Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Sublingual versus Vaginal Misoprostol for the Induction of Labor at Term: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial
79
85
EN
Bahia
Namavar Jahromi
Maternal-Fetal Medicine Research Center, Infertility Research Center, Department of Gynecology and Obstetrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
namavarb@sums.ac.ir
Foroogh
Poorgholam
Student Research Center, Department of Gynecology and Obstetrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Gholamhossein
Yousefi
Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
ghyousefi@sums.ac.ir
Leila
Salarian
Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
lilsalaria@yahoo.com
Background: We sought to compare the effectiveness and safety of sublingual versus vaginal misoprostol for the termination of pregnancy with a live full-term fetus.Methods: This randomized, triple-blind, placebo-controlled clinical trial was performed on 200 primiparous women with normal, singleton, full-term pregnancies candidated for the induction of labor. Sublingual and vaginal tablets containing misoprostol (25 mcg) or placebo in similar shapes were administered every 4 hours until the Bishop score reached above 8. Maternal and neonatal complications and outcomes were compared.Results: There were 100 parturient women in each group. The mean maternal age, gestational age, and Bishop score at the commencement of misoprostol had no statistical differences between the sublingual and vaginal groups. The mean time interval between misoprostol commencement and delivery was 497.10±291.49 and 511.67±08.46 minutes for the sublingual and vaginal groups, correspondingly. Twenty-two women had Cesarean deliveries in the sublingual group versus 14 in the vaginal group. Meconium-stained amniotic fluid was seen in 12 women in the sublingual group and 4 in the vaginal group (P=0.03). Late fetal heart rate deceleration was observed in 8 women in the sublingual group and 4 in the vaginal group (P=0.22). The mean neonatal birth weight, blood gas value at birth, Apgar score, and length of admission time in the neonatal intensive care unit were not different between the 2 groups.Conclusion: Sublingual and vaginal misoprostol had similar effectiveness; however, meconium-stained liquor was observed considerably more frequently with sublingual misoprostol than with vaginal misoprostol.Trial Registration Number: IRCT201402096541N3
Induced labor,Misoprostol,Pregnancy,Sublingual administration,Vaginal absorption
https://ijms.sums.ac.ir/article_40339.html
https://ijms.sums.ac.ir/article_40339_dc88b375e528e2bbeae18911449c7d01.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Level of Agreement between Children with Asthma and their Parents on Quality of Life
86
93
EN
Maryam
Khoshkhui
Department of Allergy and Clinical Immunology, Mashhad University of Medical Sciences, Mashhad, Iran
khoshkhuim@sums.ac.ir
Peyman
Jafari
Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
jafarip@sums.ac.ir
Maryam
Afrasiabi
Allergy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
pjbiostat@gmail.com
Marzieh
Orooj
Allergy Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
sarashalileh@gmail.com
Sara
Kashef
Allergy Research Center, Department of Pediatrics, Nemazee Teaching Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
kashefs@sums.ac.ir
Background: Child-parent agreement is a controversial aspect of measuring health-related quality of life (HRQoL) in children and adolescents. The aim of this study was to assess the agreement between the child self-reports and parent proxy reports of the PedsQL 3.0 Asthma Module in Iranian children with asthma to evaluate HRQoL. Moreover, the psychometric properties of the child and parent reports of the PedsQL 3.0 Asthma Module were assessed in the present study.Methods: Participants were 112 children with asthma and their parents, who completed the Farsi version of the PedsQL 3.0 Asthma Module. The multitrait-multimethod correlation matrix and factor analysis were used to test whether the child self-reports and the parent proxy reports measured the same construct. Additionally, convergent and discriminant validity and internal consistency were assessed using the Pearson correlation.Results: The correlation between the child and parent HRQoL perceptions ranged between 0.13 and 0.36 across the same domains. Our factor analysis revealed that the child self-reports and the parent proxy reports measured 2 different constructs of HRQoL. Furthermore, our findings showed that both the child self-reports and the parent proxy reports of the PedsQL 3.0 Asthma Module had excellent internal consistency and acceptable convergent and discriminant validity.Conclusion: Although the child self-reports and the parent proxy reports of the Farsi version of PedsQL 3.0 Asthma Module showed good psychometric properties, they were not interchangeable. Our children with asthma and their parents evaluated child HRQoL from their own viewpoints.
