG, Chernow B, Sahn SA. Hypothyroidism and pleural effusions. Chest. 1990;98:1130-2. doi: 10.1378/chest.98.5.1130. PubMed PMID: 2135384.
19
Shadmehr MB, Arab M, Dezfouli AA, Keshoofi M, Amjadi MR, Farzanegan R, et al. Role of VATS in pleural effusions with unknown etiology. Tanaffos. 2004;3:25-33.
20
Thijsen SF, Luderer R, van Gorp JM, Oudejans SJ, Bossink AW. A possible role for Epstein-Barr virus in the pathogenesis of pleural effusion. Eur Respir J. 2005;26:662-6. doi: 10.1183/09031936.05.00131204. PubMed PMID: 16204598.
21
Mortazavi Moghaddam S, Khazaee Z. Vaginal delivery related hempothorax: Report of two cases. Horizon Med Sci. 2011;17:72-7. Persian
22
. DÄ°kensoy E. The Prevalence of Pleural Effusion in Pregnant Women: A Pilot Study. Turk J Med Sci. 2006;36:291-3.
23
Pfefferkorn U, Viehl CT, Barras JP. Ruptured hydatid cyst in the right thorax: differential diagnosis to pleural empyema. Thorac Cardiovasc Surg. 2005;53:250-1. doi: 10.1055/s-2005-837643. PubMed PMID: 16037874.
24
Aktogu Ozkan S, Erer OF, Y AY, Yuncu G, Aydogdu Z. Hydatid cyst presenting as an eosinophilic pleural effusion. Respirology. 2007;12:462-4. doi: 10.1111/j.1440-1843.2007.01054.x. PubMed PMID: 17539858.
25
ORIGINAL_ARTICLE
Aqueous Extract of Anethum Graveolens L. has Potential Antioxidant and Antiglycation Effects
The aim of this study was to assess the antiglycation and antioxidant properties of aqueous extract of Anethum graveolens (dill). In the in vivo and in vitro experiments, antioxidant properties, blood glucose, and AGEs formation were determined. Dill extract was given orally to healthy and diabetic rats. Our results illustrated that different concentrations of dill extract (0.125, 0.25, 0.5, and 1 mg/ml) have potential antiradical and antioxidant activity. Aqueous extract of dill significantly reduced AGEs formation and fructosamine levels, protein carbonyl and also thiol group’s oxidation, amyloid cross-β and fragmentation. After 2 months, blood glucose levels (P=0.006) and AGEs formation (P=0.003) significantly reduced in dill treated group compared with untreated diabetic animals. In conclusion, dill can be recommended as herbal medicine for the control and prevention of diabetic complications.
https://ijms.sums.ac.ir/article_40370_75e8cb9bbea0de90f814bd4fa99133e8.pdf
2016-07-01
328
333
10.30476/ijms.2016.40370
Anethum graveolens
Antioxidants
Herbal medicine
Hypoglycemic agents
Ebrahim
Abbasi Oshaghi
7abbasi@gmail.com
1
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Iraj
Khdadadi
2
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Heidar
Tavilani
tavilani@gmail.com
3
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Mohammad Taghi
Goodarzi
mtgoodarzi@yahoo.com
4
Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; and Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
LEAD_AUTHOR
Mishra N. Haematological and hypoglycemic potential Anethum graveolens seeds extract in normal and diabetic Swiss albino mice. Vet World. 2013;6:502-7. doi: 10.5455/vetworld.2013.502-507.
1
Jana S, Shekhawat GS. Anethum graveolens: An Indian traditional medicinal herb and spice. Pharmacogn Rev. 2010;4:179-84. doi: 10.4103/0973-7847.70915. PubMed PMID: 22228959; PubMed Central PMCID: PMC3249919.
2
Bahramikia S, Yazdanparast R. Antioxidant and free radical scavenging activities of different fractions of Anethum graveolens leaves using in vitro models. Pharmacology online. 2008;2:233-19.
3
Mohammadi A, Bazrafshani MR, Oshaghi EA. Effect of garlic extract on some serum biochemical parameters and expression of npc1l1, abca1, abcg5 and abcg8 genes in the intestine of hypercholesterolemic mice. Indian J Biochem Biophys. 2013;50:500-4. PubMed PMID: 24772974.
4
Salmanian S, Sadeghi Mahoonak A, Alami M, Ghorbani M. Phenolic Content, Antiradical, Antioxidant, and Antibacterial Properties of Hawthorn (Crataegus elbursensis) Seed and Pulp Extract. J Agric Sci Technol. 2014;16:343-54.
5
Jariyapamornkoon N, Yibchok-anun S, Adisakwattana S. Inhibition of advanced glycation end products by red grape skin extract and its antioxidant activity. BMC Complement Altern Med. 2013;13:171. doi: 10.1186/1472-6882-13-171. PubMed PMID: 23849496; PubMed Central PMCID: PMC3716656.
6
Shyu YS, Lin JT, Chang YT, Chiang CJ, Yang DJ. Evaluation of antioxidant ability of ethanolic extract from dill (Anethum graveolens L.) flower. Food Chemistry. 2009;115:515-21. doi: 10.1016/j.foodchem.2008.12.039.
7
Orhan IE, Senol FS, Ozturk N, Celik SA, Pulur A, Kan Y. Phytochemical contents and enzyme inhibitory and antioxidant properties of Anethum graveolens L. (dill) samples cultivated under organic and conventional agricultural conditions. Food Chem Toxicol. 2013;59:96-103. doi: 10.1016/j.fct.2013.05.053. PubMed PMID: 23764360.
