Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Menstrual Abnormalities and Pain after Five Tubal Sterilization Methods: A Randomized Controlled Trial
51
56
40175
EN
ME.
Parsanezhad
Department of Obstetrics and
Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
SA.
Alborzi
Department of Obstetrics and
Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
B.
Namavar Jahromi
Department of Obstetrics and
Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran
Journal Article
2015
10
28
Background and Objective:Tubal sterilization is the most popular method of permanent female contraception, yet there is considerable debate concerning the influence of this procedure on the women’s health and menstrual pattern. Methods:We randomized 1358 women to one of the five methods of tubal sterilization; unipolar electrocauterization, bipolar electrocauterization, minilaparatomy, Pomeroy method, Falope ring, and Hulka clips to evaluate the effect of each method on menstrual pattern. Each woman was interviewed before sterilization and followed for 3 years. 850 women who did not undergo sterilization served as control group and were interviewed and followed. 248 women of study group and 503 cases of the control group did not fulfill the study criteria and were excluded. Results:Menstrual indices were significantly different between the control group and those women who were sterilized by unipolar, ring, and Pomery methods. The amount of bleeding, was increased by 28.3% in unipolar group (p=0.001), 19.9% in ring group (p=0.001), and by 23.9% in Pomeroy group (p=0.0001). Significant menstrual pain lasted for a maximum of 18 months was noted in unipolar coagulation group (p=0.0001). Conclusion:Sterilization methods which destroy the vascular communications along and immediately subjacent to the tube and that also disturb the countercurrent exchange of biologically active factors between the uterus and ovaries, are more likely to cause menstrual abnormalities.
https://ijms.sums.ac.ir/article_40175_b9f40d6e23f60f945a849350b4c9af1c.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Treatment of Staphylococcal Joint Infection in the Rabbit by Administration of Systemic Antibiotics and Intra-articular Corticosteroids
57
61
40178
EN
FM.
Jaberi
Department of Orthopaedic Sur-gery, Shiraz University of Medical Sciences, Shiraz, Iran
M.
Nicfar
Department of Orthopaedic Sur-gery, Shiraz University of Medical Sciences, Shiraz, Iran
N.
Tanideh
Department of Phrmacology, Shiraz University of Medical Sciences, Shiraz, Iran
B.
Gramizadeh
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Journal Article
2015
10
28
Background/objective: Despite the present routine treatment of septic arthritis with antibacterial agents, articular damage is persistent and frequently leads to loss of joint function. The aim of this study was to assess the effect of intra-articular corticosteroids added to systemic antibiotics in the treatment of experimental staphylococcal knee joint infection in rabbits. Methods: Thirty rabbits were injected in their knees by Staphylococcus aureus. The rabbits were divided into 3 equal groups. In group A, rabbits received no treatment. In group B, rabbits were treated with systemic antibiotics alone. Group C, received systemic antibiotics and intra-articular corticosteroids. After 16 days animals were killed and knee joint X-Ray as well as histopathological–histochemical parameters were assessed. Results: All rabbits survived the experiment; the treated groups (B,C) had better histological–histochemical scores in comparison with the untreated group (A). Group C had significantly better scores in joint sections in comparison with group B (mean SD = 6.7 ± 2.3 v 4.0 ± 2.4; P= 0.019). Lower damage in the former group was expressed in lesser clustering of chondrocytes, proteoglycan depletion, and severity of synovitis. Radiological soft tissue scoring was significantly better in group C in comparison with group B. Three peri-articular abcesses were observed in group C but none in group B. Conclusion: Addition of intra-articularly administered corticosteroids to antibiotic treatment of septic arthritis improved histological histochemical parameters in this experimental setting, although on account of the clinical observation of three cases with peri-articular abcesses in this group, caution is warranted in interpretation of these results.
https://ijms.sums.ac.ir/article_40178_32a146aa734b1ccd06363f10b8f2bf90.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Iron Status in Newborns Born to Iron-Deficient Mothers
62
64
40181
EN
S.
Ziaei
Faculty of Medical Science, Tarbiat Modarres University, Tehran, Iran
E.
Hatefnia
Faculty of Medical Science, Tarbiat Modarres University, Tehran, Iran
Gh.
