TY - JOUR ID - 40347 TI - Effects of Sesame Butter (Ardeh) versus Sesame Oil on Metabolic and Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Haidari, Fatemeh AU - Mohammadshahi, Majid AU - Zarei, Mehdi AU - Gorji, Zahra AD - Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran AD - Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; AD - Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran AD - Department of Nutritional Science, Arvand International Division of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Y1 - 2016 PY - 2016 VL - 41 IS - 2 SP - 102 EP - 109 KW - Antioxidants KW - diabetes mellitus KW - Hyperglycemia KW - Lipids KW - Oxidative stress KW - Sesame oil DO - N2 - Background: Diabetes is one of the most common metabolic disorders and is related to oxidative-stress-induced diseases. Given the role of dietary antioxidants in the control and prevention of diabetes, this study aimed to examine the effects of sesame butter versus sesame oil on the serum levels of glucose, lipid profile, and oxidative stress biomarkers in diabetic rats.Methods: Forty male albino rats of Wistar strain were randomly divided into 4 groups (i.e., nondiabetic control rats, diabetic rats, diabetic rats treated with sesame butter, and diabetic rats treated with sesame oil). Experimental diabetes was induced with an intraperitoneal injection of streptozotocin (55 mg/kg). Sesame butter (1.25 g/kg) and sesame oil (0.5 g/kg) were given by oral gavage to the diabetic rats for 6 weeks. Finally, serum glucose, lipid profile, total antioxidant capacity (TAC), and malondialdehyde (MDA) levels were measured and analyzed statistically.Results: Our data showed that the diabetic groups treated with sesame butter and sesame oil had significantly lower levels of glucose and higher levels of high-density lipoprotein than did the diabetic control group at the end of the study (P<0.05). Sesame butter supplementation also increased TAC and decreased MDA concentrations significantly in the diabetic rats (P<0.05).Conclusion: The antihyperglycemic, antioxidative, and partly lipid-lowering effects of sesame butter make it an excellent candidate for future human studies on diabetes, although further research is needed to determine the exact dose and duration of supplementation. UR - https://ijms.sums.ac.ir/article_40347.html L1 - https://ijms.sums.ac.ir/article_40347_e443727d25bb99306db04a42500d2d49.pdf ER -