TY - JOUR ID - 44969 TI - Effects of Tranexamic Acid on Bleeding and Hemoglobin Levels in Patients with Staghorn Calculi Undergoing Percutaneous Nephrolithotomy: Randomized Controlled Trial JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Mohammadi, Mehrdad AU - Nouri-Mahdavi, Kia AU - Barzegar, Abbas AD - Isfahan Kidney Transplantation Research Center, Department of Urology, Alzahra Research Centers, Isfahan University of Medical Sciences, Isfahan, Iran Y1 - 2019 PY - 2019 VL - 44 IS - 6 SP - 457 EP - 464 KW - Tranexamic acid KW - Staghorn calculus KW - Bleeding KW - Hemoglobin DO - 10.30476/ijms.2019.44969 N2 - Background: The incidence of renal hemorrhage during percutaneous nephrolithotomy (PCNL) is high. We sought to evaluate the effects of tranexamic acid (TXA) on bleeding and hemoglobin levels of patients with staghorn calculi treated with PCNL.Methods: In a double-blind clinical trial, 120 patients with staghorn calculi candidated for PCNL in Alzahra Hospital between January 2014 and November 2017, Isfahan, Iran, were classified into two groups in terms of the stone size (>4 cm and Results: The mean volume of blood loss was significantly higher in the control group patients than in those receiving TXA, in both stone-size categories (P<0.001). There was no significant difference in the postoperative hemoglobin level between the intervention and control groups, in both stone-size categories (P=0.26 and P=0.10, respectively). In addition, the mean volume of blood loss increased significantly with an increase in the operative duration (P<0.001). Conclusion: TXA reduced the risk of bleeding during and after PCNL and attenuated the drop in the hemoglobin level in the postoperative period. Longer operative procedures were associated with an increase in the bleeding volume. Trial Registration Number: IRCT20180209038673N1 UR - https://ijms.sums.ac.ir/article_44969.html L1 - https://ijms.sums.ac.ir/article_44969_fca8a95776b6cdc7e71d84c9a82a62c7.pdf ER -