Asthma,Child,Parents,Quality of life
https://ijms.sums.ac.ir/article_40342.html
https://ijms.sums.ac.ir/article_40342_a8d1264462f6f50e61ba386c4c4eb40b.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Comparison of the Wave Amplitude of Visually Evoked Potential in Amblyopic Eyes between Patients with Esotropia and Anisometropia and a Normal Group
94
101
EN
Mohammad Reza
Talebnejad
Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
talebnejadmr@yahoo.com
Saeedeh
Hosseinmenni
Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran and Department of Optometry, Iran University of Medical Sciences, Tehran, Iran
Ebrahim
Jafarzadehpur
Department of Optometry, Iran University of Medical Sciences, Tehran, Iran
s_hoseiny2008@yahoo.com
Ali
Mirzajani
Department of Optometry, Iran University of Medical Sciences, Tehran, Iran
Enayatollah
Osroosh
Department of Optometry, Mashhad University of Medical Sciences, Mashhad, Iran
Background: We compared the wave amplitude of visually evoked potential (VEP) between patients with esotropic and anisometropic amblyopic eyes and a normal group.Methods: The wave amplitude of VEP was documented in 2 groups of persons with amblyopia (15 with esotropia and 28 with anisometropia) and 1 group of individuals with normal visual acuity (n, 15). The amplitude of P100 was recorded monocularly with different spatial frequencies.Results: Our statistical analysis revealed that the wave amplitude in the 2 groups with amblyopia was significantly decreased compared to that in the normal group (P<0.001). There was a significant difference regarding the amplitude in high spatial frequencies in both high- and low-contrast conditions between the groups with esotropia and anisometropia and the normal group (P<0.001). There were also significant differences in large check-size stimuli and low-contrast condition between the amblyopic groups with esotropia and anisometropia and the normal group (P=0.013 and P=0.044, respectively). In large check-size stimuli and high-contrast condition, a significant difference was indicated only in the comparison between the esotropic amblyopic eyes and the normal eyes (P=0.036).Conclusion: The wave amplitude parameter of VEP was influenced by both types of amblyopia, but it seems that this parameter was more sensitive to esotropic amblyopia than anisometropic amblyopia. This outcome may reflect a non-parallel pattern of cortical responses in the comparison of the 2 types of amblyopia with each other and with the control group, which may be beneficial for the diagnosis and treatment of amblyopia.
Amblyopia,Anisometropia,Esotropia,Visual evoked potentials
https://ijms.sums.ac.ir/article_40343.html
https://ijms.sums.ac.ir/article_40343_3418200f578d3710d40fa82c86925acc.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Effects of Sesame Butter (Ardeh) versus Sesame Oil on Metabolic and Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats
102
109
EN
Fatemeh
Haidari
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
haidari58@gmail.com
Majid
Mohammadshahi
Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran;
shahi334@gmail.com
Mehdi
Zarei
Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
zarei@scu.ac.ir
Zahra
Gorji
Department of Nutritional Science, Arvand International Division of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
ghazal.gorji@yahoo.com
Background: Diabetes is one of the most common metabolic disorders and is related to oxidative-stress-induced diseases. Given the role of dietary antioxidants in the control and prevention of diabetes, this study aimed to examine the effects of sesame butter versus sesame oil on the serum levels of glucose, lipid profile, and oxidative stress biomarkers in diabetic rats.Methods: Forty male albino rats of Wistar strain were randomly divided into 4 groups (i.e., nondiabetic control rats, diabetic rats, diabetic rats treated with sesame butter, and diabetic rats treated with sesame oil). Experimental diabetes was induced with an intraperitoneal injection of streptozotocin (55 mg/kg). Sesame butter (1.25 g/kg) and sesame oil (0.5 g/kg) were given by oral gavage to the diabetic rats for 6 weeks. Finally, serum glucose, lipid profile, total antioxidant capacity (TAC), and malondialdehyde (MDA) levels were measured and analyzed statistically.Results: Our data showed that the diabetic groups treated with sesame butter and sesame oil had significantly lower levels of glucose and higher levels of high-density lipoprotein than did the diabetic control group at the end of the study (P<0.05). Sesame butter supplementation also increased TAC and decreased MDA concentrations significantly in the diabetic rats (P<0.05).Conclusion: The antihyperglycemic, antioxidative, and partly lipid-lowering effects of sesame butter make it an excellent candidate for future human studies on diabetes, although further research is needed to determine the exact dose and duration of supplementation.
