Shiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Association between the Functional Polymorphism of Vascular Endothelial Growth Factor Gene and Breast Cancer: A Meta-Analysis21239713ENJuanLiDepartment of Radiotherapy, The Second Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, Jiangsu Province, ChinaYongjianJuDepartment of Radiotherapy, The Second Affiliated Hospital of Nantong University, Nantong University, Nantong 226001, Jiangsu Province, ChinaJournal Article20140226The vascular endothelial growth factor (VEGF) gene single-nucleotide polymorphism involved in the regulation of the protein levels has been implicated in breast cancer. However, the published studies have produced contentious and controversial results. Herein, we performed a meta-analysis (from January to October 2013); to further evaluate the association between +936 C/T polymorphism and the risk of breast cancer. By searching the EMBASE, PubMed, and Web of Science databases, we identified a total of 12 case-control studies with 8,979 cancer patients and 9,180 healthy controls. The strength of the association was assessed using Odds Ratios (ORs) with 95% Confidence Intervals (CI). We found no evidence indicating that the allelic model or the genotype models of +936 C/T polymorphism were associated with the risk of breast cancer in total population (ORCC vs. TT=1.01, 95% CI=0.96-1.06, Ph=1.00; ORCC+CT vs. TT=1.00, 95% CI=0.96-1.05, Ph=1.00; ORCC vs. CT+TT=1.02, 95% CI=0.98-1.07, Ph=0.94; OR allele C vs. allele T=1.01, 95% CI=0.98-1.04, Ph=0.99; ORCT vs. TT=1.01, 95% CI=0.93-1.09, Ph=1.00). Such lack of association with breast cancer was also observed in subgroup analyses according to ethnicity as well as in the analysis by source of controls. In conclusion, this meta-analysis suggests that the functionally important +936 C/T polymorphism may not be associated with breast cancer risk. Larger well-designed studies with gene-to-gene and gene-to-environment interactions are clearly required to validate the results further.https://ijms.sums.ac.ir/article_39713_741c7f4e0f6fb53acd280839949fa7b4.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Combined Femoral and Acetabular Osteotomy in Children of Walking Age for Treatment of DDH; A Five Years Follow-Up Report131839714ENMahdiMazloumiDepartment of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IranFarzadOmidi-KashaniDepartment of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IranMohamad HoseinEbrahimzadehDepartment of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IranHadiMakhmalbafDepartment of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IranMohamad MahdiHoseinayeeDepartment of Orthopedic Surgery, Orthopedic Research Center, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IranJournal Article20150121Background: The prevalence of neglected developmental dysplasia of the hip (DDH) has been decreasing. Nowadays, the disease is rarely seen in walking age children. The purpose of this study is to assess the results of simultaneous osteotomy of femur and pelvic bones in such children.Method: We performed a retrospective study on 30 children aged 3.8±0.9 (range: 1.5-7) years old, with DDH who underwent surgical operation in our hospital from August 2001 to September 2006. Tönnis and Severin grading systems were used to classify the radiographic status of the hip in pre- and postoperative era, respectively. Improvement in function and limp was also evaluated by the modified McKay’s classification.Results: From the 30 cases, six patients excluded in the course of the study and among the remaining patients, 12 had bilateral involvement. The mean follow-up period was 7.6±0.8 (range: 5.1-11.3) years. During the last visit, radiographic status of the operated joints, according to Severin classification was as follows: Class I: 12 patients; Class II: 20 patients; Class III: 3 patients; Class IV: 1 patient; and Class VI: 1 patient. Conclusion: Although through the follow-up, two hips subluxated, necrosis happened in three and one joint was re-dislocated, simultaneous femoral and innominate osteotomy in the walking age children with DDH has relatively good clinical outcomes.https://ijms.sums.ac.ir/article_39714_9f67264f255e0e206ec232d6ad423416.