TY - JOUR ID - 45771 TI - Acantholytic and Pagetoid Variant of Bowen’s Disease with Microinvasion on the Scalp of a Young Female Patient: A Case Report JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Nasimi, Maryam AU - Azizpour, Arghavan AU - Nikoo, Azita AU - Abedini, Robabeh AU - Shakoei, Safoura AD - Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Y1 - 2019 PY - 2019 VL - 44 IS - 6 SP - 511 EP - 514 KW - Bowen’s disease KW - Pemphigus KW - Keratin-7 KW - Skin neoplasms KW - Acantholysis DO - 10.30476/ijms.2019.45771 N2 - Bowen’s disease (BD) is a non-melanoma skin cancer with several histological subtypes. Herein we describe a case of a 35-year-old woman with a 4-cm diameter crusted plaque on the parietal scalp region. She had the lesion for 2 years. It had previously been histologically diagnosed as pemphigus vulgaris and only treated with a topical cream. The lesion progressively became thicker and larger. A new biopsy showed atypical cell proliferation through the whole thickness of the epidermis and follicular epithelium, with dermal microinvasion along with acantholysis and clear cell formation. The patient underwent total lesion excision (1 cm margin) with the diagnosis of both acantholytic and pagetoid subtypes of BD and dermal microinvasion. We describe a rare case of a young female patient with both subtypes of BD present in one lesion on an area not exposed to the sunlight. The lesion was initially misdiagnosed as pemphigus vulgaris. UR - https://ijms.sums.ac.ir/article_45771.html L1 - https://ijms.sums.ac.ir/article_45771_e2fe019d8a3a732836af65177484393a.pdf ER -