Antioxidants,diabetes mellitus,Hyperglycemia,Lipids,Oxidative stress,Sesame oil
https://ijms.sums.ac.ir/article_40347.html
https://ijms.sums.ac.ir/article_40347_e443727d25bb99306db04a42500d2d49.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Relation between Working Memory Capacity and Auditory Stream Segregation in Children with Auditory Processing Disorder
110
117
EN
Yones
Lotfi
Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
lotfi1333@gmail.com
Saiedeh
Mehrkian
Department of Audiology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
Abdollah
Moossavi
Department of Audiology, Iran University of Medical Sciences, Tehran, Iran
amoosavi@gmail.com
Soghrat
Faghih Zadeh
Department of Social Medicine, School of Medicine, Zanjan, Iran
s.faghihzadeh@zums.ac.ir
Hamed
Sadjedi
Department of Engineering, Shahed University, Tehran, Iran
sadjedi@yahoo.com
Background: This study assessed the relationship between working memory capacity and auditory stream segregation by using the concurrent minimum audible angle in children with a diagnosed auditory processing disorder (APD).Methods: The participants in this cross-sectional, comparative study were 20 typically developing children and 15 children with a diagnosed APD (age, 9–11 years) according to the subtests of multiple-processing auditory assessment. Auditory stream segregation was investigated using the concurrent minimum audible angle. Working memory capacity was evaluated using the non-word repetition and forward and backward digit span tasks. Nonparametric statistics were utilized to compare the between-group differences. The Pearson correlation was employed to measure the degree of association between working memory capacity and the localization tests between the 2 groups.Results: The group with APD had significantly lower scores than did the typically developing subjects in auditory stream segregation and working memory capacity. There were significant negative correlations between working memory capacity and the concurrent minimum audible angle in the most frontal reference location (0° azimuth) and lower negative correlations in the most lateral reference location (60° azimuth) in the children with APD.Conclusion: The study revealed a relationship between working memory capacity and auditory stream segregation in children with APD. The research suggests that lower working memory capacity in children with APD may be the possible cause of the inability to segregate and group incoming information.
