Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
A Milestone: Inclusion of the Iranian Journal of Medical Sciences (IJMS) in MEDLINE
321
321
EN
Younes
Ghasemi
0000-0003-4172-0672
Editor-in-Chief,
Iranian Journal of Medical Sciences
ghasemiy@sums.ac.ir
10.30476/ijms.2021.47773
It was a great pleasure to learn that IJMS has been accepted in the eminent MEDLINE database very recently. MEDLINE is regarded as the most important database of the US National Library of Medicine and supports free access to publications through PubMed. Owing to the nature of the meticulous inclusion process, acceptance in the MEDLINE endorses the quality of our journal. The merits of enhanced global visibility of the journal as a valid biomedical resource and being indexed by Medical Subject Heading (MeSH) will provide more readership for the papers. Our recent authors would also benefit from this milestone, as MEDLINE would cover the articles published since January 2021.
MEDLINE,IJMS
https://ijms.sums.ac.ir/article_47773.html
https://ijms.sums.ac.ir/article_47773_344ad2a3ba6560ed770bacc819af1bf8.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
Association of HScore Parameters with Severe COVID-19: A Systematic Review and Meta-Analysis
322
338
EN
Mohammad Hossein
Kazemi
0000-0002-2899-9755
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
kazemi.m03@iums.ac.ir
Bentolhoda
Kuhestani Dehaghi
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
hodakuhestani@sbmu.ac.ir
Elham
Roshandel
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
elham.roshandel@gmail.com
Hossein
Bonakchi
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
bonakchih951@sbmu.ac.ir
Sayeh
Parkhideh
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
drsayehparkhideh@yahoo.com
Mahshid
Mehdizadeh
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
mehdizadeh@sbmu.ac.ir
Abbas
Hajifathali
0000-0002-2191-0594
Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
hajifathali@yahoo.com
10.30476/ijms.2021.88404.1910
Background: Several reports have associated the severe Coronavirus disease-2019 (sCOVID-19) with secondary-hemophagocytic lymphohistiocytosis (sHLH) and proposed utilizing the hemophagocytic syndrome diagnostic score (HScore) for sCOVID-19 patients. We conducted a systematic review and meta-analysis to find the possible association of HScore parameters with severity in COVID-19 patients. <br />Methods: A systematic search was performed in Medline via PubMed, EMBASE, and Cochrane databases using all HScore and COVID-19 keywords. The studies were all from 2020, and the study language was limited to English. The records were screened based on inclusion/exclusion criteria. Random/fixed-effect models were employed for meta-analysis, based on the I2 index of parameters. The pooled mean differences were estimated for continuous parameters. The pooled odds-ratio was estimated for fever. The level of significance was set at 0.05.<br />Results: Eighteen studies (comprising 2459 patients) out of 26151 screened studies were included in this meta-analysis. The results showed that the level of leukocyte, neutrophil, aspartate transaminase (AST), ferritin, and fibrinogen were significantly higher in sCOVID-19 patients than in non-severe ones. Significant lower levels of lymphocyte, platelet, and hemoglobin were also found in sCOVID-19 patients than non-severe patients. Fever was nearly associated with two times increased odds of sCOVID-19 (P=0.051).<br />Conclusion: Lymphopenia, thrombocytopenia, hypohemoglobinemia, hyperferritinemia, high levels of AST, and fever are common features of both sCOVID-19 and HLH. However, the leukocytosis, neutrophilia, and hyperfibrinogenemia found in sCOVID-19 are in contrast with HScore. Conclusively, HScore parameters could be risk factors for sCOVID-19. However, some parameters’ roles are contradictory, suggesting the need for further investigation and a new way of HScore interpretation in sCOVID-19 patients.<br />A preprint of this study was published at https://www.researchsquare.com/article/rs-54490/v2.