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Comparison of Prophylactic Infusion of Phenylephrine with Ephedrine for Prevention of Hypotension in Elective Cesarean Section under Spinal Anesthesi: A Randomized Clinical Trial192639717ENFarnazMoslemiWomen’s Reproductive Health Research Center, Department of Anesthesiology, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, IranSousanRasooliWomen’s Reproductive Health Research Center, Department of Anesthesiology, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, IranJournal Article20150121Background: Spinal anesthesia is an accepted technique in elective cesarean sections. However, hypotension, resulted from sympathectomy is a common problem, especially in pregnant women. Prevention of this complication by sympathomimetic agents is of potential clinical significance. The aim of this study is to compare the effect of prophylactic infusion of Phenylephrine versus Ephedrine in the prevention of hypotension during spinal anesthesia in elective cesarean section.Methods: Eighty-three patients were enrolled in this study and randomly divided into three groups. Group Ph received phenylephrine infusion, group E received ephedrine infusion while group P were delivered placebo. Vital signs (blood pressure, heart rate, and arterial oxygen saturation) were recorded throughout the surgery. Maternal and neonatal perioperative complications were also controlled and recorded.Results: There was an insignificant difference in demographic data between the groups. Systolic and diastolic blood pressures were higher in the phenylephrine group than control, but not higher than the ephedrine group. Maternal dysrhythmias were more common in ephedrine and phenylephrine groups than the control group. Vomiting was more common in ephedrine group (P<0.05). In addition, the fifth-minute Apgar score of neonates was higher in phenylephrine and ephedrine groups than the control group (P<0.05). Neonates of phenylephrine group had less acidosis than the other groups.Conclusion: Prophylactic infusion of phenylephrine can effectively decrease spinal anesthesia related hypotension without any significant complication for mother or her fetus. Trial Registration Number: IRCT2012120911700N1https://ijms.sums.ac.ir/article_39717_7dc3448b6b310eb288334c350ec3acb6.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Comparison of Appetite-regulating Hormones and Body Composition in Pediatric Patients in Predialysis Stage of Chronic Kidney Disease and Healthy Control Group273339720ENMohammad HassanEftekhariDepartment of Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran0000-0002-6911-3551MaryamRanjbar-ZahedaniDepartment of Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranMitraBasiratniaDepartment of Nephrology Urology Research Center, Shiraz University of Medical Sciences, Shiraz, IranAbbasRezaianzadehDepartment of Epidemiology,
Research Center for Health Sciences, Shiraz University of Medical Sciences, Shiraz, IranShivaFaghihDepartment of Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, IranJournal Article20150121Background: Protein-energy malnutrition (PEM) is a common complication in pediatric patients with chronic kidney disease (CKD). Components incorporated in the regulation of appetite and body composition appear to be of the focus in renal insufficiency and may influence the CKD-associated PEM. The purpose of this study was to investigate plasma levels of appetite-regulating hormones and their correlation with the body composition variables in a pediatric in predialysis stage of CKD.Methods: Thirty children with CKD in predialysis stage were selected and compared with 30 healthy sex- and age-matched controls. Blood samples were collected in fasting. Serum total ghrelin, leptin, and obestatin levels were measured using enzyme immunometric assay methods. Anthropometric parameters measurement and body composition analysis were done using the bioelectric impedance analysis (BIA) method.Results: Patients showed insignificant elevated total ghrelin (105.40±30.83 ng/l), leptin (5.32±1.17 ng/ml) and obestatin (5.07±1.09 ng/ml) levels in comparison with healthy participants. By using BIA, patients had significantly different Dry Lean Weight (P=0.048), Extra Cellular Water (P=0.045), Body Cell Mass (BCM) (P=0.021), Basal Metabolic Rate (P=0.033) and Body Mass Index (P=0.029) compared with controls. Furthermore, the total body water was slightly and the ECW was significantly higher in CKD participants. There were significant negative correlation between obestatin and BCM (r=-0.40, P=0.03) and fat free mass index (FFMI) (r=-0.40, P=0.029) in patients.Conclusion: It seems that our results are insufficient to clarify the role of appetite-regulating hormones in PEM in CKD patients. It is apparent that there are still many unknown parameters related to both appetite regulating and CKD-associated PEM.https://ijms.sums.ac.ir/article_39720_2afb34f11ccaf2ea706bb1ac9b858f6c.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Application of Bland-Altman Method in Comparing Transrectal and Transabdominal Ultrasonography for Estimating Prostate Volume343939723ENAliBabaei JandaghiDepartment of Radiology,
Guilan University of Medical Sciences, Rasht, IranMaryamShakibaDepartment of Epidemiology,