Togeh
Faculty of Medical Science, Tarbiat Modarres University, Tehran, Iran
Journal Article
2015
10
28
Background: Iron deficiency anemia is one of the important problems during pregnancy. Iron deficiency has several adverse effects on pregnant women and their newborns. Objective: To determine the status of iron store in newborns born to mothers with iron deficiency anemia. Methods: In a cross-sectional study, 90 mothers were categorized into three groups according to their pre-delivery hemoglobin and serum ferritin concentrations. Those with Iron-Deficiency Anemia (IDA) were defined as a hemoglobin concentration (Hb) <11 g/dl and serum ferritin concentration (SF) of <10 ng/ml; those with non-anemic iron deficiency (NIDA) with an Hb of ³11 g/dl and SF of <10 ng/ml; and those mothers with normal Hb and iron status, defined as an Hb ³11 g/dl and a SF ³10 ng/ml, who were treated as normal control. Then cord bloods of the newborn were compared among the three groups. Results: Significant differences were found in mean Hb (p<0.01) and SF (p<0.03) among normal control and IDA, with the lowest values found in neonates born to mothers with iron deficiency anemia. Conclusions: Contrary to previous beliefs, the iron status of mothers can influence their babies.
https://ijms.sums.ac.ir/article_40181_b6910311f00dd4207c70f332743ec3b9.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Abnormalitites of Visual Evoked Potential in Migraine Patients
65
68
40183
EN
N.
Ashjazadeh
Electroneurodiagnostic Clinic, Department of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
B
Varavipour
Electroneurodiagnostic Clinic, Department of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Journal Article
2015
10
28
Background: Visual evoked potential (VEP) is regarded as a useful, reliable and non-invasive technique for the diagnosis of lesions in the optic pathway. This technique was used to investigate visual function in migraine. Materials and Methods: 53 migraine patients (27 migraine cases with aura and 26 common migraine cases) and 55 controls were prospectively enrolled in this study. Visual evoked potential using the pattern reversal stimuli was performed in all patients and controls, and abnormalities of visual evoked potential were evaluated. Results: In subjects with classic migraine mean latencies of the P100 wave was increased by 6.7% (P<0.05) compared with controls. Common migraine subjects did not show significant difference with controls in regard to P100 latency (P>0.05). Also no significant difference was observed in P100-N140 peak-to-peak amplitude between the patients and controls. Conclusion: The results of this study demonstrate subtle neuronal damage within the visual system of migraine patients which may be due to repeated transient ischemia experienced during the aura or more likely as a constitutional change.
https://ijms.sums.ac.ir/article_40183_0f354a18275670365fb1cb2466a5f414.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Management of Vaginismus with Cognitive –Behavioral Therapy, Self-Finger Approach: A Study of 70 Cases
69
71
40185
EN
M.
Mousavi Nasab
Associate Professor of Psychiatry Department of Psychiatry Shiraz Medical School,
Z.
Farnoosh
Clinical Psychologist
Journal Article
2015
10
28
Background: Vaginismus is an involuntary spasm of the muscles of the outer third of the vagina caused by real or anticipated attempt of vaginal penetration. It could lead to marital disharmony, guilt feeling and depression. Cognitive behavioral models for therapy of this disorder have gained considerable attention during last three decades. Objective: To determine the efficacy of self-finger approach in the management of vaginismus. Methods: Seventy patients with the diagnosis of primary vaginismus based on DSM-IV criteria were enrolled in the study. The data were gathered by a semi-structured interview. After consent, the patients were referred to a female clinical psychologist for weekly sessions of cognitive behavioral therapy, i.e. desensitization using a self-finger approach. Those who had psychiatric co-morbidity were treated for the co-morbid disorders. Results: Sixty four patients (91.42%) of the total 70 completed the course of therapy and all of them responded well to the therapy. Conclusion: Non-instrumental cognitive-behavioral therapy, self –finger approach, was an effective method for treatment of vaginismus.
https://ijms.sums.ac.ir/article_40185_ea110173671e82489417580331304f18.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Determination of Central Venous Pressure from Intraocular Pressure
72
74
40186
EN
H.
Kamalipour
Department of Anesthesiology,
Shiraz University of Medical Sciences, Shiraz, Iran
MH.
Roozitalab
Department of Ophthalmology,
Shiraz University of Medical Sciences, Shiraz, Iran
GR.
