TY - JOUR ID - 39651 TI - Histomorphological Alterations in the Prostate Gland and Epithelium of Seminiferous Tubule of Sprague-Dawley Rats Treated with Methanolic Extract of Momordica charantia Seeds JO - Iranian Journal of Medical Sciences JA - IJMS LA - en SN - 0253-0716 AU - Oshiozokhai Eboetse, Yama AU - Francis Ikechukwu, Duru AU - Abayomi Olugbenga, Okanlawon AU - Ayodele, Oremosu Ademola AU - Cressie Caramel, Noronha AD - Department of Anatomy College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria Y1 - 2011 PY - 2011 VL - 36 IS - 4 SP - 266 EP - 272 KW - Momordica charantia KW - Sprague-Dawley rats KW - Prostate KW - testes KW - seminniferous tubules DO - N2 - Background: There is yet a dearth of literature on the antifertility effect of Momordica charantia on the male reproductive system. The aim of this study was to determine the effect of graded oral doses of methanolic seed extract of Momordica charantia on the histology of prostate gland and seminiferous tubules of rats. Methods: Forty male Sprague-Dawley rats, weighing 176±7 g were assigned randomly into four main groups A to D of 10 rats per group. Groups A to C received daily oral doses of15, 25 or 50 mg/100 g body weight of the seed extract for 56 days. Group D (control) received physiological saline. In each group, five rats were sacrificed on day 57, the remaining half on day 113 (56 days after withdrawal of the extract). The testes and prostate were processed for histological examination. Results: There was a dose-related alteration in the cytoarchitecture of seminiferous tubules with marked reduction in spermatogenic series. The prostate gland showed dilatation as well as increased intraluminal secretions with increasing dose. Moreover, there was a significant recovery of prostate tissue as the sections were similar to their control counterpart. Conclusion: the findings of the present study indicate that methanolic extract of Momordica charantia seeds caused reversible histological alterations in the prostate and testes of Sprague-Dawley rats. UR - https://ijms.sums.ac.ir/article_39651.html L1 - https://ijms.sums.ac.ir/article_39651_6ce5a09cd2bdede11c0c441e2326db03.pdf ER -