Shahid Beheshti University of Medical Science, Tehran, Iran0000-0000-0000-0000HamidrezaNassehUrology Research Center,
Guilan University of Medical Sciences, Rasht, IranYaserKoroujiUrology Research Center,
Guilan University of Medical Sciences, Rasht, IranSamanehEsmaeiliUrology Research Center,
Guilan University of Medical Sciences, Rasht, IranAli AkbarKhadem MaboudiDepartment of Biostatistics, Shahid Beheshti University of Medical Science, Tehran, IranAliKhorshidiDepartment of Epidemiology,
Shahid Beheshti University of Medical Science, Tehran, IranJournal Article20150121Background: Estimating prostate volume using less invasive transabdominal ultrasonography (TAUS) instead of transrectal ultrasonography (TRUS) is of interest in terms of identifying their agreement level. Previous reports on this subject, applied general correlation coefficient as the level of agreement. This study uses Bland-Altman method to quantify TAUS and TRUS agreement on estimating prostate volume.Methods: Total prostate gland volume of 40 patients with signs and symptoms of benign prostatic hyperplasia were measured using TAUS and TRUS. The study was carried out at the Urology Research Center, Razi Hospital, Guilan University of Medical Sciences (Rasht, Iran) from March to October 2010. Both methods were performed in one session by the same experienced radiologist. Data were analyzed using Pearson correlation coefficient and Bland-Altman method.Results: Total prostate volume estimated by TAUS and TRUS were 50.30±23 and 50.73±24.6 mL, respectively. The limits of agreement for the total prostate volume were -6.86/9.84 that was larger than predefined clinical acceptable margin of 5 mL.Conclusion: There is a lack of agreement between TAUS and TRUS for estimating the total prostate volume. It is not recommended to apply TAUS instead of TRUS for estimating prostate volume.https://ijms.sums.ac.ir/article_39723_faa73cd670e9d12180212418139e8c48.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101On-Pump Beating Coronary Artery Bypass in High Risk Coronary Patients404439724ENAbbasAfrasiabiradDepartment of Cardiac Surgery,
Madani Heart Hospital,
Tabriz University of Medical Sciences,
Tabriz, IranNaserSafaieDepartment of Cardiac Surgery,
Madani Heart Hospital,
Tabriz University of Medical Sciences,
Tabriz, IranHoseinMontazergaemDepartment of Cardiac Surgery,
Madani Heart Hospital,
Tabriz University of Medical Sciences,
Tabriz, IranJournal Article20150121Background: There are some conflicting results with Conventional Coronary Artery Bypass Grafts (CCABG) with arrested heart in coronary high-risk patients. Moreover, performing off-pump CABG in these cases may be associated with serious complications. The objective of this study is to evaluate the efficacy of the on-pump beating CABG (OPBCABG) in coronary high-risk patients in comparison with the conventional methods.Methods: In a prospective research study, 3000 off-pump CABG patients were considered during June 2003 to December 2011. Among these, 157 patients with one or more of the following risk factors were included for OPBCABG; severe left main stenosis, early post-acute myocardial infarction with ongoing chest pain, unstable angina, intractable ventricular arrhythmia, post complicated coronary intervention and severe left ventricular dysfunction. These patients were compared with 157 similar patients undergone CCABG with aortic cross clamp before 2003.Results: Preoperative patient characteristics revealed no significant differences between the two groups. The patients’ mean age and number of grafts were 57 years and 3 per patient respectively. Hospital mortality was 3.2% and 9% in OPBCABG and CCABG groups, respectively (P<0.001). Preoperative myocardial infarction, requirement of inotropic agents and intraaortic balloon pump, renal dysfunction and prolonged ventilation time were significantly higher in CCABG group.Conclusion: Our results suggest that OPBCABG is effective in coronary high-risk patients and significantly reduces mortality and the incidence of perioperative MI and other major complications.https://ijms.sums.ac.ir/article_39724_7676224bcbb4b9feb6e263cae0c2f163.