8
Selvin E, Rawlings AM, Grams M, Klein R, Sharrett AR, Steffes M, et al. Fructosamine and glycated albumin for risk stratification and prediction of incident diabetes and microvascular complications: a prospective cohort analysis of the Atherosclerosis Risk in Communities (ARIC) study. Lancet Diabetes Endocrinol. 2014;2:279-88. doi: 10.1016/S2213-8587(13)70199-2. PubMed PMID: 24703046; PubMed Central PMCID: PMC4212648.
9
Ramadan MM, Abd-Algader NN, El-kamali HH, Ghanem KZ, Farrag ARH. Volatile compounds and antioxidant activity of the aromatic herb Anethum graveolens. JASMR. 2013;8:79. doi: 10.4103/1687-4293.123791.
10
Adisakwattana S, Thilavech T, Chusak C. Mesona Chinensis Benth extract prevents AGE formation and protein oxidation against fructose-induced protein glycation in vitro. BMC Complement Altern Med. 2014;14:130. doi: 10.1186/1472-6882-14-130. PubMed PMID: 24708679; PubMed Central PMCID: PMC3985549.
11
Marzban L, Park K, Verchere CB. Islet amyloid polypeptide and type 2 diabetes. Exp Gerontol. 2003;38:347-51. doi: 10.1016/S0531-5565(03)00004-4. PubMed PMID: 12670620.
12
Sakai M, Oimomi M, Kasuga M. Experimental studies on the role of fructose in the development of diabetic complications. Kobe J Med Sci. 2002;48:125-36. PubMed PMID: 12594356.
13
Nekooeian AA, Eftekhari MH, Adibi S, Rajaeifard A. Effects of pomegranate seed oil on insulin release in rats with type 2 diabetes. Iran J Med Sci. 2014;39:130-5. PubMed PMID: 24644382; PubMed Central PMCID: PMC3957012.
14
Mozafari M, Nekooeian AA, Panjeshahin MR, Zare HR. The effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. Iran J Med Sci. 2015;40:152-60. PubMed PMID: 25821295; PubMed Central PMCID: PMC4359935.
15
Hajizadeh MR, Eftekhar E, Zal F, Jafarian A, Mostafavi-Pour Z. Mulberry leaf extract attenuates oxidative stress-mediated testosterone depletion in streptozotocin-induced diabetic rats. Iran J Med Sci. 2014;39:123-9. PubMed PMID: 24644381; PubMed Central PMCID: PMC3957011.
16
Ahmad MS, Pischetsrieder M, Ahmed N. Aged garlic extract and S-allyl cysteine prevent formation of advanced glycation endproducts. Eur J Pharmacol. 2007;561:32-8. doi: 10.1016/j.ejphar.2007.01.041. PubMed PMID: 17321518.
17
ORIGINAL_ARTICLE
miR-4284 and miR-4484 as Putative Biomarkers for Diffuse Large B-Cell Lymphoma
Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. MicroRNAs (miRNAs) are endogenous small RNA, which can regulate gene expression at the post-transcriptional level. MiRNA profiling has shown a great potential as novel diagnostic and prognostic biomarkers. The present study was performed at the Nemazee Teaching Hospital (Shiraz, Iran) from 2011 to 2013.The aim of this study was to assess the deregulation of miRNAs profiles in DLBL against hyperplasic reactive lymph node as a normal. This could serve as a biomarker for DLBL. The miRCURY LNATM microarray was used on the total RNA, which was extracted from formalin-fixed paraffin-embedded tissue of 24 de novo diffuse large B-cell lymphoma patients and 14 normal lymph nodes. The greatest changes were detected in miR-4284 and miR-4484 level in patient’s lymphoma samples. These miRNAs can act as a diagnostic biomarker for DLBL.
https://ijms.sums.ac.ir/article_40373_990989cd36c3d880daf34646f33399d8.pdf
2016-07-01
334
339
Lymphoma
Large B-Cell
Diffuse
MicroRNAs
Microarray Analysis
Gholamhossein
Tamaddon
tamadon@sums.ac.ir
1
Department of Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
AUTHOR
Bita
Geramizadeh
geramib@sums.ac.ir
2
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences,Shiraz,Iran
AUTHOR
Mohammad Hossein
Karimi
karimimh@sums.ac.ir
3
Transplant Research Center, Nemazee Teaching Hospital, Shiraz University of Medical Sciences,Shiraz,Iran
AUTHOR
Seyed Javad
Mowla
sjmowla@modares.ac.ir
4
Department of Genetics, Faculty
of Basic Sciences, Tarbiat Modares University, Tehran, Iran
AUTHOR
Said
Abroun
abroun@modares.ac.ir
5
Department of Hematology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
LEAD_AUTHOR
Macfarlane LA, Murphy PR. MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics. 2010;11:537-61. doi: 10.2174/138920210793175895. PubMed PMID: 21532838; PubMed Central PMCID: PMC3048316.
1
Pillai RS. MicroRNA function: multiple mechanisms for a tiny RNA? RNA. 2005;11:1753-61. doi: 10.1261/rna.2248605. PubMed PMID: 16314451; PubMed Central PMCID: PMC1370863.
2
Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer. 2006;6:857-66. doi: 10.1038/nrc1997. PubMed PMID: 17060945.
3
Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Delabie J, Ott G, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103:275-82. doi: 10.1182/blood-2003-05-1545. PubMed PMID: 14504078.