COVID-19,Hemophagocytic lymphohistiocytosis,Systematic review,Meta-analysis
https://ijms.sums.ac.ir/article_47693.html
https://ijms.sums.ac.ir/article_47693_71fbc17ad9529e0304f04a9d70126157.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
Upregulation of Cytotoxic T-Lymphocyte-Associated Protein 4 and Forkhead Box P3 Transcripts in Peripheral Blood of Patients with Bladder Cancer
339
346
EN
Ali
Ariafar
0000-0003-1250-5447
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
ariafara@sums.ac.ir
Mojtaba
Habibagahi
Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
habibagahim@yahoo.com
Mansooreh
Jaberipour
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
jaberipm@yahoo.com
Abdolaziz
Khezri
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Hadi
Khezri
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
hosseiniahmad59@yahoo.com
Hale
Bozorgi
Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;
halehk2@yahoo.com
Ahmad
Hosseini
0000-0002-1205-7974
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
hosseiniah@sums.ac.ir
Mahboobeh
Razmkhah
0000-0002-0875-2851
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
mrazmkhah2@gmail.com
10.30476/ijms.2020.84462.1426
Background: Regulatory T cells (Tregs) play a key role in the progression of tumors. These cells express forkhead box P3 (FOXP3) and cytotoxic T-lymphocyte-associated protein 4 (CTLA4), which are the potential targets for cancer immunotherapy. The present study aimed to evaluate FOXP3 and CTLA4 transcripts in patients with bladder cancer (BC) compared with healthy individuals.<br />Methods: Transcripts of CTLA4 and FOXP3 genes in the peripheral blood mononuclear cells (PBMCs) of 50 patients with histologically confirmed BC and 50 healthy individuals were assessed at the Institute for Cancer Research, Shiraz University of Medical Sciences (Shiraz, Iran) during 2014-2016. RNA was extracted from PBMCs, then cDNA was synthesized and subjected to quantitative real-time PCR (qRT-PCR) using appropriate primers. Statistical analysis was performed using SPSS software (version 21.0). <br />Results: Significantly higher amounts of CTLA4 and FOXP3 gene transcripts were found in the peripheral blood of BC patients compared with healthy individuals. The expression of both genes was significantly higher in patients with non-invasive and grade I/II BC. The median of CTLA4 and FOXP3 transcript expressions was 3.74 and 5.39, respectively, in non-invasive BC patients, which was significant compared with the control group (P=0.0016 and P=0.009, respectively). The median of target gene mRNA expression in grade I/II BC patients was 2.9 for CTLA4 and 6.61 for FOXP3, which was significant compared with the controls (P=0.013 and P=0.0037, respectively). <br />Conclusion: This study highlights the functional activity of Tregs in early stages of bladder cancer and showed the importance of CTLA4 and FOXP3, when it comes to screening BC.
CTLA4,FOXP3,Urinary bladder neoplasms,T-lymphocytes, Regulatory,immunotherapy
https://ijms.sums.ac.ir/article_47254.html
https://ijms.sums.ac.ir/article_47254_776128d15ac2f43334dbde8d1302c789.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
The Relationship between the Connexin 32 and Connexin 43 Genes and the Pretreatment Stage and Short-term Follow-up of Patients with Acute Myeloid Leukemia
347
354
EN
Mohamed
Fateen
0000-0002-1533-4092
Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt
mo.fateen@kasralainy.edu.eg
Alia
Seif
0000-0002-3702-4909
Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt
draliaaseif@gmail.com
Rasha
Salama
Department of Clinical Oncology, Cairo University, Cairo, Egypt
roshy.salama@yahoo.com
Ahmed
Shams
Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt
shamseldinlab@gmail.com
Dalia
Amin
0000-0003-1672-4647
Department of Clinical and Chemical Pathology, Cairo University, Cairo, Egypt
aeagipy@yahoo.com
10.30476/ijms.2020.84511.1477
Background: Connexins (Cxs) are gap junction proteins involved in the communication between acute myeloid leukemia (AML) and stromal cells. They consist of intercellular channels termed “connexions”, which can cause uncontrolled cell proliferation if dysregulated. This study aimed to evaluate the expression levels of the Cx32 and Cx43 genes and their correlations with other prognostic markers in patients with AML. <br />Methods: This cross sectional study was performed on peripheral blood samples from 60 newly diagnosed patients with AML and 40 healthy control subjects at Kasr Alainy School of Medicine, Cairo University, from June 2016 to December 2017. The quantitative real-time polymerase chain reaction (qRT-PCR) test was used to examine the relative expression level of Cx43 and Cx32 genes in the patients and the control subjects. The Chi square test or the Fisher exact test was employed to examine the relationship between qualitative variables, while the independent t test or the Mann–Whitney test was employed for quantitative data. All the tests were two-tailed, and a P value of less than 0.05 was considered significant.<br />Results: Among the patients with AML, 65% had a high Cx32 expression level, whereas 63.3% had a low Cx43 expression level. There was a statistically significant difference in the fold change values of Cx32 and Cx43 expression between the patient group and the control group (P=0.009 vs P=0.013, respectively). There was a remarkable association between both Cxs and CD34 and HLA-DR cells. <br />Conclusion: Cx expression in samples may add to the diagnostic workup of AML. Although we found a negative correlation between Cx43 expression and the peripheral blood blast percentage, the response after the first induction of chemotherapy showed no significant relationship with Cx43 and Cx32.