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Effect of S-Methyl-L-Cysteine on Oxidative Stress, Inflammation and Insulin Resistance in Male Wistar Rats Fed with High Fructose Diet45503972510.30476/ijms.2015.39725ENSitharaThomasDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaGandhipuram PeriyasamySenthilkumarDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaKuppuswamySivaramanDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaZachariahBobbyDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaSankarPaneerselvamDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaKotten ThazhathHarichandrakumarDepartment of Medical Biometrics and Informatics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaJournal Article20150121Background: S-methyl cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in garlic and onion. The purpose of the present study was to investigate the protective effect of SMC on oxidative stress, inflammation and insulin resistance in an experiment of metabolic syndrome.Methods: Male Wistar rats were divided into five groups (6 rats in each group), namely; control, control+S-methyl cysteine (SMC), high fructose diet (HFD), HFD+SMC and HFD+metformin. The 60% fructose used for 8 weeks and SMC in the dose of 100 mg/kg bw/day/rat was used in the study. The fasting glucose, insulin, insulin resistance, and tumor necrosis factor alpha and erythrocyte enzymatic antioxidants were measured.Results: Increased levels of plasma glucose, insulin, malondialdehyde, tumor necrosis factor-alpha, and insulin resistance and decreased levels of glutathione, glutathione peroxidase, and catalase were found in rats on a high fructose diet. Oral administration of SMC (100 mg/kg bw/day/rat) for 60 days resulted in significant attenuation of plasma glucose, insulin, tumor necrosis factor–alpha, insulin resistance and improved antioxidant enzyme activities.Conclusion: Oral treatment of SMC is effective in improving insulin resistance while attenuating metabolic syndrome, inflammation, and oxidative stress in male rats fed with fructose rich diet.https://ijms.sums.ac.ir/article_39725_89e46d909afa4c795a7735bec010e623.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101An Experience of Qualified Preventive Screening: Shiraz Smart Screening Software515739726ENParisaIslami ParkoohiDepartment of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranHashemZareDepartment of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranGholamrezaAbdollahifardDepartment of Community Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran0000-0002-2505-6786Journal Article20150121Background: Computerized preventive screening software is a cost effective intervention tool to address non-communicable chronic diseases. Shiraz Smart Screening Software (SSSS) was developed as an innovative tool for qualified screening. It allows simultaneous smart screening of several high-burden chronic diseases and supports reminder notification functionality. The extent in which SSSS affects screening quality is also described.Methods: Following software development, preventive screening and annual health examinations of 261 school staff (Medical School of Shiraz, Iran) was carried out in a software-assisted manner. To evaluate the quality of the software-assisted screening, we used quasi-experimental study design and determined coverage, irregular attendance and inappropriateness proportions in relation with the manual and software-assisted screening as well as the corresponding number of requested tests.Results: In manual screening method, 27% of employees were covered (with 94% irregular attendance) while by software-assisted screening, the coverage proportion was 79% (attendance status will clear after the specified time). The frequency of inappropriate screening test requests, before the software implementation, was 41.37% for fasting plasma glucose, 41.37% for lipid profile, 0.84% for occult blood, 0.19% for flexible sigmoidoscopy/colonoscopy, 35.29% for Pap smear, 19.20% for mammography and 11.2% for prostate specific antigen. All of the above were corrected by the software application. In total, 366 manual screening and 334 software-assisted screening tests were requested.Conclusion: SSSS is an innovative tool to improve the quality of preventive screening plans in terms of increased screening coverage, reduction in inappropriateness and the total number of requested tests.https://ijms.sums.ac.ir/article_39726_1568bb59d93a13d2ca235b82e8e213aa.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Transvaginal Sacrospinous Ligament Fixation for Pelvic Organ Prolapse Stage III and Stage IV Uterovaginal and Vault Prolapse586239715ENPratikshaGuptaDepartment of Gynecology and Obstetrics, Post Graduate Institute of Medical Sciences and Research, ESI Hospital, Basai Darapur, New Delhi, IndiaJournal Article20150121The result of transvaginal sacrospinous ligament fixation technique, as part of the vaginal repair procedure for massive uterovaginal (Pelvic Organ Prolapse stage III and stage IV and vault prolapse) is evaluated. A total of 32 women were included in the present case series. Marked uterovaginal prolapse was present in 28 women and four had vault prolapse following hysterectomy. Patients with vault prolapse and marked uterovaginal prolapse underwent sacrospinous colpopexy. The mean follow-up period was 2.5 years. Out of the 28 patients with previous marked uterovaginal prolapse, only one had small cystocele 3 years after the surgery. This patient was asymptomatic and did not require repeat surgery. One woman had post-operative urinary tract infection and two had buttock discomfort, one had ischiorectal abscess and two had cuff cellulitis. All complications were dealt with successfully. No other major intra- and post-operative complications occurred. Transvaginal sacrospinous colpopexy can be performed together with vaginal hysterectomy, with marked uterovaginal prolapse and vault prolapse.https://ijms.sums.ac.ir/article_39715_d92e1cf87080fc6ec209bdf11f8da50a.