TY - JOUR ID - 39638 TI - The Flare Up of Catastrophic Antiphospholipid Syndrome: a Report of an Immunosuppressive Withdrawal-Induced Case JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Mortazavimoghaddam, Sayyed Gholamreza AD - Pulmonary Ward, Vali-e-Asr Hospital, Birjand University of medical Sciences, Birjand, Iran Y1 - 2011 PY - 2011 VL - 36 IS - 3 SP - 226 EP - 230 KW - Antiphospholipid syndrome KW - immunosuppressive KW - infection DO - N2 - Antiphospholipid syndrome (APS) is a systemic disease that causes venous and arterial thrombosis in virtually any organ. Sometimes it is complicated into pulmonary infarction and cavitation, pulmonary hypertension, and catastrophic course with high morbidity and mortality. The present case is a 35-year-old woman with one episode of postpartum deep veins throm-bosis (DVT) 12 years earlier and the second one after the second labor two years later. In spite of usual therapy for each episode of DVT, the condition had progressed into severe pulmonary hypertension. The diagnosis of primary APL syndrome was confirmed four years ago. She had been on warfarin, low dose of steroid, and azathioprine since the diagnosis of APL syndrome. After one year treatment with steroid and azathiprine the patient showed progressive well being; however, because of hyperglycemia the steroid tapered and discontinued. She had several attacks of paroxismal atrial tachycardia in the last year. On the last time, she presented with severe dyspnea, hemoptesis, and lower limbs edema. Chest radiography and Lung CT scan demonsterated the presence of lung cavitations. Because of high suspicious for fungal pul-monary infection, azathioprine was also discontinued. However, constellation renal failure, hemodynamic instability, and confusion caused the patient to succumb to death. The definite diagnosis of lung cavitations was not obtained. UR - https://ijms.sums.ac.ir/article_39638.html L1 - https://ijms.sums.ac.ir/article_39638_9d189283df5cbd49513cb01bd0fe25df.pdf ER -