4
Rai D, Karanti S, Jung I, Dahia PL, Aguiar RC. Coordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphoma. Cancer Genet Cytogenet. 2008;181:8-15. doi: 10.1016/j.cancergencyto.2007.10.008. PubMed PMID: 18262046; PubMed Central PMCID: PMC2276854.
5
Roehle A, Hoefig KP, Repsilber D, Thorns C, Ziepert M, Wesche KO, et al. MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas. Br J Haematol. 2008;142:732-44. doi: 10.1111/j.1365-2141.2008.07237.x. PubMed PMID: 18537969.
6
Xi Y, Nakajima G, Gavin E, Morris CG, Kudo K, Hayashi K, et al. Systematic analysis of microRNA expression of RNA extracted from fresh frozen and formalin-fixed paraffin-embedded samples. RNA. 2007;13:1668-74. doi: 10.1261/rna.642907. PubMed PMID: 17698639; PubMed Central PMCID: PMC1986820.
7
Stenvang J, Silahtaroglu AN, Lindow M, Elmen J, Kauppinen S. The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin Cancer Biol. 2008;18:89-102. doi: 10.1016/j.semcancer.2008.01.004. PubMed PMID: 18295505.
8
Zhang L, Zhou F, Garcia de Vinuesa A, de Kruijf EM, Mesker WE, Hui L, et al. TRAF4 promotes TGF-beta receptor signaling and drives breast cancer metastasis. Mol Cell. 2013;51:559-72. doi: 10.1016/j.molcel.2013.07.014. PubMed PMID: 23973329.
9
Ikushima H, Miyazono K. TGFbeta signalling: a complex web in cancer progression. Nat Rev Cancer. 2010;10:415-24. doi: 10.1038/nrc2853. PubMed PMID: 20495575.
10
Bueno MJ, Malumbres M. MicroRNAs and the cell cycle. Biochim Biophys Acta. 2011;1812:592-601. doi: 10.1016/j.bbadis.2011.02.002. PubMed PMID: 21315819.
11
Sandhu SK, Croce CM, Garzon R. Micro-RNA Expression and Function in Lymphomas. Adv Hematol. 2011;2011:347137. doi: 10.1155/2011/347137. PubMed PMID: 21461378; PubMed Central PMCID: PMC3063410.
12
Culpin RE, Proctor SJ, Angus B, Crosier S, Anderson JJ, Mainou-Fowler T. A 9 series microRNA signature differentiates between germinal centre and activated B-cell-like diffuse large B-cell lymphoma cell lines. Int J Oncol. 2010;37:367-76. PubMed PMID: 20596664.
13
Zheng RL, Jiang YJ, Wang X. Role of microRNAs on therapy resistance in Non-Hodgkin's lymphoma. Int J Clin Exp Med. 2014;7:3818-32. PubMed PMID: 25550890; PubMed Central PMCID: PMC4276148.
14
Kwanhian W, Lenze D, Alles J, Motsch N, Barth S, Doll C, et al. MicroRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma. Cancer Med. 2012;1:141-55. doi: 10.1002/cam4.29. PubMed PMID: 23342264; PubMed Central PMCID: PMC3544448.
15
ORIGINAL_ARTICLE
Hybrid Ameloblastoma of the Maxilla: A Puzzling Pathology
Ameloblastomas are slow growing, locally invasive, benign odontogenic tumors of an epithelial origin, accounting for approximately 1% of all oral tumors. A 40-year-old man presented with a chief complaint of a swelling over the left side of his face of 4 years’ duration. On examination, gross facial asymmetry was detected, and a well-defined swelling was noted intraorally involving the left maxilla medially from the mid palatal raphe and obliterating the buccal vestibule laterally. The swelling was non-tender and exhibited dual consistencies: firm in the palate and cystic in the vestibular region. Computed tomography revealed a multilocular radiolucency, which involved the left maxilla, encroached into the left maxillary sinus and the nasal complex, and caused bony erosion. Early diagnosis and treatment are the key tools in managing ameloblastomas, failure of which may lead to a significant deterioration of the prognosis and an increased recurrence rate. Uncommon variants of ameloblastomas have been gaining interest recently. To date, 25 cases of hybrid ameloblastomas have been documented in the scientific literature. We present an extremely rare hybrid type of the ameloblastoma with combined follicular, cystic, acanthomatous, and desmoplastic variants, which render it the first of its kind to have ever been reported.
