ORIGINAL_ARTICLE
Awareness and Observance of Patient Rights from the Perspective of Iranian Patients: A Systematic Review and Meta-Analysis
Background: Recipients of healthcare services have rights, which must be acknowledged and protected. Such rights include observance of acceptable patient physical, mental, spiritual, and social needs guided by commonly accepted rules and regulations. The objective of this study was to conduct a systematic review and meta-analysis of awareness rates and observance of patient rights in Iran from the perspective of the patient.Methods: In this study, various references such as Medline (PubMed), Scopus, Scientific Information Database (SID), Google scholar, Magiran, and IranMedex were searched (from August to December 2015). Heterogeneity was assessed using the Q statistic. English and Persian search keywords and combinations included terms such as “patient bill of rights, patient rights, Iranian patient bill of rights, and Persian patient rights.” A meta-analysis of the primary search sources was accomplished using STATA (version 11.0).Results: Initial review included 20 articles of which 12 assessed observance rates of patient rights and three described service awareness rates of recipients concerning their personal rights. Five articles covered both topics and had an estimated 54.2% coverage based on the results of meta-analysis and the random-effects model with the heterogeneity.Conclusion: An Observance rate of patient bills of rights was considered somewhat adequate. However, contradictions in findings noted in this study suggest deficiencies do exist and need to be resolved. There appears a need to better describe and increase awareness rates of healthcare services by patients concerning their own bill of rights.
https://ijms.sums.ac.ir/article_40442_62a35e76f84f715022bba4eb881c34fc.pdf
2016-12-31
227
234
Patient rights
Patients
Meta-analysis
Awareness
Ghassem
Abedi
iq134589@yahoo.com
1
Department of Health Care Management, Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Jalil
Shojaee
jshojaee@yahoo.com
2
Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Mahmod
Moosazadeh
3
Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Farideh
Rostami
rostamimaskopaii@gmail.com
4
Indiana University School of Dentistry, Indianapolis, IN, USA
AUTHOR
Aliasghar
Nadi
statistic.nadi@gmail.com
5
Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Ehsan
Abedini
6
Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Charles
Palenik
7
Indiana University School of Dentistry, Indianapolis, IN, USA
AUTHOR
Mehrdad
Askarian
askariam@sums.ac.ir
8
Department of Community Medicine, Shiraz Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Local Infiltration of Tramadol versus Bupivacaine for Post Cesarean Section Pain Control: A Double-Blind Randomized Study
Background: Postoperative pain control after cesarean section (C/S) is important because inadequate postoperative pain control can result in a prolonged hospital stay. In this study, we compared postoperative somatic wound pain control between patients receiving tramadol and bupivacaine, infiltrated at the wound site.Methods: In this randomized clinical trial, 98 patients, eligible for elective C/S under general anesthesia, were randomly allocated to 2 groups. Before wound closure, 20 cc of 0.025% bupivacaine and 2 mg/kg of tramadol, diluted to 20 cc, were infiltrated at the wound site in groups A and B, respectively. After surgery, the pain score was measured using the visual analogue scale (VAS). Additionally, 24-hour total morphine consumption, nausea and vomiting, and respiratory depression were compared after 2, 4, 8, 16, and 24 hours between the 2 groups. The data were analyzed using SPSS with the Student independent t test, χ2 test, Fisher exact test, and repeated measure test.Results: Postoperatively, there was no significant difference between these 2 groups in their VAS scores until 16 hours (P>0.05). However, at the 16th and 24th hours, the mean VAS scores were 3.20±2.24 and 2.51±2.55 in the bupivacaine group and 2.51±0.99 and 1.40±0.88 in the tramadol group, respectively (P<0.05). There was no difference in nausea and vomiting during the 24-hour period between the 2 groups. Also, no respiratory depression was detected in the both groups.Conclusion: Local infiltration of tramadol (2 mg/kg) at the incision site of C/S was effective in somatic wound pain relief without significant complications.Trial Registration Number: IRCT2013070111662N2