Leukemia, Myeloid, Acute,Connexin 43,Gap junctions,Gene expression
https://ijms.sums.ac.ir/article_47392.html
https://ijms.sums.ac.ir/article_47392_20bb8fab6674699fbcdae6a223fa17ad.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
The Outcome of Locally Advanced Cervical Cancer in Patients Treated with Neoadjuvant Chemotherapy Followed by Radical Hysterectomy and Primary Surgery
355
363
EN
Azamsadat
Mousavi
0000-0003-3152-6999
Department of Oncology, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Mitra
Modarres Gilani
Department of Oncology, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
mitra.modarresgilani@gmail.com
Setareh
Akhavan
Department of Oncology, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
Shahrzad
Sheikh Hasani
Department of Oncology, Emam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
dr_sh1356@yahoo.com
Abbas
Alipour
Thalassemia Research Center, Mazandaran University of Medical Sciences, Sari, Iran
alipour_abbass@yahoo.com
Hamideh
Gholami
0000-0003-4096-7139
MD, Fellowship of Gyneco-oncology – Assistant professor of Zanjan University of Medical Sciences.
10.30476/ijms.2020.81973.0
Background: In recent years, before radical hysterectomy, neoadjuvant chemotherapy (NACT) has been administered to patients with locally advanced cervical cancer to shrink large tumors. It has been reported that this treatment significantly reduces the need for radiotherapy after surgery. The current study aimed to assess the outcome (survival, recurrence, and the need for adjuvant radiotherapy) of locally advanced cervical cancer in patients treated with NACT followed by radical hysterectomy and primary surgery.<br />Methods: In a retrospective cohort study, the records of 258 patients with cervical cancer (stage IB2, IIA, or IIB), who referred to Imam Khomeini Hospital (Tehran, Iran) from 2007 to 2017 were evaluated. The patients were assigned into two groups; group A (n=58) included patients, who underwent radical hysterectomy and group B (n=44) included those, who underwent a radical hysterectomy after NACT. The outcome measures were the recurrence rate, five-year survival rate, and the need for adjuvant radiotherapy. <br />Results: The median for overall survival time in group A and B was 113.65 and 112.88 months, respectively (P=0.970). There was no recurrence among patients with stage IB2 cervical cancer in group B, while the recurrence rate in group A was 19.5% with a median recurrence time of 59.13 months. Lymph node involvement was the only factor that affected patients’ survival. The need for postoperative adjuvant radiotherapy in group B was lower than in group A (P=0.002).<br />Conclusion: NACT before the hysterectomy was found to reduce the need for postoperative radiotherapy in patients with locally advanced cervical cancer according to disease stages. As a direct result, adverse side effects and the recurrence rate were reduced, and the overall survival rate of patients with stage IIB cervical cancer was increased.
