TY - JOUR ID - 40581 TI - The Effect of Remote Ischemic Preconditioning on the Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Bagheri, Sina AU - Shahbazi, Shahrbanoo AU - Shafa, Masih AU - Borhani-Haghighi, Afshin AU - Kiani, Mahsa AU - Sagheb, Mohammad Mahdi AD - Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Cardiac Surgery, Shiraz University of Medical Sciences, Shiraz, Ira AD - Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2018 PY - 2018 VL - 43 IS - 6 SP - 587 EP - 595 KW - schemic preconditioning KW - Reperfusion injury KW - Acute kidney injury KW - Coronary artery bypass DO - 10.30476/ijms.2018.40581 N2 - Background: Remote ischemic preconditioning (RIPC) protects other organs from subsequent lethal ischemic injury, but uncertainty remains. We investigated if RIPC could prevent acute kidney injury (AKI) in patients undergoing coronary artery bypass graft (CABG) surgery.Methods: This parallel-group, double-blind, randomized, controlled trial was done on adults undergoing elective or urgent on-pump CABG surgery from 2013 to 2017 in Shiraz, Iran. Patients were allocated to RIPC or control groups through permuted blocking. The patients in the RIPC group received three cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia. We placed an uninflated cuff on the arm for 30 min in the control group. The study primary endpoint was an incidence of AKI. Secondary endpoints included short-term clinical outcomes. We compared categorical and continuous variables using Pearson χ2 and unpaired t tests, respectively. P UR - https://ijms.sums.ac.ir/article_40581.html L1 - https://ijms.sums.ac.ir/article_40581_aea329234ca3dd437e3b9a8cc7e2a183.pdf ER -