@article { author = {Shidfar, Farzad and Faghihi, Amirhosein and Lorvand Amiri, Hamid and Mousavi, Seyedeh Neda}, title = {Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats}, journal = {Iranian Journal of Medical Sciences}, volume = {43}, number = {1}, pages = {26-31}, year = {2018}, publisher = {Shiraz University of Medical Sciences}, issn = {0253-0716}, eissn = {1735-3688}, doi = {10.30476/ijms.2018.40508}, abstract = {Background: Studies have shown that zinc and selenium deficiency is common in nonalcoholic fatty liver disease (NAFLD). However, the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD are not clear enough. The aim of this study was to compare the effects of zinc and selenium co-supplementation before and/or after disease progression on NAFLD prognosis.Methods: Forty male Sprague–Dawley rats (197±4 g) were randomly assigned to 4 dietary groups: normal-fat diet (NFD; receiving 9% of calories as fat), high-fat diet (HFD; receiving 82% of calories as fat), supplementation before disease progression (S+HFD), and supplementation after disease progression (HFD+S). The diets were implemented over a 20-week period in all the groups. Biochemical and histologic parameters were compared between the 4 groups, and between-group comparisons were also carried out.Results: There were significant differences in the average food dietary intake (P}, keywords = {Fatty liver,Trigelycerids,Lipid profile,Selenium,Zink,Cholestrol}, url = {https://ijms.sums.ac.ir/article_40508.html}, eprint = {https://ijms.sums.ac.ir/article_40508_3283036811d7fdd92b9c6ebc5b5a2530.pdf} }