https://ijms.sums.ac.ir/article_40445_53db94000db4a933e29ed0c0efbe7935.pdf
2017-01-21
235
241
Tramadol
Bupivacaine
Cesarean Section
Pain
Postoperative
Mohammad Ali
Sahmeddini
sahmeddini@sums.ac.ir
1
Department of Anesthesiology, Shiraz Anesthesiology and Intensive Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Simin
Azemati
azemati@sums.ac.ir
2
Department of Anesthesiology, Shiraz Anesthesiology and Intensive Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Ehsan
Masoudi Motlagh
ehsanm135@yahoo.com
3
Department of Anesthesiology, Shiraz Anesthesiology and Intensive Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
α-Lipoic Acid Mitigates Arsenic-Induced Hematological Abnormalities in Adult Male Rats
Background: Arsenic toxicity is a major global health problem and exposure via contaminated drinking water has been associated with hematological and other systemic disorders. The present investigation has been conducted in adult male rats to evaluate the protective ability of α-lipoic acid (ALA) against such hematological disorders.Methods: Twenty-four adult male Wister rats (b.wt.130±10g) were grouped and accordingly group I (control) received the normal diet, group II (treated) was given arsenic orally for 28 consecutive days as arsenic trioxide (3 mg/kgbw/rat/day) whereas group III (supplemented) received the same dose of arsenic along with ALA (25 mg/kgbw/rat/day) as oral supplement. Hematological profile, plasma oxidant/antioxidant status, and erythrocyte morphology were assessed. Statistical analysis was done by one-way ANOVA using SPSS software (version 16.0). Results: Arsenic exposure caused reduction of erythrocyte (P=0.021), leucocyte (P<0.001), and hemoglobin (P=0.031) associated with echinocytic transformation as evidenced by light and scanning electron microscopic studies. The other significantly altered parameters include increased mean corpuscular volume (P=0.041) and lymphocytopenia (P<0.001) with insignificant neutropenia and eosinophilia. Altered serum oxidative balance as evidenced by decreased TAS (P<0.001) and increased TOS (P<0.001) with OSI (P<0.001) was also noted. The dietary supplementation of ALA has a beneficial effect against the observed (P<0.05) arsenic toxicities. It brings about the protection by restoring the hematological redox and inflammatory status near normal in treated rats. Arsenic-induced morphological alteration of erythrocytes was also partially attenuated by ALA supplementation.Conclusion: It is concluded that arsenicosis is associated with hematological alterations and ALA co-supplementation can partially alleviate these changes in an experimental male rat model.
https://ijms.sums.ac.ir/article_40447_85c764292317d6bd3154ed7b421905d9.pdf
2017-01-07
242
250
Arsenic
α-lipoic acid
Hematology
Erythrocytes
Oxidative stress
Sonali
Ghosh
1
Department of Biological Sciences, Presidency University, Kolkata, India;
AUTHOR
Raghwendra
Mishra
2
Department of Physiology, University of Calcutta, Kolkata, India; and Department of Physiology, Ananda Mohan College, University of Calcutta, Kolkata, India;
AUTHOR
Sagnik
Biswas
3
Department of Biological Sciences, Presidency University, Kolkata, India;
AUTHOR
Rupak
Bhadra
4
Department of Infectious Diseases & Immunology, CSIR-Indian Institute of Chemical Biology, Kolkata, India
AUTHOR
Prabir
Mukhopadhyay
prabir.dbs@presiuniv.ac.in
5
Department of Biological Sciences, Presidency University, Kolkata, India;
LEAD_AUTHOR
ORIGINAL_ARTICLE
Comparison of Early Results and Complications between Multi-and Single-Port Sleeve Gastrectomy: A Randomized Clinical Study
