TY - JOUR ID - 47500 TI - The Comparison of the Efficacy of Early versus Late Administration of Dexmedetomidine on Postoperative Emergence Agitation in Children Undergoing Oral Surgeries: A Randomized Clinical Trial JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Sadeghi, Afsaneh AU - Razavi, Seyed Sajad AU - Eghbali, Ahmad AU - Mahdavi, Seyed Alireza AU - Kimia, Fereshteh AU - Panah, Ashkan AD - Anesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran AD - Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2022 PY - 2022 VL - 47 IS - 1 SP - 25 EP - 32 KW - Delayed emergence from anesthesia KW - Emergence delirium KW - Dexmedetomidine KW - Cleft Palate KW - Tonsillectomy DO - 10.30476/ijms.2020.84509.1471 N2 - Background: Emergence Agitation (EA) is a dissociated state of consciousness characterized by irritability, uncompromising stance, and inconsolability. The etiology of EA is not completely understood. Dexmedetomidine is a highly selective α2-adrenoreceptor agonist with sedative and analgesic properties, which has been used to reduce the incidence of EA. We aimed to assess the efficacy of early versus late administration of dexmedetomidine on EA in children undergoing oral surgery.Methods: A randomized, parallel, double-blind clinical trial was conducted at Mofid Children’s Hospital affiliated to Shahid Beheshti University of Medical Sciences (Tehran, Iran) from November 2016 to March 2017. A total of 81 children, who underwent adenotonsillectomy or cleft palate repair surgery were enrolled in the study. Based on simple randomization, the children were assigned to two groups, namely early (group A, n=41) and late (group B, n=40) administration of dexmedetomidine. Intra-operative and postoperative hemodynamic variables, extubation time, post-anesthesia care unit (PACU) length of stay, and the scores on Ramsay sedation scale and FLACC pain scale were measured and compared. The data were analyzed using SPSS software (version 20.0), and p Results: The mean FLACC score was lower in the late group than in the early group (2.0±1.5 vs. 4.2±1.6, p <0.001). The mean Ramsay sedation score was higher in the late group than in the early group (3.5±1.4 vs. 1.8±0.8, p <0.001).Conclusion: Late administration of dexmedetomidine 1 µg/kg reduced the incidence of EA and PACU length of stay and improved postoperative pain management.Trial registration number: IRCT 2016122031497N1. UR - https://ijms.sums.ac.ir/article_47500.html L1 - https://ijms.sums.ac.ir/article_47500_961671596fa5891a6948930670b41f1c.pdf ER -