Uterine cervical neoplasms,Hysterectomy,Recurrence,Survival
https://ijms.sums.ac.ir/article_47256.html
https://ijms.sums.ac.ir/article_47256_bc433de51f1bd15c1f8aeaa481398511.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
Multivariate Longitudinal Assessment of Kidney Function Outcomes on Graft Survival after Kidney Transplantation Using Multivariate Joint Modeling Approach: A Retrospective Cohort Study
364
372
EN
Rasoul
Alimi
0000-0001-7780-6326
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
rasulalimi@yahoo.com
Maryam
Hami
Kidney Transplantation Complications Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
hamim@mums.ac.ir
Monavar
Afzalaghaee
0000-0003-2029-6577
Management & Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
afzalaghaeem1@mums.ac.ir
Fatemeh
Nazemian
Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
nazemianf@mums.ac.ir
Mahmood
Mahmoodi
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
mohmoodim@tums.ac.ir
Mehdi
Yaseri
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
myaseri@tums.ac.ir
Hojjat
Zeraati
0000-0002-8635-4322
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
zeraatih@tums.ac.ir
10.30476/ijms.2020.82857.1144
Background: The performance of a transplanted kidney is evaluated by monitoring variations in the value of the most important markers. These markers are measured longitudinally, and their variation is influenced by other factors. The simultaneous use of these markers increases the predictive power of the analytical model. This study aimed to determine the simultaneous longitudinal effect of serum creatinine and blood urea nitrogen (BUN) markers, and other risk factors on allograft survival after kidney transplantation.<br />Methods: In a retrospective cohort study, the medical records of 731 renal transplant patients, dated July 2000 to December 2013, from various transplant centers in Mashhad (Iran) were examined. Univariate and multivariate joint models of longitudinal and survival data were used, and the results from both models were compared. The R package joineRML was used to implement joint models. P values Results: Results of the multivariate model showed that allograft rejection occurred more frequently in patients with elevated BUN levels (HR=1.68, 95% CI: 1.24-2.27). In contrast, despite a positive correlation between serum creatinine and allograft rejection (HR=1.49, 95% CI: 0.99-2.22), this relationship was not statistically significant. <br />Conclusion: Results of the multivariate model showed that longitudinal measurements of BUN marker play a more important role in the investigation of the allograft rejection.
Kidney Transplantation,Graft Survival,Survival analysis,Longitudinal studies,Multivariate analysis
https://ijms.sums.ac.ir/article_47064.html
https://ijms.sums.ac.ir/article_47064_cc3304853497a8ddc13895cfc5295e74.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
Esculetin Alleviates Acute Liver Failure following Lipopolysaccharide/D-Galactosamine in Male C57BL/6 Mice
373
382
EN
Seyed-Mahdi
Mohamadi-Zarch
0000-0002-7699-1790
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
smmohamadi1989@gmail.com
Tourandokht
Baluchnejadmojarad
0000-0002-2703-728X
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
tmojarad@yahoo.com
Davood
Nourabadi
0000-0001-6993-2701
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
dr_nourabadi@yahoo.com
Samira
Ramazi
0000-0212-7131-0002
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
samira_ramazi66@yahoo.com
Morteza
Nazari-Serenjeh
0000-0001-9564-2599
Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
mortezanazariserenjeh@gmail.com
Mehrdad
Roghani
0000-0002-9209-8484
Neurophysiology Research Center, Shahed University, Tehran, Iran
mroghani@shahed.ac.ir
10.30476/ijms.2020.84909.1474
Background: Acute liver failure (ALF) is a fatal clinical situation that rapidly leads to the loss of normal liver function. Esculetin is a natural herbal compound used for the management of various diseases such as cardiovascular and renal disorders. In this study, we evaluated the protective effects of esculetin in a mouse model of ALF.<br />Methods: This article is a report on an experimental study that was conducted at Iran University of Medical Sciences in 2019. Forty-eight male C57BL/6 mice were randomly divided into control, LPS/D-Gal, and LPS/D-Gal+Esculetin (40 mg/kg) groups (n=16 per group). ALF was induced with an intraperitoneal injection of lipopolysaccharide (LPS)/D-galactosamine (D-Gal).The LPS/D-Gal group received a mixture of LPS (50 μg/kg) and D-Gal (400 mg/kg). The LPS/D-Gal+Esculetin group received esculetin by gavage 24 hours and one hour before receiving LPS/D-Gal. Six hours after LPS/D-Gal injection, the mice were sacrificed. Liver injury markers, including alanine aminotransferase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP), were measured in the serum. Oxidative stress indices and inflammatory markers such as interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) were measured in hepatic tissue. The histopathology of liver tissue was also assessed. The data were analyzed using one-way ANOVA, followed by the post hoc Tukey test.<br />Results: Esculetin lowered oxidative stress and myeloperoxidase activity (p <0.001); reduced the serum levels of ALT (P=0.037), AST (P=0.032), and ALP (P=0.004); and decreased the hepatic levels of IL-1β (P=0.002), IL-6 (P=0.004), toll-like receptor 4 (p <0.001), TNF-α (P=0.003), and nuclear factor-kappa B (p <0.001) as compared with LPS/D-Gal. Additionally, esculetin ameliorated hepatic tissue injury following LPS/D-Gal challenge. <br />Conclusion: Esculetin can reduce liver injury through the mitigation of oxidative burden, inflammation, and neutrophil infiltration and also exerts hepatoprotective effects against ALF.