https://ijms.sums.ac.ir/article_40366_3a923bfd1e6b6517d934121772affb47.pdf
2016-07-01
340
344
Ameloblastoma
Maxillary sinus
Maxillary neoplasms
Odontogenic tumors
Chintamaneni Raja
Lakshmi
1
Department of Oral Medicine and Radiology,Drs. Sudha and Nageswara Rao Siddhartha Institute of Dental Sciences, Gannavaram Mandal, Krishna District, Andhra Pradesh, India
LEAD_AUTHOR
Sujana Mulk
Bhavana
sujana_55@yahoo.com
2
Department of Oral Medicine and
Radiology,Drs. Sudha and Nageswara
Rao Siddhartha Institute of Dental
Sciences, Gannavaram Mandal, Krishna
District, Andhra Pradesh, India
AUTHOR
Sai Madhavi
Nallamilli
shiny.dent@gmail.com
3
Department of Oral Medicine and
Radiology,Drs. Sudha and Nageswara
Rao Siddhartha Institute of Dental
Sciences, Gannavaram Mandal, Krishna
District, Andhra Pradesh, India
AUTHOR
Meka Poorna Venkata
Prabhat
drmpvprabhat@gmail.com
4
Department of Oral Medicine and
Radiology,Drs. Sudha and Nageswara
Rao Siddhartha Institute of Dental
Sciences, Gannavaram Mandal, Krishna
District, Andhra Pradesh, India
AUTHOR
Gummadapu
Sarat
saratgummadapu@rediff.co.in
5
Department of Oral Medicine and
Radiology,Drs. Sudha and Nageswara
Rao Siddhartha Institute of Dental
Sciences, Gannavaram Mandal, Krishna
District, Andhra Pradesh, India
AUTHOR
Chennupati
Anuradha
anuchennupati123@gmail.com
6
Department of Oral Medicine and
Radiology,Drs. Sudha and Nageswara
Rao Siddhartha Institute of Dental
Sciences, Gannavaram Mandal, Krishna
District, Andhra Pradesh, India
AUTHOR
Gupta A, Jindal C. Hybrid ameloblastoma: report of a rare case and review of literature. International Journal of Oral and Maxillofacial Pathology. 2011;2:68-72.
1
Gupta N, Anjum R, Gupta S, Lone P. Ameloblastoma of the Mandible: A Case Report with Review of Literature. Int J Head Neck Surg. 2012;3:56-8. doi: 0.5005/jp-journals-10001-1095.
2
Effiom O, James O, Akeju O, Salami A, Odukoya O. Hybrid ameloblastoma in a nigerian: Report of a case and review of literature. OJST. 2013;3:347. doi: 10.4236/ojst.2013.37059.
3
Oliveira LR, Matos F, Dominguete R, Zorgetto A, Ribeiro A. Ameloblastoma: report of two cases and a brief literature review. Int J Odontostomat. 2011;5:293-9. doi: 10.4067/S0718-381X2011000300014.
4
Carvalho de Melo AU, de Farias Martorelli SB, Cavalcanti PH, Gueiros LA, Martorelli Fde O. Maxillary odontogenic myxoma involving the maxillary sinus: case report. Braz J Otorhinolaryngol. 2008;74:472-5. PubMed PMID: 18661026.
5
Gade L, Patankar S, Khot K, Korde S, Alex S. Desmoplastic ameloblastoma of maxilla-A case report. J Clin Exp Dent. 2010;2:e204-6. doi: 10.4317/jced.2.e204.
6
Kawai T, Kishino M, Hiranuma H, Sasai T, Ishida T. A unique case of desmoplastic ameloblastoma of the mandible: report of a case and brief review of the English language literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;87:258-63. doi: 10.1016/S1079-2104(99)70282-9. PubMed PMID: 10052385.
7
Yamazaki M, Maruyama S, Abe T, Babkair H, Fujita H, Takagi R, et al. Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e12-e8. doi: 10.1016/j.oooo.2013.08.032.
8
Wakoh M, Harada T, Inoue T. Follicular/desmoplastic hybrid ameloblastoma with radiographic features of concomitant fibro-osseous and solitary cystic lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:774-80. doi: 10.1067/moe.2002.129182. PubMed PMID: 12464906.
9
Hirota M, Aoki S, Kawabe R, Fujita K. Desmoplastic ameloblastoma featuring basal cell ameloblastoma: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:160-4. doi: 10.1016/j.tripleo.2004.05.020. PubMed PMID: 15660085.
10
Desai H, Sood R, Shah R, Cawda J, Pandya H. Desmoplastic ameloblastoma: report of a unique case and review of literature. Indian J Dent Res. 2006;17:45-9. PubMed PMID: 16900895.
11
Yazdi I, Seyedmajidi M, Foroughi R. Desmoplastic ameloblastoma (a hybrid variant): report of a case and review of the literature. Arch Iran Med. 2009;12:304-8. PubMed PMID: 19400611.
12
Brooks JK, Al-Mubarak H, Ribera MJ, Cohen PD, Ross DS, Scheper MA. Diminutive, interradicular "hybrid" desmoplastic/acanthomatous ameloblastoma. Quintessence Int. 2010;41:209-12. PubMed PMID: 20213021.
13
Angadi PV, Kale A, Hallikerimath S, Kotrashetti V, Mane D, Bhatt P, et al. 'Hybrid'desmoplastic ameloblastoma: an unusual case report with immunohistochemical investigation for TGF-[Beta] and review of literature. East J Med. 2011;16:9.-17.
14
Rai R, Reddy SP, Shaik JA, Goyal S, Manjunath S, Sunda V, et al. Hybrid Lesion of Ameloblastoma: A Perplexing Pathological Entity. Journal of Oral Health and Dental Management. 2014;13:998-1003.
15
dos Santos JN, De Souza VF, Azevedo RA, Sarmento VA, Souza LB. "Hybrid" lesion of desmoplastic and conventional ameloblastoma: immunohistochemical aspects. Braz J Otorhinolaryngol. 2006;72:709-13. doi: 10.1016/S1808-8694(15)31030-2. PubMed PMID: 17221066.
16
Dandriyal R, Gupta A, Pant S, Baweja HH. Surgical management of ameloblastoma: Conservative or radical approach. Natl J Maxillofac Surg. 2011;2:22-7. doi: 10.4103/0975-5950.85849. PubMed PMID: 22442605; PubMed Central PMCID: PMC3304226.