AbstractBackground: In recent years, laparoscopic sleeve gastrectomy (LSG) has become more acceptable for obese patients. Single-port sleeve gastrectomy (SPSG) is more popular since each abdominal incision carries the risk of bleeding, hernia, and internal organ injury as well as exponentially affecting cosmesis. This cross-sectional study aimed at comparing multi-port sleeve gastrectomy (MPSG) and SPSG in terms of their early results and complications. Methods: Out of129 obese patients candidated for LSG, 102 patients were assigned to 2 groups of SPSG and MPSG. Complications and demographic data such as body mass index (BMI), age, gender, operation time, and hospital stay were measured. All surgeries were carried out between2013 and 2015 in Shiraz, Iran. Data analysis was performed using SPSS, version 16 for Windows (SPSS Inc., Chicago, IL). The continuous and categorical variables were compared using the Student t-test and the Chi-square test or the Fisher exact test, respectively. Results: The patients’ data from both groups were similar in terms of age, intraoperative and postoperative bleeding volume, and length of hospital stay. Mean BMI was 42.8±0.7 in the SPSG group and 45.3±1.2 in the MPSG group. Duration of surgery was significantly lower in the SPSG group (P<0.001). Only 1 patient from the SPSG group and 5 patients from the MPSG group had bleeding as an early complication.Conclusion: The differences in each complication between the groups were not statistically significant. SPSG seems to be safe and is the same as MPSG in terms of major postoperative complications.Trial Registration Number: IRCT201512229936N12
https://ijms.sums.ac.ir/article_40450_4a6b24470f862b06da3136699890720a.pdf
2017-01-03
251
257
Complications
Bariatric surgery
Gastrectomy
Single port
Seyed Vahid
Hosseini
hoseiniv@sums.ac.ir
1
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Seyed Ali
Hosseini
hoseini_a@sums.ac.ir
2
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Ahmed
Al-Hury
surgen73@yahoo.com
3
Department of Surgery, Najaf University of Medical Sciences, Kerbala, Iraq
AUTHOR
Hajar
Khazraei
colorectal92@yahoo.com
4
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Fatemeh
Ganji
5
Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Fatemeh
Sadeghi
shahrzad0100@gmail.com
6
Department of Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
ORIGINAL_ARTICLE
In Vitro Radiosensitizing Effects of Temozolomide on U87MG Cell Lines of Human Glioblastoma Multiforme
Background: Glioma is the most common primary brain tumor with poor prognosis. Temozolomide (TMZ) has been used with irradiation (IR) to treat gliomas. The aim of the present study was to evaluate the cytotoxic and radiosensitizing effect of TMZ when combined with high-dose and high-dose rate of gamma irradiation in vitro.Methods: Two ‘U87MG’ cell lines and skin fibroblast were cultured and assigned to five groups for 24, 48, and 72 hours. The groups were namely, TMZ group (2000 μM/L), IR group (5 Gy), TMZ plus IR group, control group, and control solvent group. MTT assay was applied to evaluate cell viability. Data were analyzed with SPSS 21.0 software using one-way ANOVA and Kruskal-Wallis test. P<0.05 were considered statistically significant.Results: The slope of growth curve U87MG cells in semi-logarithmic scale was equal to 27.36±0.89 hours. The viability of cells was determined for different TMZ and IR treatment groups. In terms of cell viability, there were no significant differences between the control and control solvent groups (P=0.35) and between treated group by IR (5 Gy) alone and TMZ (2000 μM/ml) alone (P=0.15). Data obtained for the cell viability of combined TMZ plus IR in both cell lines compared to TMZ or IR treated group alone showed a significant difference (P=0.002). Conclusion: The evaluation of cells viability showed that TMZ in combination with IR on glioma cells led to a significant radiosensitivity compared to IR alone.