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Identification of Aptamer-Binding Sites in Hepatitis C Virus Envelope Glycoprotein E2636739718ENFanChenDepartment of Biochemistry and Molecular Biology, Life Sciences School of Hubei University, Wuhan, ChinaSi-ChongChenEvolution and Ecology Research Centre, School of Biological, Earth and Environmental Sciences, The University of New South Wales, Sydney, AustraliaJingZhouClinical laboratory, Wuhan Tuberculosis Dispensary, Wuhan Health Bureau, Wuhan, ChinaZhi-DeChenDepartment of Biochemistry and Molecular Biology, Life Sciences School of Hubei University, Wuhan, ChinaFangChenDepartment of Biochemistry and Molecular Biology, School of Basic Medical Science, Wuhan University, Wuhan, ChinaJournal Article20150121Hepatitis C Virus (HCV) encodes two envelope glycoproteins, E1 and E2. Our previous work selected a specific aptamer ZE2, which could bind to E2 with high affinity, with a great potential for developing new molecular probes as an early diagnostic reagents or therapeutic drugs targeting HCV. In this study, the binding sites between E2 and aptamer ZE2 were further explored. E2 was truncated to 15 peptides (P1 to P15) and these peptides were used to detect the affinity with ZE2 by ELISA respectively. The peptide with high affinity was then further truncated, detected and compared with six kinds of HCV genotypes. The basic amino acid in 500 aa bound to ZE2 with high affinity, while acidic amino acid in 501 aa reduced the reaction between E2 and ZE2. The results showed the 500 aa and 501 aa of E2 were the key sites that bound to ZE2.https://ijms.sums.ac.ir/article_39718_5ccd4a2527e8f115bc37c5f9d1b566ed.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101MEFV Gene Profile in Northwest of Iran, Twelve Common MEFV Gene Mutations Analysis in 216 Patients with Familial Mediterranean Fever687239721ENFarhadSalehzadehDepartments of Pediatrics, Bouali Hospital, Ardabil University of Medical Sciences, Ardabil, Iran0000-0001-5539-4404MehdiJafari AslDepartments of Pediatrics, Bouali Hospital, Ardabil University of Medical Sciences, Ardabil, IranSaeidHosseini AslMolecular-Genetic Laboratory, Imam Khomeini Hospital, Ardabil University of Medical Sciences, Ardabil, IranSepidehJahangiriDepartments of Pediatrics, Bouali Hospital, Ardabil University of Medical Sciences, Ardabil, IranShahramHabibzadehDepartment of Infectious Diseases, Bouali Hospital, Ardabil University of Medical Sciences, Ardabil, IranJournal Article20150121Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease with autosomal recessive inheritance pattern often seen around the Mediterranean Sea. It is characterized by recurrent episodes of fever and polyserositis and rash. Recently, MEFV gene analysis determines the definitive diagnosis of FMF. In this study, we analyzed 12 MEFV gene mutations in more than 200 FMF patients, previously diagnosed by Tel-Hashomer clinical criteria, in northwest of Iran, located in the proximity of the Mediterranean Sea. In the northwest of Iran (Ardabil), 216 patients with FMF diagnosis, based on Tel-Hashomer criteria, referred to the genetic laboratory to be tested for the following mutations; P369S, F479L, M680I(G/C), M680I(G/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q. All patients were screened for MEFV gene mutations by a reverse hybridization assay (FMF Strip Assay, Vienna lab, Vienna, Austria) according to manufacturer’s instructions. Among these FMF patients, no mutation was detected in 51 (23/62%) patients, but 165 (76/38%) patients had one or two mutations, 33 patients (15/28%) homozygous, 86 patients (39/81%) compound heterozygous and 46 patients (21/29%) were heterozygous. The most common mutations were M694V (23/61%), V726A (11/11%) and E148Q (9/95%) respectively.MEFV gene mutations showed similarities and dissimilarities in different ethnic groups, while it is common among Arabs and Armenians genotype. Since common 12 MEFV gene analysis could not detect up to 50% of our patients, who had FMF on the basis of clinical Tel-Hashomer criteria, clinical criteria is still the best way in the diagnosis of FMF in this area.https://ijms.sums.ac.ir/article_39721_18bb54b305c74c6026876d404edfc4df.