Masoumi
Department of Anesthesiology,
Shiraz University of Medical Sciences, Shiraz, Iran
Journal Article
2015
10
28
Background: In many clinical situations, knowledge of central venous pressure (CVP) is important. Measurement of CVP is not always possible. Objective: To determine if intraocular pressure (IOP) can be used as an estimate for CVP. Methods: IOP and CVP were measured concurrently in 30 candidates of coronary artery bypass graft surgery. Those with carotid artery or jugular venous diseases as well as those with glaucoma or cardiac ejection fraction of less than 50% were excluded from the study. Results: A linear correlation was found between CVP and IOP (r = 0.66, p<0.001). CVP can be easily derived by halving the IOP. Conclusion: The use of this very simple method, particularly in those health care centers where due to the lack of necessary equipment for accessing central veins, CVP measurement is not possible, may provide useful information to physicians.
https://ijms.sums.ac.ir/article_40186_1383cd7c058e30b967c4f2911450f66f.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Uptake of Autologous and Allogenic Tumor Cell Antigens by Dendritic Cells
75
80
40187
EN
R.
Mahdian
Immune and Gene Therapy Lab, CCK, Karolinska Institute, Stock-holm, Sweden
MA.
Shokrgozar
National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
A.
Amanzadeh
National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, Iran
Journal Article
2015
10
28
Background: Dendritic cells (DCs) are professional antigen presenting cells (APCs), and there is considerable interest in their application as a cellular adjuvant for cancer immunotherapy. Previous studies indirectly demonstrated that DCs were able to take up tumor lysate (crude soluble tumor antigens) and also cross-present tumor associated antigens (TAA) which elicits anti-tumor immune response. Objective: To provide direct evidence that demonstrates the uptake of tumor lysate by DCs and to find out whether this capability is restricted to allogenic or autologous tumor lysate preparation. Methods: DCs were generated from magnetic bead-isolated monocytes of B-CLL patients as well as healthy donors. Proteins of tumor lysate were conjugated with FITC. Their uptake by autologous as well as allogenic DCs was analyzed using FACS flowcytometry system. Results: In both autologous and allogenic experiments, green fluorescence intensity (FL1) of immature DCs incubated with FITC-labeled tumor lysate was clearly higher than unpulsed counterparts, which were considered as background. Conclusion: Immature DCs are able to efficiently take up FITC-labeled tumor lysate of autologous as well as allogenic sources. This finding confirms the results of previous studies, which have demonstrated that tumor lysate-pulsed DCs were able to elicit cytotoxic anti-tumor response and concluded that DCs could take up tumor lysate.
https://ijms.sums.ac.ir/article_40187_b537be3d3f883865d1668cf4744008b7.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Laboratory Monitoring of Cyclosporine Pre-dose Concentration (C0) After Kidney Transplantation in Isfahan
81
85
40188
EN
Z.
Tolou-Ghamari
School of Pharmacy, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran.
A.A.
Palizban
School of Pharmacy, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran.
Journal Article
2015
10
28
Background: Cyclosporine is the main immunosuppressive agent used in organ transplantation which leads to considerable improvement in graft survival. The large inter- and intra- patient variability in cyclosporine pharmacokinetics coupled with the agent’s narrow therapeutic index and adverse effects necessitate therapeutic monitoring of cyclosporine blood levels. Objective: The aim of this study was to determine the extent of variability following oral administration of cyclosporine after kidney transplantation, and provide guidelines for administration of cyclosporine in Isfahan/Iran Methods: The results of 2163 cyclosporine pre-dose blood samples obtained from 647 kidney transplant recipients (208 females, 439 males) with a median age of 34 years (range 11-54 years) were studied. Concentration of cyclosporine in the whole blood was determined by a radioimmunoassay using monoclonal antibodies specific for the drug. Statistical analyses were performed using SPSS. Results: The frequency distribution of C0 and daily oral dosage of cyclosporine exhibited wide interindividual variability. Cyclosporine oral dosage regimen ranged from 100 mg to 400 mg. Trough cyclosporine blood concentration (C0) ranged from 18 ug/l to 1400 ug/l. The results of cyclosporine whole blood levels in 56% were always below the suggested therapeutic range (less than 200 ug/l) and in 14% of the samples seemed to be associated with the occurrence of toxic side effects. There were no significant differences in the median trough levels of kidney recipients according to gender (p = 0.36). Conclusion: For long-term management of kidney transplant recipients and in order to further optimize the use of cyclosporine, it is essential to standardize laboratory monitoring and clinical investigation of this agent.
https://ijms.sums.ac.ir/article_40188_a3a661a270003764f7ef19151d94b964.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Relationship of Conjunctival and Corneal Calcification with Secondary Hyperpara-thyroidism in Hemodialysis Patients
86
89
40189
EN
H.