https://ijms.sums.ac.ir/article_40452_95ad0de4e91f9379eee357ada7e8d895.pdf
2017-01-03
258
265
Glioblastoma
Radiation-sensitizing agents
Temozolomide
Radiotherapy
Samira
Borhani
s.borhani2014@gmail.com
1
Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Hossein
Mozdarani
mozdarah@modares.ac.ir
2
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
LEAD_AUTHOR
Somayyeh
Babalui
3
Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mohsen
Bakhshandeh
bakhshandeh@yahoo.com
4
Department of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Hassan
Nosrati
5
Radiotherapy Oncology Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
Antihypertensive Effects of Hydroalcoholic Extract of Crataegus Azarolus Subspecies Aronia Fruit in Rats with Renovascular Hypertension: An Experimental Mechanistic Study
Background: Hawthorn species decreases blood pressure and relaxes precontracted vessels. This study aimed at examining the antihypertensive effect and related mechanisms of hydroalcoholic extract of Crataegus azarolus subspecies aronia fruit in rats with renovascular hypertension.Methods: Six groups of male Sprague-Dawley rats, each containing 6 to 8 rats, were studied. The groups comprised of one sham group and 5 renal artery-clipped groups. The sham group received vehicle (distilled water 0.5 ml/day) and the renal artery-clipped groups received vehicle or the extract at 5, 10, 20 or 30 mg/kg/day. Oral vehicle or extract was administered daily for 4 weeks following sham-operation or induction of hypertension. Systolic blood pressure and heart rate were measured weekly. Isolated aorta study was performed by last week and serum superoxide dismutase and glutathione reductase were measured. The findings were analyzed using one-way analysis of variance and Duncan’s multiple range tests at P≤0.05 using SigmaStat software.Results: The data obtained after 4 weeks of treatment showed that the renal artery-clipped group receiving vehicle had significantly higher systolic blood pressure (P=0.002) and phenylephrine maximal response (P=0.01); and lower acetylcholine maximal response (P=0.01), serum superoxide dismutase (P=0.006) and serum glutathione reductase (P=0.006) than those of the sham group. The renal artery-clipped group receiving extract had significantly lower systolic blood pressure (P=0.03) and phenylephrine maximal response (P=0.01); and significantly higher acetylcholine maximal response (P=0.01), serum superoxide dismutase (P=0.015), and serum glutathione reductase (P=0.015) than those of the renal artery-clipped group receiving vehicle.Conclusion: Our findings show that the hydroalcoholic extract of Crataegus azarolus subspecies aronia fruit has antihypertensive effects, which may be partly due to antioxidant and nitric oxide releasing effects.
https://ijms.sums.ac.ir/article_40453_056bc8e87be9bcda76ff3241eac1dc2c.pdf
2016-12-31
266
274
Crataegus
Renovascular
Nitric oxide
Oxidative stress
Hypertension
Mohammad Reza
Haydari
1
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mohammad Reza
Panjeshahin
panjeshm@sums.acir
2
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Elaheh
Mashghoolozekr
3
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Ali Akbar
Nekooeian
nekooian@yahoo.com
4
Cardiovascular Pharmacology Research Lab, Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
IFN-γ and IL-2 Responses to Recombinant AlaDH against ESAT-6/CFP-10 Fusion Antigens in the Diagnosis of Latent versus Active Tuberculosis Infection
Background: Discriminating latent tuberculosis infection (LTBI) from active TBI may be challenging. The objective of this study was to produce the recombinant L-alanine dehydrogenase (AlaDH) antigen and evaluate individuals with LTBI, those with active TBI, and uninfected individuals by enzyme-linked immunospot assay (ELISPOT) in order to distinguish LTBI from active TBI.Methods: This exploratory study was performed in the Iranian city of Shiraz from 2014 to 2015. The study population (N=99) was divided into 3 groups: individuals with newly diagnosed active TBI (n=33), their household contacts (n=33), and controls (n=33). AlaDH was produced through PCR and cloning methods. The diagnostic characteristics of AlaDH vs. ESAT-6/CFP-10 were evaluated in responses to interferon-γ (IFN-γ) and interleukin-2 (IL-2) with ELISPOT. Differences between the groups were assessed with the Kruskal–Wallis and Mann–Whitney tests for nonparametric data analysis. The statistical analyses were performed with SPSS, version 16.Results: IFN-γ responses to both ESAT-6/CFP-10 (P=0.81) and AlaDH (P=0.18) revealed that there were no significant differences between the individuals with LTBI and those with active TBI. The same results were determined for IL-2 responses to ESAT-6/CFP-10 between the 2 groups, while significantly higher IL-2 responses to AlaDH were observed in LTBI than in active TBI. According to the ROC curve analysis, a cutoff value of 275 SFC showed sensitivity of 75.8% and specificity of 78.8% for distinguishing LTBI from active TBI by IL-2 responses to AlaDH.Conclusion: The current study suggests that it may be possible to discriminate LTBI from active TBI by IL-2 responses to AlaDH.