Liver failure, Acute,Lipopolysaccharides,Inflammation,Oxidative stress
https://ijms.sums.ac.ir/article_47354.html
https://ijms.sums.ac.ir/article_47354_62940eb949e859e09853acde3e13046d.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
Efficacy of Combination Therapy with Apigenin and Synovial Membrane-Derived Mesenchymal Stem Cells on Knee Joint Osteoarthritis in a Rat Model
383
394
EN
Firoozeh
Estakhri
0000-0002-6797-346X
Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
firoozehest@yahoo.com
Mohammad Reza
Panjehshahin
0000-0002-9327-7548
Medicinal and Natural Chemistry Rresearch Center, Shiraz University of Medical Sciences, Shiraz, Iran
panjeshm@sums.ac.ir
Nader
Tanideh
0000-0001-9282-1778
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
n.tanideh2000@gmail.com
Rasoul
Gheisari
0000-0001-9756-087X
Department of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
gheisarir@sums.ac.ir
Negar
Azarpira
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
negarazarpira@yahoo.com
Nasser
Gholijani
Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
gholijani@yahoo.com
10.30476/ijms.2020.83686.1301
Background: Osteoarthritis (OA) is a degenerative joint disease that causes a variety of adverse health effects. Considering the need to identify additional effective therapeutic options for OA therapy, we investigated the effect of co-injection of apigenin and synovial membrane-derived mesenchymal stem cells (SMMSCs) on OA in male rats’ knee joints.<br />Methods: The study was performed in 2019 at the Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran. Anterior cruciate ligament transection (ACLT) was used to induce OA. For three weeks, male Sprague-Dawley rats (eight groups, n=6 each) were treated once-weekly with intra-articular injections of apigenin alone or in combination with SMMSC (three million cells), phosphate-buffered saline, or hyaluronic acid. After three months, the interleukin 1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), superoxide dismutase (SOD), and malondialdehyde (MDA) levels were measured in the cartilage homogenate. The expression of extracellular matrix (ECM) components including collagen 2a1, aggrecan, IL-1β, TNF-α, inducible nitric oxide synthase (iNOS), transcription factor SOX-9, and matrix metalloproteinases 3 and 13 were assessed using real-time polymerase chain reaction (RT-PCR) analysis. Radiological evaluation and histopathological assessment were used to evaluate the knees.<br />Results: Levels of TNF-α (P=0.009), MDA (P>0.001), and IL-1β (p <0.001) decreased and the level of SOD increased (P=0.004) in the apigenin 0.3 µM with SMMSCs group. RT-PCR analysis indicated that IL-1β in the apigenin 0.3 µM with SMMSCs group reduced significantly (p <0.001). This group also exhibited increased expression levels of SOX-9, collagen 2a1, and aggrecan (p <0.001). <br />Conclusion: Apigenin may have supplementary beneficial effects on cell therapy in a rat model of OA due to its possible effect on the reduction of oxidative stress, suppression of inflammation, and promotion of production of ECM components.