Nasri
Hajar Medical, Educational and Therapeutic Center, Section of Hemodialysis, Shahrekord, Iran
A.
Baradaran
Department of Biochemistry, The Center of Research and Reference Laboratory of Iran, Tehran, Iran
F.
Doroudgar
Shahrekord University of Medical Sciences
F.
Ganji
Shahrekord University of Medical Sciences
Journal Article
2015
10
28
Background/Objective: Hyperphosphatemia is the consequence of end stage renal failure. Inadequate control of serum phosphorus results in elevated Ca×P product with subsequent soft tissue deposition in the form of conjunctival and corneal calcification. In this study, we evaluated the relationship of conjunctival and corneal calcification with secondary hyperparathyroidism in hemodialysis patients. Patients and methods: This is a descriptive–analytic study performed on 24 hemodialysis patients. We measured serum calcium, phosphorus, alkaline phosphatase, iPTH and conjunctival and corneal calcification using slit–lamp microscope according to a modification of Porter's criteria. The duration of hemodialysis was 30.7 ± 21.7 months. Results: 24 patients participated in this study. The biochemical values were: Ca: 9.1 ± 0.8 mg/dl, P: 6.5 ± 2.2 mg/dl, ipTH: 488 ± 326 pg/ml, Ca×P : 51.5 ± 16.6 The mean of conjunctival and corneal calcification score was 7.1±4.There was a positive correlation between conjunctival and corneal calcification with a duration of hemodialysis (p=0.033, r=0.436), Ca×P product (p=0.007, r=0.538). P (p=0.006, r=548) and iPTH (p= 0.028 , r=0.449). There was no correlation between conjunctival and corneal calcification with the age of the patients, serum calcium and alkaline phosphatase. Conclusion: There is a positive correlation of serum phosphorus, Ca×P product and iPTH with conjunctival and corneal calcification and no significant correlation with serum calcium implying that there is a central role for phosphorus in calcium-phosphorus deposition in soft tissues like cornea and conjunctiva, underscoring further attention to phosphorus control in hemodialysis patients.
https://ijms.sums.ac.ir/article_40189_d5605cdce94b23bc340af6f69db0291d.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Immunoblot Assay in Determination of Serum Antibody Profile of Helicobacter Pylori Infection
90
92
40176
EN
M.
Saffari
Medical Sciences of Kashan University
MA.
Motavalii
Medical Sciences of Kashan University
A.
Fazeli
Medical Sciences of Isfahan University
Journal Article
2015
10
28
A high prevalence of antibody to cag A has been observed in H. pylori seropositive patients (HP+) living in developed countries. This is felt to be correlated with the development of serious sequelae of this infection. We examined the sero-prevalence of antibody to cag A and other specific H. pylori antigens in symptomatic and asymptomatic individuals living in Kashan.Sera from 37 patients whose HP status was determined by culture, histology, RUT, and ELISA were enrolled in this study. The Helico – blot 2.1 western blot system was used for the detection of antibodies to specific antigens of H.pylori in sera obtained from both positive and negative HP.Out of 85 patients, 47 (55.3%) were HP+ and 38 (44.7%) HP- . Among the HP+ group, 37 were tested with immunoblot system. Patients and their respective clinical disease were composed of duedenitis 19, non-ulcer dyspepsia 4 , dyspepsia 4 , gastritis 24 , cancer and metaplasia 11 and 2 normal biopsies. In that order the corresponding antibodies to cag A was 73%,75%,75%,83%,81.8% and 50%.The results of this study suggest that cag A antibody is more frequent in the acute status; however, this factor is diagnostically insufficient in some disease processes. In addition,cag A+ phenotype can not be used as a single marker for high risk patients.
https://ijms.sums.ac.ir/article_40176_bbabcfa6e39a23eec3da2b00376c9919.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Serological Survey of Human Leptospirosis in tribal Areas of West Central Iran
93
95
40179
EN
A.
Ebrahimi
Department of Pathobiology-Veterinary college, Shahrekord Univers ity, Shahrekord, Iran
L.