https://ijms.sums.ac.ir/article_40454_8e98b85c1aafcdf20c938bac82be79a9.pdf
2017-03-04
275
283
Enzyme-linked immunospot assay
Interferon-gamma
Interleukin-2
Mycobacterium Tuberculosis
Bahram
Movahedi
1
Recombinant Protein Laboratory, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Pooneh
Mokarram
mokaram2@yahoo.com
2
Recombinant Protein Laboratory, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Gastroenterohepatology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mina
Hemmati
3
Department of Biochemistry, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Nader
Mosavari
mosavari@rvsri.ac.ir
4
Department of PPD Tuberculin, Razi Vaccine and Serum Research Institute, Tehran, Iran
AUTHOR
Razie
Zare
zare.razie@gmail.com
5
Recombinant Protein Laboratory, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Leila
Safaee Ardekani
leilasafaee@yahoo.com
6
Recombinant Protein Laboratory, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Zohreh
Mostafavi-Pour
zmostafavi@sums.ac.ir
7
Recombinant Protein Laboratory, Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
The Interaction between Trolox and 4,4’-diisothiocyanatostilbene-2,2’-disulfonic Acid on Hypoxic Pulmonary Vasoconstriction in the Isolated Rabbit Lung
Background: The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion exchanger in acute HPV. Methods: The present study was performed in the isolated rabbit lung. After preparation, the lungs were divided into four hypoxic groups of control, Trolox (antioxidant)-treated, 4,4’-diisothiocyanatostilbene-2,2’-disulfonic acid (DIDS, anion exchanger inhibitor)-treated, and Trolox+DIDS-treated. Pulmonary artery pressure, left atrial pressure, and lung weight were continuously registered and PVR was then calculated. PO2, PCO2, HCO3-, pH, and NO metabolites of the perfusate were measured during steady-state and at the end of experiments (30 minutes). All data were compared with ANOVA and t-test and significance was considered when P<0.05.Results: Ventilation of the lungs with hypoxic gas induced HPV in the control group. DIDS did not have a further effect on HPV compared with the control group. The combination of Trolox and DIDS decreased HPV rather than Trolox per se at 5 minutes. Furthermore, HPV was abolished in both the Trolox and Trolox+DIDS groups at 30 minutes. Concentrations of NO metabolites in the Trolox+DIDS group were more than other groups.Conclusions: The present study indicates a possible interaction between ROS and anion exchanger in acute HPV. It also suggests the modulatory effect of NO at above condition.
https://ijms.sums.ac.ir/article_40455_b5c093470f12565d4b377398fe09a33e.pdf
2017-01-07
284
291
4
4’-diisothiocyanostilbene-2
2’-disulfonic acid
Hypoxia
Lung
6-hydroxy-2
5
7
8-tetramethylchroman-2-carboxylic acid
Somayh
Mansoori
1
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Seyed Mostafa
Shid Moosavi
2
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Farzaneh
Ketabchi
ketabchif@sums.ac.ir
3
Department of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Validity and Reliability Assessment of the Persian Version of Therapy-Related Symptom Checklist
AbstractTherapy-related symptom checklist for children (TRSC-C) was developed as a symptom assessment tool in children receiving chemotherapy. The objective of the present study was to evaluate the validity and reliability of the Persian version of TRSC-C. This cross-sectional study was conducted in 2013-2014 in Tehran, Iran. TRSC-C was translated using backward-forward approach. The content validity, face validity, and comprehensiveness were investigated based on the opinion of experts. The item content validity index (I-CVI) and scale content validity index (S-CVI) were calculated by the mean approach and inter-rater agreement. The scale was revised based on the comments from a team of five experts, after which it was evaluated by an additional group of four experts. To assess the inter-rater reliability, two raters filled the scale with 29 and 30 patients in the outpatient clinic of Hazrat-e Ali Asghar Hospital. The Cronbach’s alpha was calculated and factor analysis was performed. The scores of content validity were analyzed in Excel. Other statistical analyses were performed using the SPSS software version 20.0. Based on the initial assessment, the S-CVI with less conservative approach was 60% for clarity, 33% for relevancy, and 60% for simplicity. After revising the scale, the S-CVI reached 100%. The comprehensiveness and face validity of the scale were appropriate. The scale was inter-rater reliable and the Cronbach’s alpha was 0.803. Eleven subscales were found in the TRSC-C. It is concluded that the Persian TRSC-C is a valid and reliable tool for measuring children symptoms. Availability of a valid and reliable checklist is a fundamental step in monitoring the symptoms of patients while receiving chemotherapy.
