TY - JOUR ID - 40527 TI - The Preventive Role of Pioglitazone in Glycerol-Induced Acute Kidney Injury in Rats during Two Different Treatment Periods JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Mousleh, Rama AU - Al Laham, Shaza AU - Al-Manadili, Ahmad AD - Departmentof Pharmacology and Toxicology, Faculty of Pharmacy, Damascus University, Damascus, Syria AD - Departmentof Oral Histopathology, Faculty of Dentistry, Damascus University, Damascus, Syria Y1 - 2018 PY - 2018 VL - 43 IS - 2 SP - 184 EP - 194 KW - Kidney KW - Glycerol KW - Rhabdomyolysis KW - Acute kidney injury KW - Pioglitazone KW - Reduced glutathione DO - 10.30476/ijms.2018.40527 N2 - Background: Acute kidney injury is the most life-threatening complication of rhabdomyolysis. Glycerol is commonly used to induce this injury. The aim was to investigate the renoprotective effects of pioglitazone and the possible advantage of administering the drug for a longer period.Methods: Twenty-four male Albino Wistar rats were randomly divided into 4 groups (n=6/group): (A) control, (B) glycerol (50%, 10 mL/kg intramuscularly), (C) glycerol+pioglitazone (10 mg/kg orally for 3 days), and (D) glycerol+pioglitazone (for 6 days). Serum urea and creatinine levels were measured to assess the renal function. Reduced glutathione (GSH) levels and histological alterations were also measured. Statistical analysis was performed using Prism (version 6). The numerical data were evaluated by ANOVA, followed by the Tukey tests. The categorical data were evaluated by the Mann–Whitney test and the Fisher exact tests. P UR - https://ijms.sums.ac.ir/article_40527.html L1 - https://ijms.sums.ac.ir/article_40527_65eb06354fb89d5953bfcabcbd754edd.pdf ER -