Auditory scene analysis,Stream segregation,Short-term memory,Auditory perceptual disorders,Child
https://ijms.sums.ac.ir/article_40348.html
https://ijms.sums.ac.ir/article_40348_907ede356c3b7dcf4a66e42711b54ce3.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Biphasic Response to Luteolin in MG-63 Osteoblast-Like Cells under High Glucose‑Induced Oxidative Stress
118
125
EN
Naser
Abbasi
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
abbasi-n@medilam.ac.ir
Afra
Khosravi
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
khosravi@medilam.ac.ir
Ali
Aidy
0000-0001-5624-4184
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
aliaidi11@yahoo.com
Massoumeh
Shafiei
0000-0002-8722-8088
Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
shafiei.m@iums.ac.ir
Background: Clinical evidence indicates the diabetes-induced impairment of osteogenesis caused by a decrease in osteoblast activity. Flavonoids can increase the differentiation and mineralization of osteoblasts in a high-glucose state. However, some flavonoids such as luteolin may have the potential to induce cytotoxicity in osteoblast-like cells. This study was performed to investigate whether a cytoprotective concentration range of luteolin could be separated from a cytotoxic concentration range in human MG-63 osteoblast-like cells in high-glucose condition.Methods: Cells were cultured in a normal- or high-glucose medium. Cell viability was determined with the MTT assay. The formation of intracellular reactive oxygen species (ROS) was measured using probe 2’,7’ -dichlorofluorescein diacetate, and osteogenic differentiation was evaluated with an alkaline phosphatase bioassay.Results: ROS generation, reduction in alkaline phosphatase activity, and cell death induced by high glucose were inhibited by lower concentrations of luteolin (EC50, 1.29±0.23 µM). Oxidative stress mediated by high glucose was also overcome by N-acetyl-L-cysteine. At high concentrations, luteolin caused osteoblast cell death in normal- and high-glucose states (IC50, 34±2.33 and 27±2.42 µM, respectively), as represented by increased ROS and decreased alkaline phosphatase activity.Conclusion: Our results indicated that the cytoprotective action of luteolin in glucotoxic condition was manifested in much lower concentrations, by a factor of approximately 26 and 20, than was its cytotoxic activity, which occurred under normal or glucotoxic condition, respectively.
Luteolin,Human osteoblast-like MG-63 cells,High glucose,Oxidative stress,Alkaline phosphatase
https://ijms.sums.ac.ir/article_40349.html
https://ijms.sums.ac.ir/article_40349_f192ea5912dc90795c7f415fa3390532.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Efficacy of Biofeedback Therapy before and after Sphincteroplasty for Fecal Incontinence because of Obstetric Injury: A Randomized Controlled Trial
126
131
EN
Leila
Ghahramani
Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
leila_ghahramani@yahoo.com
Mastoureh
Mohammadipour
Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
colorectal@sums.ac.ir
Reza
Roshanravan
Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Fahimeh
Hajihosseini
Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Alimohammad
Bananzadeh
Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
bananzadeh@gmail.com
Ahmad
Izadpanah
Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
izadpana@sums.ac.ir
Seyed Vahid
Hosseini
0000-0002-9228-3567
Colorectal Research Center, Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
hoseiniv@sums.ac.ir
Fecal incontinence is a challenging condition in that it exerts various psychosocial impacts on daily life. Different treatment modalities have been suggested for fecal incontinence. The present study aimed to evaluate the efficacy of biofeedback therapy in combination with surgery in the management of fecal incontinence.The present randomized controlled trial was performed on 27 women with a complaint of fecal incontinence because of delivery trauma. The patients underwent sphincteroplasty and levatorplasty via the same method by 2 colorectal surgeons. In Group I, biofeedback therapy was performed 3 months before and 6 months after the surgery; in Group II, biofeedback therapy was applied only 6 months after the surgery; and in Group III, only surgical management was performed.The results revealed a significant difference between the preoperative and postoperative Wexner scores of incontinence in all the 3 groups. Additionally, the difference between the preoperative and postoperative scores was significant only in Group I and Group III, but not in Group II. The reduction in the Wexner score was significantly less in Group III. However, no significant difference was observed between the 3 groups concerning the mean difference of preoperative and postoperative manometry.The present study revealed no significant role for biofeedback therapy alone in the improvement of manometric evaluation. However, the Wexner score, which is an indicator of patient satisfaction, increased with biofeedback therapy following sphincteroplasty.In general, surgical treatment is now reserved for selected patients with fecal incontinence and has recently been developed with biofeedback therapy.Trial Registration Number: IRCT201206039936N1