https://ijms.sums.ac.ir/article_40443_54c37b07ccdaddcc95cc26340718acff.pdf
2016-12-31
292
300
Pediatrics
Medical oncology
Reproducibility of results
Therapy-related symptom checklist
Ava
Mansouri
ava_mansouri_j@yahoo.com
1
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Rozita
Motaghedi
rozita.motaghedi@yahoo.com
2
School of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Arash
Rashidian
arashidian@tums.ac.ir
3
Department of Global Health and Public Policy, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Asieh
Ashouri
a.ashouri@gmail.com
4
School of Health, Guilan University of Medical Sciences, Rasht, Iran
AUTHOR
Mona
Kargar
mkargar@razi.tums.ac.ir
5
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Moluk
Hajibabaei
mhadjibabaie@yahoo.com
6
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Kheirollah
Gholami
khgolami@tums.ac.ir
7
Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Shahla
Ansari
shahladamavandi@yahoo.com
8
Department of Hematology and Oncology, Ali Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
ORIGINAL_ARTICLE
Relationship between Body Mass Index, Waist-to-Hip Ratio, and Serum Lipid Concentrations and Thyroid-Stimulating Hormone in the Euthyroid Adult Population
Background: The aim of this cross-sectional study was to investigate the relationship between body mass index (BMI), waist-to-hip ratio, and lipid parameters and serum thyroid-stimulating hormone (TSH) levels in healthy euthyroid individuals.Methods: This cross-sectional study was conducted between June 1st and July 20th, 2013, at Bushehr University of Medical Sciences. One hundred forty euthyroid individuals were divided into 2 groups: a high-TSH group (TSH between 2.0 and 5.5 mIU/L, n=67) and a low-TSH group (TSH between 0.3 and 2.0 mIU/L, n=73). After overnight fast, total cholesterol, triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), TSH, thyroxine (T4), and triiodothyronine (T3) were measured. Height and weight were measured with a stadiometer, and BMI was calculated as weight in kilograms divided by the square of height in meters. Waist-to-hip ratio was determined as waist circumference divided by hip circumference. The simple independent t-test and a general linear model were used for statistical analysis. All statistical analyses were done using the SPSS, version 15, statistical software package.Results: BMI and LDL-C were significantly higher in the high-TSH group than in the low-TSH group after adjustment for age, sex, calorie intake, total fat and carbohydrate intakes, and physical activity. No significant differences were found between the groups in TG, cholesterol, and HDL-C. The association between TSH levels andT4 was significant.Conclusion: Individuals with TSH levels at the upper limit of normality might be at risk of hypercholesterolemia and obesity.