Apigenin,Synovial membrane,Mesenchymal Stem Cells,Osteoarthritis,Inflammation
https://ijms.sums.ac.ir/article_47731.html
https://ijms.sums.ac.ir/article_47731_6b5866a39542fd6e8f45ffa62538f56c.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
Severe Optic Disc Cupping Following the Methanol Toxicity in a 20-Year-old Man: A Case Report
395
398
EN
Narges
Hassanpoor
0000-0001-8296-0918
Department of Ophthalmology, School of Medicine, University of Medical Sciences, Tabriz, Iran
nargesshassanpoor@gmail.com
Mohamadreza
Niyousha
0000 0002 1119 5902
Department of Ophthalmology, School of Medicine, University of Medical Sciences, Tabriz, Iran
mreza63neusha@gmail.com
10.30476/ijms.2021.88370.1914
In April 2018, a 20-year-old man with a history of methanol intoxication from an alcoholic drink two years ago, when he was 18 years old, was referred to Nikookari Eye Hospital in Tabriz, Iran. He was admitted to emergency service and underwent eight hours of hemodialysis at the time of poisoning. His past medical history was negative, and he did not take any medication after discharge. The patient had a driving license and never experienced any visual problems before. At presentation, his visual acuity was 160/200 in both eyes with the main complaint of visual field deterioration. Other neurologic exams and brain magnetic resonance imaging (MRI) were reported normal by a neurologist. Optic disc cupping was near total in both eyes with a very narrow remaining rim. Optic disc cupping was very similar to glaucomatous cupping. Intraocular pressure was checked several times via Goldmann tonometry and was 13 mmHg. There was no history of refractive surgery leading to thin cornea. Based on this case, methanol poisoning can mimic glaucomatous optic disc cupping. This is the first case report of methanol toxicity-related optic disc cupping from Iran.
Poisoning,methanol,Glaucoma,Optic disc,cupping
https://ijms.sums.ac.ir/article_47729.html
https://ijms.sums.ac.ir/article_47729_d4101168fae0168feff49462db51cf04.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
Expected Impact of Biosimilars on the Pharmaceutical Companies
399
401
EN
Shiva
Golshani
0000-0002-0853-458X
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
shiva_golshani@yahoo.com
Mohammad Ali
Faramarzi
0000-0002-8822-453X
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
faramarz@tums.ac.ir
10.30476/ijms.2021.92314.2356
In the last three decades, biological products have gradually developed to be an essential basis in the pharmaceutical industry. Advancements in this field have encouraged the frontiers of science to bring life-saving treatments to patients suffering from incurable diseases, such as cancers and has also assisted clinicians in managing chronic diseases e.g., rheumatoid arthritis.
Biosimilars,Pharmaceutical Companies,Expected impact
https://ijms.sums.ac.ir/article_47761.html
https://ijms.sums.ac.ir/article_47761_f4b91eaed7b61356c8c70e0f9095a3b5.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
1735-3688
46
5
2021
09
01
A Computerized Platform for Screening and Management of Psychological Characteristics of Healthcare Providers during Novel Coronavirus Infection
402
405
EN
Afsaneh
Rezaei-Kalat
0000-0002-0764-4998
Paychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
rezaeika961@mums.ac.ir
Arash
Javanbakht
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI 48201, USA
arjavanbakht@gmail.com
Reza
Jafarzadeh Esfehani
Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR)- Khorasan Razavi, Mashhad, Iran
drrezajafarzadeh@yahoo.com
Mohammad Reza
Fayyazi Bordbar
0000-0002-4916-1775
Paychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
fayyazimr@mums.ac.ir
10.30476/ijms.2021.89183.1990
The recent coronavirus infection (COVID-19) raised a global concern regarding the mental health of health care providers.
Burnout, Psychological,Mental disorders,Medical staff
https://ijms.sums.ac.ir/article_47701.html
https://ijms.sums.ac.ir/article_47701_53f5dfddce9e0f25edd02b0d78fb3979.pdf