Fecal incontinence,Sphincteroplasty,Biofeedback
https://ijms.sums.ac.ir/article_40338.html
https://ijms.sums.ac.ir/article_40338_d7586b4c1e4cdc57eea8649dd21d3220.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Growth Kinetics, Characterization, and Plasticity of Human Menstrual Blood Stem Cells
132
139
EN
Davood
Mehrabani
0000-0002-5738-1719
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
mehrabad@sums.ac.ir
Roshanak
Bahrami Nazarabadi
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
sctrc@sums.ac.ir
Maryam
Kasraeian
0000-0001-8182-0358
Maternal-Fetal Medicine Research Center, Perinatology Ward, Department of Gynecology and Obstetrics, Shiraz University of Medical Sciences, Shiraz, Iran
maryamkasraeian@gmail.com
Amin
Tamadon
0000-0002-0222-3035
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
amintamaddon@yahoo.com
Mehdi
Dianatpour
0000-0003-1217-9477
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
dianatpour@sums.ac.ir
Akbar
Vahdati
Department of Biology, Science and Research Branch, Islamic Azad University, Shiraz, Iran
avahdatim@yahoo.com
Shahrokh
Zare
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Farnaz
Ghobadi
Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
One of the readily available sources of mesenchymal stem cells (MSCs) is menstrual blood-derived stem cells (Men-SCs), which exhibit characteristics similar to other types of MSCs. This study was performed to determine the growth kinetics, plasticity, and characterization of Men-SCs in women. During spring 2014 in the southern Iranian city of Shiraz, menstrual blood (5 mL) was obtained from 10 women on their third day of menstruation in 2 age groups of 30 to 40 and 40 to 50 years old. Ficoll was used to separate the mononuclear cell fraction. After the Men-SCs were cultured, they were subcultured up to passage 4. Growth behavior and population doubling time were evaluated by seeding 5×104 cells into 12- and 24-well culture plates, and the colonies were enumerated. The expression of CD44, CD90, and CD34 was evaluated. The osteogenic potential was assessed by alizarin red staining. The Men-SCs were shown to be plastic adherent and spindle-shaped. Regarding the growth curves in the 12- and 24-well culture plates, it was demonstrated that in the women aged between 30 and 40 years, population doubling time was 55.5 and 62 hours, respectively, while these values in the women aged between 40 and 50 years were 70.4 and 72.4 hours, correspondingly. Positive expression of CD44 and CD90 and negative expression of CD34 were noted. In the osteogenic differentiation medium, the cells differentiated toward osteoblasts. As human Men-SCs are easily collectable without any invasive procedure and are a safe and rapid source of MSCs, they can be a good candidate for stem cell banking and cell transplantation in women.
Menstrual blood,Mesenchymal Stem Cells,Plasticity,Reverse transcriptase polymerase chain reaction
https://ijms.sums.ac.ir/article_40341.html
https://ijms.sums.ac.ir/article_40341_0224fe81a13c407bf03870c4db908f82.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Effectiveness of Spiritual Group Therapy on Quality of Life and Spiritual Well-Being among Patients with Breast Cancer
140
144
EN
Sakineh
Zamaniyan
Department of Psychology, Islamic Azad University, Karaj Branch, Karaj, Iran
zamaniyan37@gmail.com
Jafar
Bolhari
School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran
bolharij@yahoo.com
Ghasem
Naziri
Fars Sciences and Research Branch, Department of Psychology, Islamic Azad University, Shiraz, Iran
naziryy@yahoo.com
Majid
Akrami
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
akramimd@yahoo.com
Sara
Hosseini
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
s1365h@gmail.com
Cancer is deemed the century’s major health problem, and its increasing growth during the last decades has made experts concerned more than ever. Of all types of cancer, breast cancer is regarded as the second most common disease among women. The aim of this study was to determine the effectiveness of spiritual group therapy on quality of life and spiritual well-being among patients suffering from breast cancer. The present research was carried out between March and June 2011. The sample consisted of 24 participants randomly assigned to 2 groups: an experimental group (n, 12) and a control group (n, 12). All the subjects completed questionnaires on quality of life and spiritual well-being in pretest and posttest. The experimental group received 12 sessions of spiritual group therapy. The results demonstrated improvement in quality of life and spiritual well-being in the experimental group. In conclusion, spiritual group therapy can be used to improve quality of life and spiritual well-being (religious health and existential health) among patients with breast cancer.