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Sheehan’s Syndrome Presenting as Major Depressive Disorder737639716ENMehmood IQadriDepartment of General Medicine, Sher-e-Kashmir Institute of Medical Sciences, Medical College Hospital, Srinagar, IndiaMohsin BinMushtaqDepartment of General Medicine, Sher-e-Kashmir Institute of Medical Sciences, Medical College Hospital, Srinagar, IndiaIramQaziDepartment of Ophthalmology, Shri Maharaja Hari Singh Hospital, Srinagar, IndiaSameenaYousufDepartment of Preventive and Social Medicine, Sher-e-Kashmir Institute of Medical Sciences, Soura, Srinagar, IndiaAaliyaRashidDivision of Phaco Surgery, Al-Kabir Medical Center, Srinagar, IndiaJournal Article20150121Sheehan’s syndrome or Simmond’s disease is a rare endocrine disorder seen in clinical practice. The clinical spectrum is diverse and a high index of suspicion together with a good clinical acumen and proper diagnostic approach helps in early diagnosis and prompt treatment of this endocrinopathy. Sheehan’s syndrome presenting as a major depressive disorder finds less mention in the literature.The patient discussed here is a 45-year-old female who had been on antidepressants and psychiatry follow up for a long time until she presented to our Out Patient Department (OPD), where she was evaluated in detail and diagnosed as a case of Sheehan’s syndrome. The patient is doing well and is on a regular follow-up with us. Further studies are required to demystify the strength of this association in more detail and to elucidate the possible underlying mechanism.https://ijms.sums.ac.ir/article_39716_a4ad08cbe4fbd565c7af9f14f9107c8b.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Periosteal Osteoblastoma of the Pelvis: A Rare Case778039719ENSwaroopPatelDepartment of Orthopaedics,
Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, IndiaAtulAgrawalDepartment of Orthopaedics,
Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, IndiaRajeshMaheshwariDepartment of Orthopaedics,
Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, IndiaVijendra D.ChauhanDepartment of Orthopaedics,
Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, Uttarakhand, IndiaJournal Article20150121Among the rare bone tumors, the osteoblastoma is a fascinating tumor. The rarity, the predisposition to occur in any bone and the diagnostic dilemma makes this infrequent tumor interesting. It is sporadically reported in the literature and what is rarer is its occurrence in the pelvis. The unusual location and inconclusive radiographic findings with diffused diagnostic evidences delays the management of benign osteoblastoma. We encountered a patient with benign osteoblastoma of the pubic ramus of right side. An excisional biopsy was performed. Peroperatively, the tumor appeared as oval, reddish brown, bony hard mass lying just over the cortex of the right pubic ramus and not breaching the cortex. Histopathological study revealed an osteoid rich lesion. Its presence in pubis must not be ignored and periosteal osteoblastoma should be considered as a differential diagnosis.https://ijms.sums.ac.ir/article_39719_61da72faebbd0ac25952d54908aac872.pdfShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-071640120150101Low Grade Endometrial Stromal Sarcoma: A Case Report818439722ENReenaJainDepartment of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, IndiaSwarajBatraDepartment of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, IndiaAyeshaAhmadDepartment of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, IndiaArifa AnwarElahiDepartment of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, IndiaMonikaGuptaDepartment of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, India0000-0003-3438-2943PoonamSaithDepartment of Obstetrics and Gynaecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, IndiaJournal Article20150121Endometrial stromal sarcoma (ESS) is a rare malignant tumor of the endometrium, occurring in the age group of 40–50 years. We report a case of low-grade ESS in a 39-year-old woman, presenting as rapid enlargement of a uterine fibroid polyp associated with irregular and excessive vaginal bleeding. Polypectomy followed by pan hysterectomy was performed. Histopathological examination and immunohistochemistry confirmed LGESS. As the tumor is rarely encountered, management protocols are still questionable. In our case, we tried a different post-surgical protocol and the patient is being closely followed up. Although rare, ESS should be considered in the differential diagnosis of all women who present with a rapid enlargement of a uterine leiomyoma.https://ijms.sums.ac.ir/article_39722_989e64387826fdaf1c84bd6375500ffb.pdf