%0 Journal Article %T Pre-Ischemic Treatment of Pentoxifylline Reduces Infarct Volumes in Transient Focal Cerebral Ischemia in the Rat %J Iranian Journal of Medical Sciences %I Shiraz University of Medical Sciences %Z 0253-0716 %A Nekooeian, A.A. %A Vakili, A. %A Dehghani, G.A. %D 2005 %\ 12/01/2005 %V 30 %N 4 %P 169-173 %! Pre-Ischemic Treatment of Pentoxifylline Reduces Infarct Volumes in Transient Focal Cerebral Ischemia in the Rat %R %X Background: Pentoxifylline (PTX) is used in human for intermittent claudication and cerebral vascular disorders including cerebrovascular dementia. It also inhibits the synthesis of tumor necrosis factor-α (TNF-α), which is believed to be neurotoxic in animal models of cerebral ischemia. The objective of this study was to examine the role of PTX on ischemia/reperfusion injures in rat model of transient focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO). Methods:Male Sprague Dawley rats (n=31) were assigned to sham, saline or PTX (30 or 60 mg/kg)-treated groups.  Ischemia was induced by MCAO, followed by 24-hrs reperfusion. Intraperitoneal saline or PTX was administered at 30 min before ischemia. Neurological deficit score test (NDS) was performed after 24-hrs, and the animals was sacrificed for evaluation of cortical and striatal infarct volumes using triphenyltetrazolium chloride staining. Results: The sham group did not have neural dysfunction or cerebral infarction. Cortical infarct volumes in 30 or 60 mg/kg PTX-treated groups, 149±12 and 129±19 mm3 respectively, were significantly lower than that of saline-treated group (208 ±12 mm3). Similar results were also obtained about the striatal infarct volumes (39±5 and 40±6 vs. 58±5 mm3). However, there was no significant difference among the neurological dysfunctions from saline and PTX-treated rats. Conclusion: the results of this study indicate that pentoxifylline reduced cerebral infarctions, possibly by diminishing the TNF-α-induced neurotoxicity in transient focal cerebral ischemia. This finding also suggests that pentoxifylline might be suitable for clinical trials. %U https://ijms.sums.ac.ir/article_40096_840dfdaa183cfdc01edb3217496718b7.pdf