TY - JOUR ID - 48022 TI - Manifestation of Ocular Myasthenia Gravis as an Initial Symptom of Coronavirus Disease 2019: A Case Report JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Rahimian, Neda AU - Alibeik, Nazanin AU - Pishgar, Elham AU - Dini, Parisa AU - Abolmaali, Meysam AU - Mirzaasgari, Zahra AD - Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran AD - Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran AD - Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran AD - Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran Y1 - 2022 PY - 2022 VL - 47 IS - 4 SP - 385 EP - 388 KW - COVID-19 KW - Myasthenia gravis KW - SARS-CoV-2 KW - Case report DO - 10.30476/ijms.2021.89841.2061 N2 - For a while, coronavirus disease-2019 (COVID-19) has been a major global pandemic. It primarily affects the respiratory system but has extrapulmonary manifestations such as gastrointestinal and neurological symptoms. Data on myasthenia gravis (MG), as a complication of COVID-19, are limited. We herein report the manifestation of ocular MG as an initial symptom of COVID-19. In November 2020, a 31-year-old healthy woman was referred to Firoozgar Hospital (Tehran, Iran) with left upper eyelid ptosis and diplopia as well as general weakness, myalgia, fever, and nasal congestion for four days prior to admission. Although the acetylcholine receptor antibody in her serum was negative, increased jitter in several muscles led to the diagnosis of ocular MG. Nasal swab reverse transcription-polymerase chain reaction (RT-PCR) assay tested positive for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection. Computed tomography (CT) scan of the chest revealed bilateral ground-glass opacities and some foci of consolidation formation, but the thymus was normal. The patient was successfully treated with remdesivir and dexamethasone. The patient was eventually discharged in good condition and with improved neurological symptoms. A limited number of studies have suggested a possible association between MG and COVID-19. Therefore, further data are required to substantiate the proposed association. Clinicians should be aware of ocular MG during the COVID-19 pandemic to better diagnose and manage patients with SARS-CoV-2 infection. UR - https://ijms.sums.ac.ir/article_48022.html L1 - https://ijms.sums.ac.ir/article_48022_d81e4b47ea0f8c9741a3d58053981801.pdf ER -