17
Seim P, Regezi JA, O'Ryan F. Hybrid ameloblastoma and calcifying epithelial odontogenic tumor: case report. J Oral Maxillofac Surg. 2005;63:852-5. doi: 10.1016/j.joms.2005.02.024. PubMed PMID: 15944987.
18
ORIGINAL_ARTICLE
Preoperative Emboli in a Pregnant Woman with Myxoma
The left atrium is the most common location of myxomas, which are benign tumors. Only a few cases of myxomas in pregnancies have been reported. Our thorough medical literature search showed only 17 reported cases in the course of pregnancy. Myxomas during pregnancy and in the preterm period constitute a serious phenomenon that can mimic an early sign of a life-threatening pathology like severe mitral stenosis. We describe a 33-year-old woman, who presented with acute dyspnea to a gynecology center and was referred to our hospital for further evaluation of pulmonary embolism. Transthoracic echocardiography showed a huge left atrial myxoma, and computed tomography scan illustrated paradoxical pulmonary embolism in the left upper lung lobe via a large patent foramen ovale. The tumor required urgent cardiac surgery. In this article, we review causes of dyspnea in pregnancy and the cardiovascular effects of myxomas in pregnancy. We also describe the pathophysiological effects of cardiopulmonary bypass on the mother, fetus, and the feto-placental system during open-heart surgery. We performed a successful surgical resection of a myxoma in a pregnant woman. Given the rarity of such cases, individual multidisciplinary assessment and management strategies are essential.
https://ijms.sums.ac.ir/article_40371_192678c719115b2321e7491e4d8b1457.pdf
2016-07-01
345
349
Cardiopulmonary bypass
Myxoma
Pregnancy complications
Freidoun
Sabzi
1
Preventive Cardiovascular Research Centre Kermanshah, Kermanshah University of Medical Sciences, Kermanshah, Iran
LEAD_AUTHOR
Reza
Faraji
taha6045@yahoo.com
2
Preventive Cardiovascular Research Centre Kermanshah, Kermanshah University of Medical Sciences, Kermanshah, Iran
AUTHOR
Pinede L, Duhaut P, Loire R. Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases. Medicine (Baltimore). 2001;80:159-72. PubMed PMID: 11388092.
1
Whitlock R, Evans R, Lonn E, Teoh K. Giant left atrial myxoma and associated mitral valve pathology. J Cardiothorac Vasc Anesth. 2007;21:103-5. doi: 10.1053/j.jvca.2005.10.015. PubMed PMID: 17289492.
2
Abbas AE, Lester SJ, Connolly H. Pregnancy and the cardiovascular system. Int J Cardiol. 2005;98:179-89. doi: 10.1016/j.ijcard.2003.10.028. PubMed PMID: 15686766.
3
Veldtman GR, Connolly HM, Grogan M, Ammash NM, Warnes CA. Outcomes of pregnancy in women with tetralogy of Fallot. J Am Coll Cardiol. 2004;44:174-80. doi: 10.1016/j.jacc.2003.11.067. PubMed PMID: 15234429.
4
Dodd JM, Reid K. Tocolysis for assisting delivery at caesarean section. Cochrane Database Syst Rev. 2006:CD004944. doi: 10.1002/14651858.CD004944.pub2. PubMed PMID: 17054225.
5
Yaju Y, Nakayama T. Effectiveness and safety of ritodrine hydrochloride for the treatment of preterm labour: a systematic review. Pharmacoepidemiol Drug Saf. 2006;15:813-22. doi: 10.1002/pds.1317. PubMed PMID: 16981213.
6
Siu SC, Sermer M, Colman JM, Alvarez AN, Mercier LA, Morton BC, et al. Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation. 2001;104:515-21. doi: 10.1161/hc3001.093437. PubMed PMID: 11479246.
7
Drenthen W, Pieper PG, Roos-Hesselink JW, van Lottum WA, Voors AA, Mulder BJ, et al. Outcome of pregnancy in women with congenital heart disease: a literature review. J Am Coll Cardiol. 2007;49:2303-11. doi: 10.1016/j.jacc.2007.03.027. PubMed PMID: 17572244.
8
Khairy P, Ouyang DW, Fernandes SM, Lee-Parritz A, Economy KE, Landzberg MJ. Pregnancy outcomes in women with congenital heart disease. Circulation. 2006;113:517-24. doi: 10.1161/CIRCULATIONAHA.105.589655. PubMed PMID: 16449731.
9
John AS, Connolly HM, Schaff HV, Klarich K. Management of cardiac myxoma during pregnancy: a case series and review of the literature. Int J Cardiol. 2012;155:177-80. doi: 10.1016/j.ijcard.2011.05.069. PubMed PMID: 21715030.
10
Ferrari E, Tozzi P, von Segesser LK. Spontaneous coronary artery dissection in a young woman: from emergency coronary artery bypass grafting to heart transplantation. Eur J Cardiothorac Surg. 2005;28:349-51. doi: 10.1016/j.ejcts.2005.04.035. PubMed PMID: 15949946.
11
Dob DP, Yentis SM. Practical management of the parturient with congenital heart disease. Int J Obstet Anesth. 2006;15:137-44. doi: 10.1016/j.ijoa.2005.07.005. PubMed PMID: 16434181.
12
Matsushita T, Huynh AT, Singh T, Hayes P, Armarego S, Seah PW. Mitral valve annular dilatation caused by left atrial myxoma. Heart Lung Circ. 2009;18:145-7. doi: 10.1016/j.hlc.2007.10.017. PubMed PMID: 18242131.