Breast neoplasms,Spiritual therapies,Quality of life,Psychotherapy,Group,Existentialism
https://ijms.sums.ac.ir/article_40345.html
https://ijms.sums.ac.ir/article_40345_7551f7c02f5e9b532e14cb499a0a8346.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Aggressive calcifying epithelial odontogenic tumor masquerading as maxillary sinus tumor: a case report.
145
149
EN
Vidya
Rani
Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India
drvidyaranishyam78@gmail.com
Mahaboob Kadar
Masthan
Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India
masthankmk@yahoo.com
Babu
Aravindha
Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India
draravindmsdc@yahoo.co.in
Sankari
Leena
Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai, Tamil Nadu, India
drleena.sankari@gmail.com
Calcifying epithelial odontogenic tumor is a rare odontogenic neoplasm. Its occurrence in the maxillary sinus is very rare. Maxillary tumors tend to be locally aggressive and may rapidly involve the surrounding vital structures. We report a case of calcifying epithelial odontogenic tumor involving maxillary sinus in a 48 years old female patient with the oral mucosal involvement. The purpose of this article is to report an additional case of calcifying epithelial odontogenic tumor and discuss the radiologic appearance, histologic features, and to highlight its clinical behavior.
Calcifying epithelial odontogenic tumor,Maxillary sinus,Epithelium
https://ijms.sums.ac.ir/article_40337.html
https://ijms.sums.ac.ir/article_40337_5299eb5c7d82dc00ccb6889ecdc71543.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Intracardiac Thrombosis in Sickle Cell Disease
150
153
EN
Marzieh
Nikparvar
Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
marzieh_nikparvar@yahoo.com
Mohammad Reza
Evazi
Hematologist, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
mohammadreza.evazi@yahoo.com
Tasnim
Eftekhari
Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran and Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
Farzaneh
Moosavi
Internist, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive crisis. The patient had manifestations of microangiopathic hemolytic anemia, including laboratory evidence of hemolytic anemia, thrombocytopenia, respiratory distress, fever, jaundice, and abnormal liver function and coagulation tests, accompanied by clot formation on the Eustachian valve of the inferior vena cava in the right atrium and also a long and worm-like thrombus in the right ventricle. Therapeutic plasma exchange improved her clinical condition, and her intracardiac thrombus was completely resolved after 1 week. Echocardiography, as a simple and inexpensive imaging modality, had a significant role in the diagnosis and follow-up of this patient.
Sickle cell anemia,Thrombotic microangiopathy,Plasmapheresis
https://ijms.sums.ac.ir/article_40340.html
https://ijms.sums.ac.ir/article_40340_7ba79899590d7a26830f774ca82dc86f.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Exsanguinating Hemorrhage during Open Biopsy in a Primary Breast Angiosarcoma: A Case Report
154
156
EN
Majid
Akrami
Breast Diseases Research Center, Department of Surgical Oncology, Shiraz University of Medical Sciences, Shiraz, Iran
akramimd@yahoo.com
Mastoureh
Mohammadipour
Department of Surgery, Shahid Faghihi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
mohammadi_mst@yahoo.com
Maral
Mokhtari
Department of Pathology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
mmohammadipour@gmail.com
Malihe
Dayani
Department of Pathology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
mdayani2000@yahoo.com
Angiosarcomas are endothelial cell neoplasms in the lining of the blood vessel wall and account for about 0.04% of all breast malignancies with a high rate of error in primary diagnosis. The breast angiosarcoma is a rare and uncommon pathology and has been described mostly as case reports. Indeed, only a limited number of cases have been published. Accordingly, the natural history of this tumor and its clinical course remain unclear, and as a consequence, no uniform treatment strategy exists. We present the clinical course and challenges in the diagnosis of a primary angiosarcoma of the breast in a young woman, presenting with a mass in her left breast. Fine-needle aspiration and core needle biopsy failed to confer a correct diagnosis. She suffered severe bleeding at the time of open biopsy and underwent total mastectomy, followed by adjuvant chemotherapy. Young women with solid breast tumors, especially those that are highly vascular, should be considered malignant until proven otherwise. Accurate diagnosis may be difficult. Open biopsy can be diagnostic, although exsanguinating bleeding may occur. Thus, performing open biopsy in locations other than equipped operating rooms may be hazardous and should be avoided.