https://ijms.sums.ac.ir/article_40448_9c6257e6b0cda8f084ea850f13fe298e.pdf
2017-01-24
301
305
Dyslipidemias
Obesity
Thyrotropin
Ali Reza
Rahbar
1
Persian Gulf Tropical Medicine Research Center, Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
LEAD_AUTHOR
Mohamadreza
Kalantarhormozi
m.kalantarhormozi111@yahoo.com
2
Persian Gulf Tropical Medicine Research Center, Department of Endocrinology, Bushehr University of Medical Sciences, Bushehr, Iran
AUTHOR
Fatemeh
Izadi
fatemeh.izadi1993@yahoo.com
3
Persian Gulf Tropical Medicine Research Center, Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
AUTHOR
Elham
Arkia
elham.arkia@yahoo.com
4
Persian Gulf Tropical Medicine Research Center, Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
AUTHOR
Marzie
Rashidi
mrzie.rashid@yahoo.com
5
Persian Gulf Tropical Medicine Research Center, Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
AUTHOR
Fatemeh
Pourbehi
pourbehi.fatemeh@yahoo.com
6
Persian Gulf Tropical Medicine Research Center, Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
AUTHOR
Farzaneh
Daneshifard
fa.daneshi@yahoo.com
7
Persian Gulf Tropical Medicine Research Center, Department of Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran
AUTHOR
Amin
Rahbar
aminrahbar.iran@yahoo.com
8
Persian Gulf Tropical Medicine Research Center, Department of Endocrinology, Bushehr University of Medical Sciences, Bushehr, Iran
AUTHOR
ORIGINAL_ARTICLE
Olanzapine-Induced Neuroleptic Malignant Syndrome
Neuroleptic malignant syndrome (NMS) is a rare but life-threatening idiosyncratic side effect resulting from neuroleptic drugs. NMS mainly occurs in patients treated with high-potency typical antipsychotics, but rarely caused by atypical antipsychotics. Although NMS is less common with atypical antipsychotic, but it seems that its incidence is rising due to increased administration of such drugs. We present the case of a 27-year-old man with a history of paranoid schizophrenia that showed signs consistent with NMS that occurred after treatment with olanzapine. The patient was adherent to treatment. He had decreased level of consciousness, muscle rigidity, diaphoresis, fever, drooling, urinary incontinence, and high blood pressure. This patient illustrates that NMS can occur due to treatment with atypical antipsychotic drugs like olanzapine, particularly in the presence of risk factors. This phenomenon is often unrecognized, underdiagnosed, or not treated properly. Physicians should be aware that NMS with extrapyramidal syndrome could occur with olanzapine at steady state doses without recent dosage adjustments or titration. It is essential that adequate and safe dose of medication is chosen and the patient is monitored by the signs and symptoms of this lethal syndrome.
https://ijms.sums.ac.ir/article_40444_121d17285edbde425e7015c0136fed89.pdf
2017-01-03
306
309
Neuroleptic malignant syndrome
Olanzapine
Drug-related side effects
Seyedhamze
Hosseini
1
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Department of Psychiatry, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
AUTHOR
Forouzan
Elyasi
forouzan.el@gmail.com
2
Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Department of Psychiatry, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Bicuspid Aortic Valve: An Unusual Cause of Aneurysm of Left Coronary Sinus of Valsalva
Bicuspid aortic valve is traditionally considered an innocuous congenital anomaly. Due to a better and widespread availability of non-invasive imaging techniques, it has come to the fore that 30% of these cases develop complications, viz., valve abnormality (aortic regurgitation and stenosis), and aneurysm of aortic root and ascending aorta. Sinus of Valsalva aneurysm is an uncommon complication of bicuspid aortic valve and more so those arising from the left coronary sinus are the rarest. These complications generally occur in the third or fourth decade of life.We present a case of the left sinus of Valsalva aneurysm in conjunction with bicuspid aortic valve and ascending aorta aneurysm at a very young age in a girl in her early adolescence. This case is to remind the paediatricians about the not so “innocuous image”, but the serious implications of the bicuspid aortic valve and to regularly follow these cases for early diagnosis of potential complications so as to prevent catastrophic outcomes.