13
Formica F, Sangalli F, Paolini G. Unusually large left atrial myxoma causing mitral valve occlusion and hiding a severe mitral regurgitation: a case report. Heart Surg Forum. 2006;9:E849-50. doi: 10.1532/HSF98.20061077. PubMed PMID: 17060039.
14
Germing A, Lindstaedt M, Mugge A, Laczkovics A, Fritz M. Severity of mitral regurgitation may be underestimated in the presence of a left atrial myxoma. J Heart Valve Dis. 2006;15:830-2. PubMed PMID: 17152792.
15
ORIGINAL_ARTICLE
An Aortoenteric Fistula Arising after Endovascular Management of a Mycotic Abdominal Aortic Aneurysm Complicated with a Psoas Abscess
Mycotic aortic aneurysms account for 1–3% of all aortic aneurysms. The management of this disease is controversial. Since open surgical repair is associated with high morbidity and mortality rates, endovascular aneurysm repair is an alternative treatment method with promising early and midterm outcomes, although its long-term durability is unknown.Secondary aortoenteric fistulas may occur iatrogenically after either aortic reconstructive surgery or endovascular repair. As the number of aneurysms managed with endovascular aneurysm repair has substantially increased, cases of aortoenteric fistulas referred for endovascular repair are augmented.We report the case of an aortoduodenal fistula manifested with duodenal perforation after staged endovascular and surgical treatment of a mycotic aortic aneurysm.
https://ijms.sums.ac.ir/article_40374_779abae6fb8d2b19aae236ec444be987.pdf
2016-07-01
350
353
Aortic aneurysm
infection
Fistula
Endovascular aortic repair
Aytaç
Gülcü
1
Department of Radiology, Dokuz Eylul
University Faculty of Medicine, Izmir,
Turkey;
AUTHOR
Naciye Sinem
Gezer
drsinemgezer@gmail.com
2
Department of Radiology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey;
LEAD_AUTHOR
Şevket Baran
Uğurlu
baran.ugurlu@deu.edu.tr
3
Department of Cardiovascular Surgery,
Dokuz Eylul University Faculty of
Medicine, Izmir, Turkey
AUTHOR
Ahmet Yiğit
Göktay
4
Department of Radiology, Dokuz Eylul
University Faculty of Medicine, Izmir,
Turkey;
AUTHOR
Clough RE, Black SA, Lyons OT, Zayed HA, Bell RE, Carrell T, et al. Is endovascular repair of mycotic aortic aneurysms a durable treatment option? Eur J Vasc Endovasc Surg. 2009;37:407-12. doi: 10.1016/j.ejvs.2008.11.025. PubMed PMID: 19211280.
1
Sugimoto M, Banno H, Idetsu A, Matsushita M, Ikezawa T, Komori K. Surgical experience of 13 infected infrarenal aortoiliac aneurysms: preoperative control of septic condition determines early outcome. Surgery. 2011;149:699-704. doi: 10.1016/j.surg.2010.12.015. PubMed PMID: 21429546.
2
Vu QD, Menias CO, Bhalla S, Peterson C, Wang LL, Balfe DM. Aortoenteric fistulas: CT features and potential mimics. Radiographics. 2009;29:197-209. doi: 10.1148/rg.291075185. PubMed PMID: 19168845.
3
Tamura K, Yoshitaka H, Totsugawa T, Tsushima Y, Chikazawa G, Ohno T, et al. Bridge use of endovascular repair and delayed open operation for infected aneurysm of aortic arch. Ann Thorac Surg. 2013;96:1471-3. doi: 10.1016/j.athoracsur.2013.01.095. PubMed PMID: 24088465.
4
Woon CY, Sebastian MG, Tay KH, Tan SG. Extra-anatomic revascularization and aortic exclusion for mycotic aneurysms of the infrarenal aorta and iliac arteries in an Asian population. Am J Surg. 2008;195:66-72. doi: 10.1016/j.amjsurg.2007.01.032. PubMed PMID: 18082544.
5
Kan CD, Lee HL, Yang YJ. Outcome after endovascular stent graft treatment for mycotic aortic aneurysm: a systematic review. J Vasc Surg. 2007;46:906-12. doi: 10.1016/j.jvs.2007.07.025. PubMed PMID: 17905558.
6
Strahm C, Lederer H, Schwarz EI, Bachli EB. Salmonella aortitis treated with endovascular aortic repair: a case report. J Med Case Rep. 2012;6:243. doi: 10.1186/1752-1947-6-243. PubMed PMID: 22894684; PubMed Central PMCID: PMC3443667.
7
Forbes TL, Harding GE. Endovascular repair of Salmonella-infected abdominal aortic aneurysms: a word of caution. J Vasc Surg. 2006;44:198-200. doi: 10.1016/j.jvs.2006.03.002. PubMed PMID: 16828445.
8
Jia X, Dong YF, Liu XP, Xiong J, Zhang HP, Guo W. Open and endovascular repair of primary mycotic aortic aneurysms: a 10-year single-center experience. J Endovasc Ther. 2013;20:305-10. doi: 10.1583/13-4222MR.1. PubMed PMID: 23731302.
9
Chenu C, Marcheix B, Barcelo C, Rousseau H. Aorto-enteric fistula after endovascular abdominal aortic aneurysm repair: case report and review. Eur J Vasc Endovasc Surg. 2009;37:401-6. doi: 10.1016/j.ejvs.2008.11.037. PubMed PMID: 19211278.