Breast,Hemangiosarcoma,Hemorrhage,Case report
https://ijms.sums.ac.ir/article_40344.html
https://ijms.sums.ac.ir/article_40344_01e4ad74182365824d7ab09eb20eddfa.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Uterocutaneous Fistula Following Cesarean Section: Successful Management of a Case
157
160
EN
Ghodratollah
Maddah
Endoscopic and Minimally Invasive Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
maddahgh@yahoo.com
Asieh Sadat
Fattahi
Endoscopic and Minimally Invasive Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
fattahima@mums.ac.ir
Ali
Rahnama
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
rahnamaa91@mums.ac.ir
Shirin
Taraz Jamshidi
Solid Tumor Treatment Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
jamshidish@yahoo.com
A uterocutaneous fistula is a rare clinical presentation that occurs following Cesarean section and other pelvic operations. There are only a few reports discussing the treatments. We describe a patient with successful surgical management and review the literature. A 25-year-old woman referred to our department 13 months after her first Cesarean section. She had a history of an abdominal mass and collection 2 months after surgery and some fistula opening with discharge from her previous incision. She had a previous surgical operation and antibiotic therapy without complete response. We performed fistulography to evaluate the tracts. In the operation — she had fistula tracts, one of which was between the uterus and skin. We debrided the necrotic tissue in the uterus, excised the fistula tracts, and drained the uterine cavity. At 8 months’ postoperative follow-up, she had no recurrence. A uterocutaneous fistula is a rare condition with many causes and needs proper investigation and timely medical and surgical management.
Cutaneous fistula,Uterine diseases,Cesarean Section,Pregnancy
https://ijms.sums.ac.ir/article_40346.html
https://ijms.sums.ac.ir/article_40346_3b43d11ddada2d1000c57fc0f00f0f93.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Minor Contribution of inhA-15 Mutations to the Rapid Detection of Isoniazid Resistance in Mycobacterium Tuberculosis Isolates
161
163
EN
Roya
Abkar
Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
Mohammad Reza
Zolfaghari
Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
Mohammad
Arjomandzadegan
Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, Iran
mmatinam81@yahoo.com
Azam
Ahmadi
Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, Iran
Maryam
Sadrnia
Department of Biology, Payame Noor University, Iran
Manijeh
Kahbazi
Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, Iran
Hossein
Sarmadian
Tuberculosis and Pediatric Infectious Research Center, Arak University of Medical Sciences, Arak, Iran
Reza
Moaddab
Medical Laboratory Sciences and Research Center for TB and Pulmonary Diseases, Tabriz University of Medical Sciences, Tabriz, Iran
Mycobacterium Tuberculosis
https://ijms.sums.ac.ir/article_40335.html
https://ijms.sums.ac.ir/article_40335_67097946f0161f1d9b0d0f0299d174cd.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
41
2
2016
03
01
Nodular Melanoma
164
165
EN
Muhammad
Saaiq
0000-0003-1714-0491
Pakistan Institute of Medical Sciences (PIMS), Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Islamabad, Pakistan
muhammadsaaiq5@gmail.com
Bushra
Ashraf
Pakistan Institute of Medical Sciences (PIMS), Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Islamabad, Pakistan
Saad
Siddiqui
Pakistan Institute of Medical Sciences (PIMS), Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Islamabad, Pakistan
Nodular Melanoma
https://ijms.sums.ac.ir/article_40336.html
https://ijms.sums.ac.ir/article_40336_c559a6d22f72d58c75b456569b0420d9.pdf