https://ijms.sums.ac.ir/article_40446_792fd56388063393f6c00f660284bf08.pdf
2016-12-31
310
313
Bicuspid aortic valve
Sinus of valsalva
Aortic aneurysm
Euden
Bhutia
dreden3108@gmail.com
1
Department of Neonatology and Pediatric Medicine, PGIMER, Dr. RML Hospital, New Delhi, India
AUTHOR
Dinesh
Kumar
dineshkumar169@yahoo.co.in
2
Department of Neonatology and Pediatric Medicine, PGIMER, Dr. RML Hospital, New Delhi, India
LEAD_AUTHOR
Binoy
Shankar
binoypmch@gmail.com
3
Department of Neonatology and Pediatric Medicine, PGIMER, Dr. RML Hospital, New Delhi, India
AUTHOR
Shakti
Das
dr.shakti19@gmail.com
4
Department of Neonatology and Pediatric Medicine, PGIMER, Dr. RML Hospital, New Delhi, India
AUTHOR
Sunil
Kishore
dr.sunil2k2@gmail.com
5
Department of Neonatology and Pediatric Medicine, PGIMER, Dr. RML Hospital, New Delhi, India
AUTHOR
ORIGINAL_ARTICLE
Angular Ectopic Pregnancy Presenting as Rupture of Lateral Wall of the Uterus: Late Presentation in Gestation Week 20
The differential diagnosis of acute abdominal pain in pregnancy is broad and can be complicated by atypical manifestations that are due to the anatomic distortions and physiologic changes of pregnancy. Due to the lack of clinical understanding, angular pregnancy does not appear to be recognized as a clinical entity and many cases are likely to go undiagnosed. This is a case report of a 34-year-old woman who was referred to the obstetrics emergency department with sudden abdominal pain and in a state of hypovolemic shock. She had 20 weeks amenorrhea with a positive blood pregnancy test. She underwent laparatomy with internal hemorrhage diagnosis. During the emergency laparotomy, the authors were surprised to encounter the conceptus of 20 weeks angular pregnancy extruded through the left lateral angulation of uterine cavity. The placenta and amnion were removed and the uterine was repaired.
https://ijms.sums.ac.ir/article_40449_bd757b2558dd50a99daf4af868962f49.pdf
2016-12-26
314
317
Ectopic pregnancy
Angular pregnancy
Gestational age
Malihe
Hassanzadeh
hassanzadehm@mums.ac.ir
1
Oncologist Gynecologist, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Salme
Dadgar
2
Oncologist Gynecologist, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Yalda
Arian
ariany911@mums.ac.ir
3
Oncologist Gynecologist, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Yousef
Yousefi
yousefiy@mums.ac.ir
4
Endoscopic and Minimally Invasive Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
ORIGINAL_ARTICLE
High-Grade Urothelial Carcinoma of Bladder Transforming to Micropapillary Variant on Follow-Up
Micropapillary variant of urothelial carcinoma (UC) of the bladder is an aggressive tumour, comprising 0.6-6% of all UC. It generally presents with high-grade and stage, and has been reported as having a worse prognosis when compared to traditional UC. We report the case of a 58-year-old man who presented with macroscopic haematuria. The patient was diagnosed with high-grade urothelial carcinoma and returned with recurrence after 16 months. Histopathology after transurethral biopsy revealed a non-muscle invasive high-grade bladder tumour at first presentation, whereas tumour recurrence was reported after 1.5years. The histopathology at recurrence revealed a high-grade, muscle invasive, micropapillary variant of urothelial carcinoma with focal adenomatous morphology. Immunohistochemical expression of CK7+/CK20+ in tumour cells and negativity for PSA, AMACR, and CDX2 in paraffin section helped in identifying the tumour as primary in the urinary bladder. Radical cystectomy was performed and the patient has no distant metastases on follow-up. The specific morphology even within the high-grade urothelial cancer cases is important to discern for proper treatment.
https://ijms.sums.ac.ir/article_40451_cb616ec120cc8fcd321f391e1612e2b1.pdf
2016-12-26
318
321
Transitional cell carcinoma
Micropapillary variant
Bladder
Nitu
Kumari
nitu86mishra@gmail.com
1
National Institute of Pathology, Indian Council of Medical Research, New Delhi, India
AUTHOR
Anupama
Jha
uburra@gmail.com
2
National Institute of Pathology, Indian Council of Medical Research, New Delhi, India
AUTHOR
Pawan
Vasudeva
drpawanvasudeva@gmail.com
3
Deptt of Urology, VMMC and Safdarjung Hospital, New Delhi, India
AUTHOR
Usha
Agrawal
uagrawal@instpath.gov.in
4
National Institute of Pathology, Indian Council of Medical Research, New Delhi, India
LEAD_AUTHOR