10
Shree D, Jeppu S, Puneet P, Rani K. Computed tomography diagnosis of a primary aortoduodenal fistula in a patient with a partially thrombosed abdominal aortic aneurysm. Jpn J Radiol. 2010;28:534-7. doi: 10.1007/s11604-010-0457-6. PubMed PMID: 20799019.
11
Saratzis N, Saratzis A, Melas N, Ktenidis K, Kiskinis D. Aortoduodenal fistulas after endovascular stent-graft repair of abdominal aortic aneurysms: single-center experience and review of the literature. J Endovasc Ther. 2008;15:441-8. doi: 10.1583/08-2377.1. PubMed PMID: 18729556.
12
ORIGINAL_ARTICLE
Superior Vena Cava Syndrome due to Thrombosis: A Rare Paraneoplastic Presentation of Bronchogenic Carcinoma
Superior vena cava (SVC) syndrome is not an uncommon occurrence in patients with malignancy and it is often described as a medical emergency. In majority of the cases, SVC syndrome occurs due to mechanical obstruction of the SVC by extraluminal compression with primary intrathoracic malignancies. However, intraluminal obstruction due to thrombosis can also produce symptoms and signs of SVC syndrome. Clot-related SVC obstruction is mostly associated with indwelling central venous catheter and pacemaker leads, although such thrombosis can occur spontaneously in a background of a hypercoagulable state, e.g., malignancy. Here, an unusual case of sudden onset SVC syndrome has been reported, which on initial radiologic evaluation was found to have a lung nodule without any significant mediastinal mass or adenopathy compressing SVC. Subsequent investigation with Doppler ultrasonography of the neck showed thrombosis in the right internal jugular, right subclavian and right brachiocephalic vein, which was responsible for SVC syndrome. Histopathological evaluation of lung nodule confirmed presence of an adenocarcinoma. Therefore, venous thromboembolism as a paraneoplastic syndrome should be kept in mind while evaluating a case of SVC obstruction in a cancer patient. Management of the underlying disease is of prime importance in such cases and anticoagulation is the mainstay of therapy. Ability to identify paraneoplastic syndrome may have a significant effect on clinical outcome, ranging from early diagnosis to improved quality of life of the patient.
https://ijms.sums.ac.ir/article_40376_b8979decc11d6c60d574545035d6ab79.pdf
2016-07-01
354
358
Venous thromboembolism
Paraneoplastic syndrome
Superior vena cava syndrome
Bronchogenic carcinoma
Avradip
Santra
dravradip@gmail.com
1
Department of Pulmonary Medicine, Nilratan Sircar Medical College and Hospital, Kolkata, India
LEAD_AUTHOR
Saumen
Nandi
saumennandi@gmail.com
2
Department of Pulmonary Medicine, Nilratan Sircar Medical College and Hospital, Kolkata, India
AUTHOR
Saibal
Mondal
cnmc_saibal@rediffmail.com
3
Department of Pulmonary Medicine, Nilratan Sircar Medical College and Hospital, Kolkata, India
AUTHOR
Subhankar
Chakraborty
subhanchakra@gmail.com
4
Department of Pulmonary Medicine, Nilratan Sircar Medical College and Hospital, Kolkata, India
AUTHOR
May M, Seehafer M, Helke C, Uberruck T, Gunia S, Hoschke B. [Superior vena cava syndrome with bilateral jugular and subclavian vein thrombosis. Paraneoplastic manifestion of renal cell carcinoma]. Urologe A. 2003;42:1374-7. doi: 10.1007/s00120-003-0401-9. PubMed PMID: 14569387.
1
Kimura T, Chino M, Ogasawara N, Nakano T, Izumi S, Takeuchi H. Trousseau's syndrome with brachiocephalic vein thrombosis in a patient with uterine carcinosarcoma. A case report. Angiology. 1999;50:515-8. doi: 10.1177/000331979905000611. PubMed PMID: 10378829.
2
Silvestri GA, Jett JR. Clinical aspects of lung cancer. In: Mason RJ, Broaddus VC, Martin TR, King TE Jr, Schraufnagel DE, Murray JF, Nadel JA, editors. Murray and Nadelâs Textbook of Respiratory Medicine. 5th ed. Vol. 2. Philadelphia: Elsevier Saunders; 2010. p. 1116-44.
3
Heinemann S, Zabel P, Hauber H-P. Paraneoplastic syndromes in lung cancer. Cancer Therapy. 2008;6:687-98.
4
Pelosof LC, Gerber DE. Paraneoplastic syndromes: an approach to diagnosis and treatment. Mayo Clin Proc. 2010;85:838-54. doi: 10.4065/mcp.2010.0099. PubMed PMID: 20810794; PubMed Central PMCID: PMC2931619.
5
Tesselaar ME, Osanto S. Risk of venous thromboembolism in lung cancer. Curr Opin Pulm Med. 2007;13:362-7. doi: 10.1097/MCP.0b013e328209413c. PubMed PMID: 17940477.
6
Shaikh I, Berg K, Kman N. Thrombogenic catheter-associated superior vena cava syndrome. Case Rep Emerg Med. 2013;2013:793054. doi: 10.1155/2013/793054. PubMed PMID: 24194987; PubMed Central PMCID: PMC3806322.
7
Khorana AA. Cancer-associated thrombosis: updates and controversies. Hematology Am Soc Hematol Educ Program. 2012;2012:626-30. doi: 10.1182/asheducation-2012.1.626. PubMed PMID: 23233644.
