TY - JOUR ID - 48182 TI - Development of Bio-artificial Esophageal Tissue Engineering Utilization for Circumferential Lesion Transplantation: A Narrative Review JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Haghdel, Mobin AU - Imanieh, Mohammad Hadi AU - Hosseinpour, Hamidreza AU - Ghasemi, Younes AU - Alizadeh, Ali Akbar AD - Department of Tissue Engineering, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Pediatrics Gastroenterology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Surgery, Shiraz Laparoscopic Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2022 PY - 2022 VL - 47 IS - 5 SP - 406 EP - 421 KW - Tissue engineering KW - Esophagus KW - stem cells KW - Biocompatible Materials KW - Tissue scaffolds KW - Regeneration DO - 10.30476/ijms.2021.89194.1991 N2 - The esophagus is the gastrointestinal tract’s primary organ that transfers bolus into the stomach with peristaltic motion. Therefore, its lesions cause a significant disturbance in the nutrition and digestive system. Esophageal disease treatment sometimes requires surgical procedures that involve removal and circumferential full-thickness replacement. Unlike other organs, the esophagus has a limited regeneration ability and cannot be transplanted from donors. There are various methods of restoring the esophageal continuity; however, they are associated with certain flaws that lead to a non-functional recovery. As an exponentially growing science, tissue engineering has become a leading technique for the development of tissue replacement to repair damaged esophageal segments. Scaffold plays a significant role in the process of tissue engineering, as it acts as a template for the regeneration of growing tissue. A variety of scaffolds have been studied to replace the esophagus. Due to the many tissue quality challenges, the results are still inadequate and need to be improved. The success of esophageal tissue regeneration will finally depend on the scaffold’s capability to mimic natural tissue properties and provide a qualified environment for regeneration. Thereby, scaffold fabrication techniques are fundamental. This article reviews the recent developments in esophageal tissue engineering for the treatment of circumferential lesions based on scaffold biomaterial engineering approaches. UR - https://ijms.sums.ac.ir/article_48182.html L1 - https://ijms.sums.ac.ir/article_48182_df8389b7a3633b664571750cf3fe82c7.pdf ER -