Alijani
Department of Pathobiology-Veterinary college, Shahrekord Univers ity, Shahrekord, Iran
G R
Abdollahpour
Department of Clinical Sciences, Faculty of Veterinary Medicine, Te-hran University, Tehran, Iran
Journal Article
2015
10
28
Leptospirosis is one of the zoonotic diseases caused by different serovars of the species Leptospira interrogans. The source of infection in humans is usually either direct or indirect contact with the urine of infected animals. In this study, 400 human blood samples collected from tribal areas of Farsan and Koohrang cities in West Centeral Iran. The serum samples were analyzed employing Microscopic Agglutination Test (MAT). From 400 Samples, 194 Samples (48 .5%) were positive to different leptospiral sreovars at a minimum titre of 1/100. The highest seroprevalence was to serovar hardjo (54 .1% of seropositives ) and the least was to serovar grippotyphosa (1%). Seroprevalency of women were higher than men
https://ijms.sums.ac.ir/article_40179_56a0c81ed41af933a1bf6d44b0f6fd3b.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Prolonged Atrio-Ventricular Block Following Scorpion Bite: A Case Report
96
97
40177
EN
M. B.
Sharifkazemi
Department of Medicine (Cardiol-ogy), Shiraz University of Medical Sciences, Shiraz,Iran
G.R.
Rezaian
Department of Medicine (Cardiol-ogy), Shiraz University of Medical Sciences, Shiraz,Iran
M.
Zamirian
Department of Medicine (Cardiol-ogy), Shiraz University of Medical Sciences, Shiraz,Iran
S.A.R.
Hashemi
Department of Medicine (Cardiol-ogy), Shiraz University of Medical Sciences, Shiraz,Iran
Journal Article
2015
10
28
This report describes a 55-year-old woman in whom yellow scorpion sting resulted in the development of Mobitz type 1 and transient complete heart blocks unresponsive to atropine administration. It might be concluded that although autonomic involvement including parasympathetic overactivity is present in such cases, other factors such as toxic damage to the cardiac conduction system may play a role in the development of some of the cardiovascular manifestations of scorpion toxin.
https://ijms.sums.ac.ir/article_40177_a86a393bdbc44e406291fc6e4623394b.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Hypoproteinaemia and Edema Due to Giardiasis
98
99
40180
EN
M.
Baghaei
Department of Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Journal Article
2015
10
28
The present report describes a 5-years-old girl who presented with hypoproteinaemia and generalised oedema due to giardiasis. She recovered fully 2 weeks after treatment with oral metronidazole. The emphasis is on the importance of giardiasis in children with hypoproteinaemia of obscure aetiology.
https://ijms.sums.ac.ir/article_40180_fe2d7ce351cf191ba01e4ba59362facb.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Primary Malignant Melanoma of the Eye in a 17-Year-Old Girl with Acute Lymphoblastic Leukemia
100
102
40182
EN
M.
Mehryar
Department of Ophthalmology Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
M.
Farvardin
Department of Ophthalmology Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
M.
Mehdizadeh
Department of Ophthalmology Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
H.
Shahryari
Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
M.H.
Roozitalab
Department of Ophthalmology Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
H.R.
Jahadi
Department of Ophthalmology Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
N.
Owji
Department of Ophthalmology Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Journal Article
2015
10
28
Herein we describe a case of intraocular melanoma in a17-year old leukemic patient. The history, histological findings of the enucleated eye, blood and bone marrow of the patient were investigated. The enucleated eye contained epitheloid cell type melanoma instead of leukemic cell infiltration. We conclude that intraocular malignant melanoma can occur in acute lymphoblastic leukemia.
https://ijms.sums.ac.ir/article_40182_0c0746638eaf7a5d569a89baa34fce7a.pdf
Shiraz University of Medical Sciences
Iranian Journal of Medical Sciences
0253-0716
28
2
2015
10
28
Organizing Lobar Pneumonia: Report of a Case
103
105
40184
EN
M.
Sokouti
Department of Thoracic Surgery. Imam Khomeini Hospital, Tabriz University of Medical Sciences
M.
Milani
Department of Pathology Urmia University of Medical Science, Urmia, Iran
V.
Montazeri
Department Thoracic Surgery. Imam Khomeini Hospital
Journal Article
2015
10
28
Organizing Lobar Pneumonia is a rare form of Bronchiolitis Obliterans Organizing Pneumonia. Herein, we report a rare case of organizing pneumonia involving lung, mediastinum and esophagus. A 16-year-old girl was referred to our center with clinical signs and symptoms of dysphagia and weight loss. The main abnormal radiologic and endoscopic findings were stricture of the lower third of esophagus and calcified lobar pneumonia of the lung. Pathologic examination of biopsies taken from esophageal stricture and resected lung revealed fibrosis and organizing lobar pneumonia. This combination, to our knowledge, has not been reported previously.
https://ijms.sums.ac.ir/article_40184_9cc4180a31f21058005f20d78e4e4729.pdf