8
Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, et al. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 2003;349:146-53. doi: 10.1056/NEJMoa025313. PubMed PMID: 12853587.
9
Palumbo A, Cavo M, Bringhen S, Zamagni E, Romano A, Patriarca F, et al. Aspirin, warfarin, or enoxaparin thromboprophylaxis in patients with multiple myeloma treated with thalidomide: a phase III, open-label, randomized trial. J Clin Oncol. 2011;29:986-93. doi: 10.1200/JCO.2010.31.6844. PubMed PMID: 21282540.
10
ORIGINAL_ARTICLE
A Rare Complication with the Concomitant use of Warfarin and Nonsteroidal Anti-Inflammatory Drugs: Hemoperitoneum and Intramural Small Bowel Hematoma
https://ijms.sums.ac.ir/article_40368_510658d4b41b8f48c57a8574bb096804.pdf
2016-07-01
359
360
Fatma
Yıldırım
fatma_bodur2000@yahoo.com
1
Intensive Care Unit, Department of Pulmonary Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
LEAD_AUTHOR
İskender
Kara
driskenderkara@gmail.com
2
Intensive Care Unit, Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, Ankara, Turkey
AUTHOR
Burcu
Bilaloğlu
burcubilaloglu@yahoo.com
3
Intensive Care Unit, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
AUTHOR
Gonca
Erbas
gerbas@yahoo.com
4
Department of Radiology, Gazi University Faculty of Medicine, Ankara, Turkey
AUTHOR
Melda
Türkoglu
5
Intensive Care Unit, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
AUTHOR
Gülbin
Aygencel
6
Intensive Care Unit, Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey
AUTHOR
van Dijk KN, Plat AW, van Dijk AA, Piersma-Wichers M, de Vries-Bots AM, Slomp J, et al. Potential interaction between acenocoumarol and diclofenac, naproxen and ibuprofen and role of CYP2C9 genotype. Thromb Haemost. 2004;91:95-101. doi: 10.1160/TH03-05-0325. PubMed PMID: 14691574.
1
Stading JA, Skrabal MZ, Faulkner MA. Seven cases of interaction between warfarin and cyclooxygenase-2 inhibitors. Am J Health Syst Pharm. 2001;58:2076-80. PubMed PMID: 11715832.
2
Schaefer MG, Plowman BK, Morreale AP, Egan M. Interaction of rofecoxib and celecoxib with warfarin. Am J Health Syst Pharm. 2003;60:1319-23. PubMed PMID: 12901032.
3
Altikaya N, Parlakgumus A, Demir S, Alkan O, Yildirim T. Small bowel obstruction caused by intramural hematoma secondary to warfarin therapy: a report of two cases. Turk J Gastroenterol. 2011;22:199-202. PubMed PMID: 21796559.
4
Abdel Samie A, Sun R, Huber A, Hopfner W, Theilmann L. Spontaneous intramural small-bowel hematoma secondary to anticoagulant therapy: a case series. Med Klin Intensivmed Notfmed. 2013;108:144-8. doi: 10.1007/s00063-012-0184-0. PubMed PMID: 23135686.
5
ORIGINAL_ARTICLE
Recurrent Acute Pancreatitis: A Diagnostic Clue to Primary Hyperparathyroidism
https://ijms.sums.ac.ir/article_40367_a1365560b1517fd71f5c54a520d94167.pdf
2016-07-01
361
362
Sampan S.
Bist
1
Department of ENT, Himalayan Institute of Medical Sciences, SHRU University, Jolly-grant, Doiwala, Dehrdun 248140 (Uttarakhand) India
LEAD_AUTHOR
Vivek
Ahuja
vahuja@gmail.com
2
Department of Gastroenterology, Himalayan Institute of Medical Sciences, SHRU University, Jolly-grant, Doiwala, Dehrdun 248140 (Uttarakhand) India
AUTHOR
Vinish
Agarwal
vagarwal@gmail.com
3
Department of ENT, Himalayan Institute of Medical Sciences, SHRU University, Jolly-grant, Doiwala, Dehrdun 248140 (Uttarakhand) India
AUTHOR
Sagar
Modi
smodi@gmail.com
4
Department of Endocrinology, Himalayan Institute of Medical Sciences, SHRU University, Jolly-grant, Doiwala, Dehrdun 248140 (Uttarakhand) India
AUTHOR
Egea Valenzuela J, Belchi Segura E, Sanchez Torres A, Carballo Alvarez F. Acute pancreatitis associated with hypercalcemia. A report of two cases. Rev Esp Enferm Dig. 2009;101:65-9. doi: 10.4321/S1130-01082009000100009. PubMed PMID: 19335036.
1
Jacob JJ, John M, Thomas N, Chacko A, Cherian R, Selvan B, et al. Does hyperparathyroidism cause pancreatitis? A South Indian experience and a review of published work. ANZ J Surg. 2006;76:740-4. doi: 10.1111/j.1445-2197.2006.03845.x. PubMed PMID: 16916398.
2
Agarwal A, George RK, Gupta SK, Mishra SK. Pancreatitis in patients with primary hyperparathyroidism. Indian J Gastroenterol. 2003;22:224-5. PubMed PMID: 15030035.
3
Bai HX, Giefer M, Patel M, Orabi AI, Husain SZ. The association of primary hyperparathyroidism with pancreatitis. J Clin Gastroenterol. 2012;46:656-61. doi: 10.1097/MCG.0b013e31825c446c. PubMed PMID: 22874807; PubMed Central PMCID: PMC4428665.
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